HistocompatibilityMoleculesBroad antigenEpitopesMelanoma-associatedDonorGeneHumanAutoantibodiesAntibodyHumansLinkage disequilibriumAntibodiesReactivityPeptidesLeukocyteAlleleRecognitionTumorGenotypesDonorsProteinInfectionDengueImmune responseAssaysClassAntigenicCollectivelyTyphiPatientsHaplotypesTransplantationSalmonellaImmunotherapyIdentifiesBody'sVaccineAssociationsSubtypesGenesClonesProteinsTypingSpecificSequenceTransplantMechanismsDistinguishCellCellsMolecularSurvival
Histocompatibility5
- Human lymphocyte antigen B27, human leukocyte A antigen, histocompatibility leukocyte A antigen What is this test? (web.app)
- This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
- Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
- To date, high-resolution HLA typing ended up being executed along with Sanger sequencing, nevertheless for methodological motives information on added immunocompetent main histocompatibility intricate loci hasn't been uncovered. (casr-signal.com)
- Foreign antigens are first processed and presented by an individual's major histocompatibility complex (MHC). (biorxiv.org)
Molecules6
- Det innebär att de flesta av There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a Den huvudsakligen genetiska riskfaktoren för AS är HLA B27 som finns hos B. vid långvarig inflammatorisk ryggsmärta i senare skede Penttinen, MA. (web.app)
- I have used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. (cardiff.ac.uk)
- MHC class II molecules are specialized peptide receptors that play a critical role in initiating and regulating immune responses by binding peptide fragments that are 10-30 amino acids long [ 1 ] and present them on the surface of antigen-presenting cells for recognition by CD4 + T cells. (biomedcentral.com)
- However, very little is known about the precise impact of CVB on β-cells, including the presentation of viral epitopes by HLA class I (HLA-I) molecules and their recognition by cytotoxic CD8+ T cells. (institutcochin.fr)
- First, we identified by mass spectrometry the peptides presented by the HLA-A2 and HLA-A3 molecules expressed on the surface of a human ECN90 β-cell line infected with different CVB serotypes. (institutcochin.fr)
- Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DRbeta1*03 molecules induces antibody production and protection. (shengsci.com)
Broad antigen2
- HLA-A10 is a broad antigen HLA-A serotype. (wikipedia.org)
- A24 is a split antigen that is also recognized by the A9 broad antigen type and the similar A23 types. (thermofisher.cn)
Epitopes5
- We hypothesized that many tumor associated antigens (Ag) are readily susceptible to immune attack, but only in the context of identifying the tumor antigen epitopes that can reliably initiate an immune response, regardless of individual patient human leukocyte antigen (HLA) haplotype restrictions. (ndltd.org)
- We further hypothesized that epitope prediction strategies which seek to identify pan- or highly promiscuous-HLA binding epitopes would reduce the number of potential candidates and be more likely to accurately identify high-priority tumor Ag epitopes. (ndltd.org)
- Predictions resulted in identification of highly promiscuous-HLA binding epitopes. (ndltd.org)
- Mapping and definition of HLA class I and II serologic epitopes using an unbiased reverse engineering strategy. (stanford.edu)
- Current models describing HLA epitopes are both theoretical and empirical. (stanford.edu)
Melanoma-associated2
- Further investigations of melanoma-associated antigens present in Melacine and presented by HLA-A2 and HLA-Cw3 may be warranted. (northwestern.edu)
- MRP-L28 (39S ribosomal protein L28, melanoma-associated antigen recognized by T lymphocytes) is a mitochondrial protein that belongs to the ribosomal protein L28P family. (thermofisher.cn)
Donor4
- Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
- DSA-FXM: Accelerated donor specific flow crossmatch discriminating class I and II antibody specifically and only to donor HLA for determining true incompatibility. (stanford.edu)
- In the absence of autoantibodies, an incompatible crossmatch in a sensitized patient is attributed to mismatched donor human leukocyte antigens (HLA). (stanford.edu)
- Result interpretation is difficult or impossible when autoantibodies, alloantibodies, and/or therapeutic antibodies coexist.METHODS: Herein we describe a unique donor specific flow crossmatch (DSA-FXM) that distinguishes HLA class I and/or II DSA bound to HLA antigens on the donor cell surface in their native conformation that is not impacted by rituximab, ATG (after absorption), or auto-antibodies. (stanford.edu)
Gene6
- The ancestral A10 type is believed to be A*2601, which via gene conversion with other HLA-A alleles produced A*2501, A*3401, A*4301 and A*6601. (wikipedia.org)
- HLA gene distribution correlates with increased susceptibility as well as with increased resistance ( 4 ). (cdc.gov)
- The Effect of the HLA-B27 Gene on COVID-19 Evidence has long suggested that the HLA-B27 gene offers protection against HIV, hepatitis C, and possibly influenza. (web.app)
- Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. (biomedcentral.com)
- HLAA24 (A24) is an HLA-A serotype that identifies the more common HLA-A24 gene products. (thermofisher.cn)
- These genes code for proteins that are involved in cell-cell adhesions (CTNNA3), glutathione conjugation for xenobiotic metabolism (GST gene family), and immune system response (HLA gene family). (cdc.gov)
Human15
- HLA B27 (human leukocyte antigen) is a protein found on the surface of white blood cells of certain individuals. (web.app)
- The protein is called human leukocyte antigen B27 (HLA-B27). (web.app)
- Human leukocyte antigens (HLAs) are proteins that help the body's immune system tell the difference between its own cells and foreign, harmful substances. (web.app)
- HLA-B27 stands for human leukocyte antigen B27. (web.app)
- Human pDC do not express lineage specific markers, but are characterized by the expression of HLA-DR, CD4, CD123, BDCA2 and BDCA4 [ 3 ]. (biomedcentral.com)
- 2023. Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02 . (cardiff.ac.uk)
- Novel risk human leukocyte antigen (HLA) allotypes for different subgroups of spondyloarthritis (SpA) were identified in an Italian population, according to findings from a study published in Journal of Clinical Medicine . (rheumatologyadvisor.com)
- Postinfectious (reactive) arthritis may occur in human leukocyte antigen (HLA)-B27-positive patients a few days to several weeks after an episode of C. jejuni diarrhea. (msdmanuals.com)
- Manufacturing of monoclonal antibodies to group A erythrocytes, HLA and different human cell floor antigens-new instruments for genetic evaluation. (sigmabioblogs.com)
- Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)
- Patient characteristics, such as human leukocyte antigen (HLA) type, immunosuppression (e.g. (kidsnewtocanada.ca)
- This phase Ib trial evaluated the safety and immunogenicity of human serotype-5 Ad-vectored tuberculosis (TB) vaccine (AdHu5Ag85A) delivered to humans via inhaled aerosol or i.m. injection.MethodsThirty-one healthy, previously BCG-vaccinated adults were enrolled. (bvsalud.org)
- The protection against SARS-CoV-2 induced by BCG vaccination may be mediated by cross-reactive T cell lymphocytes, which recognize peptides displayed by class I Human Leukocyte Antigens (HLA-I) on the surface of infected cells. (bvsalud.org)
- Typing for human leukocyte antigen-B27 is appropriate for patients with recurrent anterior uveitis. (aafp.org)
- As the MHC is encoded by highly polymorphic human leukocyte antigen (HLA) loci in humans, this process of thymic selection occurs within the context of an individual's HLA type. (biorxiv.org)
Autoantibodies3
- [7] Circulating autoantibodies, cytokines, dermal dendrocytes, HLA serotypes, immune complexes, leukotactic mechanisms, and type 1 T helper cells have all been suggested as factors contributing to the pathogenesis of SS. (eyewiki.org)
- Both a temporal correlation between CVB infection that precedes seroconversion of autoantibodies to β-cell antigens, and a spatial association of CVB with insulitis in pancreatic tissues from T1D patients have been observed. (institutcochin.fr)
- Thus, my work shows that CVB infection generates a limited CD8+ T-cell response and memory in terms of epitope coverage and frequency, which could predispose to the persistent infections that have been associated with the seroconversion of autoantibodies to β-cell antigens. (institutcochin.fr)
Antibody2
- This is a classic type II reaction in the Gell and Coombs classification of antigen-antibody reactions. (medscape.com)
- A serum sample test showed a weak positive result for dengue virus by using IgM and IgG antibody tests, and a strong positive result for dengue virus nonstructural protein-1, or NS1, antigen, demonstrating acute dengue virus infection. (cdc.gov)
Humans2
- VSV-GP128 is a recombinant live-attenuated Vesicular Stomatitis Virus (VSV), modified to minimize the potential of neurotoxicity for humans and skin disease in animals, and engineered to contain cancer antigens, which help it induce an immune response against colorectal tumour cells. (biosafety.be)
- Dengue virus, an arthropod-borne RNA virus of the Flaviviridae family, has 4 serotypes that cause dengue fever or dengue hemorrhagic fever in humans. (cdc.gov)
Linkage disequilibrium1
- While specific DP, DQ or DR alleles at the HLA class II locus have been shown to correlate with particular autoimmune diseases, a variety of confounding factors including strong linkage disequilibrium between the different HLA alleles, especially DR and DQ, complicates the exact identification of MHC susceptibility alleles. (biomedcentral.com)
Antibodies3
- Expand your knowledge of HLA antibodies and molecular typing. (thermofisher.com)
- Neisseria meningitidis serogroups B and C have been initially subdivided into serotypes by means of two totally different classification programs based mostly upon type-specific bactericidal antibodies and immunoprecipitation in agar gels, respectively. (sigmabioblogs.com)
- Opsonization-independent antigen-specific recognition by myeloid phagocytes expressing monoclonal antibodies. (uni-heidelberg.de)
Reactivity2
- Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8(+) T cell response. (expasy.org)
- However, current physical crossmatch methods cannot distinguish reactivity to HLA from other clinically irrelevant cell surface targets nor the class of HLA if it is the target. (stanford.edu)
Peptides1
- We observed a decreased HLA-I expression after infection, associated with the presentation of only few viral peptides derived from structural and non-structural proteins (n=16). (institutcochin.fr)
Leukocyte1
- Within haematopoietic stem cell hair transplant, on the basis of completely individual leukocyte antigen (HLA)-matched contributor beneficiary frames, negative effects similar to graft vs . leukaemia and also graft compared to host tend to be seen and hard to manage. (casr-signal.com)
Allele2
- 2004). "HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia" (PDF). (wikipedia.org)
- However, we detect a significant correlation between increased HLA allele sharing and increased number of shared TCRβ clones, with each additional shared HLA allele contributing to an increase in ∼0.01% of the total TCRβ clones being shared, supporting a key role for HLA type in shaping the immune repertoire. (biorxiv.org)
Recognition4
- I have unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. (cardiff.ac.uk)
- 2020. Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion . (cardiff.ac.uk)
- Antigen recognition depends on both T-cell specificity and the molecular complex presenting the antigen. (biorxiv.org)
- Successful antigen recognition requires T cells to effectively recognize the body's MHC and coordinate a response. (biorxiv.org)
Tumor4
- This mechanistically rational antigen selection sequence, effective even for unvaccinated donors, regardless of HLA-haplotype, enables rapid identification of tumor protein regions relevant for cancer immunology, including adoptive immunotherapy, vaccines, and even identification of tumor neo-antigens unique to each patient. (ndltd.org)
- MRP-L28 potentially represents an important therapeutic reagent for HLA-A24 (A24) patients as this antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290, which targets the A24 serotype. (thermofisher.cn)
- Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
- CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
Genotypes1
- This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. (hindawi.com)
Donors1
- Between 2008 and 2013, a total of 113 consecutive patients with symptomatic peripheral E/A and 318 HLA-I and HLA-II serotyped healthy donors as control participants were included. (rheumatologyadvisor.com)
Protein3
- HLA-B27 is a blood test to look for a protein that is found on the surface of white blood cells. (web.app)
- This HLA-B27 is a blood test to check for a specific protein on your white blood cell that could trigger an auto-immune disease such as Ankylosing Spondylitis (AS). (web.app)
- Protein network functions for the DA-associated genes from this review include: antigen processing, lymphocyte activation, cytokine production regulation, and response to oxidative stress. (cdc.gov)
Infection4
- Enteric fever is an acute, life-threatening, febrile infection caused by Salmonella enterica serotypes Typhi, Paratyphi A and Paratyphi B. Each year, there are an estimated 22 million cases and 200,000 related deaths worldwide due to Salmonella typhi . (kidsnewtocanada.ca)
- C. neoformans was categorized into serotypes A and D whereas C. gattii was classified into the serotypes B and C. Inhalation of spores is a primary route of infection that mainly affects immunocompromised persons, such as HIV-infected patients, organ transplant recipients, and patients receiving corticosteroid or immunosuppressive agents. (biomedcentral.com)
- A nationwide vaccination programme in Italy against hepatitis B virus infection in infants of hepatitis B surface antigen-carrier mothers. (shengsci.com)
- In order to prevent hepatitis B virus (HBV) infection of infants of hepatitis B surface antigen (HBsAg)-positive mothers, a nation-wide immunization programme was initiated in Italy in January 1984. (shengsci.com)
Dengue1
- It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
Immune response2
- The mRNA vaccines can encode multiple antigens, strengthening the immune response against pathogens and enabling the targeting of multiple microbial variants [19] . (researchgate.net)
- T cells that encounter their specific cognate MHC-presented antigen will bind and proliferate, leading to an immune response. (biorxiv.org)
Assays2
- This series of six virtual workshops trains users on how to use LABType assays, TypeStream Visual software, LABScreen assays, AllType NGS assays, AllType FASTplex assays, and HLA Matchmaker software. (thermofisher.com)
- In the transplant population, antigen assays or PCR is used (sometimes in conjunction with cytopathology) for diagnosis and treatment determinations. (medscape.com)
Class2
- Recently my team has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen. (cardiff.ac.uk)
- Class II HLA Serotype Associations with End-Stage Renal Disease due to Membranous Nephropathy among Caucasians in the United States Charu, V., Tyan, D., Troxell, M., Kambham, N. NATURE PUBLISHING GROUP. (stanford.edu)
Antigenic2
- One such mechanism is antigenic variation, in which the antigens of B. burgdorferi exposed to the immune system can change over time, either through epigenetic modification, DNA recombination, or mutually exclusive expression (8). (insidescientific.com)
- Surprisingly, we find that shared antigen exposure to CMV leads to fewer shared TCRβ clones, even after controlling for HLA, indicative of a largely private response to major viral antigenic exposure. (biorxiv.org)
Collectively1
- As a result, VDJ recombination, HLA restriction, and antigen exposure collectively contribute to a largely private TCRβ repertoire. (biorxiv.org)
Typhi1
- Fig. 5: HlyE and CdtB are S . Typhi- and S . Paratyphi A-specific immunodominant T cell antigens. (nature.com)
Patients5
- There was no impact of HLA-A2 and/or HLA-Cw3 expression on observation arm patients. (northwestern.edu)
- An analysis of mature data from S9035 indicates a significant OS benefit from adjuvant vaccine therapy for patients with HLA-A2- and/or HLA-Cw3-expressing melanoma. (northwestern.edu)
- CD8 + CTL clones recognizing minor H antigens were isolated from five patients studied. (aacrjournals.org)
- There is no consistent evidence of a genetic predisposition for SS, however there are documented associations between HLA-B54 typing and SS, particularly amongst Japanese patients. (eyewiki.org)
- Researchers studied the HLA profile of patients with enthesitis and/or arthritis not fulfilling the ASAS criteria, with an emphasis on psoriatic arthritis and undifferentiated spondyloarthritis. (rheumatologyadvisor.com)
Haplotypes1
- Utilizing known HLA-serotype frequencies and setting a threshold of ninety percent of population coverage, regardless of race or ethnicity, twenty-nine different HLA-DRB1 haplotypes were chosen for antigen prediction utilizing the open source epitope prediction algorithm netMHCIIpan. (ndltd.org)
Transplantation1
- HLA-B27: a blood test done as part of paternity investigations, to indicate tissue compatibility with tissue transplantation, and to assist in the diagnosis of Reiter's syndrome and other conditions. (web.app)
Salmonella1
- Our results identify immune-dominant, serovar-specific, and cross-reactive T cell antigens, which should aid in the design of T cell-vaccination strategies against Salmonella . (nature.com)
Immunotherapy1
- The possibility of interactions between HLA type and outcome should be considered in future immunotherapy trials. (northwestern.edu)
Identifies1
- An HLA-B27 test is a blood test that identifies HLA-B27 proteins. (web.app)
Body's2
- The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (web.app)
- Nanovaccines can improve antigen presentation, targeted delivery, stimulation of the body's innate immune system, and a strong T-cell response without putting people at risk. (researchgate.net)
Vaccine1
- extensive use of live, attenuated oral poliovirus vaccine (OPV) in routine childhood immunization programs and mass campaigns has led to eradication of two of the three wild poliovirus (WPV) serotypes (types 2 and 3) ( 1 ). (cdc.gov)
Associations1
- The effects of treatment on relapse-free survival (RFS) and overall survival (OS) were evaluated, and prespecified analyses investigated associations between treatment and HLA expression. (northwestern.edu)
Subtypes1
- 2020-12-03 · There are multiple subtypes of HLA-B27, and the specific types associated with ankylosing spondylitis include HLA-B*2701, HLA-B*2702, HLA-B*2704, HLA-B*2705, and HLA-B*2707. (web.app)
Genes1
- Researchers reported prevalence odds ratios (PORs) for 943 comparisons in 82 different genes/serotypes. (cdc.gov)
Clones1
- Fig. 3: Analysis of libraries of CD38 + CCR7 - T cell clones and fluorescence barcoding to dissect the antigen-specific repertoire of effector CD4 + T cells. (nature.com)
Proteins2
- This test looks for HLA-B27, which are proteins called antigens. (web.app)
- The CD64 proteins are high affinity receptors (~10 -8 ‑10 -9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10 -6 ‑10 -7 M) only recognizing IgG aggregates surrounding multivalent antigens (1, 4). (novusbio.com)
Typing1
- Researchers concluded that HLA typing could help diagnose and treat E/A subgroups, and identify family members who might be at risk, particularly individuals with enthesitis and/or arthritis who do not meet the criteria for being diagnosed with uSpA. (rheumatologyadvisor.com)
Specific1
- [3] Analysis of HLA antigens in a Caucasian population, however, showed no association between SS and specific HLA-ABC antigens. (eyewiki.org)
Sequence1
- DENV-2 was the most prevalent serotype in several outbreaks in the Americas [ 6 ] and was epidemiologically classified as the most relevant serotype worldwide due to its association with the highest number of intense outbreaks, followed in sequence by DENV-3, DENV-1, and DENV-4 [ 25 ]. (hindawi.com)
Transplant1
- Learn the latest HLA technical and clinical advancements in transplant diagnostics. (thermofisher.com)
Mechanisms1
- 2023. CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms . (cardiff.ac.uk)
Distinguish1
Cell3
- The latter expressed the PD-1 marker, suggesting an exhausted phenotype, and shared expanded, yet private, antigen T-cell receptors (TCRs) with peripheral tissues. (institutcochin.fr)
- However, certain factors such as low junctional diversity, thymic selection, and T-cell proliferation upon antigen exposure can affect TCR sharing among individuals. (biorxiv.org)
- Consistent with this hypothesis, we find that increased age is correlated with decreased overall TCRβ clone sharing, indicating that the pattern of private TCRβ clonal expansion is a general feature of the T-cell response to other infectious antigens. (biorxiv.org)
Cells1
- 2020. Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells . (cardiff.ac.uk)
Molecular1
- Molecular docking, molecular dynamic simulation, and immune simulation were performed to ensure the binding between HLA and TLR4. (springeropen.com)
Survival1
- A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program. (uni-heidelberg.de)