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Schizosaccharomyces pombe ProteinsSchizosaccharomycesMolecular Sequence DataAmino Acid SequenceGenes, FungalSaccharomycetalesFungal ProteinsDNA, FungalSerineGene Expression Regulation, FungalAscomycotaMutationProtein TransportSaccharomyces cerevisiae ProteinsSequence Homology, Amino AcidSaccharomyces cerevisiaeBase SequenceVesicular Transport ProteinsSpores, FungalCloning, MolecularCell Cycle ProteinsCOP-Coated VesiclesTransport VesiclesChromosomes, FungalGenetic Complementation TestRNA, FungalMeiosisMitosisProtein BindingThiabendazoleRecombinant Fusion ProteinsGolgi Apparatustrans-Golgi NetworkProtein Structure, TertiaryGene DeletionCell CycleVacuolesEndosomesSequence AlignmentHydroxyureaPhenotypeGenome, FungalGenes, Mating Type, FungalCell NucleusCarrier ProteinsGreen Fluorescent ProteinsDNA-Binding ProteinsCytokinesisRestriction MappingTemperatureMembrane ProteinsSerine EndopeptidasesMicroscopy, FluorescenceRecombination, GeneticAdaptor Protein Complex 1Endoplasmic ReticulumProtein KinasesPlasmidsBiological TransportDNA ReplicationActivating Transcription Factor 1Models, BiologicalMutagenesisAdaptor Protein Complex 2ClathrinTwo-Hybrid System TechniquesSecretory VesiclesCentromereCoatomer ProteinKaryopherinsActive Transport, Cell NucleusNuclear ProteinsConserved SequenceBinding SitesLuminescent ProteinsAmino Acid MotifsDNA Repairrab GTP-Binding ProteinsProtein-Serine-Threonine KinasesEndocytosisDNA DamageCoated VesiclesCell MembraneCDC2 Protein KinaseCell DivisionChlorprophamPhytochelatinsTranscription, GeneticSpindle ApparatusPhosphorylationEndosomal Sorting Complexes Required for TransportTrehalaseCoat Protein Complex ISuppression, GeneticApc5 Subunit, Anaphase-Promoting Complex-CyclosomeGenes, EssentialClathrin-Coated Vesiclesalpha KaryopherinsMonomeric GTP-Binding ProteinsHeLa Cells
EukaryoticGeneRibosomalNuclear exportFunctionalComponentStructureEventComplexAminoKinasesMembraneRegulatoryAnalysis
Eukaryotic2
  • Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs. (wikipedia.org)
  • Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Structural inventory of cotranslational protein folding by the eukaryotic RAC complex, Nat. (db-engine.de)
Gene2
  • The structural details of the interaction of XPO1 with its cargos were revealed two decades after the gene was identified. (wikipedia.org)
  • Using a historic B. subtilis strain harboring the heat-sensitive SPß c2 mutant, we demonstrate that the lytic cycle of SPß c2 can be induced by heat due to a single nucleotide exchange in the mrpR gene, rendering the encoded MrpRG136E protein temperature-sensitive. (bvsalud.org)
Ribosomal1
  • The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation. (db-engine.de)
Nuclear export3
  • It was later shown to be the nuclear transport receptor for cargos with leucine-rich nuclear export signals (NES). (wikipedia.org)
  • For example, it is required for the nuclear export of HIV-1 RNA in complex with the viral protein Rev, an event that is a crucial part of the infection cycle. (wikipedia.org)
  • Nuclear mRNA transcripts acquire a protein coat composed of cap- and RNA-binding proteins that allow nuclear export and dictate the functional program of cytoplasmic mRNAs ( Moore, 2005 ). (rupress.org)
Functional1
  • functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)
Component1
  • Bacillus subtilis contains the SPß prophage whose lysogenic state depends on the MrpR (YopR) protein, a key component of the lysis-lysogeny decision system. (bvsalud.org)
Structure2
  • XPO1 (CRM1) originally was identified in the fission yeast Schizosaccharomyces pombe in a genetic screen, and investigators determined that it was involved in control of the chromosome structure. (wikipedia.org)
  • Taking into account a crystal structure of Mtr4 interacting with a truncated, short Trf4 fragment (interaction of Mtr4 and short Air2 fragment is shown as well), one can argue for ring-interaction between the phenylalanine position and a tyrosine on the interacting protein (Mtr4). (eu.org)
Event1
  • The duplication of the polymerase Trf and the zinc knuckle protein Air arose due to a whole genome duplication event in Saccharomyces cerevisiae ( 15004568 ). (eu.org)
Complex1
  • The TRAMP complex consists of a RNA helicase (MTR4), a poly(A)polymerase (Trf4 or Trf5) and a RNA-binding zinc knuckle protein (Air1 or Air2). (eu.org)
Amino1
  • A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). (wikipedia.org)
Kinases5
  • clarification needed] The mammalian MAPK family of kinases includes three subfamilies: Extracellular signal-regulated kinases (ERKs) c-Jun N-terminal kinases (JNKs) p38 mitogen-activated protein kinases (p38s) Generally, ERKs are activated by growth factors and mitogens, whereas cellular stresses and inflammatory cytokines activate JNKs and p38s. (wikipedia.org)
  • Mitogen-activated protein kinases are catalytically inactive in their base form. (wikipedia.org)
  • citation needed] This tandem activation loop phosphorylation (that was proposed to be either distributive or processive, dependent on the cellular environment) is performed by members of the Ste7 protein kinase family, also known as MAP2 kinases. (wikipedia.org)
  • MAP2 kinases in turn, are also activated by phosphorylation, by a number of different upstream serine-threonine kinases (MAP3 kinases). (wikipedia.org)
  • Manual 26.29 HN - 2002 MH - Activin Receptors UI - D029404 MN - D8.586.913.696.620.682.700.62 MN - D12.776.543.750.750.400.820.500 MS - Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). (nih.gov)
Membrane1
  • Rab41 translocates to damaged autophagic membranes via adaptor protein TOM1L2 and recruits VPS4 to complete ESCRT-mediated membrane repair in a unique GTPase-independent manner. (bvsalud.org)
Regulatory1
  • Some of these localized RNAs are noncoding structural or regulatory RNAs, whereas others become translated into localized proteins. (biologists.com)
Analysis2
  • We also discuss the advantages and disadvantages of using these methods in specific experimental contexts and highlight the need to complement LC3 and/or electron microscopy data with analysis of other autophagic effectors and lysosomal proteins that participate in the initiation and completion of autophagy flux, respectively. (bvsalud.org)
  • However, the functional analysis of these proposed cytoskeletal proteins and their mutants will require detailed analysis at the cell biological, molecular genetic, and biochemical levels. (bioone.org)