Sequences receptor gene rearrangement. Medical search. Frequent questions

Class II major histocompatibility complex mutant mice to study the germline bias of T cell antigen receptors. (nationaljewish.org)
And the antigen receptors for T cells and B cells have a lot of things in common, one of which is that they share the same mechanism - called VDJ rearrangement - to generate a massively diverse set of receptors. (osmosis.org)
First, let's look at our antigen receptors. (osmosis.org)
Immunoprofiling is used to assess the diversity of antigen receptors (ARs: antibodies and T-Cell receptors) and how this diversity changes in response to allergens, infections, or vaccines. (digitalworldbiology.com)
Cells expressing antigen receptors that are of higher affinity are then positively selected and clonally expanded by the immune system, allowing your body to tailor its response to an infection or other exposure to what it sees as foreign material. (stackexchange.com)

The efficacy of cellular or humoral immunotherapy has been demonstrated with the success of chimeric antigen receptor T-cell therapy and the bispecific engager blinatumomab in treating advanced disease. (haematologica.org)
The long road to the first FDA-approved gene therapy: chimeric antigen receptor T cells targeting CD19. (cdc.gov)

SCID results from mutations in any of more than 15 known genes. (medscape.com)
This includes actionable alterations, such as isocitrate dehydrogenase 1 (IDH1) mutations and a large variety of FGFR2 rearrangements, which are found in up to 29% and ∼10% of patients with iCCA, respectively, but are rare in eCCA. (nih.gov)
These agents show great promise in patients who harbor epidermal growth factor receptor (EGFR) activating mutations or EML4-ALK, said Antonio Passaro, MD , from the European Institute of Oncology in Milan, and colleagues, writing in a recent article in OncoTargets and Therapy . (medpagetoday.com)
Such mutations can cause diverse consequences depending on the specific location of the disrupted sequence. (cd-genomics.com)
We show that successive recombination events within genes encoding surface antigens and acquisition of quinolone resistance mutations possibly played a role in the emergence of CC4821 as an epidemic clone in China. (cdc.gov)
Indeed, overall ∼50% of bladder cancers have somatic mutations in the FGFR3 -coding sequence (Cappellen et al. (unina.it)
We found that FGFR3 rearrangements and missense mutations were associated with a lower fraction of mutated genome, compared to the FGFR3 wild-type tumors, as also observed in other oncogene-addicted cancers. (unina.it)
We give examples of mutations in genes that are predicted to be deleterious and may have a role in disease. (biomedcentral.com)
Sequencing all available tumor biopsies from 36 patients who had positive CSF ctDNA, the researchers found that CSF and tumor samples shared mutations in all 20 patients with wild type glioblastomas (GBMs) that were not hypermutated. (genomeweb.com)
Further analysis of CSF revealed a wide spectrum of protein-coding mutations, copy number alterations, promoter mutations, and structural rearrangements. (genomeweb.com)
To find out whether mutations detected in the CSF also existed in the patients' plasma, the group sequenced ctDNA from 19 patients with gliomas who were positive for CSF ctDNA. (genomeweb.com)
Some mutations in the S gene may lead to changes in the spike protein which result in inhibition of contact and entry of the virus into human cells, however in the case of the VOC, they contain mutations in the S gene that enhance the process of contact and entry into human cells, increasing transmissibility of the virus. (who.int)
Currently, manufacturers are focusing on and targeting assays to mutations in the S gene. (who.int)
3. Has confirmation that EGFR-, ALK-, or ROS1 directed therapy is not indicated as primary therapy (documentation of the absence of tumor activating EGFR mutations [eg, DEL19 or L858R], AND absence of ALK and ROS1 gene rearrangements). (who.int)
Mutations in this gene predispose humans to breast and ovarian cancer. (bvsalud.org)

High-throughput sequencing (HTS) of the immunoglobulin heavy chain ( IgH ) locus is a recent very efficient technique to monitor minimal residual disease of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). (frontiersin.org)
We analyzed structural rearrangements at the genome-wide level and carried out a detailed structural rearrangement analysis of the AR locus. (wustl.edu)
At one location or locus known as P/R, genes encode pheromones and pheromone receptors that help the fungus recognize compatible mating types. (phys.org)
At the other locus, called HD, genes govern the development of sexual structures and reproductive spores. (phys.org)
His works in Acquired immune system, Vertebrate, Gene rearrangement, Locus and Immunoglobulin heavy chain are all subjects of inquiry into Genetics. (research.com)
2) Estimation of T cell population structure by sequencing of the recombined T cell receptor (TCR) beta locus. (europeanhealthjournal.com)
Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V(alpha)-to-J(alpha) recombination and chromatin remodeling of J(alpha) segments. (duke.edu)

Nearly two decades later, in 1990, the specific strain of SpV1-R8A2 B was first reported in the publication of its complete nucleotide sequence of its genome. (wikipedia.org)
There is evidence that shows, in the partially sequenced S. citri genome, at least 20.5% of CDS are phage-related, while 47.2% of CDS are of unknown function. (wikipedia.org)
Insertion sequence elements may have resulted in gene disruptions, genome rearrangements, and genome expansions. (wikipedia.org)
In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
Experimental Design: We used whole-genome and targeted DNA-sequencing approaches to identify mechanisms underlying CRPC in an aggregate cohort of 272 prostate cancer patients. (wustl.edu)
We used genome engineering to perform experimental modeling of AR gene rearrangements and long-read RNA sequencing to analyze effects on expression ofARandtruncatedARvariants (AR-V). Results: AR was among the most frequently rearranged genes in CRPC tumors. (wustl.edu)
Staphylococcus aureus gamma-hemolysin CB (HlgCB) is a core-genome-encoded pore-forming toxin that targets the C5a receptor, similar to the phage-encoded Panton-Valentine leucocidin (PVL). (cnrs.fr)
the T cell receptors (TCR) which enable recognition of the target antigens are formed by gene rearrangement involving deletion of a genome sequence. (kyoto-u.ac.jp)
It represents more than 98% of the human genome sequence. (cd-genomics.com)
The human genome does not contain enough unique DNA sequences to code for the vast repertoire of receptors needed to recognize all of the foreign antigens a person is exposed to during their lifetime. (clinlabnavigator.com)
In the 1960's, Japanese-American geneticist and evolutionary biologist Susumu Ohno proposed a theory in which the genes determining sex first arose at various spots scattered across the entire genome , but over time were "captured" on the sex chromosomes. (phys.org)
The researchers sequenced the entire genome of C. amylolentus , mapping the location of all the genes as well as the centromeres on each of the organism's 14 chromosomes. (phys.org)
His Gene rearrangement, Immunoglobulin superfamily, Genome, Transposable element and Xenopus study are his primary interests in Genetics. (research.com)
Data from whole transcriptome sequencing of 33 breast specimens in the Harbin Medical University Cancer Center cohort and The Cancer Genome Atlas was applied to identify and validate the landscape of tumor suppressor long noncoding RNAs, which was further validated by The Cancer Genome Atlas pancancer data including 33 cancer types and 12,839 patients. (cancerindex.org)
The recent sequencing of the human genome has provided a wealth of information detailing several million genetic variations between individuals. (biomedcentral.com)
Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)
New sequencing technology provides thorough characterization of the genome and transcriptome. (lu.se)

T cell receptor (TcR) usage was studied using the "anchored" polymerase chain reaction. (ox.ac.uk)

The adaptive immune response is highly specific for each invader, and that's because the cells of the adaptive immune response have receptors that differentiate friendly bacteria and potentially deadly pathogens from their unique parts - called antigens. (osmosis.org)
VDJ rearrangement is a process by which the genes responsible for encoding the variable region of the B-cell receptor and T-cell receptor are rearranged to create a diverse repertoire of receptors capable of recognizing a wide variety of antigens. (osmosis.org)
T lymphocytes recognize and respond to foreign antigens by means of specific T cell receptors (TcR). (clinlabnavigator.com)
This process of gene rearrangement typically generates immunoglobulins with relatively low affinity for their antigens. (stackexchange.com)

Castration-resistant prostate cancer (CRPC) is a lethal stage of the disease that emerges when endocrine therapies are no longer effective at suppressing activity of the androgen receptor (AR) transcription factor. (wustl.edu)
This fusion results in the overexpression of ERG, which then inhibits the signaling of the androgen receptor and subsequently malignant transformation in the prostate. (cd-genomics.com)

and (iv) genes harboring germline non-silent variants presumed to confer a risk of sporadic ALL. (haematologica.org)
It is extremely fast because, in the first phase, no alignment is performed with database germline sequences. (vidjil.org)
Pathogenic germline sequence variants in two major susceptibility genes BRCA1 and BRCA2 confer a high relative risk and explain a proportion of familial breast cancer. (lu.se)

Identification of Subtypes in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Reveals a Gene Signature Prognostic of Outcome. (lu.se)

In the sequencing process V(D)J junctions are amplified with V and J gene specific primers and, to be quantitative, differences in amplification rates that are due to primer sequences must be factored into each assay. (digitalworldbiology.com)
According to Mellinghoff, the researchers used MSKCC's MSK-IMPACT next-generation sequencing assay to analyze samples for genes relevant to glioma. (genomeweb.com)

The process is mediated by recombination-activating genes (RAG1 and RAG2) and involves the introduction of double-strand breaks at specific recombination signal sequences (RSS) flanking the V, D, and J segments, followed by joining of the broken ends. (osmosis.org)

A maturing T cell undergoes VDJ rearrangement . (osmosis.org)
The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer. (lu.se)

A novel pathogenic mutation on the interleukin-7 receptor has been described in a newborn. (medscape.com)
One of the most powerful technologies that could target specific genes of mutation that are associated with cancer is by using cancer panels that utilize next-generation sequencing approach. (cd-genomics.com)
Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. (europeanhealthjournal.com)
By analyzing mutation levels, it was possible to distinguish sequences from cells that were recently activated from naïve B cells from those that were activated by memory recall. (nature.com)
Similar notation is used for up- and downstream sequences where either "Upstream" or "Downstream" is written before number of the mutation. (lu.se)

With 35,000 genes and hundreds of thousands of protein states to identify, correlate, and understand, it no longer suffices to rely on studies of one gene, gene product, or process at a time. (genomicglossaries.com)
CCR5 is a G protein-coupled receptor member of the CC chemokine subfamily of receptors. (rndsystems.com)
Mouse and rat CCR5 share 82% aa sequence identity with the human protein. (rndsystems.com)
Chemokine ligand receptor binding results in G protein activation as well as the activation of downstream signaling cascades, including the Akt and NFkB pathways. (rndsystems.com)
A decade ago, the echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene was identified from the DNA of a 62-year-old man with lung adenocarcinoma. (medpagetoday.com)
The DNA segments that do not encode protein sequences are known as non-coding DNA sequences. (cd-genomics.com)
Combine this with an only slightly less complex process in the light chain (as there is no D region), and the fact that a single insertion/deletion of a base pair can drastically effect the resulting protein sequence, and you get a protein with a huge number of possible sequences, potentially in the range of 10 11 . (stackexchange.com)
I was referring to the fact that an insertion or deletion of a single base pair can change the frame in which the downstream codons are interpreted, leading to (potentially) very different protein sequences. (stackexchange.com)
Restricted T cell receptor expression by human T cell clones specific for mycobacterial 65-kDa heat-shock protein: selective in vivo expansion of T cells bearing defined receptors. (ox.ac.uk)
We have examined the T cell receptor (TcR) expression of clones specific for epitopes of mycobacterial 65-kDa heat-shock protein (hsp65) in the context of two different HLA molecules, and used this system as a model to assess the selection of T cells responsive to this antigen in vivo. (ox.ac.uk)
What does this gene/protein do? (cancerindex.org)
A proportion of these will alter protein sequences, the most common of which is the non-synonymous single nucleotide polymorphism (nsSNP). (biomedcentral.com)
For over 40% of the nsSNPs, structure-based methods predicted which of these sequence changes are likely to either disrupt the structure of the protein or interfere with the function or interactions of the protein. (biomedcentral.com)
The most identifiable category of SNP is the small proportion (less than 1%) that change protein sequence, the most common of which is the non-synonymous SNP. (biomedcentral.com)
The viral S gene is important as it codes for the Spike protein which is the molecule that makes contact with, and allows entry of the virus into susceptible host cells, causing infection. (who.int)
The S gene is one of the structural genes of the virus which encodes for a protein that sits on the surface of the SARS CoV-2 virus. (who.int)
The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (bvsalud.org)

Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses. (ox.ac.uk)
However, iPS cells created by reprogramming T lymphocytes (T-iPS cells) retain the TCR gene sequence of the original T lymphocytes. (kyoto-u.ac.jp)
Vidjil is an open-source platform for the analysis of high-throughput sequencing data from lymphocytes , developed by the Bonsai bioinformatics lab and the VidjilNet consortium . (vidjil.org)
In contrast, a polyclonal proliferation of lymphocytes is due to division of millions of different B and T cells, each containing a different set of gene rearrangements. (clinlabnavigator.com)

The algorithm works on reads coming from either amplicon-based or capture-based deep sequencing strategy, as soon as they include CDR3 sequences. (vidjil.org)
Conservation of the beta chain third complementarity-determining region (CDR3) sequence was not evident, however. (ox.ac.uk)
There was conservation of alpha chain usage, since all clones expressed a member of the V alpha 1 family, but again CDR3 sequence conservation was not apparent. (ox.ac.uk)

With the emergence of pan-cancer tyrosine receptor kinase inhibitors, proper diagnosis of these tumors can help determine appropriate treatments and improve their outcomes. (bvsalud.org)
Genomic assays have had a powerful influence on the management of early-stage breast cancer, particularly estrogen receptor-positive tumors. (ascopost.com)
Breast tumors can be classified into subtypes based on patterns of gene expression, DNA methylation, nucleotide substitutions and genomic rearrangements. (lu.se)

The processes are called gene rearrangement and somatic hypermutation , and are used by maturing B-cells to generate very ( very ) large amounts of diversity in the antibody repertoire. (stackexchange.com)
During affinity maturation, a process called somatic hypermutation randomly changes individual base pairs (translated to amino acids) in the CDR in cells that are descendents of, and bear the same base sequence as, the original. (stackexchange.com)
His Nurse shark research incorporates themes from Somatic hypermutation, J chain, Exon, Sequence analysis and T-cell receptor. (research.com)
His studies in Nurse shark integrate themes in fields like Phylogenetics, Somatic hypermutation and T-cell receptor. (research.com)

With the advances in BMT and gene therapy, patients now have a better likelihood of developing a functional immune system in a previously lethal genetic disease. (medscape.com)
The resulting receptor variable region diversity is crucial for adaptive immunity , allowing the immune system to recognize and respond to a wide range of potential pathogens. (osmosis.org)
An aspect of the course will cover the ways in which industry studies and utilizes components of the immune system from vaccines to making antibodies to measuring T-Cell Receptor (TCRs) repertoires as biomarkers. (digitalworldbiology.com)
During development of the immune system the pro-B cells in the bone marrow undergo gene segment rearrangements, bringing V and J segments together for Ig light chain production, and V,D and J segments together for Ig heavy chain production. (stackexchange.com)
The scientist's investigation covers issues in Acquired immune system, Nurse shark, Gene, Genetics and Major histocompatibility complex. (research.com)
Inflammaging is driven by several factors, such as single nucleotide polymorphisms in the promoter regions of pro- and anti-inflammatory genes, chronic stimulation of immune cells with pathogens, changes in the composition of the gut microbiota, and cellular senescence [ 8 ]. (biomedcentral.com)
In this study, we used several high throughput sequence-based methods to analyze samples from the SCID-X1 trials, with the goal of probing immune mechanisms and the resulting effects on microbial communities. (europeanhealthjournal.com)
We used high-throughput B cell receptor sequencing of plasma cells produced following AS03-adjuvanted and non-adjuvanted 2009 pandemic H1N1 vaccination, as well as pre-pandemic seasonal influenza vaccination to elucidate the effect of the adjuvant on the humoral immune response. (nature.com)

TcR beta and gamma genes are located on chromosome 7 and TcR alpha and delta genes are located on chromosome 14. (clinlabnavigator.com)
They found that during evolution, a reshuffling of DNA known as translocation brought together separate chunks of sex-determining genes onto a single chromosome, essentially mimicking the human X or Y chromosome. (phys.org)
Identifying genes on each chromosome is an active area of genetic research. (medlineplus.gov)
Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. (medlineplus.gov)
Chromosome 15 likely contains 600 to 700 genes that provide instructions for making proteins. (medlineplus.gov)
However, some genes on this chromosome, including some of those in the 15q11.2-q13.1 region, are turned on (active) only on the maternal copy. (medlineplus.gov)

Because ALL cells arise from the oncogenic transformation of a single lymphoid precursor, they have clonal antigen-receptor (immunoglobulin and/or T-cell receptor) gene rearrangements in most cases, which can be used to distinguish ALL cells from normal lymphoid cells (expressing gene rearrangements with different sequences) and nonlymphoid cells (lacking the rearrangements). (ashpublications.org)
High-throughput sequencing (NGS/HTS) now enables the deep sequencing of a lymphoid population with dedicated sequencing methods and software, called either Rep-Seq or AIRR-Seq . (vidjil.org)
Integrated Genomic DNA/RNA Profiling vs Fluorescence in Situ Hybridization in the Detection of MYC and BCL2 (and BCL6) Rearrangements in Large B-Cell Lymphomas: Updates Amid the New WHO Classification of Lymphoid Neoplasms. (cdc.gov)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
the gene expression profile during B lymphoid differentiation. (lu.se)

Recent advances in next-generation sequencing (NGS) have led to the development of assays that allow comprehensive genomic profiling of large gene panels within 2-3 weeks, including in vitro diagnostic tests approved in the United States. (nih.gov)
These assays vary regarding acceptable source material (tumor tissue or peripheral whole blood), genetic source for library construction (DNA or RNA), target selection technology, gene panel size, and type of detectable genomic alterations. (nih.gov)
Most of these elements were able to identify using the combination of functional genomic approaches and in-silico methods based on sequence conservation. (cd-genomics.com)
This parent-specific gene activation results from a phenomenon called genomic imprinting. (medlineplus.gov)

As mentioned, these cis-regulatory elements may act as enhancers, promoters, or silencers of gene expression when bound by trans-regulatory elements, such as TFs or transcription factors. (cd-genomics.com)
Scholars@Duke publication: Regulation of T cell receptor-alpha gene recombination by transcription. (duke.edu)

Moreover, an understanding of the pathogenesis of primary immunodeficiencies has paved the way for immunologic interventions and new treatments, such as immunoglobulin G (IgG) replacement, bone marrow transplantation , and gene therapy. (medscape.com)

Immunoglobulin Heavy Chain High-Throughput Sequencing in Pediatric B-Precursor Acute Lymphoblastic Leukemia: Is the Clonality of the Disease at Diagnosis Related to Its Prognosis? (frontiersin.org)
1. IgH high-throughput sequencing allows new insights into the clonal architecture of BCP-ALL. (frontiersin.org)
High-throughput sequencing of T-cell receptors may be a solution to some of the challenges confronting oncologists who treat cutaneous T-cell lymphomas. (ascopost.com)
According to experts who presented talks on high-throughput sequencing of T-cell receptors at the 3rd World Congress of Cutaneous Lymphoma. (ascopost.com)
Commenting on this talk during the discussion afterward, Youn Kim, MD , of Stanford University School of Medicine, Stanford, California, said: "At our center, we use high-throughput sequencing of T-cell receptors daily in patients with cutaneous T-cell lymphomas, and it is a billable. (ascopost.com)

It detects gene rearrangements from both immunoglobulins and T-cell receptors, as well as some incomplete or uncommon rearrangements . (vidjil.org)

2021). Fibroblast Growth Factor Receptors (FGFRs) have recently emerged as a novel therapeutic target in cancer. (unina.it)

There are transcribed sequences that are not translated into peptide products that can also be involved in gene expression regulation. (cd-genomics.com)

Each child's ALL comes with a specific genetic change that can be found in the T-cell receptor gene and/or the immunoglobulin heavy chain gene. (parkwayeast.com.sg)

Second, the fusion of active regulatory elements in oncogenes, genes associated with cancer, because of structural rearrangements. (cd-genomics.com)

Role of non-coding sequence variants in cancer. (cd-genomics.com)
Few other high-risk genes are known and current knowledge supports a polygenic model, a role of common low-risk variants that may interact in multiplicative fashion, but also of rare intermediate-risk gene variants. (lu.se)

During B-cell development, the V, D, and J segments of the immunoglobulin genes are rearranged, with deletion and random insertion of nucleotides at the junctional sites, generating a unique gene sequence for each cell and its progeny. (ashpublications.org)
During VDJ rearrangement, DNA segments called V (variable), D (diversity), and J (joining) are rearranged to form the coding sequence for the receptor variable region. (osmosis.org)
Figure 4.3 from Janeway shows the number of "fragments" or gene segments of each type in humans. (stackexchange.com)

The B cell receptor , or BCR, is essentially an antibody, except that it has a transmembrane part that goes through the membrane and attaches the receptor to the surface of a B cell . (osmosis.org)
Then there's the constant region or fragment called the fragment - constant or Fc region , which is the part that determines what class of B cell receptor it will be - for example, IgM or IgD, and whether or not it will remain a membrane bound B cell receptor or if it will get secreted as a free floating antibody. (osmosis.org)

AR receptor diversity is vast due to a combinatorial rearrangement process that inserts a variable number of random DNA bases at each junction. (digitalworldbiology.com)

These sequences of unknown function could be remnants of viral sequence insertions, a common feature with other Mollicute genomes, as they contain repeated clusters of genes that could be "mobile genetic elements or remnants of ancient phage attacks. (wikipedia.org)
Sequencing and other techniques may reveal the actual genetic defects in these patients. (medscape.com)
FGFR2 rearrangements are currently the only genetic alteration in CCA for which a targeted therapy, the fibroblast growth factor receptor 1-3 inhibitor pemigatinib, has been approved. (nih.gov)
The use of next generation sequencing to describe the genetic landscape within the leukaemia cell genetic mapping is the latest technology to sub-divide childhood ALL into different groups. (parkwayeast.com.sg)
In all cases of dup15q syndrome, the duplicated genetic material results in extra copies of certain genes involved in development. (medlineplus.gov)
High grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangements: unraveling the genetic landscape of a rare aggressive subtype of non-Hodgkin lymphoma. (cdc.gov)
Recognition of a single-gene disorder as causal for a patient's 'multiple sclerosis-like' phenotype is critically important for accurate direction of patient management, and evokes broader genetic counselling implications for affected families. (medscape.com)

It also reveals the sequences of clonal rearrangements, therefore, the multiclonal structure, of BCP-ALL. (frontiersin.org)
Two indicators of clonal complexity were used, namely, the number of foster clones, described as clones with similar D-N 2 -J rearrangements but other V-rearrangement and N 1 -joining, and the maximum across all foster clones of the number of evolved clones from one foster clone. (frontiersin.org)
ALL cells can be recognized by their clonal rearrangement of immunoglobulin and T-cell receptor genes, expression of gene fusions, and leukemia-associated immunophenotypes. (ashpublications.org)
The expansion of hypervirulent sequence type 4821 clonal complex (CC4821) lineage Neisseria meningitidis bacteria has led to a shift in meningococcal disease epidemiology in China, from serogroup A (MenA) to MenC. (cdc.gov)

No single gene rearrangement predominates and none are detectable by Southern blot. (clinlabnavigator.com)
For patients with or without cancer (as defined in the policy), established standard-of-care MRD tests using single-gene PCR (i.e. (codemap.com)
Several single gene disorders share clinical and radiologic characteristics with multiple sclerosis and have the potential to be overlooked in the differential diagnostic evaluation of both adult and paediatric patients with multiple sclerosis. (medscape.com)
Here we review single gene disorders that have the potential to mimic multiple sclerosis, provide an overview of clinical and investigational characteristics of each disorder, and present guidelines for when clinicians should suspect an underlying heritable disorder that requires diagnostic confirmation in a patient with a definite or probable diagnosis of multiple sclerosis. (medscape.com)

Partially characterized gene rearrangements are listed differently, e.g. gross deletions have PINs starting from Deletion (1). (lu.se)

TcR gene rearrangements are useful in the diagnosis of T cell malignancies such as T cell ALL and lymphoblastic lymphoma, mycosis fungoides, Sezary syndrome, T cell PLL/CLL, and adult T cell leukemia. (clinlabnavigator.com)
Objective: To investigate the clinicopathological features and differential diagnosis of NTRK3 gene rearrangement thyroid papillary carcinoma (PTC). (bvsalud.org)
Molecular studies such as pan-TRK immunostaining, FISH and even next-generation sequencing are needed to confirm the diagnosis. (bvsalud.org)
The application of antigen receptor gene rearrangement of BIOMED-2 in the pathologic diagnosis of 348 cases with non-Hodgkin lymphoma in a single institution in Southwest of China. (cdc.gov)

The discovery of ALK gene rearrangements and the development of tyrosine kinase inhibitors (TKIs) that target them have achieved unprecedented success in the management of patients with ALK-positive NSCLC. (medpagetoday.com)

A new paper from Duke molecular genetics and microbiology shows how pathogenic Cryptococcus fungi evolved from having many sexes to just two through 50 million years of gene swapping. (phys.org)

B29), and the -subunit of the E-mail: [email protected] interleukin (IL)-7 receptor [5, 6]. (lu.se)

As a Plectrovirus, the phage's entry mechanism is adsorption to membrane-bound cellular receptors. (wikipedia.org)

Chemokine receptors mediate the chemotactic actions of chemokine ligands and activation of these receptors leads to cytoskeleton rearrangement and chemotactic cell migration. (rndsystems.com)

In the present report we have compared and contrasted structure- and sequence-based methods of prediction to over 5500 genes carrying nearly 24,000 nsSNPs, by employing an automatic comparative modelling procedure to build models for the genes. (biomedcentral.com)
The objective of this document is to outline the available methods and tools for screening and sequencing patient specimens for the detection of VOC or VOI, with a focus on those that offer a rapid turn-around time so as to support rapid implementation of public health actions for COVID 19 control. (who.int)

Detection of a TcR gene rearrangement indicates that a monoclonal population of T cells is present. (clinlabnavigator.com)

Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR. (nationaljewish.org)
The alpha-beta receptor is expressed on 95% of mature T cells, whereas the remaining 5% of T cells express a gamma-delta receptor. (clinlabnavigator.com)
All malignant cells contain an identical gene rearrangement pattern that is easily identifiable by Southern blot analysis. (clinlabnavigator.com)
1) Estimation of the numbers of transduced progenitor cells by monitoring unique positions of integration of the therapeutic gene transfer vector. (europeanhealthjournal.com)
PPP2R3A gene overexpression promotes, while gene silencing suppresses, the level of HK1 and glycolysis in HCC cells. (bvsalud.org)

Biomolecular analyses have revealed that a few SNPs in the promoter sequences and only one SNP in the 5' UTR of mRNA induce the differential expression of , drastically impacting mRNA translation. (cnrs.fr)
The enhancers, along with the LTR promoter sequence, supported efficient expression of the corrective IL2RG gene and allowed successful gene correction. (europeanhealthjournal.com)
A second trial (SCIDn2) was carried out to treat SCID-X1 using an improved self-inactivated vector in which the LTR strong enhancer sequences were deleted [ 19 ], and a promoter comprised of the short elongation factor 1 alpha (EF1a) promoter, devoid of enhancer regions, was used to express the therapeutic IL2RG gene. (europeanhealthjournal.com)

Such phenomenon frequently happens in 5' UTR of TMPRss2 and ETS family genes in prostate cancer. (cd-genomics.com)
Aside from that, it has been found out that modifications in ncRNAs or their binding sites can be a signature of cancer since lncRNA MALATI was observed to regulate the expression of genes that are associated with metastasis and upregulated in lung cancer. (cd-genomics.com)
This has been documented using miRNA sequestration for the BRAF gene which is a gene associated with several cancer types such as breast cancer. (cd-genomics.com)
FGFR3 gene rearrangements are typical alterations in bladder cancer (Nelson et al. (unina.it)
The mainstay of adjuvant treatment for early-stage, hormone receptor-positive breast cancer has been endocrine therapy, either with tamoxifen and. (ascopost.com)
For patients with advanced non-small cell lung cancer (NSCLC) harboring the ALK gene rearrangement, ceritinib (Zykadia) provided longer progression-free survival than chemotherapy in patients previously treated with chemotherapy and crizotinib (Xalkori), but gastrointestinal toxicity was. (ascopost.com)

Molecular analysis of the beta TcR gene rearrangements provides the most definitive assessment of T cell clonality. (clinlabnavigator.com)
His primary areas of investigation include Genetics, Gene, Major histocompatibility complex, Molecular biology and Nurse shark. (research.com)
His B cell study integrates concerns from other disciplines, such as Receptor and Molecular biology. (research.com)

Subsequent rearrangements put P/R and HD next to each other. (phys.org)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

AR gene rearrangements promoted expression of diverse AR-V species. (wustl.edu)
Cell lines with experimentally derived AR gene rearrangements displayed high expression of tumor-specific AR-Vs andwere resistant to endocrine therapies, including the AR antagonist enzalutamide. (wustl.edu)
A single sample Gene Set Enrichment-like and Ingenuity Pathway Analyses were applied to the gene expression profile of 195 OC samples from the same cohort. (bvsalud.org)
The first type of non-coding sequences is the regulatory elements that control gene expression. (cd-genomics.com)
The DN subset could be further split on the expression of CD44 and CD25 aided by the maturation sequence CD44 + CD25 a€" (DN1), CD44 + CD25 + (DN2), CD44 a€" CD25 + (DN3) and CD44 a€" CD25 a€" (DN4) pinpointing levels of growth, commitment to the T-cell lineage and rearrangement of T-cell receptor (TCR) genes. (microgreens-bg.com)
Results@#RNA sequencing data revealed that PPP2R3A siRNA significantly downregulated the expression of HK1. (bvsalud.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Mechanistically, EPB41L4A-AS2, acting at least in part as a tumor suppressor, upregulated tumor suppressor gene expression. (cancerindex.org)
Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma. (cdc.gov)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
tures and gene expression patterns. (lu.se)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

Just like antibodies, the B cell receptor has a heavy chain and a light chain. (osmosis.org)
antibodies or T-cell receptors) in a sample and is a hot area in biotechnology. (digitalworldbiology.com)

Essentially, the genes encoding the B-cell Receptor, or BCR, have many fragments of several different types in them, and through the process of gene rearrangement the final Complementarity Determining Regions, or CDRs (the antigen-binding sites), are generated into one mature sequence for each individual B-cell. (stackexchange.com)

[ 5 ] Ideally, SCID can be detected in a newborn before the onset of infections, with one well-documented example by screening of T-cell-receptor excision circles. (medscape.com)
In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)
SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analysis of the roles of T cell immunity in humans by comparing before and after gene correction. (europeanhealthjournal.com)
SCID-X1 gene therapy thus provides a unique opportunity to study the consequences of T cell function in previously deficient human subjects. (europeanhealthjournal.com)
In the first gene therapy trial to treat SCID-X1 (denoted here "SCIDn1"), early designs of gammaretroviral vectors were used [ 6 , 7 , 8 , 9 ], which were the only vector type available at the time. (europeanhealthjournal.com)

It also inhibits EMT and ROS1, a kinase that shares 77% of amino acid sequences of adenosine triphosphate (ATP)-binding sites with the ALK. (medpagetoday.com)

In C. amylolentus , dozens of genes at two different locations on the chromosomes control what's called a tetrapolar, or four-part, mating system. (phys.org)

Clinical utility of target capture-based panel sequencing in hematological malignancies: a multicenter feasibility study. (cdc.gov)
An integrated prognosis model of pharmacogenomic gene signature and clinical information for diffuse large B-cell lymphoma patients following CHOP-like chemotherapy. (cdc.gov)
The authors would like to acknowledge Clinical Genomics Lund, SciLifeLab and Center for Translational Genomics (CTG), Lund University, for providing expertise and service with sequencing and analysis. (lu.se)

Prognostic Significance of MYC Rearrangement and Translocation Partner in Diffuse Large B-Cell Lymphoma: A Study by the Lunenburg Lymphoma Biomarker Consortium. (cdc.gov)

Insertion of the viral sequences occurs by encoded putative transposases resembling those of insertion elements. (wikipedia.org)

Conclusions: AR gene rearrangements are an important mechanism of resistance to endocrine therapies in CRPC. (wustl.edu)
Conclusions: NTRK3 gene rearrangement PTC is rare. (bvsalud.org)

Anatomy12

Organisms4

Diseases30

Chemicals and Drugs36

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes69

Disciplines and Occupations1

Information Science4

Antigen receptors5

Chimeric antigen receptor2

Mutations15

Locus7

Genome17

Polymerase chain re1

Antigens4

Androgen receptor2

Germline3

Epidermal growth f1

Assay2

Recombination-activ1

Undergoes2

Mutation5

Protein17

Lymphocytes4

CDR33

Tumors3

Somatic Hypermutation4

Immune8

Chromosome6

Lymphoid5

Genomic4

Transcription2

Bone marrow1

High throughput5

Immunoglobulins1

20211

Regulation1

Immunoglobulin heavy chain1

Structural1

Variants2

Segments3

Antibody2

Combinatorial1

Genetic7

Clonal4

Single gene4

Deletion1

Diagnosis4

Tyrosine1

Pathogenic1

Interleukin1

Membrane-bound1

Mediate1

Methods2

Monoclonal1

Cells5

Promoter3

Cancer6

Molecular3

Subsequent2

Expression12

Antibodies2

Essentially1

SCID5

Kinase1

Chromosomes1

Clinical3

Significance1

Viral1

Conclusions2