ApoEProteinPolymorphismApoBAtherosclerosisDeficiency of apolipoproteinGenesCDNAMonoclonal AntibodyAPOA4AmyloidRecombinantHomologousSerumAlzheimer'sVariantsCIIICholesterolGeneticPolyclonal AntibodyDetectsTranscriptAminoNucleotideGenotypeProteinsHepaticHumanAnalysesGenomic organizationMRNAIsoformsMutationsMiceIdentificationMoleculeFunctionalDensityGenomeDiversityMolecularDetectionData
ApoE12
- Specific intracellular pathways regulated by Apolipoprotein E (ApoE), a PP2A activator or survivin, an inhibitor of Heat Shock Proteins (HSP), can impact human diseases including cancers. (fortuneonline.org)
- In this study, we have initially observed that anti-tumor Tat-survivin (shepherdin -Tat ), and ApoE mimetics, Cog or Tat-Cog &Cog-Tat, peptides contained cationic sequences that share similar physical characteristics with LL17-32, a short active sequence of the anti-microbial human cathelecidin peptide. (fortuneonline.org)
- This study highligts two major insights indicating that similarly, to LL37 or LL17-32 cathelecidin sequences, shepherdin -Tat and ApoE mimetic peptides firstly impairs the growth of S. agalactiae NEM 316 dltA strain, and secondly inhibited the survival of human glioblastoma U87G cells. (fortuneonline.org)
- In conclusion, together, our results clearly indicate that cationic peptides with survivin and ApoE anti-tumor sequences, including scrambled shepherdin Tat , a previously described biologically inactive anti-cancer molecule, behave as cathelecidin-like anti-infective host defense molecules. (fortuneonline.org)
- Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. (hindawi.com)
- Lipid metabolism in the epidermis may be regulated by the expression of apolipoprotein E (APOE), a glycoprotein which is synthesized in a wide variety of extrahepatic tissues including skin [ 27 - 29 ]. (hindawi.com)
- Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
- The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
- [ 5 ] Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
- Earlier studies were associated with Apolipoprotein E ( ApoE ) in variable diseases. (edu.pl)
- Apolipoprotein E (ApoE) is involved on cholesterol and triglycerides metabolism regulation. (biomedcentral.com)
- The characteristic components of the syndrome are mostly determined by apolipoprotein E (ApoE) modulation of atherogenic plasma Apo-B containing lipoproteins. (biomedcentral.com)
Protein14
- Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)
- Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene. (wikipedia.org)
- Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
- Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)
- Analysis of two highly expressed genes from Chlorella virus PBCV-1: Protein characterization and the DNA sequences of the major capsid protein gene and the early/late 33-kDa protein gene. (uml.edu)
- It is thought to be related in amino acid sequence to segments of apolipoprotein B and the microsomal transfer protein responsible for the assembly of low-density lipoproteins. (rcsb.org)
- 6 There are also rare forms of FH that result from mutations in genes for apolipoprotein B-100 (ApoB), proprotein convertase subtilisin/kexin type 9 (PCSK9), 8 and the low-density lipoprotein receptor adaptor protein 1 (LDLRAP1), which causes a rare form of autosomal recessive FH. (acc.org)
- The protein encoded by this gene is a component of high-density lipoprotein (HDL), but is unique in that it shares greater structural similarity to lipocalin than to other members of the apolipoprotein family, and has a wider tissue expression pattern. (genscript.com)
- These sequences represent the protein coding region of the Apod cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
- Accurate Long-read transcriptome sequencing at single-cell level is required to decipher the spectrum of protein expressions in mammalian organisms. (elifesciences.org)
- AAIR8193;Apolipoprotein O-like;CXorf33;FAM121A;family with sequence similarity 121A;Mic27;MICOS complex subunit MIC27;MICOS27;mitochondrial contact site and cristae organizing system subunit 27;Protein FAM121A;UNQ8193. (avivasysbio.com)
- Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). (assaygenie.com)
- We recently reported the identification and characterization of a novel BH3-only pro-death protein, apolipoprotein L1 (ApoL1), that, when overexpressed, induces autophagic cell death (ACD) in a variety of cells, including those originated from normal and cancerous tissues. (unm.edu)
- Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor. (shengsci.com)
Polymorphism2
- A sequence polymorphism has been identified in the 3'UTR of the third exon. (joplink.net)
- Helisalmi SLinnaranta KLehtovirta M et al Apolipoprotein E polymorphism in patients with different neurodegenerative disorders. (jamanetwork.com)
ApoB2
- The analyst should use the special sampling weights in this file to analyze Apolipoprotein B (ApoB). (cdc.gov)
- Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. (thermofisher.com)
Atherosclerosis1
- Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. (thermofisher.com)
Deficiency of apolipoprotein1
- Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia. (genscript.com)
Genes4
- Expression and Activity of Methionine Cycle Genes Are Altered Following Folate and Vitamin E Deficiency Under Oxidative Challenge: Modulation by Apolipoprotein E-Deficiency. (uml.edu)
- The aim of this study was to further investigate the role of common and rare variation in these two genes by sequencing individuals having extremely low and high HDL-cholesterol levels in two populations, U.S. Non-Hispanic Whites (NHWs), and African Blacks, and then screening the identified variants in the entire sample. (pitt.edu)
- The locus control region (LCR) of mammalian beta-globin genes covers at least 17 kb at the 5' end of the gene cluster and has been implicated in chromatin domain opening, enhancement, and insulation from neighboring sequences. (shengsci.com)
- Hepatic RNA sequence analysis revealed changes in 433 genes associated with fatty liver development and progression in the mice exposed to e-cigarettes and the Western diet compared with saline exposed mice. (medscape.com)
CDNA1
- The following B3GALT6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
Monoclonal Antibody1
- The following product was used in this experiment: Apolipoprotein B Monoclonal Antibody (F2C9) from Thermo Fisher Scientific, catalog # MIA1609, RRID AB_11152638. (thermofisher.com)
APOA42
- In the initial sequence analysis, 54 variants were identified in APOA1 (25 of which were new), and 43 in APOA4 (21 of which were new). (pitt.edu)
- According to preliminary analysis of the sequencing data for APOA1 and APOA4, no striking difference was noticed between the distribution of rare variants between high and low HDL groups in either population. (pitt.edu)
Amyloid5
- Title: Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice. (genscript.com)
- Title: Amyloid-?25-35 induces apolipoprotein D Synthesis and growth arrest in HT22 hippocampal cells. (genscript.com)
- To elucidate the mechanisms by which curcumin affects systemic amyloidosis, we investigated amyloid deposition and molecular changes in a mouse model of amyloid apolipoprotein A-II (AApoAII) amyloidosis, in which mice were fed a curcumin-supplemented diet. (elifesciences.org)
- The 11-residue amino acid sequence (6-16), which is a common sequence of type B apoA-II and type C apoA-II proteins in amyloidosis-resistant mice and amyloidosis-susceptible mice, respectively, was critical for polymerization into amyloid fibrils. (nii.ac.jp)
- AGGREGATION"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "In mice, amyloidogenic type C apolipoprotein A-II (apoA-II) forms amyloid fibrils in age-associated amyloidosis. (nii.ac.jp)
Recombinant3
- Detects mouse and rat Apolipoprotein H/ApoH in Western blots and detects recombinant mouse Apolipoprotein H/ApoH in direct ELISAs. (rndsystems.com)
- In direct ELISAs, approximately 40% cross-reactivity with recombinant human Apolipoprotein H/ApoH is observed. (rndsystems.com)
- Recombinant Human Apolipoprotein B-100 is produced by our E.coli expression system and the target gene encoding Glu28-Ser127 is expressed with a 6His tag at the N-terminus. (assaygenie.com)
Homologous1
- Its sequence, when compared to those of members of the human carcinoembryonic antigen gene family, was most homologous to the sequence of the human biliary glycoprotein (BGP) gene. (shengsci.com)
Serum1
- In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
Alzheimer's4
- Frisoni GBCalabresi LGeroldi C et al Apolipoprotein E ϵ4 allele in Alzheimer's disease and vascular dementia. (jamanetwork.com)
- Gomez-Isla TWest HLRebeck GW et al Clinical and pathological correlates of apolipoprotein E ϵ4 in Alzheimer's disease. (jamanetwork.com)
- Gustafson LAbrahamson MGrubb ANilsson KFex G Apolipoprotein-E genotyping in Alzheimer's disease and frontotemporal dementia. (jamanetwork.com)
- Association of apolipoprotein E genetic variation in Alzheimer's disease in Indian population: a meta-analysis. (edu.pl)
Variants3
- Additional variants identified in sequencing remain to be screened in the entire NHWs and Black samples. (pitt.edu)
- Next generation sequencing to identify novel genetic variants causative of autosomal dominant familial hypercholesterolemia associated with increased risk of coronary heart disease. (edu.pl)
- Whole-exome sequencing of BRCA-negative breast cancer patients and case-control analyses identify variants associated with breast cancer susceptibility. (cdc.gov)
CIII2
- Primary structure of the bovine analogues to human apolipoproteins CII and CIII. (wikipedia.org)
- Evidences have suggested that proteins primarily related to plasma lipoprotein transport, such as apolipoprotein (apo) CIII and E, may significantly affect the process of body fat accumulation. (biomedcentral.com)
Cholesterol1
- Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)
Genetic3
- The lower cost and labour associated with NGS-based testing may increase the attractiveness of a population-based approach to FH detection compared to genetic testing with conventional sequencing. (biomedcentral.com)
- Since the majority of undiagnosed FH patients receive their healthcare outside lipid clinics, we sought to assess the feasibility of targeted sequence-based genetic testing for FH in a primary care-based population subset selected for hypercholesterolaemia. (biomedcentral.com)
- Return of non-ACMG recommended incidental genetic findings to pediatric patients: considerations and opportunities from experiences in genomic sequencing. (cdc.gov)
Polyclonal Antibody1
- PVDF membrane was probed with 0.25 µg/mL of Sheep Anti-Mouse/Rat Apolipoprotein H/ApoH Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6575) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). (rndsystems.com)
Detects1
- MIA1609 detects Apolipoprotein B which has a predicted molecular weight of approximately 502 kDa. (thermofisher.com)
Transcript1
- Mus musculus apolipoprotein D (Apod), transcript variant 3, mRNA. (genscript.com)
Amino1
- The 18-residue-long amino acid sequence (48-65) is also necessary for nucleation, but not for the extension phase. (nii.ac.jp)
Nucleotide1
- The mouse biliary glycoprotein gene (Bgp): partial nucleotide sequence, expression, and chromosomal assignment. (shengsci.com)
Genotype2
- The whole cortex of wild-type and symptomatic RTT male littermates ( n = 4 per genotype) were analyzed using RNA-sequencing and data-independent acquisition liquid chromatography tandem mass spectrometry. (biomedcentral.com)
- Masullo CDaniele AFazio VM et al The apolipoprotein E genotype in patients affected by syndromes with focal cortical atrophy. (jamanetwork.com)
Proteins1
- Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)
Hepatic2
- The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. (thermofisher.com)
- RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARα activation, resulting in increased Apoa2 mRNA expression. (elifesciences.org)
Human6
- 1986). "The structure of the human apolipoprotein C-II gene. (wikipedia.org)
- MIA1609 targets Apolipoprotein B in ELISA, IP and RIA applications and shows reactivity with Human samples. (thermofisher.com)
- Mature mouse ApoH shares 76% and 42% aa sequence identity with human and rat ApoH, respectively. (rndsystems.com)
- Title: Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. (genscript.com)
- The identification and sequence of KiSS-1 (HGMW-approved symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published. (shengsci.com)
- To investigate the transcriptional diversity of BM-MSCs, we applied single-cell RNA sequencing (scRNA-seq) on freshly isolated CD271 + BM-derived mononuclear cells (BM-MNCs) from two human subjects. (ijbs.com)
Analyses1
- Whole-genome sequencing (WGS) analyses of this tumor type are limited, and we therefore interrogated eight ATCs using WGS and RNA sequencing. (lu.se)
Genomic organization1
- The genomic organization of the sequence revea. (shengsci.com)
MRNA1
- One of the more predominant mutational signatures was intimately coupled to the activity of Apolipoprotein B mRNA-editing enzyme, the catalytic polypeptide-like (APOBEC) family of cytidine deaminases implied in kataegis, a focal hypermutation phenotype, which was observed in 4/8 (50%) cases. (lu.se)
Isoforms1
- The two isoforms share a common N-terminal sequence. (thermofisher.com)
Mutations1
- The authors pair single-cell sequencing technology with the LoopSeq synthetic long-read method to examine samples of hepatocellular carcinoma and benign liver, with the goal of identifying mutations and fusion transcripts specific to cancer cells. (elifesciences.org)
Mice1
- To investigate, Dr. Friedman and his colleagues studied mice missing the gene for apolipoprotein E, which makes them more prone to heart disease and fat in the liver. (medscape.com)
Identification1
- Title: Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. (genscript.com)
Molecule1
- Click molecule labels to explore molecular sequence information. (nih.gov)
Functional1
- The complete sequences of the galago and rabbit beta-globin locus control regions: extended sequence and functional conservation outside the cores of DNase hypersensitive sites. (shengsci.com)
Density1
- Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). (thermofisher.com)
Genome2
Diversity1
- A Better Way to Find RNA Virus Needles in the Proverbial Database Haystacks Researchers combed through more than 5,000 data sets of RNA sequences generated from diverse environmental samples around the world, resulting in a five-fold increase of RNA virus diversity. (doe.gov)
Molecular1
- The resulting 10x Adapter sequence contains a 16-base pair barcode, followed by a 12-base pair unique molecular identifier (UMI) and a 30-base pair poly(dT) sequence. (elifesciences.org)
Detection3
- Detection of Rat and Mouse Apolipoprotein H/ApoH by Western Blot. (rndsystems.com)
- We previously validated a method for FH mutation detection in a lipid clinic population using next generation sequencing (NGS), but this did not address the challenge of identifying index cases in primary care where most undiagnosed patients receive healthcare. (biomedcentral.com)
- Moreover, NGS mutation detection is suited to high-throughput testing of large numbers of samples, which is not so readily achievable with standard capillary sequencing platforms. (biomedcentral.com)
Data1
- The raw sequencing data produced was processed removing the sequence reads which were of too low quality (only 'passing filter' reads were selected). (nih.gov)