• SANTA CLARA, Calif., Oct. 24, 2013 - Agilent Technologies Inc. (NYSE: A) today announced that the Massachusetts Eye and Ear Infirmary , an affiliate of Harvard Medical School, has been authorized as a Certified Service Provider of Agilent's next-generation target enrichment and microarray-based comparative genomic hybridization (aCGH) solutions. (harvard.edu)
  • High-resolution microarray-based comparative genomic hybridization (CGH) techniques have successfully been applied to study copy number imbalances in a number of settings such as the analysis of cancer genomes. (biomedcentral.com)
  • However, few studies have comprehensively evaluated its performance against current standard-of-care diagnostic tests: karyotype, chromosomal microarray (CMA), and exome sequencing (ES). (cdc.gov)
  • We hope to provide a concise review of the literature and genes involved within our deletion sequence in the hope that it will contribute to creating a phenotypic profile for this patient population. (hindawi.com)
  • Patients with gross genomic imbalances in a region harboring one or more genes targeted on PreventionGenetics' HDGC aCGH, to confirm involvement of such gene(s). (preventiongenetics.com)
  • To further confirm the results of aCGH, copy number changes of cancer-related candidate genes in AdCC patients were compared by real-time quantitative polymerase chain reaction. (korea.ac.kr)
  • Somatic mutations in phosphatase and tensin homolog (PTEN)/ phosphoinositide-3-kinase (PI3K) and RAS pathway members by Sequenom mutational profiling and targeted sequencing of candidate genes. (ucsf.edu)
  • In the past ten years, improvements in massively parallel sequencing techniques have led to the development and widespread clinical use of multigene panels, which allow simultaneous testing of two to more than 150 genes. (nih.gov)
  • These include genes selected by a clinician for analysis by clinical sequencing. (nih.gov)
  • Results for each gene on the custom multigene panel are reported to the ordering clinician, whereas the results from the remaining genes sequenced (but not requested by the clinician) are not analyzed or included in the final laboratory report. (nih.gov)
  • Exome sequencing is a laboratory test designed to identify and analyze the sequence of all protein-coding nuclear genes in the genome. (nih.gov)
  • FISH is a screening test that uses multicolour probes or comparative genomic hybridization to find any chromosome irregularities in a genome. (wikipedia.org)
  • Different types of probes may investigate a broad range of sizes of DNA sequence. (msdmanuals.com)
  • For generating a comparable rhesus macaque CNV dataset, we designed a rhesus macaque-specific array comparative genomic hybridization (aCGH) platform containing 950,843 unique 60-mer oligonucleotide probes. (biomedcentral.com)
  • This uses fluorescent-labelled DNA probes complementary to specific sequences of interest, such as those from within regions commonly deleted or duplicated in particular syndromic disorders. (dnalabsindia.com)
  • The two probes carry an additional sequence, not complementary to human DNA sequences, including PCR primer binding sites and additional 'stuffer sequences' designed so that the PCR product is of a very specific size. (dnalabsindia.com)
  • Because the MLPA amplicons (the sequences being amplified by PCR) can be designed to be of different sizes, it is possible to amplify many such pairs of ligated probes in the same reaction and with the same primers and primer sites for each of the different target sites of interest: the length of the product obtained from each site is distinct. (dnalabsindia.com)
  • While the PCR primer sites used are the same for all probes, the site-specificity derives from the sequence of the hybridising probes initially used and not from the PCR primers that are located on the sections of the probes that are not complementary to human DNA. (dnalabsindia.com)
  • In both cases, DNA from two samples are differentially labeled with fluorescent dyes and co-hybridized to immobilized genomic capture probes. (biomedcentral.com)
  • The main advantage of aCGH over conventional CGH is the increased resolution achieved by microarrays with a large number of individual probes, routinely up to hundreds of thousands, covering the entire genome [ 4 ]. (biomedcentral.com)
  • To detect CNVs, we used a set of NimbleGen whole-genome comparative genomic hybridization arrays containing 718,256 oligonucleotide probes with a median probe spacing of 500 bp. (biomedcentral.com)
  • Cancer patients, for example, had both their healthy and tumor DNA sequenced. (aacc.org)
  • By use of aCGH, DNA derived from tumor tissue can be compared with reference DNA, e.g., normal whole blood DNA, and genomic imbalances can effectively be investigated. (biomedcentral.com)
  • Data from whole transcriptome sequencing of 33 breast specimens in the Harbin Medical University Cancer Center cohort and The Cancer Genome Atlas was applied to identify and validate the landscape of tumor suppressor long noncoding RNAs, which was further validated by The Cancer Genome Atlas pancancer data including 33 cancer types and 12,839 patients. (cancerindex.org)
  • Array-based comparative genomic hybridization (aCGH) tracks chromosome deletions and or amplifications using fluorescent dyes on genomic sequences of DNA samples. (wikipedia.org)
  • We propose a new HMM which benefit of having Position-Specific Emission probabilities (PSE-HMM) for modeling the length of the genomic regions with deletions (copy loss) and tandem duplications (copy gain). (biomedcentral.com)
  • Micro-Array measurement found similar SV's for:  Duplications  Deletions  Inversions Then, common SV's are now linked to: Autism Schizophrenia Nesthor Perez 2.1 Germline Structural Variation Human Genetics Study purpose: Identify a unique DNA sequencing. (studylib.net)
  • In one case with FISH-detected deletions of 7q and 20q in 11-12% of cells, neither cfDSA nor aCGH detected any copy number aberrations. (najms.com)
  • Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. (najms.com)
  • 2009) Targeted capture and massively parallel sequencing of 12 human exomes. (insilicogen.com)
  • Prior to the development of massively parallel sequencing (also known as next-generation sequencing ), the only cost-effective way to test more than one gene was serial single-gene testing (i.e., complete testing of one gene that might account for the phenotype before proceeding to testing of the next gene) ‒ an expensive and time-consuming approach with a potentially low yield. (nih.gov)
  • Multiplex ligation-dependent probe amplification (MLPA) is an application of the polymerase chain reaction (PCR) in which it is not the patient's DNA that is amplified by PCR but, instead, carefully designed probe sequences. (dnalabsindia.com)
  • However, our gene-centric aCGH, MLPA, and CMA tests remain as options if desired. (preventiongenetics.com)
  • In the current study, a total of 279 unrelated subjects ascertained for ASDs were screened for genomic disorders associated with CI using MLPA. (biomedcentral.com)
  • Our studies also identify some limitations of MLPA, where single base changes in probe binding sequences alter results. (biomedcentral.com)
  • Methods: We applied GTG banding, array-based comparative genomic hybridization (aCGH), and whole-genome sequencing (WGS) in order to identify the causative aberrations in all affected patients. (bvsalud.org)
  • In three samples with different clonal chromosome abnormalities, aCGH and cfDSA detected comparable copy number aberrations and further defined the chromosomal abnormalities. (najms.com)
  • Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ specific metastases. (tudelft.nl)
  • aCGH provides an understanding of genetic disorders, cancers and other genomic aberrations. (enzolifesciences.com)
  • On the other hand, aCGH showed novel chromosome abnormalities (+2p and del5q) potentially associated with disease progression. (elsevierpure.com)
  • Comparative genomic hybridization (aCGH) is a powerful diagnostic tool for detecting DNA copy number gains and losses associated with chromosome abnormalities. (enzolifesciences.com)
  • Different variants of FISH can be used to retrieve information on genomes from (almost) base pair to whole genomic level, as besides only second and third generation sequencing approaches can do. (frontiersin.org)
  • In December 2018, Genomics England announced that they had reached the main goal of their ambitious "100 000 Genomes Project"-to sequence 100 000 genomes [iii] . (aacc.org)
  • This custom aCGH platform was applied to the genomes of 17 unrelated macaques, resulting in the identification of 1,160 CNVs (Table S2 in Additional file 1 ). (biomedcentral.com)
  • Changepoint analysis methods are among the best approaches that can be used to address this problem of locating important genomic variations in genomes. (edu.au)
  • Introduction Every single person: Has a different genome sequence: Nesthor Perez Based on each person genetic and genomes, special trait are applied for each disease. (studylib.net)
  • DNA sequence Next-Generation reconstruct how cancer genomes are organized at single nucleotide resolution. (studylib.net)
  • Lazova et al performed exome sequencing of 77 melanocytic specimens composed of Spitz nevi (n=29), spitzoid melanomas (n=27), and benign melanocytic nevi (n=21), and they compared the results with published melanoma sequencing data. (medscape.com)
  • We performed array-based comparative genomic hybridization (aCGH) and whole exome sequencing (WES) to analyze paired samples from ET and sAML phases. (elsevierpure.com)
  • The diagnostic utility of exome sequencing has consistently been 20%-30% (i.e., a diagnosis is identified in 20%-30% of individuals who were previously undiagnosed but had features suggestive of a genetic condition) [ Gahl et al 2012 , Lazaridis et al 2016 ]. (nih.gov)
  • Next-generation sequencing technologies have dramatically changed the approach to genetic diagnosis. (msdmanuals.com)
  • This revolutionary and rapidly evolving technology has moved a significant portion of the technical aspects of genetic diagnosis to next-generation sequencing and has become the mainstay of genetic diagnosis. (msdmanuals.com)
  • The more typical method of analysing this type of genetic defects is Comparative Genomic Hybridization arrays ( aCGH ). (labiotech.eu)
  • Not only is next generation sequencing ( NGS ) getting cheaper, it is also more effective at pinpointing the exact genetic modification causing it. (labiotech.eu)
  • The gene present in the DNA sequence can be identified directly through sequencing or through various other genetic testing methods. (my.id)
  • WGA (complete sequence analysis) is also expected to play a role in healthcare, specifically in the diagnosis of diseases for which the genetic background is not yet (or insufficiently) clear. (nature.com)
  • FISH and CGH (Comparative Genomic Hybridization) are molecular cytogenetic procedures commonly employed for genetic analysis. (ablogwithadifference.com)
  • CGH has become popularly used for genomic profiling during cancer studies as well as CNV detection or preimplantation genetic diagnostics procedures. (ablogwithadifference.com)
  • The availability of both DNA sequencing and PreventionGenetics' HDGC custom aCGH significantly improves the sensitivity of molecular clinical testing at PreventionGenetics. (preventiongenetics.com)
  • Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. (najms.com)
  • 2008) Accurate whole human genome sequencing using reversible terminator chemistry. (insilicogen.com)
  • Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia. (najms.com)
  • Array comparative genomic hybridization (aCGH) is a type of microarray now routinely used to identify deleted or duplicated regions of DNA sequence in specific chromosomes on a genome-wide basis. (msdmanuals.com)
  • Particularly we focused on analyzing array comparative genomic hybridization (aCGH) data and DNA read count data obtained through next generation sequencing (NGS) methods. (edu.au)
  • Single-stranded sequences of DNA from across the genome (or from specific areas of the genome of particular interest) are laid out in a structured array of microdots. (dnalabsindia.com)
  • The ratio of the two different light emissions from each dot on the array then indicates the relative number of copies of the corresponding sequence in the two sources of DNA. (dnalabsindia.com)
  • Array CGH is the first genomic investigation to have been introduced into clinical practice on a wide scale since the karyotype, which it has largely replaced in many laboratories. (dnalabsindia.com)
  • Array CGH itself must be regarded as a provisional or transitional technology, however, as it will become feasible to replace it with whole-genome sequencing (WGS), as the junction fragments resulting from each site of a chromosome breakpoint will reveal even complex cytogenetic rearrangements. (dnalabsindia.com)
  • Array comparative genomic hybridization (aCGH) provides a method to quantitatively measure the changes of DNA copy number with an extremely high resolution and to map them directly onto the complete linear genome sequences. (korea.ac.kr)
  • Sung, JS, Park, KH & Kim, YH 2010, ' Genomic alterations of chromosome region 11p as predictive marker by array comparative genomic hybridization in lung adenocarcinoma patients ', Cancer Genetics and Cytogenetics , vol. 198, no. 1, pp. 27-34. (korea.ac.kr)
  • Copy number alterations (gains or losses) by array comparative genomic hybridization (aCGH). (ucsf.edu)
  • 이러한 Sequence Capture 방법을 이용하여 워싱턴주립대학과 Agilent사의 연구팀이 공동으로 Target Capture Array로부터 Illumina GA를 사용하여 8명의 HapMap Individual과 4명의 희귀질환인 Freeman-Sheldon syndrome (FSS)을 가진 환자의 엑손 영역만을 시퀀싱하여 protein coding variation을 찾은 연구를 수행하였다[8]. (insilicogen.com)
  • The amplified DNA underwent exome capturing, followed by sequencing on both Illumina HiSeq® 2000 and Thermo Fisher Ion Proton platforms. (takarabio.com)
  • Cells were whole-genome amplified, followed by PCR-free library preparation and Illumina sequencing. (takarabio.com)
  • Diploid is not directly involved in the sequencing process (and so it stays away from NGS battles), but it is recommended by Genomics England , that is leading the 100,000 Genome Project - where Illumina is also involved . (labiotech.eu)
  • In the last 5 years, DNA sequence next-generation technology become commercially available to companies:  Illumina  Life Technology  Complete Genomics Nesthor Perez 1. (studylib.net)
  • 1996). In cases where the majority of the reported pathogenic variant in a gene can be detected by DNA sequencing, PreventionGenetics' aCGH is an excellent complementary test when DNA sequencing fails to identify the causative pathogenic variant(s). (preventiongenetics.com)
  • Cancer Genome Sequencing Studies identified Somatic Mutations associated with cancer progression. (studylib.net)
  • This method gives information about the number of copies of the sequence of interest and shows on which chromosomes they are found. (dnalabsindia.com)
  • The length of these sequences has become shorter with each new generation of the technology: originally consisting of bacterial artificial chromosomes (BACs) with many kilobases of human DNA inserted, they now usually consist of oligonucleotides (oligos) of some 20+ bases. (dnalabsindia.com)
  • This technology involves breaking the entire genome into small segments, sequencing the segments, and then reassembling the sequences using intensive computational techniques to provide the base-by-base sequence of the entire genome or more limited regions, such as the expressed portion of the genome known as the exome. (msdmanuals.com)
  • With optimized, proprietary reagents, the Enzo Life Sciences CGH Labeling Kits for oligo arrays produce high quality data using as little as 0.25 µg of genomic DNA, without a need for pre-amplification. (enzolifesciences.com)
  • In this paper, we emphasize the utility of sequence-based approaches in molecular diagnostics of disorders caused by regulatory structural variants. (bvsalud.org)
  • We apply the proposed variants of the CE method to both aCGH and DNAread count data obtained through NGS methods to detect copy number variations. (edu.au)
  • Patients with autosomal recessive disorders with one or no pathogenic variants identified by DNA sequencing. (preventiongenetics.com)
  • Female patients with X-linked disorders with one or no pathogenic variants have been identified by DNA sequencing. (preventiongenetics.com)
  • In this study, we used aCGH to compare genomic alterations in fresh-frozen lung cancer tissues of 21 adenocarcinomas (AdCCs) (11 early relapse and 10 nonrelapse) and identified genomic alterations that showed significant by different frequency between early relapse and nonrelapse AdCCs. (korea.ac.kr)
  • Genomic alterations of chromosome 11p region in AdCC patients were observed with aCGH, and a relapsable marker was identified in the nonrelapse group. (korea.ac.kr)
  • Epigenetic regulation of biological functions via gene expression without alterations in the DNA sequence may be an important factor. (cmttreatmentreport.com)
  • Unlocking clinically translatable genomic information, including copy number alterations (CNA), from formalin-fixed paraffin-embedded (FFPE) tissue is challenging due to low yields and degraded DNA. (biomedcentral.com)
  • In [ 8 ], an HMM with a Poisson emission probability is applied for modeling the observed read counts per genomic segment, after taking the genome-wide variation in GC contents into account. (biomedcentral.com)
  • The difficulty with high-resolution aCGH is that it detects more variation than we currently know how to interpret with confidence. (dnalabsindia.com)
  • Many bacteria display substantial intra-specific genomic diversity that produces significant phenotypic variation between strains of the same species. (inra.fr)
  • Nesthor Perez 2.3 Mechanisms of Structural Variation Cytogenetic Techniques: Chromosome Painting: Nesthor Perez 2.3 Mechanisms of Structural Variation Cytogenetic Techniques: Nesthor Perez 2.3 Mechanisms of Structural Variation Cytogenetic Techniques: Fluorescent in Situ Hybridization (FISH): Nesthor Perez (FISH) Nesthor Perez Outline 1. (studylib.net)
  • 이번 연재에서는 Next Generation Sequencing 의 첫 번째 Application인 Variation study 중에 Targeted Sequencing (Sequence Capture) 기술 에 대해 알아보도록 하겠습니다. (insilicogen.com)
  • 4. Xie C, Tammi MT. (2009) CNV-seq, a new method to detect copy number variation using high-throughput sequencing. (insilicogen.com)
  • DNA sequencing refers to a range of techniques that analyze sections of the genome to single-nucleotide resolution. (aacc.org)
  • These screening tests analyze complicated genomic interactions and help to determine the progress of a disease. (fintechnews.org)
  • In turn, this allows scientists to map out a person's DNA sequence allowing for a diagnosis to be made. (wikipedia.org)
  • Taking into account that the price of sequencing a genome is now between €1100 and €1500, this could bring the price of a successful diagnosis to less than €2000 - a more cost-effective alternative (besides about 80x more sensitive), claims Diploid. (labiotech.eu)
  • As next-generation sequencing (NGS) makes inroads into clinical applications such as cancer diagnostics, we look at some of the NGS initiatives and collaborations aiming to change the landscape of clinical sequencing and improve patient's lives. (aacc.org)
  • The traditional Sanger method is still popular in clinical applications, but high-throughput next generation sequencing (NGS) techniques are on the rise. (aacc.org)
  • In recent years, many studies apply Next Generation Sequencing (NGS) data for the CNV detection. (biomedcentral.com)
  • In recent years, development of the Next Generation Sequencing (NGS) has provided an unprecedented opportunity for the study of the genome-wide variations. (biomedcentral.com)
  • Comparative study of whole genome amplification and next generation sequencing performance of single cancer cells. (takarabio.com)
  • The company offers two certification paths: Agilent's CGH microarray platform and its upstream target enrichment next-generation sequencing platform. (harvard.edu)
  • Next-generation sequencing on maternal plasma cell-free DNA (cfDNA) has been applied to non-invasive prenatal screening for common aneuploidy in the fetuses. (najms.com)
  • Short-read genome sequencing (GS) holds the promise of becoming the primary diagnostic approach for the assessment of autism spectrum disorder (ASD) and fetal structural anomalies (FSAs). (cdc.gov)
  • These genomic regions appear to have an elevated likelihood of positive selection, based on nucleotide level conservation and transcriptional data. (biomedcentral.com)
  • PGxome and exome-based sequencing panels, including custom panels, include copy number variant (CNV) analysis via NextGen sequencing (NGS) data at no additional cost. (preventiongenetics.com)
  • The study concluded that "PicoPLEX showed the best performance in the quality of sequencing data, uniformity of read depth, amplification reproducibility and fidelity," and "recommended [PicoPLEX] for CNV calling on Ion Proton platform. (takarabio.com)
  • Diploid (Belgium) is using genome sequencing data to diagnose rare diseases - and is now charging only if its algorithms can match the genome to a specific rare disease. (labiotech.eu)
  • Whole-genome sequencing (WGS) can lead to whole-genome analysis (WGA), in which the meaning of the raw data obtained during sequencing is fleshed out. (nature.com)
  • What should happen with the (raw) sequencing data afterwards? (nature.com)
  • However, the analytic and clinical validities need to be established using a large sample series and user-friendly designed bioinformatic tools need to be developed for robust sequencing data analysis in a clinical setting. (najms.com)
  • Although valid concerns about directly adopting existing normalization techniques are expressed, proposed strategies rely on available conventional methods and the inherent properties of aCGH data have, rather than being incorporated in the strategies, mainly been used for calibration and validation. (biomedcentral.com)
  • 이러한 문제를 해결하기 위해 'Sequence Capture' 라는 기술이 개발되었고 Roche NimbleGen에서 처음 상용화 되어 관심 있는 특정 유전체의 일부분을 선택적으로 분석을 할 수 있어 NGS를 이용한 유전체 분석에서 중요한 부분을 차지하게 이르렀다. (insilicogen.com)
  • Sanger sequencing was performed on the amplified DNA to confirm the results obtained from dPCR KRAS mutation analysis. (takarabio.com)
  • From analysis of chromosomal breakpoints, as well as gene sequencing in suggestive cases, Kleefstra and colleagues identified EHMT1 as the causative gene. (wikipedia.org)
  • This paper compared the performance of the PicoPLEX DNA-seq Kit , the DOPlify WGA Kit, the REPLI-g Single Cell Kit, and the Ampli1 WGA Kit for aneuploidy screening and copy number analysis using shallow whole genome sequencing, starting from one, three, or five cells isolated from the Loucy cell line. (takarabio.com)
  • The methods used in multigene panels may include sequence analysis , deletion/duplication analysis , and/or other non-sequencing-based tests. (nih.gov)
  • Our technique enables identification of driver and prognostic CNAs in archival patient samples previously deemed unsuitable for genomic analysis due to DNA limitations. (biomedcentral.com)
  • Hybrid algorithms for multiple change-point detection biological sequences -- 5. (edu.au)
  • For more information about CNV detection via NGS, please refer to the specific sequencing test descriptions of interest on our website. (preventiongenetics.com)
  • We describe a robust, cost-effective low-coverage whole genome sequencing (LC WGS) method for CNA detection using 5 ng of FFPE-derived DNA. (biomedcentral.com)
  • Whole genome sequencing (WGS) at 30× coverage can also be used for CNA and LOH detection, but requires at least 100 ng of high quality input DNA and has challenges associated with cost, bioinformatics processing time, and storage of large datasets. (biomedcentral.com)
  • All over the world, huge NGS initiatives and collaborations are launching or ongoing-all aiming to advance our understanding of genomics and improve patients' lives through the power of DNA sequencing. (aacc.org)
  • Here, we've picked out some of the DNA sequencing initiatives, where today's scientists work together to change outcomes for patients tomorrow. (aacc.org)
  • Patients with autosomal dominant disorders with no pathogenic variant identified by DNA sequencing. (preventiongenetics.com)
  • Male patients with X-linked disorders with no pathogenic variant identified by DNA sequencing or PCR fails. (preventiongenetics.com)
  • Whole-genome screening creates a personal genomic database (personal genome) that can subsequently be used to deliver 'personalised medicine' to individual patients. (nature.com)
  • Sequence Capture 기술 은 타겟으로 하는 유전체의 각 부위와 상보적으로 결합하도록 디자인된 프로브가 올려져있는 DNA chip과 분석하고자 하는 샘플의 유전체 서열간의 hybridization을 진행하여 특이적으로 결합한 DNA 절편들을 분리 후 NGS를 이용하여 직접적으로 시퀀싱을 진행하는 방식이다(그림 5). (insilicogen.com)
  • Sequence Capture 원리. (insilicogen.com)
  • Deviations from the normal two copies of an autosomal sequence can be detected in this way with much greater sensitivity than when using light microscopy unaided. (dnalabsindia.com)
  • The PCR reaction of the probe sequence, not the human sequence, can then proceed, yielding a quantity of product that relates directly to the number of copies of the target DNA in the patient's genome. (dnalabsindia.com)
  • In addition, 300 bp of flanking intronic sequence on either side of targeted exons has enriched probe coverage. (preventiongenetics.com)
  • The human exome includes all coding nuclear DNA sequences, approximately 180,000 exons that are transcribed into mature RNA. (nih.gov)
  • PreventionGenetics' high density gene-centric (HDGC) aCGH is designed to have comprehensive coverage for coding regions (18 bp median probe spacing) and non-coding regions (87 bp median probe spacing) for each targeted gene and includes coverage of all transcripts. (preventiongenetics.com)
  • In essence, relative ratios of copy number between two DNA samples are obtained by comparing the two fluorescent signal intensities for each probe under the assumption that intensities reflect the amount of corresponding genomic DNA in the respective sample. (biomedcentral.com)
  • Lastly, EHMT1 sequencing is a process in which a single-strand of DNA from the EHMT1 gene is removed, and DNA polymerase is added in order to synthesize complementary strands. (wikipedia.org)
  • Taking opportunity of the added awareness of Rare Diseases Day , this Belgian Bioinformatics company is introducing a new business model for genomic diagnostics: pay only if you get results. (labiotech.eu)
  • Our paper emphasizes the relevance of Extreme Learning Machine (ELM) in Bioinformatics applications by addressing the problem of predicting the disulfide connectivity from protein sequences. (scitevents.org)
  • However, the sheer volume of information generated by sequencing the exome or genome results in a variety of interpretive problems that complicate understanding of the results. (msdmanuals.com)
  • Six of the ten samples had normal karyotypes, and consistently, both cfDSA and aCGH showed normal results. (najms.com)
  • Moreover, we are yet unable to predict response to a specific therapy in an individual patient and the optimal sequence of these therapies needs to be clarified. (oaepublish.com)