• nucleic
  • Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus.Thomas Simonson's Research Group. (1004682.gq)
  • Carbohydrates, lipids, vitamins, proteins, and nucleic acids in JSmol / Jmol in English or español , thanks to BioModel by Angel Herráez. (umass.edu)
  • Mutation
  • The increased rate of mutation during the SOS response is caused by three low-fidelity DNA polymerases: Pol II, Pol IV and Pol V. Researchers are now targeting these proteins with the aim of creating drugs that prevent SOS repair. (wikipedia.org)
  • genome
  • The BEND2 protein has no known paralogs within the human genome. (wikipedia.org)
  • Specifically, it allows the identification of the cistrome, the sum of binding sites, for DNA-binding proteins on a genome-wide basis. (wikipedia.org)
  • Whole-genome analysis can be performed to determine the locations of binding sites for almost any protein of interest. (wikipedia.org)
  • The goal of ChIP-on-chip is to locate protein binding sites that may help identify functional elements in the genome. (wikipedia.org)
  • For example, in the case of a transcription factor as a protein of interest, one can determine its transcription factor binding sites throughout the genome. (wikipedia.org)
  • Non-tiled arrays use probes selected according to non-spatial criteria, i.e., the DNA sequences used as probes have no fixed distances in the genome. (wikipedia.org)
  • organisms
  • One of the long-term goals ChIP-on-chip was designed for is to establish a catalogue of (selected) organisms that lists all protein-DNA interactions under various physiological conditions. (wikipedia.org)
  • In general, metazoans appear to have SR proteins and unicellular organisms lack SR proteins. (wikipedia.org)
  • repression
  • Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. (harvard.edu)
  • There has been a recent discovery of Polycomb-group Response Elements (PREs), which can allow and inhibit repression depending on the protein bound to it, and the presence of non-coding transcription. (wikipedia.org)
  • complexes
  • Shotgun identification of protein modifications from protein complexes and lens tissue. (springer.com)
  • Telomeres are specialized complexes of DNA and proteins that cap and confer stability to the ends of eukaryotic chromosomes. (lu.se)
  • Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proceedings of the National Academy of Sciences of the United States of America. (wikipedia.org)
  • scaffold
  • The eIF4F complex is composed of three non-identical subunits: the DEAD-box RNA helicase eIF4A, the cap-binding protein eIF4E, and the large "scaffold" protein eIF4G. (wikipedia.org)
  • yeast
  • Kaiso is a ubiquitously expressed BTB/POZ transcription factor that was originally identified in a yeast-two-hybrid screen for binding partners of the multifunctional Armadillo-repeat containing protein p120-catenin (hereafter p120 ctn ) ( Daniel and Reynolds, 1999 ). (biologists.org)
  • SIR proteins organize heterochromatin at telomeres, rDNA and at silent loci including, in yeast, the hidden mating type loci. (wikipedia.org)
  • In budding yeast, SIR proteins are found at the silent mating type loci, telomeres, and at the rDNA locus. (wikipedia.org)
  • mammalian
  • However, the sequences that recruit PRC2 in mammalian cells have remained obscure. (harvard.edu)
  • Our findings demonstrate a causal role for GC-rich sequences in PRC2 recruitment and implicate a specific subset of CpG islands depleted of activating motifs as instrumental for the initial localization of this key regulator in mammalian genomes. (harvard.edu)
  • 1999
  • Like other BTB/POZ proteins, Kaiso has the characteristic N-terminal protein-protein interaction POZ domain and it is through this domain that Kaiso homodimerizes and heterodimerizes with other BTB/POZ proteins ( Daniel and Reynolds, 1999 ) (our unpublished data). (biologists.org)
  • concentration
  • as local protein concentration or chromatin.En présence de tetracycline, la proteine de fusion ne peut se fixer aux séquences tetO et le. (1004682.gq)
  • When SAM concentration becomes low, the repressor dissociates from the operator site, allowing more methionine to be produced. (wikipedia.org)
  • enzyme
  • An outer membrane protein Antigen 43 (Ag43) in E. coli is controlled by phase variation mediated by two proteins, DNA-methylating enzyme deoxyadenosine methyltransferase (Dam) and the oxidative stress regulator OxyR. (wikipedia.org)
  • The cleavage agent is a chemical or enzyme that will cut at random locations in a sequence independent manner. (wikipedia.org)
  • Organism
  • The proteome represents the total complement of proteins present in a complex, an organelle, a cell, tissue, or an organism. (springer.com)
  • mTOR
  • The eIF4E subunit of eIF4F is an important target of mTOR signaling through the eIF4E binding protein (4E-BP). (wikipedia.org)
  • epigenetic
  • Unlike other mechanisms of phase variation, epigenetic modifications do not alter DNA sequence and therefore it is the phenotype that is altered not the genotype. (wikipedia.org)