Sequence receptor insulin. Medical search. Frequent questions

In contrast to the activated epidermal growth factor receptor that binds the GRB2-Sos complex directly, activation of the insulin receptor results in the interaction of GRB2-Sos with IRS-1 and Shc, thus linking the insulin receptor to Ras signaling pathways. (nih.gov)
Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. (aacrjournals.org)
The epidermal growth factor receptor (EGFR) tyrosine kinase (TK) plays an important role in the pathogenesis of NSCLC. (bmj.com)
Alterations in receptor tyrosine kinases (TKs), such as the epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor 1, include overexpression, amplification or mutations. (bmj.com)
Novel therapeutic agents, in particular those that specifically target members of the human epidermal growth factor receptor (HER (ErbB1)) pathway, have shown encouraging therapeutic efficacy. (bmj.com)
Marked accelerated evolution on this branch was also seen for some IGFBPs, but not the mannose 6-phosphate/IGF2 receptor or epidermal growth factor receptor. (figshare.com)

Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells. (wikipedia.org)
IRS1 (see also Insulin receptor substrate 1) IRS2 (see also Insulin receptor substrate 2) IRS3P - a pseudogene IRS4 van der Geer P, Wiley S, Pawson T (1999). (wikipedia.org)
Peptide used as insulin receptor tyrosine kinase substrate. (anaspec.com)
In response to insulin stimulation, this complex bound to tyrosine-phosphorylated IRS-1 (insulin receptor substrate-1) and Shc. (nih.gov)
The adaptor protein APS is a substrate of the insulin receptor and couples receptor activation with phosphorylation of Cbl to facilitate glucose uptake. (rcsb.org)
The FH1 domain is also a binding site for diverse SH3-domain containing proteins like Src-like non-receptor tyrosine kinases, WISH (WASP-interacting SH3 protein) and IRSp53 (insulin receptor substrate) in mammals, and Hof1p in yeast [ 6 ]. (biomedcentral.com)
This study aims to identify insulin receptor substrate 1 (IRS-1) gene polymorphism Gly972Arg as the risk factor for ischemic stroke among Indonesian subjects. (biomedcentral.com)
thereby ensuring that sufficient insulin mRNA is present to serve as the substrate for rapid insulin biosynthesis under conditions of greater insulin demand. (molcells.org)
Several intracellular proteins have been identified as phosphorylation substrates for the insulin receptor, the best-studied of which is insulin receptor substrate 1 or IRS-1. (sputnic-group.ru)
The extent of phosphorylation of either insulin receptor substrate 1 or Shc. (aleijten.com)

Type 2 Diabetes Mellitus (T2DM) is a complex heterogeneous group of metabolic condition characterized by elevated levels of serum glucose, caused mainly by impairment in both insulin action and insulin secretion. (scialert.net)
In healthy individuals, insulin has a suppressive effect on alpha-cell function and on glucagon secretion. (medscape.com)
This insulin secretion subsides as blood glucose concentrations decrease and approach euglycemia. (empr.com)
Impaired biosynthesis and secretion of insulin leads to somatic damage via hyperglycemia. (molcells.org)
The elevation of glucose levels induces calcium-mediated secretion of insulin, which, in turn, promotes the absorption of glucose from the blood into peripheral tissues, thereby reducing blood glucose levels. (molcells.org)
The severe insulin-deficient diabetes (SIDD) subgroup is characterised by non-autoimmune impaired insulin secretion and was previously hidden in the type 2 diabetes group. (lu.se)
Identify disease heterogeneities that influence the insulin secretion process. (lu.se)

The Insulin Receptor (INS R) and insulin-like growth factor-1 receptor (IGF-1 R) constitute a subfamily of receptor tyrosine kinases (1‑4). (rndsystems.com)

Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
The pathogenetic mechanism of inherited lipodystrophies at the molecular level has been linked to mutations of lamin A/C, peroxisome proliferator-activated receptor (PPAR-gamma), and other seemingly unrelated proteins. (medscape.com)
Familial partial lipodystrophy (FPLD) usually results from coding sequence mutations either in LMNA , encoding nuclear lamin A/C, or in peroxisome proliferator-activated receptor-gamma ( PPARG ), encoding PPAR-gamma. (medscape.com)

The insulin signaling pathway (ISP) has a key role in major physiological events like carbohydrate metabolism and growth regulation. (biomedcentral.com)
Here, we report that glucose induces the expression of PTBP1 via the insulin receptor (IR) signaling pathway in β cells. (molcells.org)

Met) in the insulin receptor gene in five sibs with familial insulin resistance. (bmj.com)
Mutations in the insulin receptor gene can cause genetic syndromes such as leprechaunism that are associated with extreme insulin resistance. (bmj.com)
In spite of a homozygous abnormality of the insulin receptor gene and many of the clinical features of severe insulin resistance, the proband's clinical syndrome was noticeably different from previously described patients with leprechaunism who usually die within the first six months of life. (bmj.com)
Mutations in the INS R gene have been linked to insulin-resistant diabetes mellitus, noninsulin-dependent diabetes mellitus and leprechaunism, an extremely rare disorder characterized by abnormal resistance to insulin that results in a variety of distinguishing characteristics, including growth delays and abnormalities affecting the endocrine system. (rndsystems.com)
Evidence suggests that obesity and insulin resistance are the major factors that contribute to the development of NAFLD. (wjgnet.com)
Type 2 diabetes is a heterogeneous disorder that results from the complex interplay of genetic susceptibility and lifestyle choices, leading to insulin resistance and impaired β-cell function ( 2 ). (diabetesjournals.org)
Metabolic syndrome is consists of abdominal obesity, hyperglycemia, insulin resistance, hypertriglyceridemia, low HDL cholesterol and hypertension and is an important risk factor for atherosclerotic cardiovascular disease [ 16 ]. (biomedcentral.com)
Hyperinsulinemia, in turn, causes a reversible reduction in receptor kinase activity, leading to insulin resistance. (biu.ac.il)
No, they do not get hypoglycemic and seize, as DKA is a form of insulin resistance . (medscape.com)

The authors searched public genome databases for viral peptide sequences that shared homology with human hormones, growth factors or cytokines and found 16 full-length sequences that encode homologues, including four insulin-like growth factor 1 (IGF1) peptides. (nature.com)
Unlike insulin made in the body, the venom's peptide sequence - which allows it to bind to human insulin receptors - is much shorter. (sflorg.com)
The newly created variants were made up of much shorter peptide chains than human insulin - lacking the last eight residues of the B-chain of the human insulin. (sflorg.com)
R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu (E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. (joplink.net)
Glucagon-like peptide-1 (GLP-1) receptor agonist. (empr.com)
Liraglutide is an acylated human Glucagon-Like Peptide-1 (GLP-1) receptor agonist with 97% amino acid sequence homology to endogenous human GLP-1(7-37). (empr.com)
Background: Although insulin-like 3 (INSL3) has been identified in the gonad of both sexes in many species, there are only limited reports on the distribution of INSL3 and its receptor, relaxin/insulin-like family peptide receptor 2 (RXFP2), in the primate ovary. (elsevierpure.com)
Topline findings on this dual glucose-dependent insulinotropic polypeptide (GIP)/glucagon-like peptide 1 (GLP-1) receptor agonist were reported in July, building on earlier results reported from SURMOUNT-1 and SURMOUNT-2 . (medscape.com)

Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor. (anaspec.com)
The intracellular region contains the kinase domain sandwiched between the juxtamembrane domain used for docking insulin-receptor substrates (IRS), and the carboxy-terminal tail that contains two phosphotyrosine-binding sites. (rndsystems.com)
The APS SH2 dimer engages two kinase molecules, with pTyr-1158 of the kinase activation loop bound in the canonical phosphotyrosine binding pocket of the SH2 domain and a second phosphotyrosine, pTyr-1162, coordinated by two lysine residues in beta strand D. This structure provides a molecular visualization of one of the initial downstream recruitment events following insulin activation of its dimeric receptor. (rcsb.org)
It belongs to the large class of tyrosine kinase receptors. (sputnic-group.ru)
Their receptor had an intact tyrosine kinase activity but a higher K(m) for ATP in the phosphorylation reaction of exogenous substrates. (biu.ac.il)
The initial effects of overeating (i.e., development of hyperinsulinemia without hyperglycemia) were associated in the sand rat with a dramatic decrease in in vitro and in vivo insulin-induced receptor tyrosine kinase activity in both liver and muscle. (biu.ac.il)
In muscle, this coincided with a decrease in receptor number and an increase in basal tyrosine kinase activity. (biu.ac.il)
Upon recovery from the diabetic state by diet restriction, the impaired receptor kinase activation was corrected. (biu.ac.il)
These observations indicate that loss and gain of receptor tyrosine kinase activity were dependent on insulin levels. (biu.ac.il)

The pharmaceutical composition contains an ADAM17 antibody (it recognizes an epitope within the membrane proximal domain of ADAM17 localized between the residues 564 and 642) characterized by the sequences of its variable chains. (justia.com)
However, PTBP1 levels were not altered in βIRKO cells transfected with IR-3YA, in which the Tyr1158/1162/1163 residues are substituted with Ala. Consistently, treatment with glucose or insulin elevated PTBP1 levels in βIRWT cells, but not in βIRKO cells. (molcells.org)
1 Insulin receptor functions as an enzyme that transfers phosphate groups from ATP to tyrosine residues on intracellular target proteins. (sputnic-group.ru)
Application of the branch-sites method showed dN/dS ratios significantly greater than 1.0 for both receptor ectodomains and for IGFBP1, and allowed identification of residues likely to have been subject to selection. (figshare.com)
These residues were concentrated in the N-terminal half of the IGF1R ectodomain but the C-terminal half of the IR ectodomain, which could have implications for the formation of hybrid receptors. (figshare.com)
For the most part, the residues that change on this branch could not be associated with specific functional aspects (ligand binding, receptor dimerization, glycosylation) and the physiological significance of this coevolution remains to be established. (figshare.com)

Synthetic viral IGF1 peptides bound to human and mouse insulin and to IGF1 receptors in vitro, stimulating downstream signalling and increasing glucose uptake and cell growth. (nature.com)
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. (joplink.net)
This enable them to link to IGF1 receptor. (proteopedia.org)
Hence, Insulin binds to IGF1R following the same mechanism and activated the intracellular pathways in the same way IGF1 does. (proteopedia.org)
All six IGFBPs share 50% homology with each other and have binding affinities at the same order of magnitude for IGF-1 and IGF-2 but have greater affinities then IGF1 for its receptor. (proteopedia.org)
Once IGF1 is bound to Insulin-like Growth Binding Protein (IGFBP), IGF-1 cannot be linked to IGF1R any longer. (proteopedia.org)
Previous work has shown that the evolution of both insulin-like growth factor 1 (IGF1) and insulin shows an episode of accelerated change on the branch leading to New World monkeys (NWM). (figshare.com)
Here the possibility that this is accompanied by a corresponding episode of accelerated evolution of IGF1 receptor (IGF1R), insulin receptor (IR) and/or IGF binding proteins (IGFBPs) was investigated. (figshare.com)
Analysis of receptor sequences from a range of primates and some non-primate mammals showed that accelerated evolution did indeed occur on this branch in the case of IGF1R and IR, but not for the similar insulin receptor-related receptor (IRRR) which does not bind insulin or IGF1. (figshare.com)
Overall the results suggest that adaptive coevolution of IGF1, insulin and their receptors and some IGFBPs occurred during the evolution of NWM. (figshare.com)

Here, we show that insulin-induced activation of ERKs was enhanced by stable overexpression of growth factor receptor-bound protein 2 (GRB2) but not by overexpression of GRB2 proteins with point mutations in the Src homology 2 and 3 domains. (nih.gov)
Therefore, the various concentration of the insulin proteins regulates the cell activity in different context, for instance in excess of glucose or lack of Growth Hormone. (proteopedia.org)
The activated receptor then phosphorylates a number of intracellular proteins, which in turn alters their activity, thereby generating a biological response. (sputnic-group.ru)

All 22 exons of the insulin receptor gene were screened for mutations using denaturing gradient gel electrophoresis. (bmj.com)
The patient was homozygous for a point mutation in exon 2 of the insulin receptor gene which results in the substitution of methionine for isoleucine at codon 119. (bmj.com)
Met mutation in the insulin receptor gene, and are clinically affected with varying degrees of severity. (bmj.com)
The candidate gene approach focuses on the search for an association between T2DM and sequence variants in or near biologically defined candidate genes which have been chosen based on their known physiological function. (scialert.net)
The two receptors share structural similarity as well as overlapping intracellular signaling events, and are believed to have evolved through gene duplication from a common ancestral gene. (rndsystems.com)
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. (cancerindex.org)
The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)
Alterations in gene sequence or expression can occur in the cell-signalling and regulatory pathways involved in cell-cycle control, apoptosis, proteosome regulation and angiogenesis. (bmj.com)
This gene includes a repeated, three-letter sequence of nucleotides, the gene's chemical building blocks. (illinois.edu)
Targeted next-generation sequencing (NGS) analyses comprising 277 shorted stature-associated candidate genes and 19 related copy number variation (CNV) regions were used to identify gene mutations in the proband. (eurospe.org)
Insulin-like growth factor-1 receptor (IGF-1R) is the effector molecule that regulates the cascade reaction of hormone receptors in the GH IGF-1 axis.Objective and hypotheses: To investigate the role of IGF-1R gene polymorphisms with regard to susceptibility to Idiopathic short stature risk in the Chinese population of Jiangxi area. (eurospe.org)

The juxtamembrane phosphorylation site Tyr960 within the insulin receptor cytoplasmic domain is an essential determinant for the tyrosine phosphorylation of IRS-1. (sputnic-group.ru)

The most common cause of hyperglucagonemia is an absence or deficiency of the restraining influence of insulin on glucagon production. (medscape.com)
One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. (sigmaaldrich.com)
Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. (sigmaaldrich.com)
The pancreas lies in the curve of the duodenum and controls the level of sugar in the blood by secreting insulin and glucagon. (medscape.com)

Peptides that are secreted in response to glucose stimulus and known to act on insulin-sensitive tissues have become important therapeutic targets for affecting insulin sensitiveness . (anaspec.com)
Our growing portfolio of diabetes-related peptides elicits important roles in glucose metabolism/modulation via insulin and non-insulin signaling pathways with therapeutic potentials. (anaspec.com)
Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: a paradigm shift for host-microbe interactions. (nature.com)
To test whether it would still bind effectively, the researchers used sequences of the insulin-like peptides in the venom of the cone snail C. geographus as a template to model six different Con-Ins analogs. (sflorg.com)

There was a family history of mild non-insulin dependent diabetes mellitus affecting her father and maternal grandmother, treated with diet alone. (bmj.com)
Our data demonstrate that SIRT1 mediates the effect of exenatide on ameliorating hepatic steatosis, suggesting the GLP-1 receptor agonist could serve as a potential drug for nonalcoholic fatty liver disease (NAFLD), especially in type 2 diabetes combined with NAFLD, and SIRT1 could be a therapeutic target of NAFLD. (diabetesjournals.org)
The insulin receptor was evaluated at different disease stages in the sand rat (Psammomys obesus), a model for nutrition-induced diabetes. (biu.ac.il)
This sequence of events may be relevant to diet- related changes in human non-insulin-dependent diabetes mellitus. (biu.ac.il)

The PTB-domain binds the NPXY sequence. (wikipedia.org)
Thus, the insulin receptor binds IRS. (wikipedia.org)
IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. (joplink.net)

History of anaphylaxis or angioedema with other GLP-1 receptor agonist. (empr.com)
Here, we speculate that SIRT1 might mediate the effect of the GLP-1 receptor agonist exenatide (exendin-4) on ameliorating hepatic steatosis. (diabetesjournals.org)
We have a consensus on starting with metformin for most people, but beyond that, decisions are based on beliefs about what happens to islets when squeezed to hormonal oblivion with glipizide , whether insulin will make patients even more obese , will they remember to inject a weekly GLP-1 receptor agonist, and can I really get the A1c to go from 12% to 7.5% with a DPP4? (medscape.com)

Ligand binding induces a conformational change of the receptor, resulting in ATP binding, autophosphorylation, and subsequent downstream signaling. (rndsystems.com)
The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. (cancerindex.org)
IGF-1 then acts as a ligand and can interact with Insulin Receptor protein and Insulin-like Growth Factor Binding Protein . (proteopedia.org)
Moreover, the INSL3 level in follicular fluid is 3-4 times higher than that in female serum which remains low throughout the menstrual cycle.Conclusions: The presence of INSL3 and its receptor in the ovary implies a potential role of the ligand-receptor pair in female reproduction in nonhuman primates. (elsevierpure.com)

Like GLP-1(7-37), liraglutide activates the GLP-1 receptor, a membrane-bound cell-surface receptor coupled to adenylyl cyclase by the stimulatory G-protein, Gs, in pancreatic beta cells. (empr.com)
In pancreatic β cells, glucose stimulates the biosynthesis of insulin at transcriptional and post-transcriptional levels. (molcells.org)
Thus, our results identify insulin as a pivotal mediator of glucose-induced PTBP1 expression in pancreatic β cells. (molcells.org)
Insulin produced in and secreted from pancreatic β cells is the most crucial hormone for the control of glucose homeostasis in the blood circulatory system. (molcells.org)

The Mc4r mutation was generated by target-selected ENU-driven mutagenesis and high-throughput resequencing of genomic sequences in Crl:Wistar background. (mcw.edu)
Now, the genomic sequencing of organisms promises to be a major contributor to this field. (rupress.org)
Along with these findings, the sequencing of the G. buenoi genome now provides us the opportunity to pursue exciting research opportunities to further understand the genomic underpinnings of traits associated with the extreme body plan and life history of water striders. (umd.edu)

Details about TEDapos, discover, toprated pharmacies cialis in the, two cialis of the major substrates of the igfi receptor. (aleijten.com)

0.1 mU/l), but insulin concentrations were very high (table 1) and glucose concentrations were consistent with impaired glucose tolerance by WHO criteria. (bmj.com)
Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. (joplink.net)
Liraglutide increases intracellular cyclic AMP (cAMP) leading to insulin release in the presence of elevated glucose concentrations. (empr.com)
PTBP1 is present in β cells of both mouse and monkey, where its levels are increased by glucose and insulin, but not by insulin-like growth factor 1. (molcells.org)
Therefore, the amount of insulin is tightly regulated in order to maintain a very narrow blood glucose range. (molcells.org)

BACKGROUND Insulin receptor is a transmembrane receptor that is activated by insulin. (sputnic-group.ru)

The present invention relates to an ADC having the following formula (I) in which Ab is an anti-IGF1R antibody characterized in that it comprises light chain CDRs of sequences SEQ ID Nos. (justia.com)

INS R is highly conserved between species, rat INS R shares 94% and 97% aa sequence homology with the human and mouse receptor, respectively. (rndsystems.com)
The interaction with the activated insulin receptor is mediated by the Src homology 2 (SH2) domain of APS. (rcsb.org)
Recent research demonstrated that the homology between IGF-1R and the insulin receptor (IR) subunits allow them to bind and form a functionnal hybrid IR/IGF-1R receptor. (proteopedia.org)

Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (nih.gov)
First, molecular events in T2DM pathogenesis have been examined directly by testing the role of sequence variants of specific candidate genes. (scialert.net)
The size of the G. buenoi genome is approximately 1,000 Mb, and this sequencing effort has recovered 20,949 predicted protein-coding genes. (umd.edu)
The use of targeted sequencing and clinical criteria makes it possible to identify carriers of rare clinically significant variants in a wide range of obesity-associated genes and to investigate their influence on phenotypic manifestations of abdominal obesity. (cdc.gov)

This work package utilises our large islet RNA data sets as well as a new human islet cell encyclopedia generated by single-cell RNA sequencing, and focuses on miRNA translation pathways, membrane receptor and intracellular Ca2+ signalling pathways. (lu.se)

Antagonizing the Leptin Receptor in Obesity. (cdc.gov)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the FU domain. (embl.de)

When mutant DMPK is converted into RNA in a first step of protein production, the repeated sequences in the RNA cause it to bind to another protein, MBNL, which regulates RNA processing. (illinois.edu)

The present disclosure relates to a novel antibody, in particular a monoclonal antibody, capable of binding to IGF-1R, as well as the amino and nucleic acid sequences coding for said antibody. (justia.com)

The present disclosure relates to IGF-IR (insulin like growth factor receptor-1) antibodies characterized by CDR sequences a, to be used in detection methods of IGF-IR expressing tumoral cells. (justia.com)

Both the A and B isoforms bind insulin with high-affinity, but the A isoform has considerably higher affinity for IGF‑I and IGF-II. (rndsystems.com)
Our work found that the modeled Con-Ins variants, or analogs, bind even better to receptors in the body than the human hormone and may work faster which could make them a favorable option for stabilizing blood sugar levels and a potential for new therapeutics. (sflorg.com)

In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. (cancerindex.org)

Pigs were treated with 2.25 mg/kg/d recombinant human IGF-1/IGF binding protein-3 complex from birth until day 5 or 9 before the collection of brain samples for quantitative immunohistochemistry (IHC), RNA sequencing, and quantitative PCR analyses. (lu.se)

Two alpha subunits and two beta subunits make up the insulin receptor. (sputnic-group.ru)

Detects human Insulin R/CD220 in direct ELISAs. (rndsystems.com)
Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains. (embl.de)
Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF. (embl.de)

This thematic series of companion papers constitutes the initial exploration of the genome biology of the waterflea (Daphnia) building on the first complete crustacean genome sequence. (biomedcentral.com)
Sequence analysis of the Daphnia pulex genome holds some surprises that could not have been anticipated from what was learned so far from other arthropod genomes. (biomedcentral.com)
We present a detailed sequence analysis of the 10 formins (ForA to J) identified in the genome of the social amoeba Dictyostelium discoideum . (biomedcentral.com)
Strikingly, the G. buenoi genome contains three insulin receptors, suggesting key changes in the rewiring and function of the insulin pathway. (umd.edu)

Anti-Phospho-Insulin Receptor (Tyr960) specifically detects endogenous levels of phosphorylated insulin receptor-beta protein. (sputnic-group.ru)

Very preterm infants show low levels of insulin-like growth factor-1 (IGF-1), which is associated with postnatal growth restriction and poor neurologic outcomes. (lu.se)
97th centile), hyperinsulinaemia, and increased insulin-like growth factor 1 for age, without evidence of bioactive or immunoreactive growth hormone excess or pituitary abnormality. (bmj.com)
However, her growth markers were increased: insulin-like growth factor 1 (IGF-1) 36 nmol/l (reference range for age 4.7-22), IGF-1 binding protein 3 (IGFBP-3) 14 mg/l (1.7-3.5), and acid labile subunit (ALS) 409 nmol/l (60-280). (bmj.com)
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. (joplink.net)
Insulin-like Growth Factor ( IGF-1 ) is a member of the insulin protein family. (proteopedia.org)
Insulin-like Growth Factor 1 Receptor ( IGF-1R ) is a transmembrane protein receptor. (proteopedia.org)

The authors would like to acknowledge Clinical Genomics Lund, SciLifeLab and Center for Translational Genomics (CTG), Lund University, for providing expertise and service with sequencing and analysis. (lu.se)

After synthesis, the single chain INS R precursor is glycosylated, dimerized and transported to the Golgi apparatus where it is processed at a furin-cleavage site within the middle fibronectin type III domain to generate the mature disulfide-linked alpha 2 beta 2 tetrameric receptor. (rndsystems.com)

Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)

Click molecule labels to explore molecular sequence information. (nih.gov)

P. damicornis cells exposed for 24 h to Triton-X100, insulin or titanium dioxide (TiO 2 ) NPs, respectively, at concentrations ranging from 0.5 to 100 µg/mL, revealed a LC50 of 0.46 µg/mL for Triton-X100, 6.21 µg/mL for TiO 2 NPs and 33.9 µg/mL for insulin. (nature.com)

Insulin-induced activation of extracellular signal-regulated kinases [ERKs, also known as mitogen-activated protein (MAP) kinases] is mediated by Ras. (nih.gov)

From 53 million TCR-β sequences, we show that the repertoire is extraordinarily diverse early in life and narrows with age independently of disease. (jci.org)
Insulin-reactive TCR-β sequences were more common and frequent in number as the disease progressed in those who developed T1D compared with genetically at risk nondiabetic children, and this was not the case for influenza-reactive sequences. (jci.org)
These results demonstrate an enrichment of preproinsulin-reactive TCR sequences during the progression to T1D, highlighting the importance of using disease-relevant TCR sequences as powerful biomarkers in autoimmune disorders. (jci.org)

Insulin activates Ras primarily by increasing the rate of guanine nucleotide-releasing activity. (nih.gov)
Thereafter, the nucleotide sequences of selected exons were determined directly. (bmj.com)
Bestsellers, suggesting that specific motifs in a codingend sequence influence nucleotide deletion and Pregion formation. (aleijten.com)

Anatomy6

Diseases7

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Psychiatry and Psychology1

Phenomena and Processes4

Epidermal Growth F6

Substrate10

Secretion7

Tyrosine kinases1

Peroxisome prolifer3

Signaling pathway2

Resistance9

Peptide8

Kinase9

Residues6

IGF110

Proteins3

Gene11

Phosphorylation1

Glucagon4

Peptides4

Diabetes4

Binds3

Agonist3

Ligand4

Pancreatic4

Genomic3

Substrates1

Glucose5

Transmembrane receptor1

IGF1R1

Homology3

Genes4

Pathways1

Obesity1

Mutations1

Regulates1

Antibody1

Antibodies1

Bind2

Interaction1

Analyses1

Subunits1

Human3

Genome4

Detects1

Growth6

Clinical1

Disulfide1

Transcriptional1

Molecule1

Concentrations1

Extracellular1

Disease3

Nucleotide3