Sequence public health genomics. Medical search. Frequent questions

He has over 20 years of experience in molecular genetics, bioinformatics, and microbial genomics, and he has worked throughout his career at the interface of academia, government, and industry. (atcc.org)
You are a UCL Senior Fellow and group leader in microbial genomics. (upf-csic.es)
The Peter Doherty Institute for Infection and Immunity (Doherty Institute) has today launched the Doherty Centre for Applied Microbial Genomics, which is set to help transform the detection, tracking and treatment of infectious diseases in Australia. (edu.au)
Opening the Doherty Centre for Applied Microbial Genomics is a major step forward for public health and clinical microbiology in Australia and will transform how we track and respond to infections caused by antibiotic resistant superbugs, amongst other uses," Professor Lewin said. (edu.au)

When Should We All Have Our Genomes Sequenced? (cdc.gov)
Over the past few years, an increasing number of healthy individuals have had their genomes sequenced, analyzed, and published . (cdc.gov)
Recently, the Empowered Genome Community initiative was launched to help people who have had their whole genomes sequenced make their genomes more scientifically useful, by exploring and sharing them with each other and with researchers. (cdc.gov)
In fact, many researchers and genomic tests developers are convinced that "consumers want their genomes sequenced, and that they have a right to have them. (cdc.gov)
As the costs of sequencing human and pathogen genomes are falling rapidly, the once futuristic vision of personalised medicine is fast becoming reality. (phgfoundation.org)
Health and social care secretary Matt Hancock has announced an expansion of the 100,000 genomes project, saying the NHS will sequence one million genomes within five years. (hsj.co.uk)
To date, viral genomes have been produced using only Illumina sequencing. (atcc.org)
As we continue to carry out whole-genome sequencing of ATCC's microbial collection, the number of reference genomes in the ATCC Genome Portal will continue to grow every month for the foreseeable future, and we encourage the research community to contact us with suggestions on taxa to prioritize in our pipeline. (atcc.org)
The long sequencing reads generated with this platform improve the data accuracy, which is beneficial when sequencing highly repetitive pathogen genomes. (lshtm.ac.uk)
This is largely as a result of unprecedented international sequencing and data sharing efforts , which have now led to in the order of millions of SARS-CoV-2 genomes being shared in close to real time. (upf-csic.es)
From the beginning, the project has also played a large part in driving the development of technology that aided the high-throughput sequencing of genomes from other model organisms such as mouse, worm and yeast. (ubc.ca)
According to Genome Canada , which leads this new initiative alongside six regional partners, the network will receive $40 million to sequence the genomes of up to 10,000 patients and 150,000 viral samples, establishing "a bank of 'virus to patient' data that will inform decision-making by public health authorities and support the development of therapies and vaccines. (universityaffairs.ca)

We develop and apply algorithms for the analysis of next-generation sequence (NGS) data sets applied to functional genomics questions: DNA-seq, RNA-seq, ChIP-seq, MNase-seq, etc. (gatech.edu)

This is particularly true of working in the field of computational genomics, where there is very high portability of methods to a range of organisms and hence always new questions to be tackled and new biology to be learned. (upf-csic.es)
This is particularly true of working in the field of computational genomics. (upf-csic.es)
Oliver Stegle is the Head of the Computational Genomics and Systems Genetics Division at the German Cancer Research Center (DKFZ) and group leader at EMBL in Heidelberg, Germany. (lu.se)

As whole exome sequencing (WES) and whole genome sequencing (WGS) technologies are increasingly used in clinical practice, there is a pressing need to understand the true costs of these technologies as well as their incremental cost-effectiveness compared to standard approaches to genetic testing. (cdc.gov)
Whole-exome sequencing and high through put genotyping identified KCNJ11 as the thirteenth MODY gene. (degruyter.com)
We are now the era of Next Generation Sequencing (NGS) which includes many platforms for sequencing the exome or other large components of the genome, eventually culminating in whole genome sequencing (WGS). (cdc.gov)
Exome sequencing identifies variants in infants with sacral agenesis. (cdc.gov)
OBJECTIVE: This study aimed to assess the diagnostic yield of prenatal genetic testing using trio whole exome sequencing (WES) and trio whole genome sequencing (WGS) in pregnancies with fetal anomalies by comparing the results with conventional chromosomal microarray (CMA) analysis. (bvsalud.org)

Kelly Oakeson] Well, public health laboratories have many core functions, for example, they assist in disease prevention, control, surveillance, they also help out with food safety, environmental health and protection, even in newborn screening for congenital disorders in newborn babies. (cdc.gov)
Genomic sequencing data are now vital in the global surveillance efforts of variant detection and for linking defined variants to viral behaviour of particular concern for the control and management of the pandemic. (mja.com.au)
He holds a joint Research Professor appointment at Syracuse University's Forensic & National Security Sciences Institute in support of microbial forensics graduate student training and research, and he actively collaborates with several US public health laboratories involved in pathogen genomics research and surveillance. (atcc.org)
You'll also get a comprehensive introduction to the SARS-CoV-2 genome structure, and learn how genome sequencing is used in COVID-19 surveillance. (futurelearn.com)
3 WGS has been used for public health surveillance in the United States of America, United Kingdom of Great Britain and Northern Ireland, and the European Union. (who.int)
Genomic sequencing of pathogens has revolutionized the field of pathogen surveillance and outbreak investigation. (alliedacademies.org)
Whole-genome sequencing enables the detection of resistance genes, mutations, and mobile genetic elements, aiding in surveillance efforts and guiding antibiotic prescribing practices. (alliedacademies.org)
Genomics has revolutionized pathogen detection and surveillance, enabling rapid and accurate identification of infectious agents. (alliedacademies.org)
Overall, the project's goal is to translate pathogen surveillance into effective public health responses and interventions. (debategraph.org)
Helix's COVID-19 Surveillance Dashboard was created to provide broad public awareness of the emergence and prevalence of novel SARS-CoV-2 variants circulating within the United States. (helix.com)
First public-private partnership with CDC and Illumina for variant sequencing which helped establish the importance of national surveillance. (helix.com)
Helix is working together with the CDC and other public health agencies on national viral surveillance efforts. (helix.com)
Raw sequence information is transferred to Helix as well as to the CDC for nationwide testing and surveillance. (helix.com)
507 174 (6437), 1.3%] objectives and implementation of a genomics collaborations for health interventions and surveillance strategy. (who.int)
1 576 915 (30 643), 1.9%] genomic surveillance capacity established during public health responses. (who.int)

Phenotypic heterogeneity in monogenic diabetes: The clinical and diagnostic utility of a gene panel-based next-generation sequencing approach. (degruyter.com)
One can argue that WGS is part of the unique characteristics of each person (age, gender, ancestry, ethnicity) and can be used for a variety of purposes other than clinical practice, such as genealogy, recreation, forensics, and health literacy. (cdc.gov)
Today screening is well established in clinical practice and public health and includes many diseases such as cancer, diabetes, heart disease and infectious diseases. (cdc.gov)
As a U.S. presidential panel studies the ethical issues associated with whole-genome sequencing in clinical care, it may do well to look across the Atlantic at the U.K. The Wellcome Trust Sanger Institute and research partners have a two-prong survey under way involving healthcare professionals and patients. (genengnews.com)
Next Steps in the Sequence emphasized the necessity for suitable clinical bioinformatics support and education, possibly as a whole new healthcare subprofession. (genengnews.com)
The institute, according to the report, would build and maintain the evidence base needed to allow clinical interpretation of genome-wide sequence data, with standardized databases of normal and pathogenic genomic variation as well as linked analytical tools. (genengnews.com)
I studied Medicine in Mexico City at the National University of Mexico and came in 2001 to London to do an MSc and PhD. I am the Virology clinical lead at Barts Health, one of the largest NHS Trusts. (futurelearn.com)
NIH CC indicates National Institutes of Health Clinical Center. (jamanetwork.com)
This Notice of Funding Opportunity (NOFO) solicits applications for Clinical Sites (CS) to participate in forming a genomic-enabled learning health system (gLHS) network to identify and improve approaches for clinical integration of genomic information in a virtuous learning health system cycle of implementation, evaluation, refinement, and re-implementation. (nih.gov)
This Notice of Funding Opportunity (NOFO), RFA HG-23-041, invites applications for Clinical Sites (CS) to participate in a Genomic-Enabled learning health system (gLHS) Network. (nih.gov)
The Network will consist of a Coordinating Center (CC, RFA-HG-23-042 ) and 4-6 CS working collaboratively with NHGRI to identify and improve approaches for clinical integration of genomic information in a virtuous learning health system cycle of implementation, evaluation, refinement, and re-implementation. (nih.gov)
We hypothesized that integrated germline sequencing could improve clinical interpretation and enhance the identification of germline variants with significant hereditary risks. (bvsalud.org)
In tumor-only sequencing, 308 of 434 (71%) single-nucleotide variants reported were present in the germline, including 31% with suggested clinical utility. (bvsalud.org)
The ethics of sequencing infectious disease pathogens for clinical and public health. (ox.ac.uk)
We are working with collaborators in Colombia, Panamá and Cuba to develop analytical platforms in support of clinical genomics. (gatech.edu)

However, many microbiologists remain unable to exploit large genomics datasets to address key questions in microbiology, because they lack access to the relevant computational resources, bioinformatics tools or expertise in data analysis. (ukri.org)
Sarah Gregory] Today, I'm talking with Dr. Kelly Oakeson about bioinformatics and genome sequencing in a public health lab. (cdc.gov)
Dr. Oakeson is a bioinformatics and genomics research analyst with the Utah Department of Health. (cdc.gov)
Sarah Gregory] I understand that the ability of this sequencing to work optimally is dependent on bioinformatics. (cdc.gov)
So, bioinformatics combines computer science and biology in order to make heads or tails out of all of this sequence data we're making. (cdc.gov)
I think a general lack of understanding as to what bioinformatics is and how important it is, especially when dealing with next generation sequence data. (cdc.gov)
Sarah Gregory] Can you tell us what the public health impact of bioinformatics is? (cdc.gov)
Kelly Oakeson] Yeah, bioinformatics has a wide-ranging impact on public health. (cdc.gov)
Dr. Jonathan Jacobs leads ATCC's Sequencing & Bioinformatics Center and the development of the ATCC Genome Portal. (atcc.org)
Acquire new technical skills currently being applied in drug discovery, pharmacogenomics, bioinformatics and genomics. (techwomen.org)
My first degree ignited a passion in scientific research, particularly genomics, pharmaceutical biotechnology, bioinformatics and genetics, whilst my second degree sharpened me in pharmacology, toxicology, public health affairs and Chemo-genomics. (techwomen.org)
The goal of this work is to facilitate the application of bioinformatics and genomics technologies to regional-specific challenges in public health and economic development. (gatech.edu)
I teach courses that are part of Lund University Master's program in Bioinformatics, including Bioinformatics and Sequence Analysis (BINP11), Programming in Python (BINP16), DNA Sequencing Informatics I (BINP28), DNA Sequencing Informatics II (BINP29), and Research Project (BINP37-39 and BINP50-51). (lu.se)

Bringing DNA sequencing close to where disease outbreaks occur, should make it possible to identify the responsible pathogens in real-time and to more quickly implement appropriate interventions. (lshtm.ac.uk)
Furthermore, genomics can aid in identifying sources of contamination in foodborne and waterborne outbreaks, leading to improved control measures and prevention strategies [ 2 ]. (alliedacademies.org)
As variants emerge, you're going to get new outbreaks," said Bart Weimer, professor of population health and reproduction at the UC Davis School of Veterinary Medicine. (ucdavis.edu)
In Singapore, however, bursts of variation were associated with smaller outbreaks that public health authorities were able to quickly bring under control. (ucdavis.edu)

During the 2020 COVID-19 global pandemic, Awandare led a group of scientist at the University of Ghana and the Noguchi Memorial Institute of Medical Research to sequence SARS-COV2 virus isolates from Ghanaian patients. (wikipedia.org)
Genomic sequencing of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been rapidly implemented and scaled‐up in Australia and globally during the first 12 months of the coronavirus disease 2019 (COVID‐19) pandemic. (mja.com.au)
1 The COVID‐19 pandemic has seen pathogen genomics integrated into day‐to‐day public health responses in many countries, including in Australia. (mja.com.au)
Symposium marks public launch of Center for Antiviral Medicines & Pandemic Preparedness (CAMPP) to develop new antiviral therapies in preparation for future pandemics. (scripps.edu)
On this three-week course, you'll learn key concepts in viral genomics, how they can be applied to the COVID-19 pandemic, and how they can help us prepare for future pandemics. (futurelearn.com)
Ultimately, this course will show you how important genomics is for developing effective strategies, not only against the COVID-19 pandemic but, importantly, against pandemics in general. (futurelearn.com)
This course is designed for anyone interested in learning more about the genomics response to the current pandemic. (futurelearn.com)
SARS-CoV-2 is the first pandemic of the post-genomic era and the public health response has really catapulted viral evolutionary genomics into a new paradigm. (upf-csic.es)
The COVID-19 pandemic highlighted a myriad of opportunities and challenges in practicing public health genomics. (debategraph.org)
The team will seek to produce models that are effective, practical and reliable for applications to public health issues for COVID-19 as well as boost Canada's future pandemic preparedness. (debategraph.org)

These examples show some early applications of genomics in healthcare. (phgfoundation.org)
This article aims to explore the applications of genomics in infectious diseases and highlight its potential in transforming prevention, diagnosis, and treatment [ 1 ]. (alliedacademies.org)

Over the last decade, genetic testing has evolved from examining a few well-defined variants in one or a few genes to the capability to examine much of the human genome using next generation sequencing (NGS). (cdc.gov)
The UK has made a very significant contribution to international efforts to track and understand new variants: about 30% of genomic sequencing results shared internationally come from the UK, making it the largest single contributor. (nao.org.uk)
Genome sequencing of thousands of SARS-CoV-2 samples shows that surges of COVID-19 cases are driven by the appearance of new coronavirus variants, according to new research from the School of Veterinary Medicine at the University of California, Davis, published April 1 in Scientific Reports . (ucdavis.edu)
WES analysis provided a more reliable identification of mosaic sequence variants than WGS because of its higher sequencing depth. (bvsalud.org)
Germline sequencing identified 38 pathogenic or likely pathogenic variants among 35 (22%) patients. (bvsalud.org)
CONCLUSION: A paired approach to analyzing tumor and germline sequencing data would be expected to improve the efficiency and accuracy of distinguishing somatic mutations and germline variants, thereby facilitating the process of variant curation and therapeutic interpretation for somatic reports, as well as the identification of variants associated with germline cancer predisposition. (bvsalud.org)
Here, we present the NyuWa genome resource, based on deep (26.2×) sequencing of 2,999 Chinese individuals, and construct a NyuWa reference panel of 5,804 haplotypes and 19.3 million variants, which is a high-quality publicly available Chinese population-specific reference panel with thousands of samples. (bvsalud.org)

Michiel combines approaches from microbiology, evolutionary ecology and population genomics to study bacterial evolution, focusing on horizontal gene transfer, sociomicrobiology and pathogens in the environment. (gw4water.com)

Weimer and Bandoy then looked at 20,000 sequences of SARS-CoV-2 viruses collected from February to April 2020 in the United Kingdom and compared them with data on cases. (ucdavis.edu)

Newborn screening in the genomics era: are we ready for genome sequencing? (cdc.gov)
Pulsed-field gel electrophoresis (PFGE), real-time PCR, sequence-based typing (SBT), and whole-genome sequencing (WGS) were used to characterize human and environmental L. pneumophila isolates from the investigation. (cdc.gov)
The cost and accuracy of genome sequencing have certainly improved dramatically. (cdc.gov)
He clearly sees the health benefits of whole genome sequencing. (cdc.gov)
I also do whole genome sequencing. (cdc.gov)
Gain insights into tracking, treating, preventing, and preparing for pandemics through genome sequencing and data sharing. (futurelearn.com)
Once you're comfortable with the basics of genome sequencing and the contributing factors of pandemics, you'll move on to vaccines and therapeutics. (futurelearn.com)
This study examined the added value of whole genome sequencing (WGS) for investigating a non-point source outbreak of Salmonella ser. (who.int)
2 Whole genome sequencing (WGS) is a high-resolution typing method that can help foodborne disease investigators distinguish outbreak cases from non-outbreak cases. (who.int)
Intentions to receive individual results from whole-genome sequencing among participants in the ClinSeq study. (jamanetwork.com)
The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. (jamanetwork.com)
Genome sequencing technology has led to many recent scientific breakthroughs. (ubc.ca)
These major accomplishments in genome sequencing provide a wealth of information that aid in the understanding of basic biological processes. (ubc.ca)
The lack of haplotype reference panels and whole-genome sequencing resources specific to the Chinese population has greatly hindered genetic studies in the world's largest population. (bvsalud.org)
When I started this thread it was not clear to me if there were viable methods to separate chromosomes for sequencing from the whole genome without full genome sequencing. (seqanswers.com)
4. Illumina Inc. also uses a process for separating the chromosomes in their whole genome sequencing. (seqanswers.com)
But I'm still very skeptical that a market exists between the current array-based tests ($0.1K) & full genome sequencing ($5K-$12K) for a Y-specific test. (seqanswers.com)
High-throughput genome sequencing provided a more detailed real-time assessment of genetic traits characteristic of the outbreak strains than could be achieved with routine subtyping methods. (biomedcentral.com)
The study, published in the journal Nature Genetics, is the largest of its kind to date and uses whole-genome sequencing data from more than 120 patients with malignant pleural mesothelioma. (who.int)

Very high frequency of novel mutations (42%) in our study population, supports that in heterogenous disorders like MODY sequence analysis provides rapid, cost effective and accurate genetic diagnosis. (degruyter.com)
Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications. (degruyter.com)
While WGS in healthy individuals has the potential, using genetic risk stratification, for improving health and preventing disease, it can also lead to potential medical and psychological harms, cascading or inappropriate healthcare interventions and increasing costs. (cdc.gov)
That judgment, Professor Parker and others in the DDD project agreed, should begin with learning how patients and their families plus health professionals, researchers, and members of the public would like to see genetic data managed. (genengnews.com)
Among challenges is also the absence of a central repository for genetic data, Philippa Brice, Ph.D., a spokeswoman for the PHG Foundation, told GEN. Typically, she noted, different health trusts use locally developed systems. (genengnews.com)
The National Health Service's (NHS') Regional Genetic Services traditionally use family-based health records, but the electronic systems between centers are often poorly interoperable. (genengnews.com)
This raises questions about concerns relating to potential risks of DTC genomics users and users' understanding of genetic information including their awareness of privacy risks. (karger.com)
With the rise of personalized medicine, and rapid advances in genomic sequencing technology and diagnostic testing, healthcare providers and consumers have an increased need for accurate information about genetic testing, genomics, and heritable conditions. (csms.org)
A Portable Sequencing device is ideal for field studies and outbreak situations, where genetic information on pathogen strains can help map disease transmission and inform treatment strategies. (lshtm.ac.uk)
Genomics provides critical insights into the genetic determinants of drug resistance, allowing for the rapid identification of resistance mechanisms and the development of targeted therapies. (alliedacademies.org)
DPhil research opportunities include projects associated with large prospective cohorts, large randomised trials, systematic reviews and meta-analysis with individual patient data, genetic epidemiology, perinatal epidemiology, prevention of non-communicable diseases, health services research, ethics and other topics related to population health. (ox.ac.uk)
High-throughput pyrosequencing of two L. monocytogenes isolates was used to rapidly provide the genome sequence of the primary outbreak strain and to investigate the extent of genetic diversity associated with a change of a single restriction enzyme fragment during PFGE. (biomedcentral.com)

The goal is to identify changes in the viral sequence as it spreads. (universityaffairs.ca)

The tension between genomic data reliability and its traceability to source materials is a growing area of concern that has significant real-world impacts on public health epidemiology, drug discovery, and environmental biosurveillance research. (atcc.org)
You'll see how sharing genomic sequencing helps experts understand disease epidemiology, allowing them to give better advice and to be more prepared for the future. (futurelearn.com)
The DPhil in Population Health will equip students with the core knowledge and skills to generate and disseminate reliable evidence to improve health outcomes, and to work in a multi-disciplinary environment that includes epidemiology, statistics, health economics and ethics. (ox.ac.uk)
Combining traditional epidemiology and genomics could be used to predict the course of future pandemics. (ucdavis.edu)
The merger of classical epidemiology with genomics provides a tool public health authorities could use to predict the course of pandemics, whether of coronavirus, influenza or some new pathogen. (ucdavis.edu)
This work includes the creation of software tools for molecular epidemiology and the computational analysis of microbial genome sequences. (gatech.edu)
This study confirms that the latest generation of DNA sequencing technologies can be applied during high priority public health events, and laboratories need to prepare for this inevitability and assess how to properly analyze and interpret whole genome sequences in the context of molecular epidemiology. (biomedcentral.com)

The Centre for Infectious Disease Genomics and One Health at SFU is an interdisciplinary group of researchers interested in solving practical health problems using multidisciplinary approaches and in a One Health framework. (sfu.ca)
The Centre for Infectious Disease Genomics and One Health at SFU is an interdisciplinary group of researchers with backgrounds in microbiology, molecular biology, computer science, cognitive science, statistics, public health, and genomics. (sfu.ca)

We work in close collaboration with partners from the Centers for Disease Control and Prevention (CDC) and the Emory School of Medicine to develop and apply novel computational approaches to public health challenges. (gatech.edu)

We are interested in solving practical health problems using multidisciplinary approaches and in a One Health framework. (sfu.ca)

Semisupervised Calibration of Risk with Noisy Event Times (SCORNET) using electronic health record data. (harvard.edu)
Informative missingness: What can we learn from patterns in missing laboratory data in the electronic health record? (harvard.edu)
November 9, 2018-The promises of big data in health care are seemingly endless. (harvard.edu)
The Personal Genome Project has been dedicated to creating public genome, health, and trait data resources and is based on willing participants that agree to publicly share their personal data for improving the health of many. (cdc.gov)
High-throughput sequencing has transformed microbiology, delivering an explosion in genomic and metagenomic big data. (ukri.org)
This new CLIMB-BIG-DATA partnership will occupy a distinctive position in the UK, underpinning research in the academic sector alongside the front-line work of government agencies and the health service, while also supporting research that maps on to a wide variety of national/UKRI and international strategic priorities and Official Development Assistance objectives. (ukri.org)
a capability to share VMs, containers, data and software across the entire CLIMB-BIG-DATA infrastructure and with public cloud providers (with cloud bursting on to public clouds, should demand spike on our own infrastructure). (ukri.org)
Sarah Gregory] Ok, so what does sequence data in a public health lab do for us? (cdc.gov)
Kelly Oakeson] Well, whole genome sequence data provides a very high-resolution tool for everything from identifying what types of microbes or viruses you might have in any given sample to determining antimicrobial resistance and identifying clusters of related microbes in the case of a foodborne illness outbreak. (cdc.gov)
It allows us to quickly generate huge amounts of data and DNA sequence in a very short period of time. (cdc.gov)
Kelly Oakeson] Yeah, so Next Generation Sequencing generates a lot of sequence data that need to be translated into meaningful biological information. (cdc.gov)
Genomic data may ultimately deliver not only better disease prevention and personalised medical care, but also underpin a fundamental shift in how we understand health and disease. (phgfoundation.org)
Ms. Grande, American College of Preventive Medicine (ACPM) CEO, will share data and insights on the field of preventive medicine-what the training requirements are, what differentiates a preventive medicine physician from other specialties of medicine, and why they are relevant and important for today's public health workforce. (cdc.gov)
A critical activity for public health laboratories responsible for sequencing and reporting SARS‐CoV‐2 genomic data is to ensure that they remain cognisant of all emerging evidence concerning mutations and lineages, so that their reporting ensures appropriate public health awareness and responses. (mja.com.au)
While the introduction of consequential data provenance policies may potentially mitigate these issues, public databases largely do not have these requirements. (atcc.org)
Each genome entry is provided with sequencing and assembly quality metrics, annotation metrics, and additional metadata for each strain such as antibiotic susceptibility, geographical origins, and phenotypic data. (atcc.org)
The Oxford Nanopore MinION Sequencer is unique in its ability to directly sequence DNA/RNA in the field, yielding rapid, high-quality sequence data for downstream analysis in real time. (lshtm.ac.uk)
Realtime sequencing and data sharing platforms enable early detection of novel strains, facilitating timely public health responses. (alliedacademies.org)
The public effort produced results which were freely available whereas the data from Celera was available for a fee. (ubc.ca)
Toronto, Ontario - Today, a Canadian consortium including Autism Speaks and Autism Speaks Canada is announcing the launch of a new project to expand the development of a software platform to enable federated, AI-powered insights across networks of genomics and health data. (autismspeaks.org)
The Canadian Platform for Genomics & Precision Health (CP4GPH) is a $14.5M initiative co-funded by Digital that brings together domain experts with a shared vision to deliver better outcomes for Canadians by making it easier to connect and analyze exponentially growing volumes of distributed genomics and health data. (autismspeaks.org)
With this new platform, health data stewards can easily connect datasets into distributed networks and grant permissions for data consumers to be able to derive privacy-preserving federated insights across them. (autismspeaks.org)
Led by world-renowned bioinformatician Associate Professor Torsten Seemann from the Victorian Life Sciences Computation Initiative, these capabilities allow us to use the large amount of data generated by sequencing the microbes to ultimately fast track our investigations and respond to any outbreak. (edu.au)
Helix and/or our partners may also submit raw data, consensus sequence, and metadata to NCBI and GISAID. (helix.com)
Helix monitors the data that becomes publicly available and, in turn, makes these identifiers available in an aggregated report in our public Github repository: https://github.com/myhelix/helix-covid19db. (helix.com)
Developing technologies to foster data harmonization and sharing, and building trusted networks of health care practitioners, researchers, and policy makers are therefore key focuses of the Centre. (sfu.ca)
The Rare Cancers Genomics Team at IARC has used sequencing data to uncover sources of molecular variation in malignant pleural mesothelioma, paving the way for a revised classification system that could change the manner in which the disease is diagnosed and treated. (who.int)
The infection is propagated through the virtual population through simulated social contacts, and the progress of the disease in infected individuals and their trajectory through the healthcare system is then simulated, based on public health data. (lu.se)

In health protection, genomic analysis allows very fast and precise identification of pathogens and their characteristics. (phgfoundation.org)
Genomics has emerged as a powerful tool in the fight against infectious diseases, enabling researchers to delve deeper into the molecular characteristics of pathogens and their interactions with hosts. (alliedacademies.org)
Genomics has shed light on the complex interactions between pathogens and their hosts, unravelling the mechanisms underlying virulence, immune evasion, and disease progression. (alliedacademies.org)
This is one of many efforts that Helix is involved in with the CDC, local public health agencies, and other organizations to better understand and contain the COVID-19 virus, as well as, future pathogens. (helix.com)
tool for identifying and monitoring pathogens' and expansion of sequencing capacities to cover 2019-2023 mutations that impact pathogen fitness, vaccine new pathogens, lack of expertise in novel and efficacy or impact molecular diagnostics. (who.int)

This seminar will present research delineating the costs of various WES and WGS platforms, and the use of these estimates in evaluations of sequencing technologies for diagnosing autism spectrum disorder, unexplained developmental disabilities, and multiple congenital anomalies. (cdc.gov)
Nevertheless, if we want to use WGS in the course of regular preventive care and health promotion, research should be conducted to evaluate its benefits, harms and added value to what we are currently doing. (cdc.gov)
It has started a programme of research to understand why the registration of test results is so low and is working to increase public awareness of the need to register results and improve its ability to track tests. (nao.org.uk)
These courses enable participants to refresh their skills and keep up to date with the latest research and knowledge in public and global health. (lshtm.ac.uk)
She is a board certified occupational and environmental health physician and epidemiologist with over 30 years of experience and expertise in environment and occupational exposures and human health research and training. (gw4water.com)
MfPH☜Mathematics for Public Health (MfPH), led by Dr. V. Kumar Murty, Director of the Fields Institute and Professor at the University of Toronto, will aim to bridge the gap between mathematical research and real public health issues. (debategraph.org)
The race to publish human genome sequence information was fuelled by competition between research from the publicly funded HGP and the privately owned company, Celera Genomics. (ubc.ca)
With genome sequence in-hand scientists are now more effectively able to study gene function and explore new areas of research such as how human variation contributes to different diseases worldwide. (ubc.ca)
Population and global health research generates evidence that reliably answers important questions about human health. (ox.ac.uk)
A strong and distinctive focus of population and global health research in Oxford is to generate reliable evidence on the burden and determinants of the major causes of disability and premature death. (ox.ac.uk)
Research conducted in the Nuffield Department of Population Health aims to reduce premature death and disability from human disease. (ox.ac.uk)
The Nuffield Department of Primary Care Health Sciences' primary research focus is on the prevention, early diagnosis and management of common illness in general practice in both a local and global setting. (ox.ac.uk)
Orient research beyond the biomedical and public health spheres and address research questions touching on multiple sectors including social and economic sciences. (who.int)
2013 (6 mo): Research Associate in Mental Health. (lu.se)

The aim of this study is to investigate both novel and proven mutations of 11 MODY genes in Turkish children by using targeted next generation sequencing. (degruyter.com)
Studies of index cases was done with MISEQ-ILLUMINA, and family screenings and confirmation studies of mutations was done by Sanger sequencing. (degruyter.com)

In 2007, he graduated with a PhD in Infectious Diseases and Microbiology from the School of Public Health, with a thesis on severe malarial anemia. (wikipedia.org)
Professor Elizabeth Hartland, Head of the Department of Microbiology and Immunology, noted that the establishment of Centre was the result of renewed collaboration between the public health program and academic researchers from the Department, and would be vital to progressing their extensive work in antibiotic resistance and infection. (edu.au)

For example, genomics has been instrumental in tracking the spread of antimicrobial resistance genes, allowing for tailored antibiotic stewardship programs and the development of novel therapeutics [ 3 ]. (alliedacademies.org)

Each bacterial and fungal genome is sequenced on both Illumina and Oxford Nanopore platforms, resulting in a "hybrid-assembly" incorporating both sequencing technologies. (atcc.org)

In late February 2021, the World Health Organization established the SARS‐CoV‐2 Virus Evolution Working Group. (mja.com.au)

We are halfway through the 12-month prospective snapshot, with 160 sequences and their corresponding metadata from across Australia contributed to the AusTrakka platform. (createsend.com)

Through the ATCC Genome Portal, you can easily search, access, and analyze thousands of reference-quality genome sequences. (atcc.org)

Sarah Gregory] What are the functions of a public health lab and what part do you play in the Utah Public Health Laboratory? (cdc.gov)
At the Utah Public Health laboratory, I oversee the area of the lab that performs Pulsed-field gel electrophoresis, also known as PFGE. (cdc.gov)
Two projects will be used to evaluate the MinION.The first project is, in collaboration with Martin Antonio, Director of World Health Organisation Regional Reference Laboratory for Invasive Bacterial Diseases, and will re-sequence Cerebrospinal fluid specimens collected from suspected meningitis cases during a historical outbreak/ epidemic in the region. (lshtm.ac.uk)
Established by the The University of Melbourne at the Doherty Institute, the new Centre located in the Microbiological Diagnostic Unit Public Health Laboratory (MDU PHL) is home to state-of- the-art technology that utilises next-generation DNA sequencing, which provides unparalleled speed and accuracy to genetically identify and track disease-causing microbes. (edu.au)

Samples are collected by the NHS and NHST&T and processed by the COVID-19 Genomics Consortium, Wellcome Sanger Institute and the public health agencies in the four nations. (nao.org.uk)
I have excellent sequencing skills, from Sanger to Next Generation Sequencing, plus experience in operating the Genexus Ion torrent integrated Sequencing machine and the Genexus software. (techwomen.org)

Download Cancer Genomics Best Practices for Connecticut Healthcare Providers at www.ct.gov/dph/genomics . (csms.org)
While no prior knowledge about COVID-19 is required, it is likely to be most useful to researchers, healthcare professionals, science journalists, policymakers, and those working in public health. (futurelearn.com)
The George Institute undertakes several large-scale population based studies to investigate a range of healthcare issues including cardiovascular conditions, childhood cancer, women's health. (ox.ac.uk)

Generally, however, we tend to overestimate the positive health impact of screening and underestimate the potential for harmful effects such as overdiagnosis, inappropriate interventions, and anxiety . (cdc.gov)
This informs interventions to improve health outcomes and reduce future disease risk (such as prophylactic mastectomy or statin treatment). (phgfoundation.org)

Additionally, genomics has facilitated the discovery of novel biomarkers and therapeutic targets for infectious diseases, aiding in the development of vaccines and immunotherapies The rise of antimicrobial resistance poses a significant threat to public health. (alliedacademies.org)

Lora is the director of the Centre for Environment and Human Health and chair of oceans and human health at the University of Exeter Medical School. (gw4water.com)

With increasing utility and decreasing cost of genomic sequencing, augmentation of standard newborn screening (NBS) programs with newborn genomic sequencing (nGS) has been proposed. (frontiersin.org)

In this One-on-One interview with Medscape Editor-in-Chief Eric Topol, she talks about the many chapters of her career, focusing on the launch of a "precision public health" movement in her current role as CEO of the Bill & Melinda Gates Foundation. (medscape.com)

Kelly Oakeson] The purpose of our perspective in EID was really to help public health laboratories around the country understand sort of basics of typical bioinformatic pipelines and analyses, right? (cdc.gov)

By comparing sequences from these different model organisms, scientists gain a better understanding of the important pieces of code in genomic DNA sequence since conservation of sequences between two organisms that diverged phylogenetically millions of years ago, like humans and worms, implies that the conserved sequence is important for function. (ubc.ca)
The systematic study of the complete DNA sequences (GENOME) of organisms. (bvsalud.org)

Kelly Oakeson] Next Generation Sequencing is a very high throughput, massively parallel method for sequencing DNA. (cdc.gov)

Maturity onset diabetes of the young in India - a distinctive mutation pattern identified through targeted next-generation sequencing. (degruyter.com)
Sarah Gregory] And following on that, what is Next Generation Sequencing? (cdc.gov)

The collection of time points to include details such as the date received at the PHL and the date the isolate was sequenced will provide valuable information about the sequence generation process, and suitability to inform public health response. (createsend.com)
Current public health events of expertise to diagnose or sequence SARS-CoV 2 concern to inform public health decision making. (who.int)
Understanding correlates of awareness and use, particularly judgments about harm and addictiveness, can inform public health communications about these products. (who.int)

Scientific and implementation principles for screening have been discussed by many organizations, most notably the 1968 criteria from the World Health Organization [PDF 7.25 MB] , and have evolved over time. (cdc.gov)

The main purpose of screening is early detection of asymptomatic disease or risk assessment for future disease to improve health outcomes. (cdc.gov)

This unique, collective thinking has the ability to deliver individualized care, guide health decisions for autistic individuals and families and serve as a driver for discovering new, effective therapies. (autismspeaks.org)

More than a decade after the completion of the human genome project, the genome sequence has reached the clinic . (cdc.gov)
Our understanding of the complex interactions that underpin human susceptibility and resistance to disease is just beginning, and the key to this knowledge is genomics. (phgfoundation.org)
The HGP was an initiative started in the early 1990's that has involved the efforts of hundreds of scientists to generate high-quality reference sequence for the 3 billion base pairs of nucleotide sequence that make up the human genome. (ubc.ca)
This DNA sequence contained in a genome contains the complete code that determines which genes and proteins will be present in human cells. (ubc.ca)
By reading the sequence of the human genome, scientists hope to gain an understanding of the underlying code that determines how a complex biological system, such as a human cell, acts and reacts. (ubc.ca)
Insights from deciphering the human genome have potential to be applied to a better understanding of human health and could help to develop better treatments for disease. (ubc.ca)
Officially, funding for the project began in the 1990 with the goal of sequencing the human genome by 2005. (ubc.ca)
Two large groups of scientists published the first analyses of this human genome sequence in the February 2001 issues of the journals Nature [1] and Science [2]. (ubc.ca)
This first working draft of the human genome sequence was hailed with much excitement and fanfare as the "completion of the human genome" in the media. (ubc.ca)
For scientists, the high-quality reference sequence publicly released in April 2003 represents the first real step to having "finished" human sequence on hand (this draft represents sequence information that is considered to be 99% complete) [3]. (ubc.ca)
For instance, as a first step in understanding the genomic code we have learnt that the human genome is made of 3.2 billion nucleotide bases (of which there are four types: A, C, T, G). It is thought that over 30,000 genes are encoded by this sequence. (ubc.ca)
Yet we have also discovered that over 50% of the human genome is repetitive sequence that does not code for any proteins and the function of this large portion of "junk" DNA is still puzzling scientists. (ubc.ca)
There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. (nih.gov)
We are studying the relationship between human ancestry and genomic determinants of health and fitness with an emphasis on admixed populations from Latin America. (gatech.edu)

Recently, George Church, a prominent genomics researcher and leader of the Personal Genome Project asked why so few people are opting to inspect their genome . (cdc.gov)

MATERIALS AND METHODS: Tumors from pediatric patients with high-risk, extracranial solid malignancies were sequenced with a targeted panel of cancer-associated genes. (bvsalud.org)

Sequencing Technologies. (ukri.org)
The HSJ Digital Transformation Summit unites technology leaders from trusts, CCGs and ICSs to explore technologies, innovations and improvements that will have a transformative effect on our future health and care system. (hsj.co.uk)
and · Focus innovations and technologies on the post COVID-19 situation and other health issues, not only limiting them to emergencies. (who.int)

RESULTS: One hundred sixty participants with both tumor-only and germline sequencing reports were eligible for this analysis. (bvsalud.org)
6] Sequencing and copy number analysis of both PAX3 and MITF should be considered as part of the routine molecular diagnostic evaluation of these patients. (medscape.com)

The course starts with a review of how viruses cause diseases and pandemics, examining the factors that can lead to a public health emergency. (futurelearn.com)

Working with public health officials and health researchers, the group will oversee a blood - testing campaign to better understand the scope of the coronavirus infection and COVID-19 immunity in this country, which will ultimately help with vaccine development and in determining which public health measures have been most effective. (universityaffairs.ca)

Diseases5

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Psychiatry and Psychology12

Phenomena and Processes10

Disciplines and Occupations17

Anthropology, Education, Sociology and Social Phenomena48

Technology, Industry, Agriculture5

Humanities7

Information Science21

Named Groups7

Health Care165

Geographicals12

Microbial Genomics4

Genomes12

Functional Genomics1

Computational genomics3

Exome5

Surveillance15

Clinical15

Bioinformatics13

Outbreaks4

Pandemic10

Applications of genomics2

Variants7

Population genomics1

20201

Genome Sequencing19

Genetic12

Viral1

Epidemiology7

Infectious disease2

Centers1

Approaches1

Data28

Pathogens5

Research14

Mutations2

Microbiology2

Therapeutics1

Illumina1

20211

Metadata1

Search1

Laboratory4

Sanger2

Healthcare3

Interventions2

Vaccines1

Centre1

Newborn1

Precision Public Health1

Laboratories1

Organisms2

Massively1

Next generation2

Inform public health3

World Health Organ1

Improve health outcomes1

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Human14

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Genes1

Technologies3

Analysis2

Viruses1

Vaccine1