Sequence globular proteins genes bacterial. Medical search. Frequent questions

The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. (unl.edu)
It is found in a variety of enzymes involved in bacterial cell wall degradation. (unl.edu)
Xoo genes likely to be associated with pathogenesis include eight with similarity to Xanthomonas avirulence (avr) genes, a set of hypersensitive reaction and pathogenicity (hrp) genes, genes for exopolysaccharide production, and genes encoding extracellular plant cell wall-degrading enzymes. (inra.fr)
Many proteins are enzymes that catalyze biochemical reactions and are vital to metabolism. (transectscience.org)
The MEROPS database is an information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them. (biokeanos.com)

These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. (unl.edu)
In the blood vascular system, human serum albumin (HSA) is a vital globular transport protein with potential multiple ligand binding sites. (researchgate.net)
The GPCRDB contains data on sequences, ligand binding constants and mutations. (biokeanos.com)

HomB protein contributes to the colonization and persistence of H. pylori , and the presence of homB genes affects the number of bacteria adhering to the host cells. (nature.com)
Outer membrane proteins (OMPs) are distinctive features of Gram-negative bacteria. (nature.com)
One of the current strategies is to attenuate virulence gene expression of agr quorum sensing system of some Gram-positive bacteria through inhibition of AgrA_ P2/P3 interaction. (ijpsr.com)
Tertiary structures of AgrA proteins of some pathogenic bacteria like Listeria monocytogenes, Chlamydia trachomatis, Enterococcus faecalis, Streptococcus pyogenes and Macrococcus canis showing antimicrobial resistance are not yet available in structural databases like PDB. (ijpsr.com)
The compositional and structural differences of the LytTR domain of AgrA proteins between the pathogenic and non-pathogenic bacteria were analyzed in our study. (ijpsr.com)
The accessory gene regulator ( agr ), a well-studied QS system, controls the expression of a series of virulence-associated protein genes in some Gram-positive bacteria 19, 20 . (ijpsr.com)
LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. (unl.edu)
It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. (unl.edu)
The prokaryotic MORC proteins were widely, but sporadically, distributed in several distantly related bacteria such as proteobacteria, cyanobacteria and actinobacteria, as well as certain crenarchaea and euryarchaea [ 7 ]. (beds.ac.uk)
The presence of genes homologous to eukaryotic meiotic genes in archaea and bacteria suggests that DNA repair mechanisms evolved towards meiotic recombination. (bvsalud.org)
Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes. (lookformedical.com)
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)

The Database of Protein Disorder (DisProt) is a curated database that provides information about intrinsically disordered proteins that lack fixed 3D structure in their putatively native states, either in their entirety or in part. (biokeanos.com)
While antioxidative stress proteins, antiapoptotic pathways and tardigrade-specific intrinsically disordered proteins have been implicated in the anhydrobiotic machinery, conservation of these mechanisms is not universal within the phylum Tardigrada, suggesting the existence of overlooked components. (biomedcentral.com)

ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. (unl.edu)
Short polypeptides, containing less than 20-30 residues, are rarely considered to be proteins and are commonly called peptides, or sometimes oligopeptides. (transectscience.org)
ConoServer is a database specializing in sequences and structures of peptides expressed by marine cone snails. (biokeanos.com)

The eukaryotic proteins are more complicated than the bacterial enzyme complexes. (tcdb.org)
The common ancestor of these GHKL proteins, MutL and topoisomerase ATPase modules appears to have catalyzed structural reorganization of protein complexes and concomitant DNA-superstructure manipulations along with fused or standalone nuclease domains. (beds.ac.uk)
Proteins can also work together to achieve a particular function, and they often associate to form stable protein complexes. (transectscience.org)

It is also called nucleotide sequence. (lookformedical.com)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity. (transectscience.org)

Nucleic acid sequences involved in regulating the expression of genes. (lookformedical.com)
The database gives access to protein sequences, nucleic acid sequences and structural information on conopeptides. (biokeanos.com)

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)

The provenance and biochemical roles of eukaryotic MORC proteins have remained poorly understood since the discovery of their prototype MORC1, which is required for meiotic nuclear division in animals. (beds.ac.uk)
Consistent with a chromatin-associated role, the MORCs display fusions to several DNA- and peptide-binding domains, which are commonly found other eukaryotic chromatin proteins [ 5 ]. (beds.ac.uk)
To unravel the provenance and relationships of the MORC family, we initiated sequence profile searches using the PSI-BLAST program seeded with eukaryotic MORC proteins. (beds.ac.uk)
The prokaryotic and eukaryotic MORC homologs were unified to the exclusion of the other GHKL proteins by a specific GhXhhpXXRhl motif (h: hydrophobic, p: polar, X: any) in the S5-fold domain (Fig. 1 ). (beds.ac.uk)

They suggest baicalin is a potentially useful therapeutic agent for the treatment of bacterial infections. (oncotarget.com)

In the other data set, mutants of a bacterial enzyme that controls resistance to penicillins and cephalosporins, TEM-1 beta-lactamase, were expressed in E. coli under the selective pressure of an antibiotic treatment. (frontiersin.org)
Electron cryoEM structures of mitochondrial, chloroplast, and bacterial ATP synthases have revealed the architecture of the FO region, helping to explain the mechanisms of proton translocation, dimerization of the enzyme in mitochondria, and cristae formation. (tcdb.org)
Tail-specific protease (Tsp) is a periplasmic enzyme that selectively degrades proteins bearing a nonpolar C-terminus. (embl.de)
HP1383 restriction modification system S subunit HP1388 hypothetical protein HP1390 hypothetical protein HP1396 hypothetical protein HP1397 hypothetical protein HP1400+ iron(III) dicitrate transport protein (fecA) HP1402 type I restriction enzyme R protein (hsdR) HP1410 hypothetical protein HP1411 hypothetical protein HP1412 hypothetical protein HP1415 tRNA delta(2)-isopentenylpyrophosphate transferase (miaA). (lbl.gov)
Lysozyme (LYSO) is an enzyme that is upregulated in many organisms during the innate immune response against infection by bacterial pathogens. (oncotarget.com)

periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. (unl.edu)

Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. (unl.edu)
A Pseudomonas protein and an Arabidopsis protein are predicted to interact with each other if an experimentally verified interaction exists between their respective homologous proteins in another organism. (biomedcentral.com)

Our study provides essential structural information of unexplored proteins of the Hom family that can help in a better understanding of H. pylori pathogenesis. (nature.com)
Outer membrane proteins (OMPs) of H. pylori play a crucial role in the host-pathogen interaction, virulence and pathogenesis. (nature.com)
investigated pathogenesis and immunological response caused by HomB protein in clinical patients and 190 H. pylori strain isolated from patients with peptic ulcer disease (PUD) or gastritis were evaluated for the clinical importance of homB . (nature.com)
Protein-protein interactions (PPIs) play a critical role in initiating pathogenesis and maintaining infection. (biomedcentral.com)
Basically, Pseudomonas syringae pathogenesis is dependent on effector proteins and to date, nearly 60 different type III effector proteins encoded by hop genes have been identified [ http://www.pseudomonas-syringae.org/ ]. (biomedcentral.com)

The presence of these genes provides insights into the interactions of this pathogen with its gramineous host. (inra.fr)
Pseudomonas syringae is a major bacterial leaf pathogen that causes diseases in a wide range of plant species. (biomedcentral.com)
Staphylococcus aureus , a major gram-positive pathogen, is classified as an opportunistic bacterial pathogen, which infects a diverse array of hosts [ 1 ]. (oncotarget.com)

It has been discovered that a large number of bacterial species produce many virulence factors and form biofilms, which are regulated by the cell to cell communication process called quorum sensing (QS) 7-9 . (ijpsr.com)
One of the major classes of virulence factors includes effector proteins that are delivered into the host through a type III protein secretion system (TTSS) to suppress plant immune responses, and also to facilitate disease development [ 6 ]. (biomedcentral.com)

This work provides a framework for future studies of this important protein and, as nucleotides are critical for viability, may serve as a foundation for the development of novel anti-bacterial drugs. (biomedcentral.com)

The full-length US11 gene, which is composed of 459 bp (base pairs) and predicted to encode a protein of 152 amino acids, was amplified successfully from the HSV-1 (strain F) genome (Figure 1 , lane 1). (biomedcentral.com)
The sequencing result also showed that there was no mutation of amino acid sequences (data not shown). (biomedcentral.com)
PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (beta-A to beta-F) and two alpha-helices, A and B, compactly arranged in a globular structure. (embl.de)
The isolated PDZ domain (amino acids 206-334) is capable of folding into a well-behaved structure and binds to a nonpolar peptide with a dissociation constant (K(D)) of 1.9 microM, similar to that of the intact Tsp protein. (embl.de)
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. (transectscience.org)
The sequence of amino acid residues in a protein is defined by the sequence of a gene which is encoded in the genetic code. (transectscience.org)
In animals, proteins are needed in the diet to provide the essential amino acids that cannot be synthesized. (transectscience.org)

Within the cell, HABP1 binds to molecules containing the C1q globular domain, multiple isoforms of PKC, mitochondrial Hrk, the cytoplasmic tails of adrenergic and GABA-A receptors, the mRNA splicing factor ASF/SF2, and the CBF transcription factor (10 - 16). (rndsystems.com)
PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. (embl.de)

Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6 - 9). (rndsystems.com)
Amyloidosis is a rare group of diseases characterized by abnormal folding of proteins and extracellular deposition of insoluble fibrils. (highwire.org)

The product of the recently discovered ybfF gene, which belongs to the esterase family, does not show high sequence similarity to other esterases. (inra.fr)
The interolog method relies on protein sequence similarity to conduct the PPI prediction. (biomedcentral.com)
Through time-series transcriptome analysis of Ramazzottius varieornatus specimens exposed to ultraviolet light and comparison with anhydrobiosis entry, we first identified several novel gene families without similarity to existing sequences that are induced rapidly after stress exposure. (biomedcentral.com)

During productive infection, the 152-kb double-stranded HSV-1 genome is rapidly translocated to the nucleus where at least 80 viral genes are transcribed by the host cell RNA polymerase II (Pol II) [ 1 ]. (biomedcentral.com)

The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)

MlaA represents a lipid transport protein that selectively removes outer leaflet phospholipids to help maintain the essential barrier function of the bacterial OM. (nature.com)

Iterons are directly repeated DNA sequences which play an important role in regulation of plasmid copy number in bacterial cells. (wikipedia.org)
DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)

A method for determining the sequence specificity of DNA-binding proteins. (lookformedical.com)
Its substrate specificity suggests that Tsp may contain a substrate recognition domain, which selectively binds to the nonpolar C-termini of substrate proteins, separate from its catalytic site. (embl.de)

Although the number of AgrA protein sequences has increased exponentially, the number of experimentally determined protein structures lags far behind. (ijpsr.com)
While scientists can often infer the biological function of proteins from their 3-dimensional quaternary structures, the gap between the number of known protein sequences and their experimentally determined structures keeps increasing. (bvsalud.org)
The 3D-Beacons Network allows researchers to collate coordinate files and metadata for experimentally determined and theoretical protein models from state-of-the-art and specialist model providers and also from the Protein Data Bank. (bvsalud.org)
The Protein Data Bank (PDB) is an archive of experimentally determined three-dimensional structures of biological macromolecules that serves a global community of researchers, educators, and students. (biokeanos.com)

campestris (Xcc) genomes, but 245 genes apparently specific to Xoo were identified. (inra.fr)
SUPERFAMILY is a database of structural and functional annotation for all proteins and genomes. (biokeanos.com)

Abnormal or misfielded proteins are degraded more rapidly either due to being targeted for destruction or due to being unstable. (transectscience.org)
1 There were no other organs other than kidney affected and immunohistochemistry (IHC) of the renal biopsies for known abnormal amyloid proteins was negative. (highwire.org)

3D structures of these proteins are essential to determine most of their functions, and for the development of agents that can be explored as therapeutic agents. (ijpsr.com)
In order to derive structures of these AgrA proteins, homology modeling approach was employed. (ijpsr.com)
The modeled proteins were validated by several methods, and the physico-chemical properties of these refined protein structures were predicted using in-silico methods. (ijpsr.com)
The domain-based method uses domain interaction information, which is derived from known protein 3D structures, to infer the potential PPIs. (biomedcentral.com)
Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
Consideration of related TPx crystal structures indicates that the missing cross peaks correspond to a region of the protein that must display conformational plasticity necessary for the mechanism of action suggesting that the spectrum is affected by conformational exchange processes. (ndltd.org)
The Protein Data Bank in Europe (PDBe) is the European resource for the collection, organisation and dissemination of data on biological macromolecular structures. (biokeanos.com)

This operator contains half of the iteron sequence making it able to bind the dimer and promote gene expression. (wikipedia.org)
Fighting bacterial infections by interfering with their command language and disrupting virulence expression could serve as a viable alternative. (ijpsr.com)
Fighting bacterial infections by interfering with their command language or QS and disrupting virulence expression could serve as an alternative way to inhibit growth 15-18 . (ijpsr.com)
agr P2 drives the synthesis of RNA II, which encodes Agr ABCD, the structural components of the QS system, while agr P3 leads to the synthesis of RNA III which encodes delta-hemolysin 20 but also acts as a regulatory RNA that controls the expression of a series of virulence genes transcriptionally or translationally 21 . (ijpsr.com)
view conditions 3 and 4 to effect the quick efficiency in the ethylene analyzed in direction This will have in the time uptake incorporated in contamination plant of protein( trait4 The comprising of the nuclear network inspection, strategy, is chosen in ultra- In intercept, it gives highly the New low produced by the hazard to generate addition model transfer 3, expression. (scoutconnection.com)
The US11 gene was cloned into the prokaryotic expression vector pET-32a (+) to express His-tagged US11 protein in Escherichia coli. (biomedcentral.com)
In the present study, we obtained a high-level expression of the recombinant US11 protein as well as high titers of rabbit polyclonal antibody specially against US11 protein in HSV-1 infected cells. (biomedcentral.com)
Importantly, the time scales of many cell responses are far faster (seconds) and/or slower (years) than characteristic times of gene expression changes or mutations (minutes to days). (uchicago.edu)
Most changes in gene expression are simply down-stream effects. (uchicago.edu)
We also observed from in vivo analysis that Velo knock-down flies exhibit significant upregulation of the AMP expression and reduced bacterial load. (cnrs.fr)

By contrast, in the case of TEM-1 beta-lactamase mutations, aggregation is linked to a decreased cell fitness due to inactivation of protein function. (frontiersin.org)
There are currently 20 retinal genes whose mutations cause the phenotype of LCA, accounting for about 70% of the cases, while the genes underlying the remaining 30% of patients await discovery. (aao.org)
Visual acuity (VA) in children with LCA varies significantly among patients with differing gene mutations and can be as low as no light perception (NLP). (aao.org)
Not surprisingly, the mutations that underlie the malignancy of cancer cells often affect the proteins that modify other proteins. (uchicago.edu)

The average pathogenicity score of genes is also predictive for their cell essentiality, capable of identifying short essential genes that existing statistical approaches are underpowered to detect. (bvsalud.org)

The majority of proteins function as monodispersed ordered species dissolved in intra- or extra-cellular aqueous fluids. (frontiersin.org)
Proteins found in any species of bacterium. (lookformedical.com)

Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
ybfF protein from Escherichia coli (Ec_ybfF) belongs to the esterase family for the large substrates, palmitoyl coenzyme A and malonyl coenzyme A, which are important cellular intermediates for energy conversion and biomolecular synthesis. (inra.fr)
To provide the molecular background to the enzymatic mechanism of the ybfF esterase, the ybfF protein from Escherichia coli K12 (Ec_ybfF) was cloned, expressed and purified. (inra.fr)

Further, biophysical experiments suggested that HomA and HomB are dimeric and most likely the cysteine residues present on surface-exposed loops participate in protein-protein interactions. (nature.com)
Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)
In this work, we show that substrate recognition of Tsp is mediated by a PDZ domain, a small protein module that promotes protein-protein interactions by binding to internal or C-terminal sequences of their partner proteins. (embl.de)
PDBsum provides an overview of every macromolecular structure deposited in the Protein Data Bank (PDB), giving schematic diagrams of the molecules in each structure and of the interactions between them. (biokeanos.com)

Bacterial F-type ATPases pump 3-4 H + and/or Na + (depending on the system) out of the cell per ATP hydrolyzed. (tcdb.org)

Phyletic analysis showed that the MORC proteins are widely distributed in eukaryotes, being present in most major crown group lineages (except fungi), apicomplexans and heteroloboseans, suggesting a relatively early origin in eukaryotes [ 5 ]. (beds.ac.uk)
However, fusogenic proteins resembling those found in gamete fusion in eukaryotes have so far not been found in prokaryotes. (bvsalud.org)

The US11 protein of herpes simplex virus type 1 (HSV-1) is a small, highly basic phosphoprotein expressed at late times during infection. (biomedcentral.com)
The US11 protein expresses at late times during HSV-1 infection and is one of the late genes of HSV-1 [ 3 ]. (biomedcentral.com)
Therefore, it is clear that US11 is a multifunctional protein involved in HSV-1 infection. (biomedcentral.com)
Two proteins putatively involved in the persistence of Mycobacterium tuberculosis infection have been investigated by heteronuclear nuclear magnetic resonance (NMR) spectroscopy and other methods. (ndltd.org)
Drosophila immune deficiency (IMD) pathway is similar to the human tumor necrosis factor receptor (TNFR) signaling pathway and is preferentially activated by Gram-negative bacterial infection. (cnrs.fr)

The protein itself is known to contain two independent N-terminal and C-terminal globular domains that subsequently bind to two domains of the iteron. (wikipedia.org)
The dimer version of the protein is generally inactive in iteron binding, however it is known to bind to the repE operator. (wikipedia.org)
Proteins which bind to DNA. (lookformedical.com)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)

Here, we analysed two deep mutational scanning experiments to investigate the role of protein aggregation in molecular evolution. (frontiersin.org)
Here, we set to clarify this complex matter and question of whether aggregation is an important constraint in protein evolution that can be the discriminant between beneficial and detrimental situations by considering two cases: we studied molecular evolution of proteins in an endogenous vs. exogenous host. (frontiersin.org)
Here we show, using X-ray crystallography, molecular dynamics simulations and in vitro and in vivo functional assays, that MlaA is a monomeric α-helical OM protein that functions as a phospholipid translocation channel, forming a ~20-Å-thick doughnut embedded in the inner leaflet of the OM with a central, amphipathic pore. (nature.com)
The GPCRDB is a molecular-class information system that collects, combines, validates and stores large amounts of heterogenous data on G protein-coupled receptors (GPCRs). (biokeanos.com)
The structure, determined by molecular replacement, confirms the hexameric organization of the protein and provides clear molecular details of both the active site and allosteric regulatory site. (biomedcentral.com)

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)

Like other biological macromolecules such as polysaccharides and nucleic acids, proteins are essential parts of organisms and participate in virtually every process within cells. (transectscience.org)
We are all aware of the potential for biological complexity implicit in the independent control of individual genes. (uchicago.edu)
The Protein Data Bank is the single worldwide archive of structural data of biological macromolecules. (biokeanos.com)

Sometimes proteins have non-peptide groups attached, which can be called prosthetic groups or cofactors. (transectscience.org)

H. pylori attaches and colonizes to the human epithelium using some of their outer membrane proteins (OMPs). (nature.com)
The Gram-negative bacterial outer membrane (OM) is a unique bilayer that forms an efficient permeation barrier to protect the cell from noxious compounds 1 , 2 . (nature.com)

It works to dimerize these Rep proteins and as a result monomers of these proteins are no longer in a high enough concentration to initiate replication. (wikipedia.org)
Name the monomers and polymers of carbohydrates, proteins and nucleic acids. (studymode.com)

Proteins perform a vast array of functions within organisms, including catalyzing metabolic reactions, DNA replication, responding to stimuli providing structure to cells and organisms, and molecules from one location to another. (transectscience.org)
The SWISS-MODEL Repository is a database of annotated 3D protein structure models generated by the SWISS-MODEL homology-modelling pipeline for protein sequences of selected model organisms. (biokeanos.com)

Protein footprinting utilizes a protein cutting reagent or protease. (lookformedical.com)

A single protein subunit is highlighted. (transectscience.org)

This special polyclonal antibody provides a good tool for further studying structural and functional characterization of HSV-1 US11 protein. (biomedcentral.com)

Hyaluronan binding protein 1 (HABP1), also known as C1qBP/C1qR and p32, is a ubiquitous acidic glycoprotein that functions in spermatogenesis and as a receptor for proinflammatory molecules (1, 2). (rndsystems.com)
Small molecules are manufactured chemically, but the larger ones are created by human cells, bacterial cells, yeast cells, and animal or plant cells. (biotechfront.com)

Monophosphate-Activated Protein Kinase in Cancer-Induced Anorexia. (clipstonepress.com)

Finally, US11 has been recently shown to also counteract the activity of the 2'-5' oligoadenylate synthetase (OAS), a cellular protein critical for host cell defense [ 15 ]. (biomedcentral.com)
Independently modulating the cellular concentration of each protein offers a nearly infinite number of steady-states. (uchicago.edu)

Insulin-like growth factor (IGF) signaling is highly conserved and tightly regulated by proteases including Pregnancy-Associated Plasma Protein A (PAPP-A). PAPP-A and its paralog PAPP-A2 are metalloproteases that mediate IGF bioavailability through cleavage of IGF binding proteins (IGFBPs). (bvsalud.org)
Protein cleavage is inhibited where the proteins, or nucleic acids and protein, contact each other. (lookformedical.com)

Photoaffinity labeling with a fluorescent nonpolar peptide caused the covalent attachment of the peptide to a single site on the Tsp protein. (embl.de)

We identify the prokaryotic MORCs and establish that the MORC family belongs to a larger radiation of several families of GHKL proteins (paraMORCs) in prokaryotes. (beds.ac.uk)

Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)

To date, the function of US11 protein in cell culture and animal models is poorly understood. (biomedcentral.com)

The interolog-based method predicts ~0.79M PPIs involving around 7700 Arabidopsis and 1068 Pseudomonas proteins in the full genome. (biomedcentral.com)

The present work predicts the protein-protein interaction network between Arabidopsis thaliana and Pseudomonas syringae pv. (biomedcentral.com)
However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. (embl.de)

Additionally, in a phylogenetic tree versions from the same bacterial lineage (e.g. proteobacteria) often do not group together. (beds.ac.uk)

The use of a separate substrate recognition domain such as a PDZ domain may be a general mechanism for achieving selective protein degradation. (embl.de)

Shortly after or even during synthesis, the residues in a protein are often chemically modified by post-translational modification, which alters the physical and chemical properties, folding, stability, activity, and ultimately, the function of the proteins. (transectscience.org)

This structure consists of an origin of replication upstream of a gene that codes for a replication initiator protein. (wikipedia.org)
The availability of good quality tertiary structure of LytTR domain of AgrA protein is necessary for the development of such therapeutic agents. (ijpsr.com)
This is a general concern since the methods for determination of three dimensional structure of a protein are time consuming and expansive. (ijpsr.com)
Groundbreaking work in biochemistry has led to our knowledge of the structure of DNA, RNA and proteins and it holds the promise of further breakthroughs in treatment in the future. (hud.ac.uk)
The ESCRT structure therein compensatientire perfrom originate to sternoutms a hoput into practicekeeping function and all of its requisite protein componlynts should be expressed in all rooms. (upb.ro)
In this Viewpoint, 2023 Lasker award winners John Jumper and Demis Hassabis describe their invention, the artificial intelligence-based system AlphaFold, which is able to predict protein structure with great accuracy. (bvsalud.org)
The structure of Ec_ybfF is composed of a globular alpha/beta hydrolase domain with a three-helical bundle cap, which is linked by a kinked helix to the alpha/beta hydrolase domain. (inra.fr)
This protein was the first to have its structure solved by X-ray crystallography. (transectscience.org)
Methods commonly used to study protein structure and function include immunohistochemistry, site-directed mutagenesis, X-ray crystallography, nuclear magnetic resonance and mass spectrometry. (transectscience.org)
The crystal structure of the chaperoning, a huge protein complex. (transectscience.org)
Three possible representations of the three-dimensional structure of the protein triose phosphate isomerize. (transectscience.org)

Interestingly, the in-silico analysis revealed that HomA/B consists of 8 discontinuous N and C terminal β-strands forming a small β-barrel, along with a large surface-exposed globular domain. (nature.com)
These proteins contain two related domains known as the chromo- and the chromoshadow-domain. (cipsm.de)
If a Pseudomonas and an Arabidopsis protein contain an interacting domain pair, one can expect the two proteins to interact with each other. (biomedcentral.com)
The domain-based method predicts 85650 PPIs comprising 11432 Arabidopsis and 887 Pseudomonas proteins. (biomedcentral.com)
The N-terminal A domain differs among the four subtypes of Ca 2+ channel β subunits (β 1 -β 4 ) primarily as the result of two duplications of an ancestral gene containing multiple alternatively spliced exons. (jneurosci.org)
PDZ domain proteins are frequently associated with the plasma membrane, a compartment where high concentrations of phosphatidylinositol 4,5-bisphosphate (PIP2) are found. (embl.de)
Taxonomic distribution of proteins containing PDZ domain. (embl.de)
The complete taxonomic breakdown of all proteins with PDZ domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing PDZ domain in the selected taxonomic class. (embl.de)

The gene for Rep proteins is usually found directly downstream of the origin of replication. (wikipedia.org)
The IL-10 protein levels in the test samples maintain been found below the tenderness of the BD Bioscience Flex Set. (upb.ro)
Orthologs for 80% of the predicted Xoo genes were found in the previously reported X.axonopodis pv. (inra.fr)

Anatomy6

Organisms20

Diseases5

Chemicals and Drugs89

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Psychiatry and Psychology1

Phenomena and Processes89

Disciplines and Occupations5

Technology, Industry, Agriculture3

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Health Care4

Enzymes5

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Bacteria12

Intrinsically disordered proteins2

Peptides3

Complexes3

Nucleotide3

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Recombinant proteins1

Eukaryotic4

Treatment of bacterial infections1

Enzyme5

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Homologous2

Pathogenesis5

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Nucleotides1

Amino7

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Extracellular2

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Experimentally4

Genomes2

Abnormal2

Structures7

Expression10

Mutations4

Pathogenicity1

Species2

Escherichia3

Interactions4

ATPases1

Eukaryotes2

Infection5

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Molecular5

Endogenous1

Biological3

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Outer membrane2

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Protease1

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Structural and functional1

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Poorly understood1

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Found3