• Plasma alanine aminotransferase levels, hepatic expression of tumor necrosis factor-α, interleukin-6, fatty acid synthesis-related genes, oxidative stress biomarker 8-hydroxydeoxyguanosine (8-OHdG), and apoptosis marker terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells in the liver were decreased in the HW and PGZ groups. (researchgate.net)
  • by a powerful in vivo screening method following the simultaneous randomization of the codons for two c-helix residues, 113 and 116, near the distal heme pocket of cooa, we have isolated a series of novel cooa variants. (liverpool.ac.uk)
  • Therefore, sequence-activity relationships and key residues were identified by elongating sequence to different extents, designing cyclic peptides, and performing an alanine scan of L7. (cnr.it)
  • A subclass of ANTIFREEZE PROTEINS that contain four amphipathic alpha-helices folded into an antiparallel helix bundle. (lookformedical.com)
  • The existence of a short antiparallel beta-sheet between the two loops in each domain has been confirmed. (nih.gov)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
  • These proteins differ widely in size and oligomeric state, and have limited sequence homology. (wikipedia.org)
  • these synthetases are further divided into three subclasses, a, b and c, according to sequence homology. (wikipedia.org)
  • Homology-based cloning is an efficient approach for isolation of wheat genes following known rice gene sequences. (frontiersin.org)
  • Through molecular biology techniques, the pentapeptide sequence, molecular weight, and architecture of the ELP can be precisely controlled for subsequent an purified as a recombinant polypeptide, resulting in monodisperse, non-immunogenic (Urry et al. (justia.com)
  • The ability of mutant peptides to induce activation of signal transduction pathways and release of TNF-alpha and IL-6 has been determined, and, in conjunction with CD spectra, bioinformatics analysis, and molecular dynamics data, showed that 6 out of 8 amino acids contribute significantly to the overall activity. (cnr.it)
  • This work provides insights into essential molecular details of P2 that may impact on the pathogenesis of Hib infections where interruption of the signaling cascade could represent an attractive therapeutic strategy. (cnr.it)
  • A subclass of ANTIFREEZE PROTEINS that are 3-5 kDa in size and contain a single alanine-rich amphipathic alpha-helix. (lookformedical.com)
  • A subclass of ANTIFREEZE PROTEINS that are globular, 6.5 kDa in size and contain compact beta-sheet structures. (lookformedical.com)
  • V/I)XPX sequence is a general OS localization signal that can function in the context of both integral and peripheral membrane proteins. (jneurosci.org)
  • in each case, a short N- or C-terminal sequence is shared among structurally diverse proteins that are targeted to the same subcellular destination. (jneurosci.org)
  • By analogy with other subcellular sorting systems, OS sorting must involve the recognition of one or more sequences or conformations that distinguish OS proteins from other proteins within the cell. (jneurosci.org)
  • The NK-2 gene is-activated but not expressed in the most ventral horizontal stripe of nuclei, the mesodermal anlage, due to repression by snail, a zinc finger protein, or in the adjacent horizontal stripe of nuclei, the mesectodermal anlage, due to repression by single-minded and Enhancer of split m8, which are basic, helix-loop-helix proteins. (nih.gov)
  • Sequence analyses of the SPs and their cognate proteins revealed four properties that correlated positively with SP performance for NucA: high hydrophobicity, the presence of a transmembrane helix predicted by TMHMM, the absence of an anchoring motif in the cognate protein, and the length of the H+C domain. (biomedcentral.com)
  • Many of the biological activities identified for BPV1 E5 are likely to extend to the E5 proteins of the related BPV2, BPV5, deer papillomavirus (DPV), European elk papillomavirus (EEPV) and ovine papillomavirus (OvPV), all of which have extremely similar sequences. (nih.gov)
  • DNA flanking the P-element insertion sites were cloned from 15 of the most interesting transgenic fly lines and corresponding cDNA clones were obtained and were sequenced partially. (nih.gov)
  • 204, 191-204], which consists of two pairs of a "helix-loop-helix" motif in each globular domain. (nih.gov)
  • The secondary structure of this protein in solution has been elucidated by a qualitative interpretation of nuclear Overhauser effects, hydrogen exchange data, and 3JHNH alpha coupling constants. (nih.gov)
  • A clear correlation between the 13C alpha chemical shift and secondary structure is found. (nih.gov)
  • Although this secondary binding site shares little sequence similarity across orthogonal species, the lateral surface of eIF4E where it interacts is conserved. (biomedcentral.com)
  • The gene was located on chromosome 7A, designated as TaTGW-7A with a complete genome sequence and an open reading frame (ORF). (frontiersin.org)
  • However, only a few major QTL have been cloned due to large genome size and limited genome sequence information in wheat. (frontiersin.org)
  • Transposition of a P-element that contains the [beta]-galactosidase gene from 1 site in the Drosophila genome to another yielded many transgenic fly lines that express [beta]-galactosidase only in the nervous system during embryonic development. (nih.gov)
  • First, the pocket, conservation, structural and energy profiles, and physicochemical properties of (non)covalently bound cysteines were collected from both protein sequences and 3D structures of protein-ligand complexes. (uni-freiburg.de)
  • PMID- 5428635 TI - Circadian rhythms in plasma concentration of 11-hydroxycorticosteroids in men working on night shift and in permanent night workers. (nih.gov)
  • The developmental time and location of [beta]-galactosidase expression then is determined by regulatory signals of the genes that contain the inserted [beta]-element DNA. (nih.gov)
  • In this work, we describe the complete identification, cloning and heterologous expression of the cacaoidin biosynthetic gene cluster, which shows unique RiPP genes whose functions were not predicted by any bioinformatic tool. (mdpi.com)
  • Efficient OS localization requires both membrane association and the prRDH sequence. (jneurosci.org)
  • Significant alterations in network topology and connectivity in function were observed, despite similarity in gut microbial alpha diversity ( P = 0.30) and beta-diversity ( P = 0.123) between control and BBR treatment. (researchsquare.com)
  • cooa is the co-sensing transcriptional activator from rhodospirillum rubrum, in which co binding to its heme prosthetic group triggers a conformational change of cooa that allows the protein to bind its cognate target dna sequence. (liverpool.ac.uk)
  • It consists of a highly conserved N-terminal P-Loop ATPase subdomain with an alpha-beta-alpha conformation, and a less-conserved C-terminal subdomain with an all alpha conformation. (nih.gov)
  • In the present study, a candidate gene associated with TGW was identified through specific-locus amplified fragment sequencing (SLAF-seq) of DNA bulks of recombinant inbred lines (RIL) derived from the cross between Jing 411 and Hongmangchun 21. (frontiersin.org)
  • have been cloned based on rice gene sequences. (frontiersin.org)
  • We hypothesize that vitronectin, bound to alpha-helix F on the side opposite to the epitopes of the mAbs, potentiates the mAb-induced delay in RCL insertion and the associated substrate behavior by selectively decreasing the rate constant for the inhibitory branch of PAI-1 reaction (ki) . (morulaivf.com)
  • Aptamers are oligonucleotide sequences that can bind to a variety of targets with high specifificity and selectivity, and they are often combined with different transduction technologies, thereby constructing various types of aptamer sensors. (encyclopedia.pub)
  • Compared to traditional ML models with only sequenced-based features or only 3D structural features, HyperCys is more accurate at predicting hyper-reactive druggable cysteines. (uni-freiburg.de)
  • Mutation of the single tryptophan residue located in a loop at position 113 (position 535 in the reverse transcriptase sequence) to an alanine resulted in much improved spectral properties with no apparent change in structure. (nih.gov)
  • PMID- 5428632 TI - Examination of the liver in personnel working with liquid rocket propellant. (nih.gov)
  • MH - 2-Hydroxypropyl-beta-cyclodextrin UI - D000073738 MN - D4.345.103.333.500 MN - D9.301.915.400.375.333.500 MN - D9.698.365.855.400.375.333.500 MS - Derivative of beta-cyclodextrin that is used as an excipient for steroid drugs and as a lipid chelator. (nih.gov)
  • Coaltar derivative dyes were the work of William Perkin, a british chemist. (microrao.com)
  • V/I)XPX at the extreme C terminus, which closely resembles the C-terminal sequence that targets opsin/rhodopsin to the OS. (jneurosci.org)
  • PMID- 5428631 TI - Bronchitis in two integrated steel works. (nih.gov)
  • Clinical trials are currently exploring future directions, including combinations of approved agents and the optimal sequencing of these agents. (medscape.com)
  • The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. (lookformedical.com)
  • several core light-harvesting complexes from both sulfur and non-sulfur purple photosynthetic bacteria have been identified to be methylated at the n-terminal alpha-amino group of beta-polypeptides by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nuclear magnetic resonance. (liverpool.ac.uk)
  • NIAAA continues to work with a group of college presidents to help meet their needs and inform them of research-supported strategies to reduce harmful drinking on campus. (nih.gov)
  • Multi-omics (bile acid metabolomics, 16S rDNA sequencing, cecal metatranscriptomics) were performed in order to provide a simple in vivo model from which to identify network-based correlations between bile acids and bacterial transcripts in the presence and absence of dietary BBR. (researchsquare.com)
  • Their well-designed investigation, named the 'Cornell model' by the academic institute wherein the research was conducted, can be regarded a main work on mycobacterial latency and its relation to tuberculosis chemotherapy [ 7 ]. (e-trd.org)
  • The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. (mdpi.com)
  • Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices, and are mostly dimeric or multimeric, containing at least three conserved regions. (wikipedia.org)
  • Now, Americans sometimes have a hard time understanding the way class works in a place like London. (nih.gov)
  • The results for NucA provide some hints as to the sequence-based prediction of SP functionality, but the general conclusion is that such prediction is difficult. (biomedcentral.com)
  • The eight alpha-helix segments identified from the NMR data are located at Glu-6 to Phe-19, Thr-29 to Ser-38, Glu-45 to Glu-54, Phe-65 to Lys-77, Glu-82 to Asp-93, Ala-102 to Asn-111, Asp-118 to Glu-127, and Tyr-138 to Thr-146. (nih.gov)
  • This is not underachievement which is performance, usually in school work, poorer than that predicted from aptitude and/or intelligence testing. (nih.gov)
  • NIEHS has a goal to ensure job opportunities and career enhancements programs for both our work force and our community. (nih.gov)
  • This work has important implications for interpreting the effects of BBR on structure and function of the complex gut microbiome, which may lead to targeted pharmaceutical interventions aimed to achieve the positive physiological effects previously observed with BBR supplementation. (researchsquare.com)
  • Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases. (morulaivf.com)
  • with a fluorescent tag at the reactive center loop (RCL) was used to study the effects of vitronectin and monoclonal antibodies (mAbs) directed against alpha-helix F (Mab-2 and MA-55F4C12) on the reactions of PAI-1 with tissue-type and urokinase-type plasminogen activators. (morulaivf.com)
  • CHARMM Developer's Change Log Entries in each node are recorded by CHARMM developers to indicate new and modified features of CHARMM during the development cycle, i.e., the alpha version period. (nih.gov)