• 1996). "Molecular genetic analysis of the human Lewis histo-blood group system. (wikipedia.org)
  • Qualitative RT-PCR for HCV RNA Test to detect HCV RNA by amplification of viral genetic sequences. (cdc.gov)
  • Quantitative assays for HCV RNA Tests to detect HCV RNA concentration (viral load) by amplification of viral genetic sequences or by signal amplification. (cdc.gov)
  • He has led genome-wide studies of human genome variation, heritable gene expression variation, human genetic disorders, tumor evolution, mouse strain variation, genome stability in reprogrammed stem cells, and single-neuron somatic mosaicism in the human brain. (yale.edu)
  • She uses genetic approaches to identify novel disease genes for dominantly inherited polycystic kidney and liver diseases: a phenotypic spectrum from autosomal dominant polycystic kidney disease (ADPKD) to isolated polycystic liver disease (PCLD), and both in vitro and animal models to further disease gene mechanism investigation. (yale.edu)
  • Dr. Besse has an active research program recruiting patients with genetically unresolved polycystic kidney and/or liver disease or other inherited kidney diseases for projects involving gene/pathway discovery and variant analysis in genetic kidney diseases. (yale.edu)
  • Chromosomes are the cellular storage units for genes contained within the nucleus (which is the genetic center) of the cell and are analogous to a spool with the DNA or genetic message being the thread on the spool. (sarcomahelp.org)
  • Next generation sequencing (NGS) of the hypervariable region (HVR1) of HCV and Global Hepatitis Outbreak and Surveillance Technology (GHOST) were used to determine HCV genotype, genetic heterogeneity, and construct transmission networks. (cdc.gov)
  • Immunocytochemical analysis of the 3-D cultures also showed no detectable presence of histo-blood group antigens that participate in NV binding and host tropism. (cdc.gov)
  • FUT2 encodes an enzyme that produces histo-blood group antigens (HBGA) on the surface of epithelial cells and in mucosal secretions ( 21 , 22 ). (cdc.gov)
  • These species were validated primarily on the basis of DNA-DNA hybridization, 16S rRNA gene sequence analysis, antimicrobial susceptibility and biochemical profiles, and, to a lesser degree, on high-performance liquid chromatography ( 22 , 54 , 55 , 69 ). (antimicrobe.org)
  • CONCLUSIONS: Smaller MMN indicates a NMDAR system that is more vulnerable to disruption by the NMDAR antagonist ketamine. (neurotransmitter.net)
  • Seventeenth-century English anatomist William Harvey, who questioned some of Galen's conclusions, described the heart as a 4-chambered pump that moves blood through arteries and veins, not air. (medscape.com)
  • Since the epigenetic status differs in each tissue type, in addition to the DNA from the peripheral blood, studies using DNA from nerve cells induced from postmortem brains or induced pluripotent stem cells are being carried out. (springer.com)
  • Clonal expansion of T cells correlating with disease activity has been observed in peripheral blood (PB) of SLE subjects. (biomedcentral.com)
  • The principal studies used to establish the diagnosis of PNH are flow cytometry of peripheral blood and bone marrow analysis. (medscape.com)
  • 1995). "Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). (wikipedia.org)
  • The idea is that very broadly speaking, increased methylation at gene regulatory regions generally represses expression of those genes. (worldhealth.net)
  • The coupling of alternative splicing with NMD is intriguing and could provide a general means of regulating gene expression. (berkeley.edu)
  • He received a B.A. in Integrative Biology from the University of California at Berkeley (1998), and worked as a technician for 2 years in Sarah Hake's plant genetics group at the USDA/ARS Plant Gene Expression Center. (yale.edu)
  • Because allelic exclusion leads to the expression of only one TCR chain in mature T cells [ 29 ], each unique CDR3 sequence is a proxy for T cell clonotype. (biomedcentral.com)
  • As docking units, they influence the recruitment of the transcriptional machinery, thus establishing unique gene expression patterns that ultimately promote different biological outcomes. (aging-us.com)
  • How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
  • Humans have a duplicate set of 23 chromosomes (or a total of 46 chromosomes) in any given cell that carries all of the human genes. (sarcomahelp.org)
  • The genotypes of H. pylori virulence factors were determined by polymerase chain reaction (PCR)-based sequencing. (biomedcentral.com)
  • Rapid molecular identification and typing methods that may be useful include 16S rRNA gene sequencing, random amplified polymorphic DNA and a combination polymerase chain reaction-restriction fragment length polymorphism analysis ( 39 , 116 ). (antimicrobe.org)
  • However, the same immunosuppressive medications that are required to prevent the child's immune system from attacking and rejecting the transplanted organ can predispose these individuals to developing a very serious cancer that is linked to Epstein-Barr virus (EBV). (stanford.edu)
  • Computer systems and the ribosome/DNA system both rely on highly specific and varying streams of digital codes to produce anything functional and useful. (uncommondescent.com)
  • Brain function is typically measured using task-based functional MRI (tfMRI) in which subjects perform tasks or experience sensory stimuli, and uses imaging sensitive to local changes in blood oxygenation and flow caused by brain activity in grey matter. (biorxiv.org)
  • Cell assemblies and central pattern generators (CPGs) are related types of neuronal networks: both consist of interacting groups of neurons whose collective activities lead to defined functional outputs. (degruyter.com)
  • To explore if the strength of MMN generation reflects the functional condition of the NMDAR system in healthy volunteers, we analyzed correlations between MMN recorded before drug administration and subsequent responses to the NMDAR antagonist ketamine or the 5-HT2a agonist psilocybin. (neurotransmitter.net)
  • To these ends, several groups have classified and catagorized known alternative isoforms in terms of changes in gene structure between alternative isoforms or by the functional classes of the genes that are involved[ 4 , 16 ]. (berkeley.edu)
  • The only general conclusion that can be drawn from these analyses, however, is that alternative splicing affects genes of nearly every functional class by modifying gene structure in every conceivable way, such as using mutually exclusive exons or alternative donor sites. (berkeley.edu)
  • An updated interface of the system became much more interesting, more functional and more comfortable. (banglaforexacademy.com)
  • The aim of this study was to assess the wide spectrum of adaptive responses in humans regarding the different tissues, organs and functional systems being exposed to such chronic physical endurance load with limited time for regeneration and resulting negative energy balance. (biomedcentral.com)
  • This article is the reference for contemporary result reports on the different scientific topics of the TEFR project, which may reveal additional new knowledge on the physiological and pathological processes of the functional systems on the organ, cellular and sub-cellular level at the limits of stress and strain of the human body. (biomedcentral.com)
  • Clinical manifestations of PNH occur when a HSC clone carrying somatic PIGA mutations acquires a growth advantage and differentiates, generating mature blood cells that are deficient of GPI-anchored proteins. (medscape.com)
  • 1995) Achondro- plasia is defined by recurrent G380R mutations of FGFR3. (binaryoptiontradingscam.com)
  • These PBP3 sequences are not mosaic but show an accumu- lation of point mutations. (forex-consultant.com)
  • His current work is focused on two broad goals: (1) mapping variants and genes that confer risk to human disease, with ongoing projects focused on coronary artery disease and cardiometabolic traits in unique and underrepresented populations, and (2) developing methods for the detection and interpretation of human genome variation, with an emphasis on structural variation and other difficult-to-detect forms, and on comprehensive trait association in human disease studies. (yale.edu)
  • Subsequently, these two tumors have been grouped into a class of cancers entitled Ewing's Sarcoma Family of Tumor (ESFT), all of which demonstrate this translocation. (sarcomahelp.org)
  • He has also served as an Associate Editor at Genome Research (2009-2014) and Genes, Genomes and Genetics (2011-2018).Most recently, Dr. Hall has played a leadership role in several large collaborative projects funded by NIH/NHGRI including the Centers for Common Disease Genomics, the AnVIL cloud-based data repository and analysis platform, and the Human Pangenome Project. (yale.edu)
  • Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene. (wikipedia.org)
  • 1995). "Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. (wikipedia.org)
  • A major finding from human NV volunteer studies is that persons with strains containing 2 mutated alleles of the α(1,2) fucosyltransferase ( FUT2 ) gene were resistant to NV infection ( 16 - 20 ). (cdc.gov)
  • In addition, Mollerup's 2016 Journal of Clinical Microbiology review regarding P. acnes , using similar next-generation sequencing as the Bristol group, cautioned: "Our results show that P. acnes can be detected in practically all sample types when molecular methods, such as next-generation sequencing, are employed. (j-alz.com)
  • Rossen said this about species identification (such as the species P. acnes ) using next generation sequencing: "when one gets down to the species level such molecular methods need "a priori" knowledge of the likely pathogenic species that could be present in the sample" [5]. (j-alz.com)
  • The goal of her lab is to have the identification of novel disease genes serve as an entry point for molecular biology investigation that contributes to a better understanding of disease mechanism and the identification of successful targets for treatments. (yale.edu)
  • The donor and both kidney recipients were found to have a genetically identical strain of HAV using a next-generation sequencing-based cyber molecular assay (Global Hepatitis Outbreak Surveillance Technology), confirming donor-derived HAV infections in kidney recipients. (cdc.gov)
  • Moreover, CDK7 ablation specifically suppressed p38α/MYC-associated genes, and THZ1 inhibited MYC transcriptional activity through downregulating p38α. (biomedcentral.com)
  • Infection by VMV and CAEV can lead to Visna/Maedi (VM) and Caprine Arthritis-Encephalitis (CAE) respectively, slow progressive inflammatory diseases primarily affecting the lungs, nervous system, joints and mammary glands. (mdpi.com)
  • Our understanding of the immune system stems, in great part, from studying the host response to infection, which in most individuals leads to the absence of clinical disease and establishment of highly apt immunological memory. (frontiersin.org)
  • therefore the bacteria identified here may be due to secondary infection after BBB [blood-brain barrier] breakdown. (j-alz.com)
  • Attenuation of experimental autoimmune neuritis in the Lewis rat by treatment with an antibody to L-selectin. (2medicalcare.com)
  • The most frequently employed model for GBS is experimental autoimmune neuritis (EAN) generated in Lewis rats. (biomedcentral.com)
  • Although recent advances in next-generation sequencing have increased the accuracy of this line of research, there has been greater emphasis placed on epigenetic changes versus DNA sequence changes as the probable cause of discordant psychiatric disorders in MZs. (springer.com)
  • Recently, next-generation sequencing (NGS) of the T cell receptor (TCR) β loci has emerged as a sensitive way to measure the T cell repertoire. (biomedcentral.com)
  • The histological features of squamous cell carcinoma from the transplanted cell systems in nude mice might suggest a secondary onset of malignancy from a pre-existing benign adenoma. (biomedcentral.com)
  • Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)
  • This, in turn, affects the excitability of the nervous system. (medscape.com)
  • The advantage is that ample amounts of haemoglobin can be obtained from a blood sample, and, given the four-month lifetime of red blood cells, the adducts formed with the amino acids of the protein will indicate the total exposure during this period. (iloencyclopaedia.org)
  • Her identification and investigation of multiple genes has contributed understanding to how the central PKD protein, Polycystin-1, matures through the endoplasmic reticulum. (yale.edu)
  • His group has developed bioinformatics tools for variant detection, variant interpretation, sequence alignment, data processing, and data integration. (yale.edu)
  • Furthermore, translocation of immune cells from one anatomical compartment to another, i.e., the gut-lung axis via the lymphatics or blood has been identified as an important factor in perpetrating systemic inflammation, tissue destruction, as well as modulating host-protective immune responses. (frontiersin.org)
  • Multiple differences were found, specifically in blood concentrations of antioxidants and amino acids, as well as in microbiota composition. (hindawi.com)
  • and overall 17 genes involved in development, pathway signalling and plasticity. (biorxiv.org)
  • results suggest that in terms of microbiome diversity, both weight loss interventions are equally successful, all participants in both groups experienced positive changes in the overall taxonomic structure of their microbiome composition. (worldhealth.net)
  • Gas chromatography/mass spectrometry, liquid chromatography/tandem mass spectrometry, clinical chemistry analysis, dual-energy X-ray absorptiometry, and 16S pyrosequencing were used to characterize blood metabolic, clinical, and fecal microbiome systems, respectively. (hindawi.com)
  • The three methods that use backup waterflooding need a permeability of greater than 10 md in order to inject the chemicals or emulsions and to produce the released oil from the rock.2002, 109, 269-276 (lutropin alfa) Lewis, R. (forex-consultant.com)
  • All of the chemicals discussed of this chemical was raised to carci- lung and the nasal cavity were iden- here are IARC Group 1 agents and nogenic to humans (Group 1) based tified as target organs in humans as such can be characterized as on strong mechanistic evidence and rats, respectively. (who.int)
  • Among this group of chemicals, tected in epidemiological studies of IARC evaluations of the carcinogen- there is remarkable concordance in exposed workers. (who.int)
  • Names for H (ISBT 018) Blood Group Alleles" (PDF). (wikipedia.org)
  • It's one of the multiple epigenetic mechanisms that regulate our genes without directly altering our DNA sequences," he says. (worldhealth.net)
  • One of the biggest appeals of epigenetic mechanisms is that they are a means through which the environment can act to alter our genes and our health," he continues. (worldhealth.net)
  • These exon-junction complexes are important both for facilitating export from the nucleus and for remembering gene structure[ 31 ]. (berkeley.edu)
  • Ann Rev Microbiol 49:117-143 Sherwin T, Gull K (1989) The cubicle division sequence of Trypanosoma brucei brucei: timing of event markers and cytoskeletal modulations. (wgc2010.sk)
  • Trypanosoma cruzi trypomastigotes in a mouse blood smear (Giemsa, x625). (medscape.com)
  • When we looked at differences between the two intervention groups, there weren't really any differences in terms of alpha diversity. (worldhealth.net)
  • Differences between isoforms of an alternatively spliced gene may be subtle or profound. (berkeley.edu)
  • An early dose-finding study by the Radiation Therapy Oncology Group (RTOG) 7301 study was conducted from 1973 to 1978 and studied four different doses and schedules: 40 Gy split course, 40 Gy continuously, 50 Gy, and 60 Gy. (frontiersin.org)
  • Lewis y monoclonal antibody (1:1000) was used to detect Lewis y antigen. (pdesignal.com)
  • It offers a comprehensive resource of tissue-specific and sex-specific aging dysregulations and highlights age-related intercellular communication changes widespread across the whole body, such as the upregulation of immune system processes and inflammation, the downregulation of developmental processes, angiogenesis and extracellular matrix organization and the deregulation of lipid metabolism. (nature.com)
  • They were characterized by immunofluorescence, classical cytogenetics, p53 gene mutational analysis, fluorescence in-situ hybridization, and histopathological and immunohistochemical examinations of their xenografts, to demonstrate their potency of secondary transformation. (biomedcentral.com)
  • 1984. Agents affecting the male reproductive system: Effects of structure on activity. (cloudaccess.net)
  • Most commonly, biomarkers of exposures to stable compounds, such as metals, comprise measurements of the metal concentrations in appropriate samples, such as blood, serum or urine. (iloencyclopaedia.org)
  • DNA adducts may be detected in white blood cells or tissue biopsies, and specific DNA fragments may be excreted in the urine. (iloencyclopaedia.org)
  • The completion rate for planned MRI investigations was more than 95%: 741 MR-examinations with 2,637 MRI sequences (more than 200,000 picture data), 5,720 urine samples, 244 blood samples, 205 ECG, 1,018 BIA, 539 anthropological measurements and 150 psychological questionnaires. (biomedcentral.com)
  • The name of the disorder is a descriptive term for the clinical consequence of red blood cell (RBC) breakdown with release of hemoglobin into the urine, which manifests most prominently as dark-colored urine in the morning (see image below). (medscape.com)
  • Near the thyroid are 4 tiny pea-shaped organs, the parathyroids, that secrete parathormone to control and balance the levels of calcium and phosphate in the blood and tissue fluids. (medscape.com)
  • We describe the RNA sequence as information because that's how we (as humans) understand it. (uncommondescent.com)
  • Infected insects take blood meals from humans and their domestic animals and deposit parasite-laden feces. (medscape.com)
  • Peripheral nervous system (PNS) alterations were characterised using standard morphological techniques, including nerve fibre teasing and transmission electron microscopy. (biomedcentral.com)
  • And although Streptothrix had always been identified as a rare central nervous system pathogen, its lookalike, tuberculosis, is extremely neurotropic and fully capable of breaching and then entering the brain parenchyma or meninges at the level of this same blood-brain barrier (BBB) [2]. (j-alz.com)
  • The posterior pituitary is controlled by the nervous system. (medscape.com)
  • Meanwhile, the autonomic nervous system stimulates the suprarenal medulla to secrete hormones such as epinephrine into the bloodstream. (medscape.com)
  • In the human gastroduodenal junction where NV has been shown to bind HBGA type 1 (Lewis b [Le b ]), is found exclusively on epithelial surfaces, whereas HBGA type 2 is primarily found at the glandular level ( 19 , 24 - 26 ). (cdc.gov)
  • The word biomarker is short for biological marker, a term that refers to a measurable event occurring in a biological system, such as the human body. (iloencyclopaedia.org)
  • Alternative splicing has been shown to affect more than one-third of all human genes. (berkeley.edu)
  • Recent reports have shown that more than one third of all human genes may be affected by alternative splicing[ 4 - 9 ]. (berkeley.edu)
  • For example, the human Bcl-x gene can be processed to generate several isoforms with markedly different activities. (berkeley.edu)
  • We did not observe any overlap of CDR3 amino acid sequences or a preferential Vβ or Jβ gene usage among the top 100 expanded clones from all SLE patients. (biomedcentral.com)
  • The intricate interplay between the immune system and microbes is an essential part of the physiological homeostasis in health and disease. (frontiersin.org)
  • The lack of an efficient cell culture system in which to study NoV infections has hindered development of antiviral drugs to control or limit NoV outbreaks ( 5 ). (cdc.gov)
  • For this study one group of participants was instructed to fast for three non-consecutive days a week, they were told to eat 25% of what they would normally consume on fasting days and consume whatever they wanted on non-fasting days. (worldhealth.net)
  • Correlations between ERP amplitudes (MMN, N1, and P2) and drug-induced effects were calculated in each study group and compared between them. (neurotransmitter.net)
  • Forty-four study volunteers (67% of the participants) were cluster randomized into two groups for MRI measurements (22 subjects each) according to the project protocol with its different research modules: musculoskeletal system, brain and pain perception, cardiovascular system, body composition, and oxidative stress and inflammation. (biomedcentral.com)
  • This impedes study of persistent infections in vulnerable groups, where such information has a limited use. (cdc.gov)
  • In groups of exposed workers, some exposure biomarkers can be applied to assess the extent of compliance with pollution abatement regulations or the effectiveness of preventive efforts in general. (iloencyclopaedia.org)
  • However, it is useful for us, as scientists belonging to a common research group, to reflect over these issues and provide answers that can guide us in our own planning. (lu.se)
  • Decrease in arterial the pCO2 resulting in decreased cerebral blood flow is the proposed mechanism for stocm effects of hyperventilation. (binaryoptiontradingscam.com)
  • However, this risk cannot be assessed since the prevalence, involved in the trade were asked for permission to sample diversity, and geographic distribution of SIV infections in wild blood and tissues from carcasses, which were then returned. (cdc.gov)
  • The endocrine system consists of endocrine glands that produce and secrete hormones into the blood stream to reach and act on target cells of specific organs. (medscape.com)
  • Each CagA is assigned to a sequence type consisting of the names of the EPIYA segments in its sequence (that is, ABC, ABCC, or ABCCC for Western-type- and ABD for East-Asian-type- cagA ). (biomedcentral.com)
  • The sequence of the second repeat region was found to differ considerably between East-Asian-type- cagA and Western-type- cagA . (biomedcentral.com)
  • We have found that many alternative isoforms are apparent targets of nonsense-mediated mRNA decay (NMD), an mRNA surveillance system. (berkeley.edu)
  • But specifically, the Bristol group found an Actinobactor called Propionibacterium acnes ( P. Acnes ) in autopsied AD brains-a common organism, traditional felt to be non-pathogenic and commonly found on our skin which can cause, among other things, acne. (j-alz.com)
  • [ 1 ] T cruzi mostly is found in blood-sucking triatomine insects (kissing bugs) and small mammals in a sylvatic cycle that is enzootic from the southern and southwestern United States to central Argentina and Chile. (medscape.com)
  • The trypomastigote is the infective flagellated form of the parasite found in the blood of the mammalian hosts (blood trypomastigote) and in the hindgut of vectors (metacyclic trypomastigote). (medscape.com)
  • You have certain genes whose activity put you at a greater risk of some type of disease, but if you live a healthy lifestyle, they aren't activated," Konigsberg says. (worldhealth.net)
  • The CDK7/MYC/PD-L1 signature and infiltrating T cell status collectively stratified NSCLC patients into different risk groups. (biomedcentral.com)
  • Local and distant failure remains high in this group of patients, so dose escalation has been studied in both single institution and national clinical trials. (frontiersin.org)
  • Histological severity of the gastric mucosa was classified into 4 grades, according to the updated Sydney system. (biomedcentral.com)
  • In addition, they all had a common deletion of the last base G of codon 249 (AGG to AG_) of the p53 gene, which resulted in generation of its nonsense gene product. (biomedcentral.com)
  • It produces 2 hormones: vasopressin, which causes blood pressure to rise and regulates the amount of water in the body's cells, and oxytocin, which causes the uterus to contract during childbirth and lactation to begin. (medscape.com)
  • Built upon scDiffCom, scAgeCom is an atlas of age-related cell-cell communication changes covering 23 mouse tissues from 58 single-cell RNA sequencing datasets from Tabula Muris Senis and the Calico murine aging cell atlas. (nature.com)
  • This presents the problem of whether candidates such as cell-wall-deficient filamentous forms of a microbe like those of M. tuberculosis would or could through existing known sequences even be considered. (j-alz.com)
  • We have established five cell systems from a benign pleomorphic adenoma of the parotid gland of a 61-year-old woman. (biomedcentral.com)
  • We established and characterized five cell systems (designated as SM-AP1 to SM-AP5) from a benign pleomorphic adenoma of the parotid gland. (biomedcentral.com)
  • Among them, der(9)t(9;13)(p13.3;q12.3) was shared by all five of the cell systems. (biomedcentral.com)
  • Ninety-five percent of T cells in the blood express T cell receptor (TCR) consisting of heterodimers of αβ chains [ 29 ]. (biomedcentral.com)
  • It is important to en- sure that the drainfield is installed with care to keep the porous pipe level, or at a very gradual downward slope away from the distribution box or pump chamber, according to specifications stipulated by public health officials. (top5binarybrokers.com)
  • The scarcity of resources available for health care delivery system and the political instability that characterise the West African countries would continue to impede efforts for the control of Lassa fever in the sub-region. (folkhalsomyndigheten.se)
  • In summary, metabolites from each blood sample were extracted and analyzed by GC/MS (Thermo Fischer, DSQ mass spectrometer) and LC/MS (Thermo Fischer, LTQ mass spectrometers). (hindawi.com)