The neurosensory structures involved in hearing and equilibrium are located in the membranous labyrinth: the organ of Corti is located in the cochlear canal, while the maculae of the utricle and the saccule and the ampullae of the semicircular canals are located in the posterior section. (cloudaccess.net)
The basilar membrane forms the inferior surface of the cochlear canal, and supports the organ of Corti, responsible for the transduction of acoustic stimuli. (cloudaccess.net)
The bodies of the cochlear sensory cells resting on the basilar membrane are surrounded by nerve terminals, and their approximately 30,000 axons form the cochlear nerve. (cloudaccess.net)
NGS of RNA from inner ear sensory epithelial cells led to the identification of 455 miRNAs in both cochlear and vestibular sensory epithelium, with 30 and 44 miRNAs found in only cochlea or vestibule, respectively. (biomedcentral.com)
In order to further identify and characterize miRNAs in the mammalian inner ear, we used NGS for the first time to identify miRNAs in cochlear and vestibular sensory epithelia. (biomedcentral.com)
Increasing age leads to degeneration of cochlear tissues, including the sensory hair cells and stria vascularis. (bvsalud.org)
Neurons4
The vestibular ganglion houses the cell bodies of the bipolar neurons and extends processes to five sensory organs. (wikipedia.org)
All auditory information is transduced by only 15,000 hair cells (organ of Corti), of which the so-called inner hair cells, numbering 3,500, are critically important, since they form synapses with approximately 90% of the 30,000 primary auditory neurons (figure 2). (cloudaccess.net)
These conditional knock-out mouse mutants have been instrumental in demonstrating that miRNAs are vital for inner ear morphogenesis and development of the sensory epithelia and sensory neurons. (biomedcentral.com)
Utricle1
Hair cells of the maculae in the utricle activate afferent receptors in response to linear acceleration, while hair cells of the maculae in the saccule respond to vertically directed linear force. (wikipedia.org)
Vestibular2
Vestibular rehabilitation is an evidence-based approach to managing dizziness, vertigo, motion sensitivity, balance and postural control issues that occur due to vestibular dysfunction. (physio-pedia.com)
A comprehensive identification of miRNAs in the sensory epithelia and their gene targets will enable pathways of auditory and vestibular function to be defined. (biomedcentral.com)
Cristae2
Hair cells of the cristae activate afferent receptors in response to rotational acceleration. (wikipedia.org)
The mammalian inner ear contains sensory organs, the organ of Corti in the cochlea and cristae and maculae in the vestibule, with each comprised of patterned sensory epithelia that are responsible for hearing and balance. (biomedcentral.com)
Cochlea1
The spiking activity of auditory nerve fibers (ANFs) transmits information about the acoustic environment from the cochlea to the central auditory system. (bvsalud.org)
Mammalian1
L-type Ca 2+ channels (LTCCs) drive the bulk of voltage-gated Ca 2+ entry in vertebrate inner ear hair cells (HCs) and are essential for mammalian auditory processing. (jneurosci.org)
Organ2
It is the inner hair cells of the organ of Corti that are responsible for activation of afferent receptors in response to pressure waves reaching the basilar membrane through the transduction of sound. (wikipedia.org)
The ear is the sensory organ responsible for hearing and the maintenance of equilibrium, via the detection of body position and of head movement. (cloudaccess.net)
Outer hair cells1
The inner and outer hair cells are separated from each other by an abundant layer of support cells. (cloudaccess.net)
Cells4
This is the nerve along which the sensory cells (the hair cells) of the inner ear transmit information to the brain. (wikipedia.org)
Traversing an extraordinarily thin membrane, the cilia of the hair cells are embedded in the tectorial membrane, whose free end is located above the cells. (cloudaccess.net)
In this study, we used Next-Generation Sequencing (NGS) to identify the most prominent miRNAs in the inner ear and to define miRNA-target pairs that form pathways crucial for the function of the sensory epithelial cells. (biomedcentral.com)
The results provide further support of the essential regulatory role of miRNAs in inner ear sensory epithelia and in regulating pathways that define development and growth of these cells. (biomedcentral.com)
Responsible1
Macular degeneration- A progressive eye condition where the macula, responsible for central vision, deteriorates over time. (misnylaw.com)
Results1
After pure-tone testing, if the AC and BC responses at all frequencies 500-8000 Hz are better than 25 dB HL, meaning 0-24 dB HL, the results are considered normal hearing sensitivity. (wikipedia.org)
Temporal2
It emerges from the pontomedullary junction and exits the inner skull via the internal acoustic meatus in the temporal bone. (wikipedia.org)
Whereas the sensory cortical areas are located in the occipital, temporal, and parietal lobes, motor functions are largely controlled by the frontal lobe (See Figure 13.7). (foobrdigital.com)
Responses1
After pure-tone testing, if the AC and BC responses at all frequencies 500-8000 Hz are better than 25 dB HL, meaning 0-24 dB HL, the results are considered normal hearing sensitivity. (wikipedia.org)
Receptor1
Let's start with sensory stimuli that have been registered through receptor cells and the information relayed to the CNS along ascending pathways. (foobrdigital.com)