AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
SuraminSensationSensation DisordersThermosensingPurinergic P2 Receptor AntagonistsReceptors, Purinergic P2HypesthesiaSomatosensory DisordersTouchAdenosine TriphosphatePyridoxal PhosphateUridine TriphosphateMucunaReceptors, PurinergicSensory ThresholdsParesthesiaPruritusPainPurinergic AntagonistsPhysical StimulationPurinergic P2 Receptor AgonistsNociceptorsReceptors, Purinergic P2XPurinergic P2X Receptor AntagonistsSkin TemperaturePain ThresholdPhantom LimbDose-Response Relationship, DrugElectric StimulationPain MeasurementCold TemperatureBoredomExploratory BehaviorTasteTime FactorsTouch PerceptionPerceptionPurinergic AgonistsOphthalmic NerveTrypanocidal Agents
ExtensivelyTissuePatientsDiseaseLossIntravenouslySolesDrug
Extensively2
  • Suramin is not extensively metabolized and about 80% is eliminated via the kidneys. (wikipedia.org)
  • In some forms, the degree and type of autonomic system involvement varies extensively. (medscape.com)
Tissue1
  • CONCLUSIONS: The involvement of ocular tissue by the virus can lead to permanent sequelae such as severe visual loss, and clinicians should be aware of and recognize ophthalmic manifestations of this disease to prompt early intervention. (bvsalud.org)
Patients2
  • Suramin has been applied clinically to HIV/AIDS patients resulting in a significant number of fatal occurrences and as a result the application of this molecule was abandoned for this condition. (wikipedia.org)
  • however, the pharmacokinetics of suramin can vary substantially between individual patients. (wikipedia.org)
Disease2
  • In regions of the world where the disease is common suramin is provided for free by the World Health Organization (WHO). (wikipedia.org)
  • HSAN I has an autosomal dominant inheritance, and the disease is characterized by distal limb involvement with marked sensory loss, including loss of pain sensation, making affected individuals more susceptible to injury. (medscape.com)
Loss2
  • Suramin can also cause loss of appetite and irritability. (wikipedia.org)
  • Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision. (wikipedia.org)
Intravenously2
  • Suramin is not orally bioavailable and must be given intravenously. (wikipedia.org)
  • The trial studies by Naviaux et al found that the administration of the drug Suramin given at small doses intravenously, normalizes the cell danger signaling and markedly improves the presenting symptoms in autism (11). (metabolichealing.com)
Soles1
  • It is also common to experience various sensations in the skin, from crawling or tingling sensations, tenderness of palms and the soles, and numbness of hands, arm, legs or feet. (wikipedia.org)
Drug1
  • The mechanism of action for suramin is unclear, but it is thought that parasites are able to selectively uptake suramin via receptor-mediated endocytosis of drug that is bound to low-density lipoproteins and, to a lesser extent, other serum proteins. (wikipedia.org)