Selective biomedical research animals inbred strains. Medical search. Frequent questions

[4] Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally occurring albino animals exist in the wild, e.g. (wikipedia.org)
Through the analysis of five separate colonies of T1D susceptible NOD mice, we identified similarities in NOD microbiome that were independent of animal facility. (biomedcentral.com)
In the inbred non-obese diabetic (NOD) mouse model of T1D, susceptible NOD mice were shown to harbor a distinct gut microbiota to a variety of T1D-protected inbred strains [ 8 ]. (biomedcentral.com)
Mice, Inbred DBA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
This graph shows the total number of publications written about "Mice, Inbred DBA" by people in this website by year, and whether "Mice, Inbred DBA" was a major or minor topic of these publications. (ouhsc.edu)
Below are the most recent publications written about "Mice, Inbred DBA" by people in Profiles. (ouhsc.edu)
The 2003 EC proposal for the In the USA, laboratory animal use is federally reg- Registration, Evaluation and Authorisation of ulated by the Animal Welfare Act 1966 (amended in Chemicals (REACH), similarly aims to assess the 1985), which excludes laboratory-bred mice and toxicity of chemicals produced or imported in high rats, as well as non-mammals, from consideration quantities (15-20). (drugstorepdfsearch.com)
The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi − and CBi/L inbred mice lines. (biomedcentral.com)
When CBi mice are s.c. challenged with M-406, tumor growths exponentially in 100% of animals, while in CBi − the tumor growths briefly and then begins a rejection process in 100% of the animals. (biomedcentral.com)
CBi is an inbred mouse strain derived from an outbred population generated by crossing BALB/c, Rockland, NIH and Swiss mice. (biomedcentral.com)
We used a 4 h whole-body hyperthermia (WBH) protocol and, separately, systemic inflammation induced by bacterial endotoxin (LPS) at 250 µg/kg, to dissociate temperature and inflammatory elements of fever in two ASD animal models: C58/J and Shank3B- mice. (beds.ac.uk)
Inbred male C57BL/6 mice (8 weeks old) were used. (hindawi.com)
Mice were obtained from the animal's facility of the Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo. (hindawi.com)
In this study, we demonstrate that mice with a selective depletion of LC exhibit attenuated CHS only upon sensitization with a low hapten dose but not with a high hapten dose. (cnrs.fr)

Biological pigments are substances produced by living organisms that have a colour resulting from selective colour absorption . (wikipedia.org)

Most importantly, a qualified cancer NIR sensor should have high specificity for cancer-selective detection. (dovepress.com)

The avoidance of expression of such deleterious recessive alleles caused by inbreeding, via inbreeding avoidance mechanisms, is the main selective reason for outcrossing. (wikipedia.org)
Animals can appear coloured due to two mechanisms, pigments and structural colours . (wikipedia.org)
Our studies lay out one way for characterization of CNVs in the pig genome, provide insight into the pig genome variation and prompt CNV mechanisms studies when using pigs as biomedical models for human diseases. (biomedcentral.com)

Offspring of biologically related persons are subject to the possible effects of inbreeding, such as congenital birth defects. (wikipedia.org)
Albinism is the congenital absence of melanin in an animal or plant resulting in white hair, feathers, scales and skin and reddish pink or blue eyes. (wikipedia.org)

Here, we add to the literature on the cerebellum in mouse models of autism with the characterization of the cerebellum in the idiopathic BTBR T + Itpr3 tf /J (BTBR) inbred mouse strain, which has behavioral phenotypes that are reminiscent of ASD in patients. (mdpi.com)
To further dissect these relationships, we established a panel of 21 recombinant inbred lines that showed a broad range of aggregation phenotypes, independent of differences in expression levels. (biomedcentral.com)

Disease-protected strains exhibited a restoration of immune regulatory pathways within the gut which could also be reestablished using IL-2 therapy. (biomedcentral.com)
We used the TRPV1 antagonist, capsazepine, to assess whether TRPV1 is able to modulate the innate immune response to malaria in animals infected with Plasmodium berghei ANKA. (hindawi.com)

Monkeys are one of the main types of lab animals used in such experiments, because they are biologically similar to humans. (sixthtone.com)

3 Department of Animal and Avian Sciences, University of Maryland, College Park, USA . (scirp.org)
Open Journal of Animal Sciences , 11 , 304-332. (scirp.org)
It is assumed that destructive changes in cultured nerve cells subjected to ischemia and reoxygenation are associated with the activation of caspase-3 (the data were obtained in collaboration with the laboratory of experimental neurocytology of the Research Institute of the Brain of the Russian Academy of Medical Sciences). (ihna.ru)
You'll join a community of outstanding researchers and skilled professionals devoted to conduct excellent interdisciplinary research at the frontiers of engineering and life sciences. (ibecbarcelona.eu)

Inbreeding can significantly influence gene expression which can prevent inbreeding depression. (wikipedia.org)
In 20 reviews in which clinical utility was examined, the authors con- cluded that animal models were either significantly useful in contributing to the development of clinical interventions, or were substantially consistent with clinical outcomes, in only two cases, one of which was contentious. (drugstorepdfsearch.com)
The number of biomedical web APIs has grown significantly over the past years, however, the interoperability of APIs remain a big challenge. (stanford.edu)

Veterinarians act as spokespeople for laboratory animals, interpreting their behaviors to ensure both the quality of the research and the welfare of the animals. (sixthtone.com)

These cells are found in a wide range of animals including amphibians , fish , reptiles , crustaceans and cephalopods . (wikipedia.org)

These potential health benefits are attributed to the presence of a plethora of bioactive zoochemicals, including lactoferrin, immunoglobulins and peptidoglycan recognition protein 11 , however, other functional components could be derived from camel milk proteins via fermentation using probiotic strains 12 . (scialert.net)

Inbreeding results in homozygosity, which can increase the chances of offspring being affected by recessive traits. (wikipedia.org)
An individual who inherits such deleterious traits is colloquially referred to as inbred. (wikipedia.org)
Nearly one-third of this sum is used for modeling lab monkeys - breeding animals with desirable traits for particular experiments. (sixthtone.com)

however, because the increased proportion of deleterious homozygotes exposes the allele to natural selection, in the long run its frequency decreases more rapidly in inbred populations. (wikipedia.org)
Having a high homozygosity rate is problematic for a population because it will unmask recessive deleterious alleles generated by mutations, reduce heterozygote advantage, and it is detrimental to the survival of small, endangered animal populations. (wikipedia.org)
We found no significant difference between the populations in their genetic diversity (i.e., heterozygosity, level of inbreeding), nor any evidence that the family and kenneled populations originated from different genetic pools. (frontiersin.org)
Selecting for such animals could strongly improve the welfare of kenneled dog populations. (frontiersin.org)

Inbreeding is the production of offspring from the mating or breeding of individuals or organisms that are closely related genetically. (wikipedia.org)
Inbreeding is a technique used in selective breeding. (wikipedia.org)
For example, in livestock breeding, breeders may use inbreeding when trying to establish a new and desirable trait in the stock and for producing distinct families within a breed, but will need to watch for undesirable characteristics in offspring, which can then be eliminated through further selective breeding or culling. (wikipedia.org)
Inbreeding is also used to reveal deleterious recessive alleles, which can then be eliminated through assortative breeding or through culling. (wikipedia.org)
In plant breeding, inbred lines are used as stocks for the creation of hybrid lines to make use of the effects of heterosis. (wikipedia.org)
On the other hand, dogs bred and kept solely for breeding or research purposes ("kenneled dogs") are kept and handled under standardized conditions, and are usually of the same breed, thus the effects of environmental and breed-specific genetic variability on their individual behavioral variability is small. (frontiersin.org)
Pure Strains as Artifacts of Breeding The American Naturalist 43: 241-242. (esp.org)

An inbred strain of mouse. (ouhsc.edu)
The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi − and CBi/L, is a good murine model to study the process of tumor immunoediting. (biomedcentral.com)

Isolated bacterial strains were identified on the basis of morphological and biochemical tests. (bvsalud.org)

Brief summaries describing the function of each gene's product are of great value to the research community, especially when interpreting genome-wide studies that reveal changes to hundreds of genes. (stanford.edu)

Eyes of adolescents could reveal risk of cardiovascular disease, study finds New research has found that poorer well-being or 'health-related quality of life' (HRQoL) in adolescence could be an indicator of future cardiovascular disease risk. (bionyt.dk)

Most of these dogs are raised and live in intraspecific groups, and their interaction with humans is mostly limited to feeding, cleaning their enclosure, and research procedures. (frontiersin.org)
A common issue in these animal facilities is overgrazing which is the main cause of mud, resulting in serious threats to the environment as well as to animals and humans. (umass.edu)

Through international collaboration with CIMMYT and the Ethiopian Institute of Agricultural Research this technique has been further developed into a portable platform called Mobile And Real-time PLant disEase (MARPLE) diagnostics that is allowing scientists in Ethiopia to track the spread of individual strains of wheat yellow rust in near real-time. (agbt.org)
Alexandre Reymond carried out his thesis in the laboratory of Dr. Viesturs Simanis at the Swiss Institute for Experimental Cancer Research (ISREC) and received his Ph.D. from the University of Lausanne in 1993. (agbt.org)
After completion of his postdoctoral training with Dr Roger Brent in the Department of Molecular Biology, Massachusetts General Hospital and in the Department of Genetics, Harvard Medical School in Boston, he moved to the Telethon Institute of Genetics and Medicine (TIGEM) in Milan in 1998 to lead a research group. (agbt.org)

It is not used with animals that do not possess a cortex, i.e., it is used only with mammals. (lookformedical.com)

Consequently, conservation of farm animal breeds had been for several reasons, for example, to retain potentially useful genes and gene combinations such as the Booroola fecundity gene in sheep [10], the exploitation of heterosis, and to overcome selection plateaus, in addition to cultural motivations, research, and food security. (scirp.org)
Through systematically enrichment analyses based on simulations and bioinformatics analyses, we revealed CNV-related genes undergo a different selective constraint from those CNV-unrelated regions, and CNVs may be associated with or affect pig health and production performance under recent selection. (biomedcentral.com)

Oct. 2 Presentation by Brody Holohan, PhD, CIBM postdoctoral fellow (Center for Human Genetics, Marshfield Clinic Research Inst. (wisc.edu)

Inbreeding in plants also occurs naturally in the form of self-pollination. (wikipedia.org)

In the natural image domain, spatial embedding-based instance segmentation methods are known to yield high-quality results, but their utility to biomedical data is largely unexplored. (mpi-cbg.de)
Results have been variable and need some verification with further research. (umass.edu)
IBEC is committed to turning research results into practical applications, providing innovative solutions to industry and to hospitals, and, ultimately, to society. (ibecbarcelona.eu)

A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)

Inbreeding can result in purging of deleterious alleles from a population through purifying selection. (wikipedia.org)

The poor human clinical and toxicological utility of most animal models for which data exists, in conjunction with their generally sub- stantial animal welfare and economic costs, justify a ban on animal models lacking scientific data clearly establishing their human predictivity or utility. (drugstorepdfsearch.com)

Selective AHR deletion in eosinophils depleted Clec4a4+ eosinophils, augmented innate lymphocytes producing type 2 cytokines, and enhanced helminth clearance. (stanford.edu)

The signal amplification through non-covalent interaction of biotin with streptavidin has been extensionally used by many laboratories for several diagnosis diseases and scientific research in enzyme-linked immunosorbent assay (ELISA). (preprints.org)

Monkeys are also used for basic research into areas such as viruses, diseases, and neurology, as well as cutting-edge biology research into areas like stem cells and gene editing. (sixthtone.com)
Systematic Reviews of Animal Experiments DemonstratePoor Human Clinical and Toxicological Utility Animal Consultants International, London, UK Summary - The assumption that animal models are reasonably predictive of human outcomes provides the basis for their widespread use in toxicity testing and in biomedical research aimed at developing cures for human diseases. (drugstorepdfsearch.com)
Animal models are useful tools for studying diseases such as cancer. (biomedcentral.com)

Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. (researchgate.net)

A selective D1 dopamine receptor agonist used primarily as a research tool. (lookformedical.com)

Non-animal models are generally required to pass formal scientific validation prior to their regulatory acceptance. (drugstorepdfsearch.com)

Diane's research focuses on (re-)emerging plant pathogens that pose a significant threat to agriculture. (agbt.org)
Diane's fundamental research has provided new knowledge on how pathogens successfully invade susceptible plant hosts and influence a host plant' s circuitry during infection. (agbt.org)

1 Department of Animal Production, College of Food Science and Agriculture King Saud University, Riyadh, Saudi Arabia . (scirp.org)

volume = {171}, number = {1879-0542 (Electronic)}, pages = {5--14}, abstract = {Antibodies play an important role in therapy and investigative biomedical research. (cnrs.fr)
Antibodies play an important role in therapy and investigative biomedical research. (cnrs.fr)

During selection, the lines were inbred by limiting the population size [ 9 ] until an average theoretical inbreeding coefficient of approximately 0.985 was reached. (biomedcentral.com)
From then on, a regular system of inbreeding involving full-sib (FS) mating was applied and maintained for more than 30 generations giving rise to CBi/L FS, CBi − FS and CBi FS lines. (biomedcentral.com)

UNLABELLED: Clostridium perfringens epsilon toxin (ε-toxin) is responsible for a devastating multifocal central nervous system (CNS) white matter disease in ruminant animals. (cornell.edu)
Epsilon toxin (ε-toxin)-carrying Clostridium perfringens strains are responsible for a devastating white matter disease in ruminant animals that shares similar features with human multiple sclerosis. (cornell.edu)
This review summarizes currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. (researchgate.net)

The advantages of inbreeding may be the result of a tendency to preserve the structures of alleles interacting at different loci that have been adapted together by a common selective history. (wikipedia.org)
When deleterious recessive alleles are unmasked due to the increased homozygosity generated by inbreeding, this can cause inbreeding depression. (wikipedia.org)

With a legacy of putting patients first, Weill Cornell Medicine is committed to providing exemplary and individualized clinical care, making groundbreaking biomedical discoveries, and educating generations of exceptional doctors and scientists. (cornell.edu)

In contrast, animal models are simply assumed to be predictive of human outcomes. (drugstorepdfsearch.com)
The consistent application of formal validation studies to all test models is clearly warranted, regardless of their animal, non-animal, historical, contem- porary or possible future status. (drugstorepdfsearch.com)
Likely benefits would include, the greater selection of models truly pre- dictive of human outcomes, increased safety of people exposed to chemicals that have passed toxicity tests, increased efficiency during the development of human pharmaceuticals and other therapeutic interven- tions, and decreased wastage of animal, personnel and financial resources. (drugstorepdfsearch.com)
However, there are human data supporting the idea that fever can improve symptoms in some individuals, but those data are limited and there are almost no data to support this from animal models. (beds.ac.uk)
We aimed to test the hypothesis that elevated body temperature would improve function in two animal models of ASD. (beds.ac.uk)

The use of antibiotics grown promoter has been banned, due led problems with drug residues in animal products and increased bacterial resistance. (preprints.org)
Strain K-2157 exhibited resistance to carbapenems and was identified as a high-risk virulent clone belonging to capsular serotype K1 and sequence type 23 (ST23). (bvsalud.org)

Trade restrictions and an increase in biomedical research, including into COVID-19 vaccines, have driven the price of animals used in experiments to new heights. (sixthtone.com)
Regulations state that every lab monkey must have detailed genetic and health records, and that only second-generation human-reared monkeys and their offspring can be used for experiments and research. (sixthtone.com)
To investigate the validity of this assumption, the comprehensive Scopus biomedical bibliographic databases were searched for published systematic reviews of the human clinical or toxico- logical utility of animal experiments. (drugstorepdfsearch.com)
Possible causes include interspecies differences, the distortion of outcomes arising from experimental environments and protocols, and the poor methodological quality of many animal experiments, which was evident in at least 11 reviews. (drugstorepdfsearch.com)
No reviews existed in which the major- ity of animal experiments were of good methodological quality. (drugstorepdfsearch.com)

However, for most BBB transporters, it is still difficult to synthesize selective probes and inhibitors to enable specific evaluation of the transport activities of the target transporters, because of the effects of other transporters, including functionally unknown transporters, as well as binding to brain tissues. (aspetjournals.org)
Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS. (ouhsc.edu)

OpenSPIM is an Open Access platform for Selective Plane Illumination Microscopy (SPIM) and allows hundreds of laboratories around the world to generate and process light-sheet data in a cost-effective way due to open-source hardware and software. (mpi-cbg.de)

EmbedSeg: Embedding-based Instance Segmentation for Biomedical Microscopy Data. (mpi-cbg.de)
Automatic detection and segmentation of biological objects in 2D and 3D image data is central for countless biomedical research questions to be answered. (mpi-cbg.de)
Here we introduce EmbedSeg, an embedding-based instance segmentation method designed to segment instances of desired objects visible in 2D or 3D biomedical image data. (mpi-cbg.de)
We believe that this renders EmbedSeg accessible to virtually everyone who requires high-quality instance segmentations in 2D or 3D biomedical image data. (mpi-cbg.de)
We discuss the general utility of this approach for other databases that capture data from the research literature. (stanford.edu)

help and wife animals 've spent broad studies in browser virtues. (southwayinc.com)

The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. (mdpi.com)

The continuous increase in the human population coupled with rising incomes and urbanization necessitates the need to conserve the genetic potential of animals to avoid or lower the consequences of biodiversity loss. (scirp.org)

Non-point source pollution including excess nutrients, organic particles, fecal coliform bacteria, and additional pathogens is considered high risk at many animal operations, especially equine facilities. (umass.edu)

Anyone can be an innovator, research finds Innovators aren't born, but they can be made, a recent study suggests. (bionyt.dk)

With a focus on research strategy and outcome measures, his mission is to accelerate biotech innovation and forge efficient collaborations to rapidly discover treatment for children affected by KIF1A. (agbt.org)

Identification was confirmed by culturing bacteria on selective media. (bvsalud.org)

To read the full-text of this research, you can request a copy directly from the authors. (researchgate.net)

In extreme cases, this usually leads to at least temporarily decreased biological fitness of a population (called inbreeding depression), which is its ability to survive and reproduce. (wikipedia.org)

[3] It is a common misconception that all albino animals have characteristic pink or red eyes (resulting from the lack of pigment in the iris allowing the blood vessels of the retina to be visible), however this is not the case for some forms of albinism. (wikipedia.org)

Anatomy3

Organisms22

Diseases7

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology10

Phenomena and Processes39

Disciplines and Occupations36

Anthropology, Education, Sociology and Social Phenomena26

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Mice14

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