Administration, OralDrug Administration ScheduleInjections, IntravenousTime FactorsUnited States Food and Drug AdministrationDose-Response Relationship, DrugRats, Sprague-DawleyDrug Administration RoutesAbnormalities, MultipleDisease Models, AnimalRats, WistarChromosome AberrationsAdministration, IntranasalMice, Inbred C57BLBrainInjections, IntraperitonealLiverInjections, SubcutaneousPregnancyMagnetic Resonance ImagingCongenital AbnormalitiesChromosome DisordersAdministration, RectalBiological AvailabilityKaryotypingEye AbnormalitiesInjections, IntramuscularInfusions, IntravenousAdministration, TopicalTreatment OutcomeHalf-LifeDogsKidneyDrug InteractionsArea Under CurveMice, KnockoutAdministration, IntravenousBlood PressureInjections, IntraventricularAnalysis of VarianceMice, Inbred BALB CRats, Inbred StrainsTissue DistributionBody WeightBehavior, AnimalDouble-Blind MethodRNA, MessengerAdministration, CutaneousOrgan SizeProspective StudiesLungPhenotypeCross-Over StudiesRandom AllocationSyndromeMice, TransgenicInfusions, ParenteralCardiovascular AbnormalitiesRetrospective StudiesInfant, NewbornAdministration, InhalationImmunohistochemistryAdministration, SublingualMutationElectrocardiographyCraniofacial AbnormalitiesRecombinant ProteinsHemodynamicsMotor ActivityHeart RateCells, CulturedBlood GlucoseInjectionsMice, Inbred ICRMice, Inbred StrainsDrug ToleranceRabbitsPlant ExtractsMorphineReference ValuesSkin AbnormalitiesChromatography, High Pressure LiquidAntineoplastic AgentsMetabolic Clearance RateInjections, SpinalAnimals, NewbornUrogenital AbnormalitiesEthanolTrisomyRats, Inbred F344In Situ Hybridization, FluorescenceInsulinAcute DiseaseFollow-Up StudiesMusculoskeletal AbnormalitiesHeartSpleenSensitivity and SpecificityEstradiolDrug Therapy, Combination