Background The α1-adrenergic receptor (α1AR) agonist phenylephrine (PE), acts via ERK1/2 to phosphorylate (i.e. activate) p90 ribosomal S6 kinases (RSKs). (bmj.com)
Background and purpose: In mouse tailarteries, selective α 2 -adrenoceptor antagonism with rauwolscine caused powerful dilation during constriction to the α 1 -adrenoceptor agonist phenylephrine. (johnshopkins.edu)
We investigated the involvement of AC1 in the response of intact mouse atrial tissue and isolated guinea pig atrial and sino-atrial node (SAN) cells to the α-adrenoceptor agonist phenylephrine (PE) using the selective AC1 inhibitor ST034307. (ox.ac.uk)
Agonists7
More selective agonists are more useful in pharmacology. (wikipedia.org)
The α1B mediates cardiac hypertrophy induced by non-selective α1-AR agonists like phenylephrine. (unc.edu)
Selective α 1 agonists include phenylephrine and phenylpropanolamine, although the latter is no longer commercially produced in any meaningful quantity in the United States. (unboundmedicine.com)
Although rauwolscine alone did not affect concentration-effect curves to phenylephrine, noradrenaline or cirazoline, it caused marked transient dilation when administered during constriction to these agonists. (johnshopkins.edu)
b2-Adrenoceptor protein density was decreased in b2-adrenoceptor agonists in the absence or presence of membrane aorta homogenates of Pnmt-KO mice, and this selective b1- or b2-adrenoceptor antagonists. (marysfamilymedicine.org)
Albuterol (Ventolin, Proventil), terbutaline (Brethine, Brethaire) and metaproterenol (Metaprel, Alupent) are classified as β 2 -selective adrenergic agonists and as such reduce smooth muscle tone. (pharmacology2000.com)
Inhibitor7
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinase (Ki = 140 nM for p160 ROCK (ROCK-I). Also inhibits ROCK-II with almost equal potency. (sigmaaldrich.com)
Also acts as a potent inhibitor of agonist-induced Ca 2+ sensitization of myosin phosphorylation and smooth muscle contractions (IC 50 = 700 nM for phenylephrine-induced contractions in aortic strips). (sigmaaldrich.com)
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (K i = 140 nM for p160 ROCK ). (sigmaaldrich.com)
Q.3 Rofecoxib is selective cox-2 inhibitor that possess ………heterocyclic ring system. (pdfmedarticles.com)
The contribution from cGMP-dependent signalling pathways was examined by exposing arteries to 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), a selective inhibitor of soluble guanylyl cyclase, while the contribution through potassium channels was assessed with different sub-type-selective potassium channel blockers. (ox.ac.uk)
and TRAM-34 (1µm), a selective inhibitor of IKca. (pacific.edu)
are taking prescription medication for depression, psychiatric or emotional conditions e.g. a monoamine oxidase inhibitor (MAOI), selective serotonin reuptake inhibitor (SSRI) or for Parkinson's disease, or for 2 weeks after stopping the medication. (mydr.com.au)
Epinephrine3
Epinephrine and carbachol did not affect the Ca2+ channel current reduced by the dihydropyridine, PN 200-110 (1 microM), suggesting a selective inhibition of dihydropyridine-sensitive Ca2+ channels. (mdc-berlin.de)
Clinician documentation of shock meets this criterion, including shock diagnosis documented in the medical record or receipt of vasopressors such as epinephrine, norepinephrine, milrinone, vasopressin, phenylephrine, or dopamine. (cdc.gov)
Isoproterenol increased the beating rate, which was blocked with CGP20712A (β 1 , -selective blocker). (elsevierpure.com)
Norepinephrine2
Atomoxetine belongs to a family of medications known as selective norepinephrine reuptake inhibitors . (medbroadcast.com)
The was to characterize b-adrenoceptor-mediated relaxation selective b2-adrenoceptor antagonist ICI 118,551 [(6 and facilitation of norepinephrine release in the aorta of KO) mice. (marysfamilymedicine.org)
A selective adrenergic receptor against used prmarily as a decongestant whose effectiveness stems from its vasoconstriction of nasal blood vessels leading to decreased mucosal edema. (ikeirdorf.com)
Oxymetazoline is an example of a non-selective α-adrenergic receptor agonist. (pharmacology2000.com)
Yohimbine is classified as a selective α 2 -adrenergic receptor antagonist. (pharmacology2000.com)
Methoxamine1
Phenylephrine and methoxamine are examples of drugs that selectively activate α 1 -adrenergic receptors (adrenomimetic). (pharmacology2000.com)
In more severe episodes, additional pharmacologic interventions may include beta-blocker therapy to reduce right ventricular infundibular spasm and phenylephrine to increase systemic vascular resistance. (medscape.com)
This approach also clearly emphasizes the poor selectivity of phenylephrine at vascular α-adrenoceptors. (johnshopkins.edu)
Aortic2
However, guanidinium derivatives for detection of aortic relaxation were not observed except agmatine and amiloride which induced a marked relaxation in isolated aortic rings precontracted with phenylephrine or KCl. (hindawi.com)
Aortic rings were mounted in a myograph to concentration-dependent increases in tritium overflow in WT determine concentration-response curves to selective b1- or mice only. (marysfamilymedicine.org)
Antagonist2
Meanwhile, only agmatine-induced relaxation was abolished by BU224, a selective antagonist of imidazoline I 2 -receptors. (hindawi.com)
Key results: The α 2 -adrenoceptor agonist UK14, 304 caused low-maximum constriction that was inhibited by rauwolscine (3 × 10 -8 M) but not by the selective α 1 -adrenoceptor antagonist prazosin (10 -7 M). Concentration-effect curves to phenylephrine, cirazoline or noradrenaline were unaffected by rauwolscine but were inhibited by prazosin, which was more effective at high compared with low levels of constriction. (johnshopkins.edu)
Receptor3
Q.1 Which one of the following drug is selective β1 receptor agonist? (pdfmedarticles.com)
Selective inhibition of RSK1 (rather than RSK2) may preserve the compensated hypertrophic state and, thus, reduce heart failure progression. (bmj.com)
Stimulation1
Coronary vasoconstriction was examined in response to the selective stimulation of α 1 - and α 2 -adrenoceptors in chronically instrumented conscious dogs. (researchwithrutgers.com)
Endothelial1
Endothelial cells regulate the passage of gases, fluid and various molecules across blood vessels by acting as selective filters. (bvsalud.org)
Adrenoceptor1
Phenylephrine (PE) is a canonical α1-adrenoceptor-selective agonist. (bvsalud.org)
Decongestant1
Phenylephrine is also used topically as a decongestant and a mydriatic agent. (brainkart.com)
Abstract1
Bhole, R. P. 2013-05-04 00:00:00 Abstract:This paper presents the development and validation of a method for the simultaneous analysis of Cetirizine hydrochloride (CTZ) and Phenylephrine hydrochloride (PHE) using high performance thin-layer chromatography (HPTLC) with densitometric detection. (sagepub.com)
Blood3
Small intravenous boluses of 50-100 µ g (0.5- 1 mcg/kg) of phenylephrine rapidly reverse reduc-tions in blood pressure caused by peripheral vasodi-lation (eg, spinal anesthesia). (brainkart.com)
We know that Phenylephrine (which is in Visine) will blanch the blood vessels, but Visine can cause rebound redness that in some patients is worse than the original redness. (drcremers.com)
All eyeMDs know that anything with Phenylephrine will blanch the conjunctiva (which is the clear saran wrap covering of the white wall of the eye=sclera) and some of the scleral blood vessels and make the eye appear whiter if there is no scleritis (inflammation of the sclera). (drcremers.com)
Drugs1
Statistical analysis proves that the method is repeatable and selective for estimation of both the drugs. (sagepub.com)
Drug1
We recently showed that an oral selective α1A agonist drug, dabuzalgron, preserves ATP content and mitochondrial function in mouse HF models. (unc.edu)
Conditions1
Under K + current-selective conditions at 35°C and whole-cell patch clamp, membrane depolarization elicited transient (I t ) and steady-state (I ss ) outward current components. (aspetjournals.org)
Activity1
Phenylephrine is a noncatecholamine with predominantly selective α1-agonist activity. (brainkart.com)
Current1
Phenylephrine failed to inhibit the Ca2+ channel current. (mdc-berlin.de)
Solution1
Phenylephrine must be diluted from a 1% solution (10 mg/1-mL ampule), usually to a 100 mcg/mL solution. (brainkart.com)