• antigen
  • However, L-selectin shedding from antigen-activated T cells prevents reentry into PLNs. (rupress.org)
  • Naive lymphocytes constantly recirculate through lymphoid organs via the bloodstream and lymphatics to maximize encounters with antigen-presenting cells and initiate immune responses ( 1 ). (rupress.org)
  • L-Selectin is rapidly down-regulated from the T cell surface within 30-60 min after antigen receptor engagement ( 16 ) and antigen-activated T cells that have migrated into nonlymphoid organs are generally L-selectin low ( 24 - 26 ), but the precise contribution of L-selectin shedding to determining L-selectin expression patterns and trafficking of T cells has not been determined. (rupress.org)
  • Flow
  • Inclusion of synthetic hydroxamic acid-based matrix metalloproteinase (MMP) inhibitors, such as KD-IX-73-4, that block L-selectin shedding, reduces the rolling velocity, increases the number of cells that tether from flow, and increases the transit time through blood vessels in mice ( 12 , 13 ). (rupress.org)