• Dublin, 4 March 2019 - FutureNeuro, the SFI Research Centre for Chronic and Rare Neurological Diseases, based at RCSI (Royal College of Surgeons Ireland), has partnered with global biopharmaceutical company, UCB, to unlock the power of healthcare data to inform improvements in clinical care of people with epilepsy. (eurekalert.org)
  • Mary Fitzsimons, Funded Investigator with FutureNeuro at RCSI and Director of the Epilepsy Lighthouse Project said: "By analysing aggregated clinical data for a population of people with epilepsy, we can help explain the factors that predict response to treatment. (eurekalert.org)
  • Director of Research and Innovation at RCSI, Professor Ray Stallings, said: "The partnership between FutureNeuro and UCB will harness clinical data to further enable healthcare professionals to provide the most effective treatment for people with epilepsy. (eurekalert.org)
  • The risk of premature death in people with epilepsy is 2-3 times higher than for the general population in high-income countries and more than six times higher in low- and middle-income countries. (who.int)
  • People with epilepsy often suffer from comorbidities such as depression and anxiety, associated intellectual disabilities, especially in children, and physical injuries (for instance, fractures and burns). (who.int)
  • People with epilepsy are often subjected to stigmatization and discrimination because of misconceptions and negative attitudes surrounding the disease. (who.int)
  • Up to 75% of people with epilepsy can live a normal life, free from seizures, if they are appropriately treated with antiepileptic medicines. (who.int)
  • Despite the availability of affordable treatment, up to 90% of people with epilepsy may not be properly diagnosed or treated in resource-poor settings. (who.int)
  • The so-called "treatment gap" (the percentage of people with epilepsy whose seizures are not being appropriately treated at a given point in time) is estimated to be 75% in low-income countries and substantially higher in rural areas than in urban areas. (who.int)
  • The International League Against Epilepsy (ILAE) promotes evidence-based treatment for people with epilepsy through its 128 National Chapters. (who.int)
  • Despite the fact that an annual course of effective anti-seizure medicines costs only five US dollars, fewer than one in five people with epilepsy in Africa have access to treatment. (who.int)
  • A structural brain lesion is detectable on MRI in approximately 65% of people with epilepsy. (neurology.org)
  • BACKGROUND: Primary care providers (PCPs) provide a large proportion of care for people with epilepsy (PWE) and need regular training for updates. (cdc.gov)
  • Of the roughly 3 million people with epilepsy in the U.S., about 30% still have seizures despite being on medication. (medlineplus.gov)
  • How do you hope this research will help people with epilepsy? (medlineplus.gov)
  • Agreeing to surgery is a big step for people with epilepsy, and we want to make sure it's going to be very successful. (medlineplus.gov)
  • Suggested citation for this article: Thompson AW, Kobau R, Park R, Grant D. Epilepsy care and mental health care for people with epilepsy: California Health Interview Survey, 2005. (cdc.gov)
  • Evidence indicates deficiencies exist in the care received for both epilepsy-related care and for mental health care in people with epilepsy. (cdc.gov)
  • Evidence indicates there are deficiencies in both these areas for people with epilepsy. (cdc.gov)
  • Our objective was to evaluate treatment gaps in epilepsy and mental health care among California adults with epilepsy and to compare the mental health services and treatment received by people with epilepsy to that of the general population. (cdc.gov)
  • The risk for suicide among people with epilepsy is 5 times the rate of the national population, reflecting the burden of untreated mental illness in this population (3-5). (cdc.gov)
  • People with epilepsy require complex care but often face barriers accessing quality treatment, which hinder care and increase health disparities (6-8). (cdc.gov)
  • Healthy People 2020, a set of national objectives to improve population health in the United States, includes a goal of increasing the proportion of people with epilepsy and uncontrolled seizures who receive appropriate medical care (11). (cdc.gov)
  • Glutamate excitotoxicity is thought to play an important role in the initiation and maintenance of epileptic seizures. (wikipedia.org)
  • If too little is removed, the epileptic seizures may persist. (helmholtz.de)
  • Epileptic seizures from abnormal networks: why some seizures defy predictability. (springer.com)
  • Interneuron replacement has been used in animal models to modify plasticity, prevent spontaneous epileptic seizures, ameliorate hemiparkinsonian motor symptoms, and prevent PCP-induced cognitive deficits. (ca.gov)
  • Confusion and epileptic seizures were the most common clinical indications, with 64% of the patients displaying these symptoms. (frontiersin.org)
  • Neurological impairments may result in an encephalopathy, meningoencephalitis, necrotizing encephalitis ( 2 ) documented by imaging ( 3 ) and lumbar puncture ( 4 ) and may be accompanied by epileptic seizures or stroke ( 5 , 6 ). (frontiersin.org)
  • Despite certain progress in antiepileptic drug development in about 30-40% of cases epileptic seizures do not respond to conventional pharmacological treatment therapies. (lu.se)
  • Initially focusing on Epilepsy and Motor Neuron Disease, FutureNeuro will build rapidly to help transform the lives of the approximately 800,000 people affected by neurological disorders in Ireland. (eurekalert.org)
  • Having first developed its solutions for epilepsy, the company expanded its offerings in 2015 to address motor (Parkinson's disease) and cognitive (Alzheimer's disease, autism and schizophrenia) disorders, providing its international clients with Go/No-Go decision capability to progress the discovery of new treatments for CNS disorders. (businesswire.com)
  • Selective Neuromodulation Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy. (umn.edu)
  • C.elegans has been used for decades as a model animal to study the genetic and molecular underpinnings of neurological disorders through a number of techniques including bio imaging, electrophysiology and behavior. (fau.edu)
  • Welcome to the Coping With Epilepsy forums - a peer support community for folks dealing (directly or indirectly) with seizure disorders. (coping-with-epilepsy.com)
  • The Alvarez-Buylla lab at UCSF is part of a collaboration that is pioneering the investigation of therapeutic interneuron replacement for the correction of neurological disorders arising from defects in neural excitation/inhibition. (ca.gov)
  • Towards the therapeutic development of inhibitory neuron precursor transplantation for human neurological disorders, we have made significant progress in the differentiation of these cells from human ESCs and will complete optimization of this protocol. (ca.gov)
  • Moreover, the neurological damages could be due to or aggravated by cerebral hypoxemia and metabolic acidosis induced by respiratory disorders ( 10 , 11 ). (frontiersin.org)
  • Respiratory disorders could in turn be aggravated by a dysfunction of the respiratory centers, located in the brainstem, a predominant target of SARS-CoV-2 as demonstrated in a mouse model of infection ( 10 ). (frontiersin.org)
  • Our laboratory conducts cerebrovascular research to better understand brain physiology and function in neurological disorders (e.g., epilepsy and epilepsy with other comorbidities such as stroke or depression), with a focus on the blood-brain barrier. (ccf.org)
  • We also investigate the consequence of metabolic disturbances at the blood-brain barrier in epilepsy and other neurological disorders. (ccf.org)
  • Achar A, Ghosh, C. COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Relevance. (ccf.org)
  • Williams, S, Ghosh, C. Neurovascular glucocorticoid receptors and glucocorticoids: implications in health, neurological disorders and drug therapy. (ccf.org)
  • Action Plan on Epilepsy and Other Neurological Disorders at the 75th World Health Assembly earlier this year. (who.int)
  • ILAE looks forward to working with member states and WHO on the Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders to achieve a world where no person's life is limited by epilepsy. (who.int)
  • SAN FRANCISCO, April 24, 2023 (GLOBE NEWSWIRE) -- Neurona Therapeutics, a clinical-stage biotherapeutics company advancing regenerative cell therapies for the treatment of neurological disorders, announced the presentation of updated clinical data from its ongoing Phase I/II clinical trial of a single dose of NRTX-1001 in people with drug-resistant mesial temporal lobe epilepsy (MTLE). (ucbventures.com)
  • The epilepsies are common neurologic disorders characterized by spontaneous recurrent seizures. (tamu.edu)
  • Inhibitory neuronal activity is critical for the normal functioning of the brain, but is thought to go awry during neurological disorders such as epilepsy. (biomedcentral.com)
  • Session evaluation included participants' comfort in treating patients with neurological disorders and confidence in knowledge of the topic area. (cdc.gov)
  • Over 97% of respondents reported greater interest in improving care of patients with epilepsy or neurological disorders, and over 98% reported greater comfort and self-efficacy when treating patients with these conditions. (cdc.gov)
  • Epilepsy, a complex spectrum of disorders, merits enhanced public health action. (cdc.gov)
  • Kareem Zaghloul, M.D., Ph.D., is a principal investigator at the National Institute of Neurological Disorders and Stroke. (medlineplus.gov)
  • Efforts should be made to improve access to quality epilepsy care that includes assessment and treatment of mental health disorders. (cdc.gov)
  • Characterised by the occurrence of recurrent unprovoked seizures, epilepsy can also have significant psychosocial consequences. (eurekalert.org)
  • PURPOSE: Epilepsy is a common neurological condition characterised by recurrent unprovoked seizures and often treatable with appropriate medication. (ox.ac.uk)
  • Epilepsy is a neurological disorder characterized by recurrent unprovoked seizures that affects ~1% of youth (Russ, Larson, & Halfon, 2012). (medscape.com)
  • The term "epilepsy" refers to recurrent, unprovoked seizures from known or unknown causes. (medscape.com)
  • recurrent, unprovoked seizures ( 1 ). (cdc.gov)
  • With BigBrain, surgeons can integrate information about the distribution of neurons into a mathematical brain model that is also enriched with their patients' data - creating a personalized model. (helmholtz.de)
  • Benayoun M, Cowan J.D, van Drongelen W, Wallace E. Avalanches in a stochastic model of spiking neurons. (springer.com)
  • The study, "Modulating Behavior in C.elegans Using Electroshock and Antiepileptic Drugs," just published in PLOS One ( http://dx.plos.org/10.1371/journal.pone.0163786 ), has led the researchers to build on the current animal models for inducing seizures via electroconvulsion in the genetically modifiable C.elegans that only has 302 brain cells called neurons. (fau.edu)
  • MicroRNA function is disrupted in epilepsy and targeting microRNAs in neurons alleviates seizures. (dcu.ie)
  • Sloviter RS: Calcium-binding protein (calbindin-D28k) and parvalbumin immunocytochemistry: localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity. (jpccr.eu)
  • Animal models have suggested both decreased and increased inhibition as possible initiators of epileptic activity, but it is not known if, or how, human inhibitory neurons shape seizures. (biomedcentral.com)
  • Here, using large-scale recordings of neocortical single neurons in patients with secondarily generalized tonic-clonic seizures, we show that fast-spiking (FS) inhibitory activity first increases as a seizure spreads across the neocortex, impeding and altering the spatial flow of fast epileptic traveling waves. (biomedcentral.com)
  • Thus, it may be possible to curtail human seizures by preventing inhibitory neurons from entering potassium-dependent depolarization block, a novel and potentially powerful therapeutic avenue in treating multiple kinds of epilepsies. (biomedcentral.com)
  • A collaborative study from Mirjana Malatic-Savatic 's lab used animal models of epilepsy to demonstrate how seizures prevent formation of new neurons and offers new insights into potential therapeutic strategies for epileptic patients. (texaschildrens.org)
  • The second goal is to learn more about how seizures affect the actual neurons and the cells surrounding them. (medlineplus.gov)
  • The lead researcher of that work, neurologist Jonathan Vöglein of the German Center for Neurodegenerative Diseases and LMU Munich, nevertheless called Keret's research "very, very interesting," and said the results could be in keeping with previous research showing that seizures can occur before the onset of dementia in some people with Alzheimer's disease. (scientificamerican.com)
  • Epilepsy is a frequent neurological disorder, although onset and progression of seizures remain difficult to predict in affected patients, irrespective of their epileptogenic condition. (uni-koeln.de)
  • The new mathematical model can take this data and learn each patient's unique brain signals, looking out for precursors, or patterns of brain activity that show a "pre-ictal" state, in which a patient is at risk of seizure onset. (cureepilepsy.org)
  • RESULTS: Centella asiatica 400 mg/kg increased the latency to the first generalized seizure and SE onset and significantly reduced the time to the first generalized seizure compared to values in the vehicle group. (bvsalud.org)
  • A time course of brain glycogen utilization after onset of seizure activity revealed a reduction of brain glycogen in wild-type mice. (bsu.edu)
  • The glycogen synthase activity ratio increased after onset of seizure activity, while the glycogen phosphorylase activity ratio remained constant. (bsu.edu)
  • Brain and blood glucose levels increased after seizure onset in wild-type mice. (bsu.edu)
  • No differences were observed in seizure intensity, onset time, and duration between genotypes. (bsu.edu)
  • Lower Full-Scale IQ predicted memory impairments across all TLE subtypes, with early age at seizure onset a predictor unique to MRI-negative TLE. (neurology.org)
  • However, its application in the developmental evaluation and follow-up of children with early-onset epilepsy has not been profoundly studied yet. (helsinki.fi)
  • Therefore, the current study aimed to investigate the association between the gaze behaviour of infants with early-onset epilepsy and their future neurodevelopmental outcome. (helsinki.fi)
  • Sixty-three infants with epileptic seizure onset before 12 months of age participated in the study with the voluntary consent of their parents. (helsinki.fi)
  • These findings suggest that gaze behaviour at an early age is an essential predictor of later development in infants with early-onset epilepsy. (helsinki.fi)
  • Hence, eye-tracking could provide means to evaluate the later neurocognitive outcome of infants with early-onset epilepsy at an early age. (helsinki.fi)
  • Febrile infection-related epilepsy syndrome (FIRES) characteristically affects previously healthy children, who experience a sudden and explosive onset of super-refractory status epilepticus preceded by febrile infection and accompanied by fulminant neurogenic inflammation. (annchildneurol.org)
  • FIRES is a rare type of epileptic encephalopathy with rapidly progressive onset of seizures and a devastating prognosis, as drug-resistant epilepsy often follows without a latency period. (annchildneurol.org)
  • Febrile infection-related epilepsy syndrome (FIRES), a subcategory of new-onset refractory status epilepticus (NORSE), is a rare and devastating neurological condition with a high incidence of mortality and poor neurocognitive outcomes [ 1 ]. (annchildneurol.org)
  • It often begins as new-onset intermittent seizures. (annchildneurol.org)
  • In this regard, CBD inhibition of 5-HT 3 receptors may contribute to its role in modulation of nociception and emesis, potentiation of GABA receptors may account for its anti-seizure, anxiolytic and analgesic effects, and potentiation of glycine receptors may be relevant for CBD anti-nociceptive actions [3,16, 22] . (researchgate.net)
  • The anti-seizure drugs currently used to treat epilepsy are not effective with all forms of the disease, and many such drugs have serious side effects. (berkeley.edu)
  • The seizures subsequently increase in frequency and duration, and then progress to refractory status epilepticus (RSE) over 2 to 7 days with minimal response to anti-seizure medications (ASMs). (annchildneurol.org)
  • With this understanding, and through industry partnerships, new technologies and solutions for the treatment, diagnosis and monitoring of chronic and rare neurological diseases will be developed. (eurekalert.org)
  • FutureNeuro is a new SFI Research Centre dedicated to developing new technologies and solutions for the treatment, diagnosis, and monitoring of chronic and rare neurological diseases. (eurekalert.org)
  • CHARLOTTESVILLE, Va. & CAMBRIDGE, Mass.--( BUSINESS WIRE )--Cavion, Inc., a clinical stage biotechnology company developing novel therapeutics for neurological diseases, announced today that their first-in-class T-type calcium channel modulator CX-8998 significantly suppressed seizures in two translational animal models of absence epilepsy. (businesswire.com)
  • Cavion, Inc . is a privately held clinical stage biotechnology company creating therapies aimed at modulating the T-type calcium channel for the treatment of chronic and rare neurological diseases. (businesswire.com)
  • Cavion's portfolio of T-type calcium channel modulators is being developed to restore the brain's natural rhythms in a variety of neurological diseases such as essential tremor, Parkinson's disease tremor, neuropathic pain, and epilepsy with absence seizures. (businesswire.com)
  • Epilepsy is one of the most common serious chronic neurological diseases affecting people of all ages globally. (who.int)
  • Treatment with first-line antiepileptic medicines (phenobarbital, phenytoin, carbamazepine and valproic acid) is among the identified "best buys" for neurological diseases with the cost of treatment with phenobarbital as low as US$ 5 per person per year.2 All the medicines are included in the WHO Model List of Essential Medicines. (who.int)
  • Identifying these changes can help us understand how diseases such as epilepsy affect these cells and may represent viable therapeutic targets. (dcu.ie)
  • Transplantation of interneuron precursors therefore holds therapeutic potential for treatment of human neurological diseases involving an imbalance in circuit inhibition/excitation. (ca.gov)
  • Sridevi Sarma, professor in the Department of Biomedical Engineering and vice dean for graduate education at the Whiting School of Engineering, develops computational, data-driven, and biological approaches to advance the knowledge and treatment of diseases of the nervous system including epilepsy, chronic pain, Parkinson's disease, and insomnia. (jhu.edu)
  • Other neurological conditions are also associated with neurodegeneration, for example, stroke, head injury and chronic neurodegenerative diseases. (jpccr.eu)
  • Some neurological diseases are linked to a particular type of error called nucleotide repeat expansion (NRE), in which a short DNA segment is repeated over and over in hundreds or more copies. (mcknight.org)
  • In her role as a pediatric clinician specializing in epilepsy, Dr. Knowles sees firsthand how this neurological disorder (actually a collection of several related but distinct diseases) is experienced and how it progresses. (mcknight.org)
  • In 2010, Texas Children's Hospital and Baylor College of Medicine inaugurated the Jan and Dan Duncan Neurological Research Institute (NRI), a basic research facility committed to understanding the pathogenesis of devastating neurological diseases with the ultimate goal of developing treatments. (texaschildrens.org)
  • Hugo Bellen 's team has demonstrated how dysfunctional voltage-gated calcium channels may lead to certain neurodegenerative diseases like spinocerebellar ataxia or neurological conditions like migraines. (texaschildrens.org)
  • Epilepsy is one of the most devastating neurological diseases affecting about 1% of the population of the western countries. (lu.se)
  • CBD appears to reduce seizure frequency and severity in patients with Epilepsy, according to several studies. (famagusta-news.com)
  • This neurological impairment seems to be correlated with the severity of the infection ( 7 ). (frontiersin.org)
  • So far, there are no clinical data whether the neuroprotective effects of AEDs in experimental models of epilepsy possess any impact on the severity of epilepsy. (jpccr.eu)
  • The primary courses of treatment are pharmacological, dietary, and/or surgical, depending on several factors, including the areas of the brain affected and the severity of the epilepsy. (tamu.edu)
  • The approval of Epidiolex was based on the results of several clinical trials that demonstrated its efficacy in reducing the frequency and severity of seizures in patients with these conditions. (carolinahemphut.com)
  • In the clinical diagnosis of various seizures, electroencephalogram (EEG) signal detection plays a crucial role [ 3 ]. (hindawi.com)
  • Based on aggregated clinical data analytics, the project will provide insights into disease progression and responses to treatment, which can be used to determine risk factors and inform treatment planning for individuals living with epilepsy. (eurekalert.org)
  • Clinicians, researchers and data scientists will collaborate to complete a feasibility study to demonstrate the potential of the Irish National Epilepsy eHealth System (Electronic Patient Record (EPR) and Electronic Patient Portal) as a tool to support better clinical analytics. (eurekalert.org)
  • Based on this promising preclinical research, Cavion is conducting T-WAVE, an open-label Phase 2a clinical trial assessing the safety, tolerability and efficacy of CX-8998 in adolescents and adults with absence seizures," said Margaret Lee PhD, Cavion's Senior Vice President, Preclinical and Translational Sciences. (businesswire.com)
  • T-WAVE (ClinicalTrials.gov NCT03406702 ) is an open-label 15-patient Phase 2a epilepsy clinical trial assessing the safety, tolerability, pharmacokinetics and pharmacodynamics of CX-8998 in adolescents and adults with generalized epileptic syndromes with absence seizures. (businesswire.com)
  • Our chapter introduces some of the key concepts of epilepsy from a clinical perspective, before describing some of the classical approaches to modelling brain activity across multiple levels of description. (springer.com)
  • We then focus on how these models have been used to explain and predict experimental and clinical phenomena within the field of epilepsy research. (springer.com)
  • Here we focus on techniques that seek to integrate computational modelling with experimental and clinical measures, as we believe this "systems approach" to epilepsy research is from where the most significant new advances, particularly with regards model validation, will occur. (springer.com)
  • Blenkinsop A, Valentin A, Richardson MP, Terry JR. The dynamic evolution of focalonset epilepsies: combining theoretical and clinical observations. (springer.com)
  • The research, published in the Journal of Neural Engineering , is led by corresponding authors Dong Song, research associate professor of biomedical engineering at USC Viterbi School of Engineering and Pen-Ning Yu, former PhD researcher in Song's lab, in collaboration with Charles Liu, professor of clinical neurological surgery and director of the USC Neurorestoration Center. (cureepilepsy.org)
  • A clinical-grade gene therapy vector for pharmacoresistant epilepsy successfully overexpresses NPY in a human neuronal cell line. (ox.ac.uk)
  • CONCLUSION: This first demonstration that an AAV-NPY construct can successfully transduce human neuronal cells supports the pre-clinical development of a clinical trial using AAV-based NPY for pharmacoresistant epilepsy. (ox.ac.uk)
  • In this review, we discuss sex differences in types of epilepsies, associated comorbidities, pathophysiological mechanisms, and antiepileptic drug efficacy in both clinical patient populations and preclinical animal models. (tamu.edu)
  • Overall, the results of these clinical trials provided strong evidence to support the approval of Epidiolex for the treatment of seizures and other neurological conditions, and helped to establish CBD as a potential therapeutic agent for these conditions. (carolinahemphut.com)
  • GW Pharmaceuticals conducted several clinical trials to evaluate the efficacy and safety of CBD in patients with epilepsy, and the results of these trials provided strong evidence to support the approval of Epidiolex for the treatment of seizures and other neurological conditions. (carolinahemphut.com)
  • The clinical spectrum of seizures includes simple and complex focal or partial seizures and generalized seizures. (medscape.com)
  • 2. Thymia research questionnaires will be used to gather more context and information to further develop the thymia AI model [not part of the current clinical trial]. (who.int)
  • The etiology of epilepsy is complex, yet has a strong genetic component. (biologists.com)
  • During development, epilepsy is often but not always diagnosed in association with cognitive and behavioral impairment, which may be the result of the underlying etiology and/or the consequences of epilepsy and treatments as factors of age and sex. (elsevierpure.com)
  • Strikingly, this absence of FS inhibitory activity is accompanied by dramatic increases in local seizure amplitude along with unobstructed traveling waves and is seen during all secondarily generalized seizures examined, independent of etiology or focus. (biomedcentral.com)
  • The control brain tomography showed persistent ventriculomegaly and cerebral edema, which led to RG, Caltagirome R, Blanco the diagnosis of encephalitis of viral etiology complicated by epilepsy secondary to a demyelinating structural lesion of Pimiento EC, et al. (bvsalud.org)
  • Hiromasa Mori, UCB Head of Neurology Patient Technology, Europe said: "We are excited to start our partnership with FutureNeuro to develop a deeper understanding of the disease progression in epilepsy and how we can predict patient's responses to treatment. (eurekalert.org)
  • Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. (jpccr.eu)
  • Jequier Gygax, M & Moshé, SL 2013, ' Animal models of early life seizures and epilepsies ', Neurology Asia , vol. 18, no. (elsevierpure.com)
  • The Gordon and Mary Cain Pediatric Neurology Research Foundation funds epilepsy research programs at the Cain Laboratories which are located within the NRI building. (texaschildrens.org)
  • An interesting study published in the Annals of Neurology by Dr. Lennart Mucke's team at the University of California at San Francisco's Gladstone Institute of Neurological Disease demonstrates that genetic ablation of tau in a mouse model of Dravet syndrome reverses most of the symptoms. (texaschildrens.org)
  • We used an established telementoring program, Project ECHO (Extension for Community Healthcare Outcomes), and combined epilepsy education with general neurology topics to generate more interest among PCPs. (cdc.gov)
  • Interviews with PCPs indicated a combination of epilepsy and general neurology topics would be better received, so epilepsy topics alternated monthly with general neurology topics (e.g., headache, stroke, and dementia). (cdc.gov)
  • Combining epilepsy and other neurology topics was an effective strategy in garnering interest among PCPs, but additional methods are needed to encourage participants to present their own cases. (cdc.gov)
  • With 50 million people living with epilepsy worldwide, about one in 26 people will continue experiencing recurring seizures during their lifetime. (uwaterloo.ca)
  • In a recent publication, we have shown a potent interaction between the cholinergic and GABAergic systems in regard to seizure generation and developed the pilocarpine(pilo)/picrotoxin(PTX) model, in which combined injections of these agents have induced status epilepticus (SE) in rats. (unifesp.br)
  • Epilepsy is a chronic condition of unpredictable and recurrent seizures produced by abnormal neuronal activity in the central nervous system (CNS). (biologists.com)
  • Sarma's additional research in pain control includes constructing computational models of the dorsal horn (DH) circuit in the spinal cord to predict how different electrical stimulation treatments alter neuronal activity in the DH. (jhu.edu)
  • Brain glycogen is utilized for neuronal function, prompting us to investigate the role of brain glycogen during seizure activity in mouse models. (bsu.edu)
  • Among newer AEDs, felbamate, gabapentin, tiagabine and topiramate proved to be neuroprotective agents against seizure, or ischemia-generated neuronal death. (jpccr.eu)
  • Five patients with RE carried a rare CNV that disrupted genes associated with other epilepsies ( KCTD7 , ARHGEF15 , CACNA2D1, GRIN2A and ARHGEF4 ), and 17 cases carried CNVs that disrupted genes associated with other neurological conditions or that are involved in neuronal signalling/development. (bmj.com)
  • Knowles and her team are focusing their research on the role of neuronal activity in myelination in patients with generalized epilepsy, a common form of the disease that is characterized by the presence of seizures and absence seizures. (mcknight.org)
  • A seizure is an episode of neurologic dysfunction caused by abnormal neuronal activity that results in a sudden change in behavior, sensory perception, or motor activity. (medscape.com)
  • A focal or partial seizure consists of abnormal neuronal firing that is limited to 1 hemisphere or area of the brain and that manifests itself as seizure activity on 1 side of the body or one extremity. (medscape.com)
  • A seizure results when abnormal neuronal firing manifests clinically by changes in motor control, sensory perception, behavior, or autonomic function. (medscape.com)
  • This sudden biochemical imbalance between excitatory neurotransmitters and the N-methyl D aspartate (NMDA) receptor and inhibitory forces (eg, gamma-aminobutyric acid [GABA]) at the neuronal cell membrane results in repeated, abnormal electrical discharges that may stay within a certain area of the brain or they may propagate throughout the brain resulting in generalized seizures. (medscape.com)
  • For example, in the event that these neuronal discharges are confined to the visual cortex, the seizure manifests itself with visual phenomena. (medscape.com)
  • These seizures disrupt the normal electrical patterns in the brain, causing sudden and synchronized bursts of electrical energy. (wikipedia.org)
  • This is because the epileptic brain releases characteristic waves during seizures. (hindawi.com)
  • High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), and neurological damage associated with epilepsy, fetal alcohol syndrome, and inherited conditions such as Down and Rett syndromes. (mdpi.com)
  • With BigBrain, they created the most detailed digital model of the human brain. (helmholtz.de)
  • We are now expanding this ultra-high-resolution model of the human brain, which we developed together more than ten years ago, to include information on the interconnection of cells and their molecular properties. (helmholtz.de)
  • However, the reverse is also true - how can we develop new AI tools around this brain model, based on the architecture of the brain? (helmholtz.de)
  • For example, a colleague in Marseille has used it to improve individual brain models of patients undergoing surgery for epilepsy. (helmholtz.de)
  • The high-resolution digital model of the human brain created with BigBrain is used by researchers all over the world. (helmholtz.de)
  • But because brain damage can cause seizures, they were long thought to be just one more casualty of a deteriorating brain. (scientificamerican.com)
  • Finding an association between seizures and dementia is by no means proof of causality, but the new studies excluded people with known risk factors for both epilepsy and Alzheimer's, such as cerebrovascular disease and traumatic brain injury. (scientificamerican.com)
  • In this chapter we present a review of computational models for studying the dynamic mechanisms that describe the function of the human brain, with a specific focus on epilepsy. (springer.com)
  • A unifying explanation of primary generalized seizures through nonlinear brain modeling and bifurcation analysis. (springer.com)
  • Previous studies in animal models as well as human epileptic brain tissue revealed a remarkably diverse pattern of gene expression implicating epigenetic changes to contribute to disease progression. (uni-koeln.de)
  • Other findings suggest that the brain may be capable of self-repair after seizures, because it produces new nerve cells that naturally migrate to the place where damaged cells were located. (sfn.org)
  • The mathematical model works by learning from large amounts of brain signal data collected from an electrical implant in the patient. (cureepilepsy.org)
  • This reduces inflammation of the brain which can lead to seizures. (famagusta-news.com)
  • Background: Epilepsy is a chronic neurological condition that disrupts the normal functioning of the brain and it is characterized by seizures. (coping-with-epilepsy.com)
  • Research suggests the involvement of the Gut-Brain axis in epilepsy. (coping-with-epilepsy.com)
  • We also study the brain blood vessel response to stroke in aging, and in longer term models of dementia. (stanford.edu)
  • Sarma's team also created the first-ever computational model of the motor network under Parkinson's Disease (PD) conditions to study the effects of deep brain stimulation (DBS). (jhu.edu)
  • Seizures were induced with Pentylenetetrazole (PTZ) in both wild-type mice and mice lacking brain glycogen (MGSKO/GSL30 mice). (bsu.edu)
  • Despite lacking brain glycogen, MGSKO/GSL30 mice exhibited acute seizure activity. (bsu.edu)
  • These findings suggest that brain glycogen is important, but not required for PTZ-induced acute seizure activity in mice. (bsu.edu)
  • Experimental models of epilepsy or status epilepticus (SE) provide evidence that seizures result in diffuse brain damage. (jpccr.eu)
  • Turski WA, Czuczwar SJ, Kleinrok Z, Turski L: Cholinomimetics produce seizures and brain damage in rats. (jpccr.eu)
  • We use multifaceted approaches to study the neurovascular properties ex vivo and in vitro using a humanized dynamic neurovascular unit established with primary brain cells isolated from resected brain tissues post-epilepsy surgery, and in vivo by using rodent models of seizure/epilepsy. (ccf.org)
  • Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy. (ccf.org)
  • Achar A, Ghosh C . Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation. (ccf.org)
  • Ghosh, C. Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy. (ccf.org)
  • There is a growing appreciation that sex differences in underlying brain function and in the neurobiology of epilepsy are important factors that should be accounted for in the design and development of new therapies. (tamu.edu)
  • Despite evolutionary and biological differences between rodent and human brain development, the possibility to model early life epilepsy and seizures in mice and rats helped the understanding of numerous factors involved in seizures pathophysiology: neurotransmitter maturation, inhibitory and excitatory pathways imbalance, genetic and epigenetic influences and the association between epileptic activity and learning deficits. (elsevierpure.com)
  • A compelling study from a research team led by Anne Anderson , the medical director of the Epilepsy Monitoring Unit at Texas Children's and associate professor of pediatrics at Baylor, demonstrates that lowering mTOR hyperactivity in adult animals, after brain circuitry has fully developed, is sufficient to stop seizures in an animal model of Tuberous Sclerosis Complex. (texaschildrens.org)
  • We use rats and trasngenic mice in combination with in vivo epilepsy models (kindling, status epilepsitcus) and in vitro approaches (patch-clamp in brain slices, optogenetics). (lu.se)
  • How do seizures affect the brain? (medlineplus.gov)
  • There are still some very big questions about epilepsy, including how it starts in the brain. (medlineplus.gov)
  • The only way that surgery can be useful, though, is if we can identify the exact spot in the brain that's causing the seizures. (medlineplus.gov)
  • When we don't know exactly where a patient's seizures are coming from, we surgically implant electrodes in and around the brain. (medlineplus.gov)
  • Identifying the areas of the brain involved in the seizures will help us develop a surgical strategy to target those regions. (medlineplus.gov)
  • This has allowed us to ask questions about what's happening in the fundamental biology of the brain during a seizure. (medlineplus.gov)
  • Patients with these so-called partial seizures might stop and stare, or experience psychic phenomena like deja vu. (scientificamerican.com)
  • the group injected with 75/7.5 mg kg(-1) presented an extensive period during which the majority of the animals exclusively developed partial seizures (50 days). (unifesp.br)
  • Targeting microRNAs to influence astrocyte morphology, and increase local translation of ion channels, could allow the clearing of excess glutamate and potassium from the synaptic cleft and prevents seizure generation, offering a novel therapeutic strategy for epilepsy. (dcu.ie)
  • Innovative therapeutic strategies are highly needed to tackle the major medical needs of epilepsy, like prevention of epilepsy development in at-risk individuals, treatment of severe and drug-resistant forms, control of co-morbidities. (bvsalud.org)
  • There is an ever growing interest in improvement of treatment outcomes in epilepsy and also in the development of newer therapeutic options, especially in the population of patients that do not attain seizure relief from available antiseizure medications (ASMs). (coping-with-epilepsy.com)
  • Further attention placed on potential sex differences in epilepsies, comorbidities, and drug effects will enhance therapeutic options and efficacy for all patients with epilepsy. (tamu.edu)
  • GW Pharmaceuticals chose CBD as the main compound in Epidiolex because of its potential therapeutic benefits for patients with epilepsy and other neurological conditions. (carolinahemphut.com)
  • However, PCPs treat patients in so many therapeutic areas that epilepsy often becomes a less important concern. (cdc.gov)
  • To address the mechanism underlying epileptogenesis, we used zebrafish to characterize Pk1a function and epilepsy-related mutant forms. (biologists.com)
  • In the present study, we tested the effects of NRP2945 on the development of epilepsy (epileptogenesis) and on chronic, spontaneous seizures, by using the pilocarpine model of temporal lobe epilepsy. (bvsalud.org)
  • These effects appear to depend on modulation of the epileptogenesis process and not on seizure suppression, because NRP2945 did not reduce frequency or duration of spontaneous seizures when administered to already epileptic animals. (bvsalud.org)
  • It may be assumed that the neuroprotective effects of AEDs in models of epilepsy or SE may prevent continuous progression of epileptogenesis, thus improving the condition of epileptic patients. (jpccr.eu)
  • This research will help in better understanding of the mechanisms for epileptogenesis and might lead to development of new gene therapy-based strategies for epilepsy treatment. (lu.se)
  • However, one of those studies, which is also unpublished, looked for evidence of seizures before a diagnosis of Alzheimer's, and failed to find such an association. (scientificamerican.com)
  • The electroencephalogram (EEG), which is one of the tools for neurological explorations, could be of interest in the diagnosis of encephalopathy in the context of patients with COVID-19 and those suffering from neurological symptoms. (frontiersin.org)
  • The analysis of gaze behaviour is nowadays commonly employed to help with the diagnosis and exclusion of differential neurological conditions as well as to help researchers better understand cognition in the early stages of life. (helsinki.fi)
  • If untreated, TBM may have a poor outcome and permanent neurological sequelae, thus requiring rapid diagnosis and treatment. (medscape.com)
  • Methods Caregivers of 118 children aged 2-12 years old with epilepsy completed the Pediatric Epilepsy Medication Self-Management Questionnaire at nine time points over 2 years post diagnosis. (medscape.com)
  • 2011), children with nonadherence in the first 6 months of therapy are 3.24 times more likely to have continued seizures 4 years post diagnosis (Modi, Rausch, et al. (medscape.com)
  • Epilepsy is a relatively common and chronic neurological condition, affecting 1-2% of the population. (nih.gov)
  • Lennart Mucke, director of the Gladstone Institute of Neurological Disease and a professor at UC San Francisco, has been examining the relationship between epilepsy and Alzheimer's in both animal models and people since the early 2000s. (scientificamerican.com)
  • During seizures, injury or life-threatening events may occur owing to the distraction or involuntary spasms of the patient [ 1 , 2 ]. (hindawi.com)
  • Epilepsy can occur throughout the human life span, with peaks during early life and senescense/ageing. (elsevierpure.com)
  • when Knowles and her team blocked the OPCs' response to neural activity, seizure-induced myelination did not occur, and the seizures didn't progress. (mcknight.org)
  • Prompt treatment is essential, as death or signfiicant neurological disability may occur as a result of missed diagnoses and delayed treatment. (medscape.com)
  • Additionally, transient hyperthermia may occur in up to 40% of patients and is thought to result from vigorous muscle activity that occurs in a seizure. (medscape.com)
  • Epilepsy affects more than 60 million people worldwide, making it one of the most common neurological conditions. (eurekalert.org)
  • Current methods to control epilepsy, which affects 1 in 26 Americans, are not only inefficient but haven't improved in more than 150 years when the first anticonvulsant drug was developed. (fau.edu)
  • A third aim will explore how disrupting the post-synaptic receptors on oligodendrocytes affects the progression of epilepsy, not just in terms of seizures, but related symptoms such as disrupted sleep and cognitive impairment, both of which are common in individuals affected by epilepsy. (mcknight.org)
  • It affects about 1% of the population, or about 3 million people in the U.S. The first approach to treating it is to use medication, but about a third of those people still have seizures despite the best medical therapy. (medlineplus.gov)
  • Epilepsy, a chronic neurological disorder, affects approximately 2 million Americans and is more common than autism, cerebral palsy, multiple sclerosis, and Parkinson disease combined (1). (cdc.gov)
  • Neuropeptide Y (NPY) has anticonvulsant and anti-epileptogenic properties in animal models of temporal lobe epilepsy when delivered by an adeno-associated viral (AAV) vector. (ox.ac.uk)
  • 1 In temporal lobe epilepsy (TLE), the most common pathology is hippocampal sclerosis (HS), 2 with the study of HS-TLE informing TLE's archetypal neuropsychological profile of anterograde memory impairment. (neurology.org)
  • Six epileptic and six control animals were observed for 120-131 days for the occurrence of spontaneous recurrent seizures (SRS). (unifesp.br)
  • At birth, litters were divided into standard care (SC) and EE groups until postnatal day 14 (PD14) when a model of febrile convulsions was used to determine seizure susceptibility of the various groups. (nih.gov)
  • Febrile seizures in children are a distinct entity and are discussed in a separate article. (medscape.com)
  • I look forward to the outcomes of this collaboration and the potential benefits it will bring to future epilepsy care. (eurekalert.org)
  • FutureNeuro is dedicated to improving the lives of epilepsy patients through greater understanding of the disease and its progression, as well as more effective treatment and better outcomes. (eurekalert.org)
  • T-WAVE will study whether CX-8998 can significantly reduce seizures and improve outcomes for humans who have not achieved satisfactory response to currently available therapies. (businesswire.com)
  • For these patients, the goal is to achieve seizure control while limiting side effects and negative impacts, especially on cognitive outcomes. (businesswire.com)
  • Large retrospective studies conducted at five epilepsy centers across the nation have demonstrated that EZTrack not only can predict surgical outcomes with 25 percent more accuracy than can clinicians, but also can predict all failures with 100 percent accuracy. (jhu.edu)
  • Given the modifiable nature and significant medical and economic ramifications of nonadherence to AEDs, adherence and barriers to adherence are ideal target areas for interventions aimed to improve the health outcomes of children with epilepsy. (medscape.com)
  • 3. Gilliam F. Optimizing health outcomes in active epilepsy. (cdc.gov)
  • Many factors such as age, diet, family history, comorbidities can contribute to how a person with epilepsy responds to treatment. (eurekalert.org)
  • Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies. (tamu.edu)
  • In this review, we discuss the current knowledge on sex differences in epilepsy and associated comorbidities, with emphasis on those aspects most informative for the development of new pharmacotherapies. (tamu.edu)
  • SIGNIFICANCE STATEMENT: Epilepsy is a common neurological disorder that often presents together with various comorbidities. (tamu.edu)
  • Scientists who study Alzheimer's disease have mostly ignored the role of seizures, but that is beginning to change, and new research suggests they may provide insight into the progression of the disease and pave the way for treatments. (scientificamerican.com)
  • This raises the possibility that seizures may be intimately tied up with the progression of the disease. (scientificamerican.com)
  • Administration of a ketogenic, high-fat, low-carbohydrate diet attenuated seizure progression and ameliorated DNA methylation mediated changes in gene expression. (uni-koeln.de)
  • Animals that received 150/0.5 mg kg(-1) presented a relatively short latent period, partial events as their most common initial seizure manifestations and a considerable subsequent progression towards generalization. (unifesp.br)
  • CX-8998 was more effective than the commonly prescribed anti-epileptic drug ethosuximide in reducing absence seizures in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a highly predictive model of absence epilepsy. (businesswire.com)
  • In the GAERS rats, CX-8998 showed near complete suppression of seizure activity (99% reduction in both number and cumulative duration of spike wave discharges) at 10 mg/kg, a well-tolerated dose that results in human-achievable drug concentrations. (businesswire.com)
  • Therefore, we aimed to evaluate the effect of a standardized extract of Centella asiatica L. Urb with tested anticonvulsant activity on biochemical and haematological parameters in rats subjected to lithium/pilocarpine-induced seizures. (bvsalud.org)
  • Cortical dysplasia in rats provokes neurovascular alterations, GLUT1 dysfunction, and metabolic disturbances that are sustained post-seizure induction. (ccf.org)
  • To determine epilepsy prevalence after migraine, stroke, and Alzheimer's disease ( 1 ) but is among adults, assess their access to care, and provide baseline not as well understood as less prevalent conditions such as estimates for a Healthy People 2020 objective ("Increase the Parkinson's disease and multiple sclerosis. (cdc.gov)
  • CX-8998 is one of the most powerful compounds that we have seen in the GAERS model for absence seizures to date - virtually eliminating them. (businesswire.com)
  • While some generalized epileptic syndrome patients with absence seizures respond to first line antiepileptic drugs and have a generally good prognosis, a significant proportion fail to achieve adequate control with existing therapeutics or experience intolerable side effects. (businesswire.com)
  • In earlier research, Knowles uncovered that the neural activity of absence seizures promotes myelination of the seizure circuit, making it more efficient. (mcknight.org)
  • We are hopeful that the partnership will enable us to identify risk factors and inform treatment decisions for individuals living with epilepsy and will identify any potential gaps in the existing data that we have which could provide further insights into this complex neurological condition. (eurekalert.org)
  • Epilepsy is a common chronic neurological disorder characterised by spontaneous seizures which can severely impact quality of life. (dcu.ie)
  • BACKGROUND: Status epilepticus (SE) is a type of epileptic activity characterized by a failure of the inhibitory mechanisms that limit seizures, which are mainly regulated by the GABAergic system. (bvsalud.org)
  • We use biophysically-realistic computational models to show that this cessation is due to FS cells entering depolarization block as a result of extracellular potassium accumulation during the seizure and not because they are inhibited by other inhibitory subtypes. (biomedcentral.com)
  • Recently neuropeptides and neurotrophic factors emerged as strong regulators of excitatory and inhibitory synaptic transmission in the CNS thus offering a potent tool to counteract the seizure activity. (lu.se)
  • One study looked at 55 patients between the ages of 50 and 69 who were admitted to an Israeli medical center with their first known seizure. (scientificamerican.com)
  • In addition, multiple other factors, including stress, lack of sleep, and caffeine use, may contribute to seizures in patients with known seizure disorder, but these are diagnoses of exclusion. (medscape.com)
  • Background Rolandic epilepsy (RE) is the most common genetic childhood epilepsy, consisting of focal, nocturnal seizures and frequent neurodevelopmental impairments in speech, language, literacy and attention. (bmj.com)
  • Shors says that these data may apply to patients with neurological or psychological disease, generally, rather than any specific disease. (sfn.org)
  • Objective To determine the stability and influence of adherence barriers on medication adherence and seizure control in pediatric epilepsy. (medscape.com)
  • Epilepsy Res 2002, 51, 31-71. (jpccr.eu)
  • Antiepileptic drugs (AEDs) are the primary treatment modality for most patients with epilepsy, and the overall goal of treatment is no seizures, no side effects and best quality of life (Glauser, 2002). (medscape.com)
  • The EEG was altered in 85% of the cases of confusion, in 57% of the cases of epileptic symptoms (general or focal seizure or prolonged loss of contact) and 20% of the cases of malaise or brief loss of consciousness. (frontiersin.org)
  • EZTrack uses the concept of nodal fragility in dynamical networked systems, where the most fragile nodes are more likely to cause seizures. (jhu.edu)
  • Additionally, only 18% of children maintain normal cognitive function in the acute phase, while more than 90% develop refractory epilepsy that requires lifelong treatment [ 1 - 3 ]. (annchildneurol.org)
  • Unfortunately, surviving patients often develop severe cognitive decline and chronic refractory epilepsy [ 5 , 6 ]. (annchildneurol.org)
  • Epilepsy is a common neurological disease that can cause recurrent seizures. (hindawi.com)
  • Ultimately, the eHealth project has the potential to promote a model of proactive and personalised care which can prevent disease deterioration and tailor treatment to individual's needs. (eurekalert.org)
  • It's no surprise to neurologists that some people experience convulsive seizures in the later stages of the disease. (scientificamerican.com)
  • When we looked at patients who had come to UCSF with both epilepsy and Alzheimer's disease, it became clear that a lot of the epilepsy they had was non-convulsive," said Mucke. (scientificamerican.com)
  • Epilepsy accounts for 0.5% of the total global burden of disease. (who.int)
  • Klitgaard H, Pitkanen A: Antiepileptogenesis, neuroprotection, and disease modification in the treatment of epilepsy: focus on levetiracetam. (jpccr.eu)
  • We found that NRP2945 exerts a robust anti-epileptogenic effect, reducing the frequency of spontaneous seizures, exerting a significant neuroprotective effect and attenuating anxiety-like behaviors and cognitive impairment. (bvsalud.org)
  • Epilepsy is the fourth however, nationally representative U.S. estimates of the preva- most common neurologic disorder in the United States, lence of epilepsy are scant ( 2 ). (cdc.gov)
  • There are data indicating that in spite of clear-cut neuroprotection in models of SE, the subsequent occurrence of spontaneous seizure activity was not prevented. (jpccr.eu)
  • The goal of treatment is a reduction or elimination of seizures to enable individuals to lead as productive a life as possible, without significant side-effects of therapy. (eurekalert.org)
  • Factors that widen the gap, many of which are interconnected, include an insufficiency of staff, poor access to antiepileptic medicines, societal ignorance and misconceptions, poverty, and low prioritization for the treatment of epilepsy. (who.int)
  • This is the first report of unsupervised clustering of an epigenetic mark being used in epilepsy research to separate epileptic from non-epileptic animals as well as from animals receiving anti-convulsive dietary treatment. (uni-koeln.de)
  • CBD has shown promise as a treatment option for Epilepsy. (famagusta-news.com)
  • CONCLUSION: The dose of Centella asiatica that produces anticonvulsant activity in the lithium/pilocarpine model devoid of hepatotoxicity, nephrotoxicity, and alterations in haematological parameters suggests that the standardized extract of this plant could be of utility in the development of new safe therapies for the treatment of convulsions associated with epilepsy. (bvsalud.org)
  • As an example, her groundbreaking research and tools are helping to shape treatment of epilepsy. (jhu.edu)
  • Drug treatment does not work for 30 percent of the world's 60-million-plus epilepsy sufferers. (jhu.edu)
  • Potential in the treatment of epilepsy. (jpccr.eu)
  • And not treating epilepsy is also extremely costly - it is estimated that worldwide over 650 billion US dollars are lost each year due to lack of adequate treatment for epilepsy. (who.int)
  • And over 70% of people receiving treatment achieve good seizure control. (who.int)
  • 90% reduction in seizure frequency in the first and second patient at nine- and five-months post-treatment, respectively. (ucbventures.com)
  • Epidiolex is an oral solution containing cannabidiol (CBD) that was approved by the US Food and Drug Administration (FDA) for the treatment of two rare and severe forms of epilepsy: Lennox-Gastaut syndrome and Dravet syndrome. (carolinahemphut.com)
  • CONCLUSIONS: We successfully piloted a telementoring program using Project ECHO methodology, which was effective in educating PCPs about epilepsy treatment. (cdc.gov)
  • Prior studies have shown that 58% of young children with epilepsy exhibit nonadherence to AEDs in the first 6 months of treatment (Modi, Rausch, & Glauser, 2011). (medscape.com)
  • The quent inadequate treatment increase the risk for additional results of that analysis indicated that, in 2010, an estimated seizures, disability, decreased health-related quality of life, 1.0% of U.S. adults and 1.9% of those with annual family and, in rare instances, death ( 3 ). (cdc.gov)
  • Adults with epilepsy and psychological distress appeared to have received more mental health treatment than psychologically distressed adults without epilepsy. (cdc.gov)
  • For the study, researchers treated the worms with several antiepileptic drugs approved for human use, which improved recovery from electroshock seizures worsened by genetic or pharmacological pro-convulsants. (fau.edu)
  • Because this new method is rapid, inexpensive and has shown relevance with existing antiepileptic drugs, the C.eleganselectroshock assay developed at FAU has the potential to become an efficient screening tool for human seizure therapeutics. (fau.edu)
  • In this review, the neuroprotective effects of a number of newer or potential antiepileptic drugs (AEDs) are considered in general in models of experimental epilepsy and ischemia. (jpccr.eu)
  • Understanding , stresses that although effective treatments agencies can work with Epilepsy Foundation state affiliates and are available for many types of epilepsy, 1) timely refer- other health and human service providers to eliminate identi- rals and access to those treatments are lacking, 2) epilepsy fied barriers to care for persons with epilepsy ( 2,4 ). (cdc.gov)
  • The likelihood of premature death increases with some types of epilepsy, especially if seizures are not well controlled (2). (cdc.gov)
  • Epilepsy is a neurological disorder characterised by an increased likelihood of recurrent seizures, which in turn are characterised by transient, pathological episodes of hypersynchronised neural activity resulting in a variety of behavioural symptoms. (springer.com)
  • This work shows the interest of the EEG in exploring COVID-19 patients suffering from neurological or general symptoms looking for cerebral alteration. (frontiersin.org)
  • As with any severe viral infection, there is a risk of dissemination to the central nervous system with general neurological symptoms such as fatigue, headache, confusion, myalgia, and more specifically anosmia and agueusia ( 1 ). (frontiersin.org)
  • It occurs when the brain's electrical activity becomes unbalanced, leading to repeated seizures. (wikipedia.org)
  • In contrast, ethosuximide suppressed 60% of seizure activity at exposures associated with the optimal human dose. (businesswire.com)
  • Michela Gallagher, a professor of psychology and neuroscience at Johns Hopkins University, said the researchers used "good criteria for defining unprovoked seizures independent of things that could be causing [epileptic activity]," and pointed to the large sample size and long time period for tracking each veteran's health trajectory as two of the study's strengths. (scientificamerican.com)
  • Further, analysis of FosB-immunoreactive (-ir) patterns revealed an activity dependent distribution, reflecting individual seizure susceptibility. (nih.gov)
  • I'm not sure what to make of this study that measured chemical changes in mouse poop along with mice seizure activity. (coping-with-epilepsy.com)
  • Seizure activity is the primary symptom in a common but very serious neurological disorder known as epilepsy. (bsu.edu)
  • The features of epilepsy and seizure activity as well as comorbid afflictions can vary between men and women. (tamu.edu)
  • A second aim will compare neuron-to-OPC synaptic activity and synaptic gene expression in healthy or epileptic mice - specifically focusing on how myelination promoted by a seizure differs from that promoted by learning. (mcknight.org)
  • Eventually, seizure activity weakens, and consciousness of varying degrees is gradually restored in surviving patients. (annchildneurol.org)
  • A generalized seizure consists of abnormal electrical activity involving both cerebral hemispheres that causes an alteration in mental status. (medscape.com)
  • Traditionally, the patient with 30 minutes of continuous seizure activity or a series of seizures without a return to full consciousness is defined as being in status epilepticus (SE). (medscape.com)
  • Newer definitions suggest that SE is defined by duration of 5 continuous minutes of generalized seizure activity or 2 or more separate seizure episodes without return to baseline. (medscape.com)
  • In the setting of prolonged convulsive seizure activity or status epilepticus (SE), there is pronounced systemic decompensation, including hypoxemia, hypercarbia, hypertension followed by hypotension, hyperthermia, depletion of cerebral glucose and oxygen, cardiac dysrhythmias, and rhabdomyolysis. (medscape.com)
  • Our research has been focused on trying to pinpoint those spots and identify which areas are most likely to be involved in seizure activity. (medlineplus.gov)
  • These electrodes collect data on seizure activity. (medlineplus.gov)
  • Researchers from FAU, in collaboration with The Scripps Research Institute, have opened up the possibilities for rapid drug screens to treat seizures in the near future by using a microscopic nematode worm. (fau.edu)
  • Researchers from Florida Atlantic University, in collaboration with The Scripps Research Institute, have opened up the possibilities for rapid drug screens to treat seizures in the near future by developing the smallest whole-animal electroconvulsive seizure model using a microscopic nematode worm. (fau.edu)
  • A research team at USC Viterbi School of Engineering and Keck Medicine of USC is tackling this dangerous problem with a powerful new seizure predicting mathematical model that will give epilepsy patients an accurate warning five minutes to one hour before they are likely to experience a seizure, offering enhanced freedom for the patient and cutting the need for medical intervention. (cureepilepsy.org)
  • Dr. Auerbach's scientific work is just one example of CURE Epilepsy's influence on the field, where supporting a promising scientist early in their career has exponential impact when they go on to gain additional government funding, train new epilepsy researchers, and advance their research which will ultimately impact the millions of people living with epilepsy. (cureepilepsy.org)
  • Join our email list for the latest epilepsy research news, discoveries, and more. (cureepilepsy.org)
  • We're excited to share snippets of groundbreaking research published in the last six months by our researchers at the Neurological Research Institute and the Cain Foundation Labs at Texas Children's. (texaschildrens.org)
  • This aesthetically pleasing and user-friendly website features detailed profiles of our labs, faculty and trainees, as well as synopses of important discoveries from the Cain Labs ( Our Research ) and elsewhere around the globe ( Trends in Epilepsy Research ). (texaschildrens.org)
  • Epilepsy Research. (lu.se)
  • He has focused much of his research on epilepsy and how advanced surgery techniques can help treat patients when medication isn't enough. (medlineplus.gov)
  • What is the focus of recent epilepsy research? (medlineplus.gov)
  • National estimates of epilepsy prevalence using NHIS data from surveillance and research, 3) education of persons have not been reported since 1994 ( 5 ), and no recent estimates with epilepsy and their families should be thorough and of access to care have been reported using nationally repre- include health literacy and cultural considerations, and sentative samples of adults with epilepsy. (cdc.gov)
  • Intermittent fasting (IF), the abstinence or strong limitation of calories for 12 to 48 h, alternated with periods of regular food intake, has shown promising results on neurobiological health in animal models. (mdpi.com)
  • ATLANTA, October 16, 2006 - Recent studies have shown a correlation in animal models between learning and cell survival in the hippocampus. (sfn.org)
  • Here we report on the chronic features of this new animal model of epilepsy. (unifesp.br)
  • Another study found CBD had antidepressant-like effects on animal models. (famagusta-news.com)
  • CBD also decreased inflammation among animal models of Multiple Sclerosis. (famagusta-news.com)
  • In one of these, CBD reduced drug-seeking in animal models. (famagusta-news.com)
  • We will continue our investigation of rodent-derived interneuron transplantation to obtain relevant preclinical data for dose response, safety and efficacy in animal models. (ca.gov)
  • Using a new animal model developed in his lab for epilepsy, the fruitfly, Drosophila , Tanouye seeks to determine whether the newly discovered seizure-suppressor genes can lead to the development of novel anti-epileptic drugs, particularly those that would be effective in treating intractable epilepsy or would have fewer side effects than current treatments. (berkeley.edu)
  • In early preclinical studies, CBD was shown to have a potent anticonvulsant effect and was effective in reducing seizures in animal models of epilepsy. (carolinahemphut.com)
  • We also explore seizure-suppressant effects of optogenetic and chemogenetic approaches in vitro and in vivo in animal models of epilepsy. (lu.se)
  • Our study showed that doing yoga can alleviate the burden of epilepsy and improve the overall quality of life by reducing this perceived stigma. (cureepilepsy.org)
  • For example, in 1975, the Plan for Nationwide Action on Epilepsy, commissioned by Congress and led by the former Department of Health, Education, and Welfare, identified the burden of epilepsy in the population and released a first set of groundbreaking recommendations to federal and state agencies (5). (cdc.gov)
  • Lapique's introduction of the integrate-and-fire model neuron (1907). (springer.com)
  • One aim will document the neuron to OPC synapses in both epileptic and healthy mouse models. (mcknight.org)