• Ribosomes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. (nih.gov)
  • Together, these studies unravel unexpected gene regulation directly mediated by rRNA and how ribosome evolution drives translation of critical developmental regulators. (nih.gov)
  • We have investigated potential mechanisms of regulation of rotavirus gene expression by functional evaluation of two differentially expressed viral mRNAs. (microbiologyresearch.org)
  • The condition usually results from the abnormal regulation of genes in a particular region of chromosome 11 . (medlineplus.gov)
  • Abnormal methylation disrupts the regulation of these genes, which leads to overgrowth and the other characteristic features of Beckwith-Wiedemann syndrome. (medlineplus.gov)
  • Dr Hedda Meijer, co-investigator on the project explains, "Regulation of gene expression occurs at several different levels. (dundee.ac.uk)
  • The project aims to identify the regulatory processes governing regulation of messenger activity and stability of segmentation clock genes. (dundee.ac.uk)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • Instead, the non-coding RNA was suspected to play a role in hGH gene regulation. (sciencedaily.com)
  • It is presumed that Dri, like Osa, which is a member of the Trithorax Group of genes implicated in the modification of chromatin structures required for epigenetic regulation (Vazquez, 1999), is acting to establish stable chromatin structures. (sdbonline.org)
  • Androgen regulation of gene expression in human meibomian gland and conjunctival epithelial cells. (iu.edu)
  • Our paper reviewed data from many labs on the temporal and spatial patterns of expression of homeobox genes in mouse embryos. (the-scientist.com)
  • The data support the hypothesis that homeobox genes play a central role. (the-scientist.com)
  • Furthermore, 4 genes from these two sets of significant genes, coiled-coil domain containing-99 (Ccdc99), muscle segment homeobox gene-2 (Msx2), nitric oxide synthase-2 (Nos2), and wingless-type inhibitory factor-1 (Wif1), showed significant mRNA expression perturbations at both time points. (cdc.gov)
  • I think beside the benefit of genetic reassortment, having a segmented genome in influenza would probably mean all 8 segments can be made into proteins at the same time, shortening replication time. (virology.ws)
  • Genes are segments of DNA that contain instructions for making proteins. (proprofs.com)
  • Proteins are essential molecules that perform various functions in the cell, such as catalyzing chemical reactions, providing structural support, and regulating gene expression. (proprofs.com)
  • Genes can be compared to books in a library because they contain the instructions or information for making proteins, similar to how books contain knowledge. (proprofs.com)
  • It will provide greater understanding of the mechanisms regulating the 'correct' amount of the messengers and proteins made by clock genes. (dundee.ac.uk)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • Although non-coding RNAs fail to produce functional proteins, researchers believe that in some cases these RNAs may control gene expression. (sciencedaily.com)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • Each section was scanned using multispectral imaging and sequenced: whole-genome and targeted gene expression using the 10X Genomics human neuroscience panel. (speakerdeck.com)
  • The report says, "Our analysis identified 2,546 sites across 1,537 genes where DNAm differed significantly in association with SES, suggesting that DNAm is an important mechanism through which SES becomes biologically embedded across a large proportion of the genome. (evanstonroundtable.com)
  • In other words, poverty leaves a mark on nearly 10% of the genes in the genome," said Northwestern News in a prepared statement. (evanstonroundtable.com)
  • Virology question of the week: why a segmented viral genome? (virology.ws)
  • What evolutionary advantage is conferred by having a segmented genome? (virology.ws)
  • But I'd guess there are at least two important advantages of having a segmented RNA genome. (virology.ws)
  • Having a segmented genome is another way to get around the limitation that eukaryotic mRNAs can only encode one protein. (virology.ws)
  • This was possible in the lab because the molecular biology of replication is well characterised and that measles virus is polyploid allowing the engineering of a tri-segmented genome that can replicate and be packaged into virions. (virology.ws)
  • Southern analysis suggests that each gene maps to a different TrIV genome segment, with homologous sequences apparently present on other segments. (gc.ca)
  • Southern and Northern analyses, using DNA and RNA extracted from infected Cf-124T cells, revealed the presence of both TrV1- and TrV4-carrying genome segments and transcripts, but neither DNA, at least in episomal form, nor mRNA persisted for more than a few days p.i. (gc.ca)
  • The human genome is comprised of both non-coding DNA and coding regions, or genes. (sciencedaily.com)
  • Using limma we identified differentially expressed genes between the pathology groups in the gray matter of the cortex only. (speakerdeck.com)
  • Using a genetically modified mouse model, Nancy E. Cooke, MD, Stephen A. Liebhaber, MD, Professors of Genetics and Medicine, and colleagues, demonstrated a critical role of two non-coding regions on the activation of the hGH gene. (sciencedaily.com)
  • By carefully analyzing the 14,000 base pairs separating the hGH gene and its locus control region, co-authors Yugong Ho, PhD, an Instructor of Genetics at Penn and a Cooke/Liebhaber lab member, and Felice Elefant, PhD, Assistant Professor at Drexel University and former member of the Cooke/Liebhaber lab, found that the locus control region was copied into RNA, and discovered a gene called CD79b within this region. (sciencedaily.com)
  • Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
  • Double minute chromosomes (dmins) are a form of gene amplification presenting as small spherical paired chromatin bodies. (hindawi.com)
  • The current study attempts to demonstrate the existence of double minute chromosomes via FLT3 gene amplification in a patient diagnosed with chronic myelomonocytic leukemia (CMML). (hindawi.com)
  • Double minute chromosomes (dmins) are cytogenetic indicators of extrachromosomal gene amplification which usually act as small spherical paired chromatin particles [ 1 ]. (hindawi.com)
  • Chromosomes can be compared to the building that houses the library because they are structures that contain many genes, similar to how a building contains many books on its shelves. (proprofs.com)
  • An allele with incomplete (low) penetrance may not be expressed even when the trait is dominant or when it is recessive and the gene responsible for that trait is present on both chromosomes. (msdmanuals.com)
  • In this study the cell specificity and expression pattern conferred by the short beta-PDE 5' flanking sequence in vivo were examined. (nih.gov)
  • Photoreceptor-specific reporter gene expression is driven in vivo by a 350-bp segment of the beta-PDE 5' flanking sequence. (nih.gov)
  • ST-segment elevation myocardial infraction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) showed 0.8 and 0.88, respectively, less expression of MIF mRNA with regard to CG. (hindawi.com)
  • ACS surrounds three clinical conditions that result from an acute imbalance between myocardial oxygen supply and demand: unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) [ 2 , 3 ]. (hindawi.com)
  • Genetic variants, gene expression, and soluble CD36 analysis in acute coronary syndrome: Differential protein concentration between ST-segment elevation myocardial infarction and unstable angina. (cdc.gov)
  • Histone deacetylase (HDAC) inhibitors are important epigenetic mechanisms that regulate gene expression and transcription. (pharmiweb.com)
  • orthogonal exPeriMental changes and pathways induced by EGE investigated the impact of aSSeSSMent of ePigenetic environmental factors in cancer causation, both current H. pylori infection and driver geneS and their link to underpinning studies of etiology e , pigenetic memory of past (eradicated) environMental carcinogenS carcinogen evaluation, and prevention. (who.int)
  • The diverse cell types are genetically identical, but differ in their form and function due to differences in gene expression. (edu.au)
  • These parent-specific differences in gene expression are caused by a phenomenon called genomic imprinting. (medlineplus.gov)
  • Are BALB/c mice relevant models for understanding sex-related differences in gene expression in the human meibomian gland? (iu.edu)
  • The combination of gene expressions, fusion gene transcripts, and mutation gene expressions significantly improved the classification of liver cancer cells versus benign hepatocytes. (elifesciences.org)
  • Mutation in the Drosophila retained/dead ringer ( retn ) gene leads to female behavioral defects and alters a limited set of neurons in the CNS. (sdbonline.org)
  • Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. (nature.com)
  • These MLLT1 mutations were associated with changes in binding to H3K9ac, evidence of HOX and MYC (MYC-C) expression dysregulation, and were often accompanied by CTNNB1 mutations and evidence of Wnt pathway activation. (nature.com)
  • While protein expression is dictated by the level of gene expression, the structure and function of the protein is largely determined by the isoforms of the mRNA of a given gene and are impacted by mutations or other structural alterations to the amino acids ( Faustino and Cooper, 2003 ). (elifesciences.org)
  • While mutations to the hGH gene often lead to abnormal growth in children and adults, these mutations have provided researchers with key clues regarding the genomic areas that appear to control expression of the hGH gene. (sciencedaily.com)
  • SCID results from mutations in any of more than 15 known genes. (medscape.com)
  • Six variants (all identified by WGS) involved MLLT1 , a gene not previously reported to be involved in WT. (nature.com)
  • Using these variants, we map and validate gene-disease associations in two independent biobanks containing exome sequencing from 10,900 and 32,268 individuals, respectively, and elucidate their impact on protein expression in human cells. (nature.com)
  • These data define a regulatory mechanism for the difference in amounts of VP6 and NSP1 and provide evidence for post-transcriptional control of rotavirus gene expression mediated by the translational efficiency of individual viral mRNAs. (microbiologyresearch.org)
  • This mechanism involves a newly discovered set of "non-coding RNAs" expressed in the vicinity of the hGH gene. (sciencedaily.com)
  • By examining the relationship between these non-coding RNAs and the hGH gene, researchers hope to understand how these remote regions impact hGH gene expression and dysfunction. (sciencedaily.com)
  • Nucleotide sequence and expression in Escherichia coli of the gene encoding the nonstructural protein NCVP2 of bovine rotavirus. (microbiologyresearch.org)
  • Cloning and nucleotide sequence of the simian rotavirus gene 6 that codes for the major inner capsid protein. (microbiologyresearch.org)
  • Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. (nih.gov)
  • Instructions for creating the protein are encoded in the sequence of nucleotide bases contained in a single segment of DNA. (databasefootball.com)
  • Lab-on-a-chip is further segmented into clinical diagnostics, genomics, IVD (In-Vitro Diagnostic) & POC (Point of care), Proteomics, Drug Discovery, and others. (medgadget.com)
  • Based on technology, the market has been segmented into microarrays and microfluidics. (medgadget.com)
  • A construct containing the bacterial LacZ gene driven by a fragment of the beta-PDE 5' flanking region (-297 to +53) was used to generate transgenic mice. (nih.gov)
  • Mice homozygous for a knock-out allele exhibit abnormalities in retinal rod cell outer segment morphology and rod electrophysiology. (jax.org)
  • In order to determine whether the CD79b RNA in the pituitary gland served a function, Ho inserted a segment of human DNA that included hGH, the hGH locus control region, and CD79b into a group of mice. (sciencedaily.com)
  • To test whether the transcription of the locus control region and CD79b played a significant role in hGH expression in transgenic mice, Ho then inserted a special piece of DNA into the locus control region. (sciencedaily.com)
  • At 7 and 56days post-exposure, a set of 7 genes and a set of 11 genes, respectively, showed differential expression in the lungs of mice exposed to MWCNT vs. the control group. (cdc.gov)
  • The large share of this regional segment is primarily attributed to the presence of a large number of pharmaceutical and biotechnology companies, growing number of clinical trials, and increasing government funding for R&D activities in this region. (biospace.com)
  • The biochips market, by end user, has been segmented into biotechnology and pharmaceutical companies, hospitals and diagnostics centers, academic & research institutes, and others. (medgadget.com)
  • Here, we identify and characterize the single Drosophila ortholog of the HB9/MNR2 gene family. (jneurosci.org)
  • Drosophila genes expressed specifically in all motoneurons have not been described, although a growing number of genes are known to be expressed in subsets of motoneurons. (jneurosci.org)
  • To test the basis for defects in patterning, genes required for segment formation in the Drosophila embryo were examined. (sdbonline.org)
  • We devised a scoring system using 145 genes from published datasets to categorize DLBCL samples. (aacrjournals.org)
  • An example of the evolutionary importance of reassortment is the exchange of RNA segments between mammalian and avian influenza viruses that give rise to pandemic influenza. (virology.ws)
  • Genomic imprinting is the differential expression of genetic material depending on whether it has been inherited from the father or mother. (msdmanuals.com)
  • the primary pair-rule genes even-skipped, hairy and runt , and the segment polarity genes wingless and engrailed were examined in embryos lacking germline and zygotic dri function. (sdbonline.org)
  • The most consistent effect on expression of the segmentation genes in the dri maternal and zygotic mutant embryos is a disruption to the expression of even-skipped ( eve ) stripe 4, observed in nearly all embryos lacking both maternal and zygotic dri product. (sdbonline.org)
  • The target identification and validation segment includes services such as target gene sequencing, target protein expression, and cell-based assays. (biospace.com)
  • Our results suggest translation disrupting mechanisms relating uORF variation to reduced protein expression, and demonstrate that translation at uORFs is genetically constrained in 50% of human genes. (nature.com)
  • Specific uORFs are known to control protein expression by tuning translation rates of downstream protein-coding sequences, and potential uORFs have been identified in ~50% of all human protein-coding genes 1 , 2 . (nature.com)
  • Target Protein Expression on Tetrahymena thermophila Cell Surface Using the Signal Peptide and GPI Anchor Sequences of the Immobilization Antigen of Cryptocaryon irritans. (researchmap.jp)
  • Transcriptional activity is regulated by DNA binding transcription factors, but these typically act in more than one cell lineage activating different subsets of target genes in each. (edu.au)
  • The aim of this study was to assess the mRNA expression of MIF gene and its serum levels in the clinical manifestations of ACS and unrelated individuals age- and sex-matched with patients as the control group (CG). (hindawi.com)
  • B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
  • In the vertebrate CNS, HB9/MNR2 transcription factors are specifically expressed in all somatic motoneurons and are necessary to distinguish motoneurons from interneurons, in part by repressing interneuron-specific gene expression. (jneurosci.org)
  • On the basis of recent vertebrate studies, the HB9/MNR2 gene family is a prime candidate for a general determinant of somatic motoneuron cell type. (jneurosci.org)
  • Thus, vertebrate HB9/MNR2 genes are expressed specifically in somatic motoneurons and are essential for distinguishing motoneuron/interneuron cell types. (jneurosci.org)
  • The periodicity of segmentation is regulated by the periodic expression of a set of genes known as the segmentation clock. (dundee.ac.uk)
  • If the segmentation clock genes are not switched on and off at the correct times this results in bigger or smaller segments which can lead to birth defects such as scoliosis. (dundee.ac.uk)
  • For the segmentation clock a lot is known about how the genes are activated but our knowledge on how the activity levels and stability of these messengers are regulated is very limited. (dundee.ac.uk)
  • Dr Philip Murray, co-investigator on the project explains, "Almost all the existing mathematical models of the segmentation clock describe how clock protein inhibits clock gene transcription via a negative feedback loop. (dundee.ac.uk)
  • DLBCL segmentation of patient tumor samples is possible using a number of expression platforms. (aacrjournals.org)
  • FluSurv-NET has helped to determine the risk for influenza-associated illness in various segments of the US population, define the severity of influenza seasons and the 2009 pandemic, and guide recommendations for treatment and vaccination programs. (cdc.gov)
  • Finally, we profiled biopsies from patients with relapsed/refractory DLBCL enrolled in the fostamatinib phase IIb clinical trial using three independent RNA expression platforms: NanoString, Affymetrix, and qNPA. (aacrjournals.org)
  • Impact of the ABCD-GENE Score on Clopidogrel Clinical Effectiveness after PCI: A Multi-Site, Real-World Investigation. (cdc.gov)
  • Abnormalities involving genes on chromosome 11 that undergo genomic imprinting are responsible for most cases of Beckwith-Wiedemann syndrome. (medlineplus.gov)
  • The study also proposed another possible mechanism of FLT3 genes in leukemogenesis. (hindawi.com)
  • Therefore, gene activity is an important mechanism in embryonic development and adult stem cell differentiation. (edu.au)
  • Researchers recently discovered a novel mechanism that works over an extensive genomic distance and controls the expression of human growth hormone (hGH) in the pituitary gland. (sciencedaily.com)
  • Researchers at the University of Pennsylvania School of Medicine recently discovered a novel mechanism that works over an extensive genomic distance and controls the expression of human growth hormone (hGH) in the pituitary gland. (sciencedaily.com)
  • A total of 63 identified lung cancer prognostic biomarker genes and major signaling biomarker genes were analyzed in mouse lungs (n=80) exposed to 0, 10, 20, 40, or 80µg of MWCNT by pharyngeal aspiration at 7 and 56days post-exposure using quantitative PCR assays. (cdc.gov)
  • Together, these regulate the timing of the formation of the segments. (dundee.ac.uk)
  • RNA interference knockdown of HB9 levels leads to defects in motoneuron ventral muscle target recognition, ectopic expression of a marker for dorsally projecting motoneurons (Even-skipped), and defects in serotonergic interneuronal projections. (jneurosci.org)
  • In particular, upstream open reading frames (uORFs) are segments of 5′UTR mRNA sequences that can initiate and terminate translation upstream of protein-coding start codons. (nature.com)
  • Other segmented viral genomes include those of reoviruses, arenaviruses, and bunyaviruses. (virology.ws)
  • We have further proceeded to assessing the expression levels of individual NAT transcripts in the presence or absence of BOA and 2,4-dichloroaniline in the growth medium of each strain. (usda.gov)
  • Our data so far indicate little or no effect of the xenobiotic compounds on NAT gene expression in A. nidulans, F. oxysporum and F. graminearum, while they appear to induce a decrease in the levels of certain NAT transcripts in A. flavus. (usda.gov)
  • How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
  • Gene expression was analyzed by measuring beta-galactosidase activity in tissue homogenates or visualizing enzymatic activity or protein production at a cellular level by in situ histochemistry or immunocytochemistry. (nih.gov)
  • However, following gastrulation, dri expression becomes exquisitely tissue and stage specific (Gregory, 1996), raising the possibility that it may specify spatial-specific expression at later stages of development. (sdbonline.org)
  • Paternal UPD causes people to have two active copies of paternally inherited genes rather than one active copy from the father and one inactive copy from the mother. (medlineplus.gov)
  • People with paternal UPD are also missing genes that are active only on the maternally inherited copy of the chromosome. (medlineplus.gov)
  • Mosaic paternal UPD leads to an imbalance in active paternal and maternal genes on chromosome 11, which underlies the signs and symptoms of the disorder. (medlineplus.gov)
  • 1 % of alleles, expression is possible only from the paternal or maternal allele. (msdmanuals.com)
  • Rotavirus mRNAs are transcribed from 11 genomic dsRNA segments within a subviral particle. (microbiologyresearch.org)
  • The data show that tolvaptan inhibits the expression of mRNAs that were previously shown to be increased in response to vasopressin including aquaporin-2, but also reveals mRNA changes that were not readily predictable and suggest off-target actions of tolvaptan. (bvsalud.org)
  • We measured the levels of gene 5 and gene 6 mRNA and showed that they were not significantly different, and protein analysis indicated no difference in stability of NSP1 compared with VP6. (microbiologyresearch.org)
  • The oncology segment held the highest market size of around USD 85.48 million in 2018 owing to huge patient base and increasing need for novel therapies for the treatment of cancer patients. (pharmiweb.com)
  • The oncology clinics segment registered the highest market share of 48.16% in 2018 and is anticipated to dominate the market in the forecast period owing to growing adoption of novel therapies for cancer treatment and increasing frequency of cancer worldwide. (pharmiweb.com)
  • The results showed evolutionary patterns of single molecule mutational gene expression from benign hepatocytes to liver cancer cells. (elifesciences.org)
  • This study demonstrates the utility of the human beta-PDE promoter for directing the expression of foreign genes to photoreceptors and suggests that the -297 to +53 beta-PDE 5' flanking region fragment may have important implications for therapeutic gene delivery to the visual cells. (nih.gov)
  • The RNAi segment develops drugs with therapeutic activity based on reducing or silencing gene expression. (businessinsider.com)
  • Infinium data for four matched tumor-normal pairs and a dilution series of a tumor cell line mixed with its paired normal cell line are available in NCBI's Gene Expression Omnibus with accession [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE11976 GSE11976]. (lu.se)
  • Additionally, SOX9-positive cells demonstrate a capacity to differentiate toward other nephron segments. (lu.se)
  • Accurate Long-read transcriptome sequencing at single-cell level is required to decipher the spectrum of protein expressions in mammalian organisms. (elifesciences.org)
  • Exon 8 of the mouse α 6 subunit gene was disrupted by homologous recombination. (jneurosci.org)
  • This tolerance results from biotransformation of these benzoxazolinones into non-toxic metabolites, a pathway involving an N-acyltransferase enzymatic activity encoded by a 1038bp intronless NAT-homologous gene (Genebank ID: EU552489) residing at the FDB2 locus on chromosome 3 of F. verticillioides [1]. (usda.gov)
  • We have undertaken characterization and cloning of NAT-homologous genes in the mycotoxigenic F. verticillioides M3125 and Fusarium graminearum (teleomorph Gibberella zeae) NRRL 31084 strains, the related tomato pathogen Fusarium oxysporum f.sp. (usda.gov)
  • Sequencing of the amplified products was performed to experimentally annotate the NAT-homologous genes and determine their exon-intron structure. (usda.gov)
  • Since emergence of the pandemic (H1N1) 2009 virus segments are derived from the North American triple reas- in April 2009, three infl uenza A viruses--seasonal (H3N2), sortant swine infl uenza virus lineage ( 9 ). (cdc.gov)
  • Within the retina, the reporter gene was specifically expressed in photoreceptors, consistent with the localization of endogenous beta-PDE. (nih.gov)
  • GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
  • Conversely, ectopic HB9 expression causes an expansion of ventral motoneuron projections and repression of Even-skipped. (jneurosci.org)
  • This blockade led to the five-fold repression of hGH gene expression. (sciencedaily.com)
  • We previously demonstrated that 350 bp of the human rod cGMP phosphodiesterase beta-subunit (beta-PDE) gene promoter are sufficient to direct high levels of gene expression in human Y-79 retinoblastoma cells in vitro. (nih.gov)
  • However, the biological and evolutionary consequences of giving measles virus a tri-segmented have not really been explored but would shed light on this process. (virology.ws)
  • It operates through the following segments: Oncology, Diagnostics, and RNAi. (businessinsider.com)
  • The Diagnostics segment focuses in the development and marketing of diagnostic kits. (businessinsider.com)
  • Farther back still is the inner segment, a specialized part of the cell full of mitochondria. (wikipedia.org)
  • The classic view of information processing in the cell by gene expression occurs through transcription followed by translation. (nature.com)
  • Genes are found in the __________ of a cell. (proprofs.com)
  • Hairy roots are induced by the incorporation of a bacterial-derived segment of DNA transferred (T-DNA) into the chromosome of the plant cell. (bioone.org)
  • To understand the role of each cell in an organism, broad spectrum mRNA isoform and mutational gene expression analyses at the single-cell level is necessary. (elifesciences.org)
  • However, little progress has been made in developing a technology to analyze mutated mRNA expressions at the single-cell level. (elifesciences.org)
  • Dysfunctional endothelium is a key factor in atherosclerosis that favors the increase of the expression of chemotactic and adhesion molecules (such as, intercellular adhesion molecule 1, ICAM1, and vascular cell adhesion molecule 1, VCAM1, as well as E-selectin and P-selectin) and enhanced recruitment and accumulation of monocytes [ 6 , 8 , 9 ]. (hindawi.com)
  • The most established subtyping approach, the "Cell of Origin" (COO) algorithm, categorizes DLBCL into activated B-cell (ABC) and germinal center B-cell (GCB)-like subgroups through gene expression profiling. (aacrjournals.org)
  • SOX9 expression was found to colocalize with a proportion of so-called scattered tubular cells in the uninjured kidney, a cell population previously shown to be involved in kidney injury and regeneration. (lu.se)
  • CellexalVR is a virtual reality platform for the visualisation and analysis of single-cell gene expression data. (lu.se)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
  • Multi-walled carbon nanotube -induced gene expression in the mouse lung: association with lung pathology. (cdc.gov)