• Olaparib, a poly (ADP-ribose) polymerase inhibitor, has demonstrated an improvement in median progression-free survival (PFS) in select patients with metastatic castration-resistant prostate cancer (mCRPC). (bmj.com)
  • Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer. (cdc.gov)
  • In this cohort study of 962 men with metastatic castration-resistant prostate cancer, mismatch repair deficiency or microsatellite instability-high was significantly more frequent in Black men than White men. (cdc.gov)
  • Genomic alterations in DNA damage response (DDR) genes are common in metastatic castration-resistant prostate cancer (mCRPC). (cdc.gov)
  • Though castration began to phase out in many parts of the world through the Medieval period, it was still practised officially in the Ottoman empire, even up until the 20th century. (dailymail.co.uk)
  • But in the early 20th century, decisions regarding castration were based on the belief that the prostate was the equivalent of the uterus in the woman. (liu.se)
  • In her thesis, Elin Björk investigates the treatment method that was prevalent from the late 19th century to the early 20th century: castration. (liu.se)
  • When an "irritant" becomes trapped in a mollusk, the animal senses this element and coats it with mother-of-pearl, which is the same composite it uses to build its shell (Kennedy J. P., thoughtco.com). (lu.se)
  • Thus, knowledge of how the female body functioned was transferred to the male body, and by extension, knowledge of women's bodies was used as an argument for the castration of men. (liu.se)
  • Previous research has found that there was a very restrictive stance on male castration, although there were few alternatives. (liu.se)
  • An internal sense of being male, female, or something else, which may or may not correspond to an individual's sex assigned at birth or sex characteristics. (msdmanuals.com)
  • This guy is so nuts it makes sense to let him speak for himself - here's that Associated Press transcript (someone recently countered an AP article saying "AP is fake news. (legalectric.org)
  • For men with prostate problems, castration was a treatment method for many years. (liu.se)
  • But by studying castration as a treatment for benign prostate enlargement, Elin Björk discovered that the prevalent notion in medicine of the man as norm is not always accurate. (liu.se)
  • Castration as a treatment method for prostate hypertrophy 1893-1910. (liu.se)
  • My thesis shows that when it comes to the castration of men, the female body has been the norm. (liu.se)
  • Banemanie, a Raelian Bishop-Guide in Burkina Faso was among the first women to experience the operation and discover her new sense of pleasure. (religionnewsblog.com)
  • Crawford adds images of skin color dilution as a type of castration to the field of race and psychoanalysis. (cornell.edu)
  • However, as the Grapevine reported, pig farmers have been aware of the illegality of anaesthetic-free castration for at least the past three years now. (grapevine.is)
  • The first recorded practice of castration to intentionally produce eunuchs dates as far back as 2,000BC - more than 4,000 years ago - in the ancient city of Lagash - located in what would now be modern day Iraq. (dailymail.co.uk)
  • I'd go with the 100 lashes, 20 years in jail, and castration. (black-iris.com)
  • Defying contemporary claims of an alleged 'death of psychoanalysis,' and in contrast with recent attempts to minimize the relevance of Oedipus for the psyche, Nasio approaches Oedipus as a legend that helps to make sense of the origins of sexual identity and neurotic suffering. (sunypress.edu)
  • But does that really make sense? (menoforder.com)
  • In retrospect it's always difficult to make sense of why this particular incident was the catalyst. (wamc.org)
  • Common Sense Media. (wikipedia.org)
  • The minister told RUV that "I believe that this is being worked on in a natural fashion, with common sense, as quickly as possible. (grapevine.is)
  • Washington - February 28, 2018) - Veterans for Common Sense this week was among 111 organizations to send a letter to Congressional leadership of the Armed Services committees expressing concern about possible renewed efforts to that would have a detrimental impact on research at the Congressionally-Directed Medical Research Program (CDMRP) and other medical research conducted by the U.S. Department of Defense (DoD). (veteransforcommonsense.org)
  • Veterans for Common Sense (VCS) is a charter and executive committee member of the DHRC. (veteransforcommonsense.org)
  • This information for parents is provided by Common Sense Media , a non-profit organization dedicated to improving kids' media lives. (netflix.com)
  • and, as we learn more and more about the impacts of traditional canine neutering (castration), vasectomy surgery is becoming increasingly popular. (speakingforspot.com)
  • In the traditional sense, poaching has existed for millennia, particularly after exclusive land ownership became a thing. (schalkenbach.org)
  • The phallic mother childish fantasy shows denial's action in maintaining irrational beliefs and their effects on the sense of reality. (bvsalud.org)
  • His sense of humor shows through, as well, with lines like "I'm standing naked in front of you with castration fears," and "pimps down, hoes up. (t-sides.com)
  • As a result, the English version has a better sense of accomplishment as a story than the original version. (semo.edu)
  • An undercurrent of light-skinned blackness as a type of castration emerges within an ongoing story about the feminizing of light skin and the masculinizing of dark skin. (cornell.edu)
  • Nasio makes the provocative claim that the entirety of the psychoanalytical corpus, all of its concepts, including repression, sublimation, the theory of the drives, desire, as well as the phantasm of the phallus and castration anxiety, revolves around the idea that the child desires the parents. (sunypress.edu)
  • The scenes of their courtship, as Maurizio falls for Reggiani, are sweet and give a sense of the family dynamics she was marrying into. (buzzfeednews.com)
  • As he matured and became more aware of his sense of self and how he would carry himself, he began to see how homosexuals were mocked and that he was displaying some of those behaviors and stereotypes. (christianpost.com)
  • castration was indeed considered a solution by the medical profession. (liu.se)
  • This article analyzes the unconscious family transmissions and their relationship with the simultaneous admission and nonadmission of castration. (bvsalud.org)
  • It also refers to a person's sense of personal and social identity based on those attractions, related behaviors, and membership in a community of others with similar attractions and behaviors. (msdmanuals.com)
  • Physical castration isn't that common among prostate cancer patients, but does make sense for many. (cancer.org)
  • Prostate cancer at advanced stages including metastatic and castration-resistant cancer remains incurable due to the lack of effective therapies. (oncotarget.com)
  • The usual progression of prostate cancer goes from castration-sensitive to -resistant, inevitably developing highly metastatic properties [ 2 ]. (oncotarget.com)
  • I think prostate cancer was really front and center again this year, with some really important updates in the field of metastatic castration resistant prostate cancer. (globaloncologyacademy.org)
  • The objective of this study was to analyze the safety and efficacy of 177 Lu-labeled DOTAGA-based prostate specific membrane antigen (PSMA) ligand 177 Lu-DOTAGA-(I-y)fk(Sub-KuE) ( 177 Lu-PSMA) in patients with metastatic castration-resistant prostate cancer (mCRPC). (snmjournals.org)
  • Men with prostate cancer are often treated with the suppression of testosterone through long-acting injectable drugs termed chemical castration or androgen deprivation therapy (ADT). (biomedcentral.com)
  • Abiraterone is an antiandrogen used to treat metastatic, castration-resistant prostate cancer. (illnesshacker.com)
  • Abiraterone acetate is a steroidal CYP17A1 inhibitor and by extension androgen synthesis inhibitor which is used in combination with prednisone in metastatic castration-resistant prostate cancer (previously called hormone-resistant or hormone-refractory prostate cancer) - i.e., prostate cancer not responding to androgen deprivation or treatment with androgen receptor antagonists. (illnesshacker.com)
  • Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer. (illnesshacker.com)
  • 6. High dose androgen suppresses natural killer cytotoxicity of castration-resistant prostate cancer cells via altering AR/circFKBP5/miRNA-513a-5p/PD-L1 signals. (nih.gov)
  • 16. Current status and future perspective on the management of metastatic castration-sensitive prostate cancer . (nih.gov)
  • Circulating tumor DNA alterations in patients with metastatic castration-resistant prostate cancer. (cdc.gov)
  • While most patients respond to androgen deprivation using surgery or hormones, increased androgen receptor expression can cause the cancer to re-grow and become so-called castration-resistant prostate cancer (CRPC), a terminal disease. (cancer.org)
  • Nilutamide through its antiandrogenic activity can complement surgical castration, which suppresses only testicular androgens. (nih.gov)
  • The performance juxtaposes the narrative of gay computing pioneer Alan Turing's forced chemical castration with algorithmic mutations of Guillaume Apollinaire's 1917 play "Les Mamelles de Tirésias (The Breasts of Tiresias). (newcity.com)
  • That's a very brief summary of some of this historic figure's greatest feats, but it should give you a sense of Turing's vital importance. (denofgeek.com)
  • But as I assessed the degree of spread of my CA it seemed to me that immediate and aggressive measures were necessary hence my decision for castration and docetaxel. (cancer.org)
  • In the end, they all assured me there's no surgical reason why we don't routinely perform what amounts to an easier, quicker, less invasive procedure than traditional castration. (embracepetinsurance.com)
  • Castration is any action, surgical, chemical, or otherwise, by which an individual loses use of the testicles: the male gonad. (wren-clothing.com)
  • For maximum benefit, NILANDRON treatment must begin on the same day as or on the day after surgical castration. (nih.gov)
  • Castration Celebration is a 2009 young adult novel by Jake Wizner. (wikipedia.org)
  • Scaling between stories of chemical castration (Chicago's Atom-r) to an "Upgrade You" makeover of normal shoes into expensive ones (China's Miao Jiaxin), Rapid Pulse thrives on diversity. (newcity.com)
  • Charged with gross indecency for homosexual relations - because homosexuality was a crime at the time - Turing was offered the choice of prison or chemical castration. (denofgeek.com)
  • Editors, who may be themselves writers, are more and more conceptually proactive, and no longer just "edit" in a subtractive sense, but impose an editorial narrative on the aggregate of work they publish. (htmlgiant.com)
  • Progressive intimate wellness pros point out but not that castration may distance themself sexual urges and also the capacity to make love, however it does not build a person asexual. (tiendacolegiomalvar.com)
  • But, after all, the burning question is : Does the removal of the uterine appendages affect the sexual sense of the woman, or in any way unsex her? (nih.gov)
  • After that, we interrogate the creation itself of the categories of heterosexuality and homosexuality in Freud´s work in order to reflect upon in what sense the hegemony of the Phallic/Oedipal model produces one truth of the subject which is forged by the sexual and binary split, leading to hierarchies and asymmetries. (bvsalud.org)
  • Evo and Proud: Does Nyborg's study make sense? (blogspot.com)
  • Does it make sense? (blogspot.com)
  • But, yes, Nyborg's study does make sense, if only because his population projection holds true regardless of how imperfect his data may be. (blogspot.com)
  • Mass slaughtering of stray cats does not make sense. (one-voice.fr)
  • This will all make sense at the end of this little fiction, which you'll never find out since all the stories are unfinished. (htmlgiant.com)
  • No testicles left, but still behaviours exhibited that only make sense in the presence of testicles. (huliganov.tv)
  • This has been explained by the differences between the sexes in the development of the castration complex and by the absence of a reassuring effect from showing a penis because of anatomic differences in women. (medscape.com)
  • The Oedipus/Castration complex would be then questioned in function of the genital difference between sexes. (bvsalud.org)
  • The role of women in society has been purposefully dictated in order to maintain this false sense of societal uniformity. (ipl.org)
  • Makes complete sense. (davidicke.com)
  • Cutting spending for renewable energy and energy efficiency is not only the wrong thing to do from an environmental perspective -- it makes no economic sense whatsoever. (zmescience.com)
  • For me, it makes no sense," she told DW. (dw.com)
  • Allowing biological males who identify as women to enter women's competitions makes no more sense than allowing heavyweights to box as flyweights or adults to compete as under-18s. (dailymail.co.uk)
  • However, the only 100% effective methods of birth control are castration, removal of the ovaries, and total abstinence. (skepdic.com)
  • In my Lessons in Gynecology and in my early teachings I maintained that the removal after pu- berty of the ovaries and the tubes does not unsex the woman-at least not to a greater extent than castration after puberty unsexes the man. (nih.gov)
  • The specialists having studied the question all agree on only one effective strategy: to sterilize and release the cats, simple castration proving more effective. (one-voice.fr)
  • Common Sense Media. (wikipedia.org)
  • You are absolutely right - physical castration is not very common. (cancer.org)
  • The news follows earlier reports of Trump's budget cuts to the Environmental Protection Agency (EPA), in yet another blow to the environment and common sense. (zmescience.com)
  • The general sense of the word "environment" as something exterior to the person is retained, even if that something influences intraperson processes. (hawaii.edu)
  • Though the committee members have outstanding credentials in a general sense, it appears that only Joanne Paul-Murphy, Laurel Degernes, Barry Hartup, and Cheryl Greenacre have worked with birds on a regular basis. (nih.gov)
  • After all, if population control is the primary imperative behind castration, why not just do a smaller snip-snip and leave those "balls" alone? (embracepetinsurance.com)
  • Certain relational aspects of child psychosis can affect professionals, leading them to refer to a child as « perverse », more colloquially rather than in a true diagnostic sense, i.e. in response to what is felt as disturbing. (fiuc.org)