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ClonidineAntihypertensive AgentsHypnotics and SedativesHypertensionAdrenergic alpha-AgonistsBlood PressureAdrenergic alpha-2 Receptor AgonistsHydrochlorothiazideDiureticsPreanesthetic MedicationMethyldopaConscious SedationAngiotensin-Converting Enzyme InhibitorsAmlodipineAtenololAdrenergic alpha-AntagonistsDexmedetomidineRats, Inbred SHRSodium Chloride Symporter InhibitorsMidazolamHydralazineYohimbineReceptors, Adrenergic, alpha-2Calcium Channel BlockersSympatholyticsChlorthalidoneDouble-Blind MethodHeart RateImidazoline ReceptorsAnalgesicsGuanfacineDose-Response Relationship, DrugDoxazosinAnti-Anxiety AgentsReceptors, Adrenergic, alphaAdrenergic beta-AntagonistsTranquilizing AgentsLisinoprilBlood Pressure Monitoring, AmbulatoryTetrazolesDrug Therapy, CombinationPrazosinCaptoprilEnalaprilAngiotensin II Type 1 Receptor BlockersBlood Pressure DeterminationTrichlormethiazidePropofolTime FactorsImidazolesHypertension, RenalAdjuvants, AnesthesiaInjections, SpinalThiazidesHemodynamicsNorepinephrineDrug InteractionsLosartanRats, Inbred WKYAngiotensin Receptor AntagonistsTreatment OutcomeDihydropyridinesAdrenergic alpha-2 Receptor AntagonistsIndapamideReninBendroflumethiazideBenzothiadiazinesLabetalolNifedipineAnalgesics, OpioidGuanabenzProspective StudiesBenzimidazolesRisk FactorsAdministration, OralIdazoxanPremedicationChlormethiazoleReserpineHypertrophy, Left VentricularMeprobamatePatient ComplianceOxymetazolineBenzodiazepinesSympathetic Nervous SystemAnesthesiaBiphenyl CompoundsPropranololReceptors, AdrenergicLorazepamMinoxidilNordefrinMorphineSystoleDrug PrescriptionsRats, Sprague-DawleyFelodipineChloral HydrateXylazineMedication Adherence

Alpha-agonist hypotensive agentEffects of clonidineAlcoholAnalgesicHydrochloride tabletsMedicationsHypotensiveOpioidsStimulantHypnoticsAnti-hypertensiveAttention deficitDosesWithdrawalSedationHypersensitivityKAPVAYPharmacologicalAtenololHypertensionCardiacEffectOrallyInhibitorDrugsTabletsMildDrugHypotensionSubstanceAnxietyMedicationDecreaseDosageBloodTreatmentBeatsOverviewPainCurrentActionResultPatientsIndividual

Alpha-agonist hypotensive agent1

• Clonidine is an alpha-agonist hypotensive agent to decrease blood pressure employed alone or in combination with other antihypertensive drugs. (kuikdose.com)

Effects of clonidine2

• Lofepramine may reduce the antihypertensive effects of clonidine. (wikipedia.org)
• Direct inhibition of cardiac HCN pacemaker channels contributes to the bradycardic effects of clonidine in gene-targeted mice. (uni-wuerzburg.de)

Alcohol2

• Clonidine can be used to relieve the withdrawal and containment symptoms associated with the use of long-term narcotics and alcohol, such as benzodiazepines and nicotine (smoking). (scopeheal.com)
• Clonidine causes increase of sedative effect of barbiturates, narcotic pain relievers and alcohol. (kuikdose.com)

Analgesic2

• As expected, sedative and analgesic actions of clonidine were completely absent in alpha2ABC-KO mice, confirming the sole role of alpha2-receptors in these properties of clonidine. (uni-wuerzburg.de)
• Clonidine is often used as an adjunctive sedative and analgesic in children but a well designed and adequately powered randomized trial is required to test the effect of clonidine-based sedation. (druglib.com)

Hydrochloride tablets3

• Clonidine hydrochloride tablets are indicated in the treatment of hypertension. (rwmansiononpeachtree.com)
• Clonidine hydrochloride tablets may be employed alone or concomitantly with other antihypertensive agents. (rwmansiononpeachtree.com)
• Clonidine hydrochloride tablets must be adjusted according to the patient's individual blood pressure response. (wikidoc.org)

Medications6

• In this brief overview, medications used to treat insomnia such as hypnotics, sedatives, medications inducing sedation as a side effect, medications directed at the sleep-associated circadian neuroendocrine system, and agents utilized in treating insomnia-inducing sleep diagnoses such as restless leg syndrome are discussed. (springer.com)
• Sedatives and other medications used off-label for sedative side-effects are a contributing factor to drug induced hypersomnolence, a factor in more than 30% of motor accident deaths. (springer.com)
• Medications for treating insomnia are classified as hypnotics, sedatives, medications inducing sedation as a side effect, medications directed at the sleep-associated circadian neuroendocrine system, and agents utilized in treating insomnia-inducing sleep diagnoses such as restless leg syndrome (RLS) (Curry et al. (springer.com)
• KAPVAY® (clonidine hydrochloride) extended-release is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy and as adjunctive therapy to stimulant medications. (pillintrip.com)
• Providing effective sedation for children in the PICU requires careful balancing of the need for sedation with the adverse effects associated with sedative medications. (druglib.com)
• Concomitant prescription of Clonidine with medications which lower heart rate (beta-blockers) should be done with cautiousness. (kuikdose.com)

Hypotensive1

• Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine ( 7.3 ). (nih.gov)

Opioids1

• Some medical professionals also prescribe clonidine to help people withdraw safely from opioids or control the symptoms of attention-deficit hyperactivity disorder. (help.org)

Stimulant1

• Some studies show that Clonidine is more sedating than guanfacine, which can be better when lying down with a stimulant in the morning. (scopeheal.com)

Hypnotics2

• It is supplied by Merck, Sharpe & Dohme Corp.. Belsomra is used in the treatment of insomnia and belongs to the drug class miscellaneous anxiolytics, sedatives and hypnotics. (rwmansiononpeachtree.com)
• Studies of the use of sedative-hypnotics to treat sleep disorders are limited to adults, and no FDA indications are approved for children younger than 18 years. (medscape.com)

Anti-hypertensive1

• Clonidine, an anti-hypertensive medication, is likewise sometimes added to both reduce the duration of withdrawal as well as to alleviate physical symptoms and signs. (heroinhelpcenter.com)

Attention deficit3

• The United States Food and Drug Administration (FDA) has approved Clonidine to treat attention deficit hyperactivity disorder, under Kapvay alone or with stimulants in 2010, for pediatric patients between 6 and 17 years. (scopeheal.com)
• The Therapeutic Goods Administration (Clonidine) is an accepted but not approved use for attention deficit hyperactivity disorder in Australia. (scopeheal.com)
• The contiguous Clonidine with methylphenidate has been studied for attention deficit hyperactivity disorder medication and treatment. (scopeheal.com)

Doses1

• Individuals who develop a tolerance for clonidine must take larger and larger doses just to experience the same effects, which can lead to addiction. (help.org)

Withdrawal3

• Clonidine has also been suggested as a treatment for rare cases of dexmedetomidine withdrawal. (scopeheal.com)
• Clonidine has also been used to treat diarrhea associated with irritable bowel syndrome, fecal incontinence, diabetes, diarrhea associated with withdrawal, intestinal insufficiency, neuroendocrine tumors, and cholera. (scopeheal.com)
• Furthermore, clonidine can produce undesirable withdrawal symptoms, making it difficult to stop using the substance. (help.org)

Sedation2

• Other pharmacological agents producing sedation (sedatives and agents used off-label for sedative side-effects) should be used cautiously for the treatment of insomnia due to the increased risk of next day sleepiness as well as for known toxicities and adverse side effects. (springer.com)
• Clonidine is an agonist at alpha2-adrenergic receptors that mediate a wide variety of the physiological responses to epinephrine and norepinephrine, such as inhibition of neurotransmitter release as well as sedation and analgesia. (uni-wuerzburg.de)

Hypersensitivity2

• KAPVAY is contraindicated in patients with a history of a hypersensitivity reaction to clonidine. (pillintrip.com)
• Hypersensitivity to Clonidine or any component of the formulation. (kuikdose.com)

KAPVAY1

• Due to the lack of controlled clinical trial data and differing pharmacokinetic profiles, substitution of KAPVAY for other clonidine products on a mg-per-mg basis is not recommended. (pillintrip.com)

Pharmacological1

• These alpha2ABC-KO mice were an ideal model in which to examine the pharmacological effects of the centrally acting antihypertensives clonidine, moxonidine and rilmenidine in the absence of alpha2-adrenergic receptors. (uni-wuerzburg.de)

Atenolol1

• clonidine, atenolol. (medscape.com)

Hypertension2

• Clonidine is a central alpha-2 adrenergic agonist that is FDA approved for the treatment of hypertension . (wikidoc.org)
• Hypertension treatment with clonidine can be administered orally (tablets) or by transdermal patches. (wikidoc.org)

Cardiac1

• Antihypertensives/cardiac glycosides may lower blood pressure. (nih.gov)

Effect9

• Increased sedative effect. (wikipedia.org)
• A similar bradycardic effect of clonidine was observed in isolated spontaneously beating right atria from alpha2ABC-KO mice. (uni-wuerzburg.de)
• It is concluded that the antihypertensive effect of Abana might be due to its alteration of cation transport into the cell. (ijp-online.com)
• Certain antidepressants may diminish pharmaceutical effect of Clonidine. (kuikdose.com)
• When clonidine activates these receptors, it can have a sedative effect on the body. (help.org)
• Clonidine also reduces anxiety and has a mild euphoric effect, which can cause cravings and make it difficult for users to stop taking the substance. (help.org)
• blocks sympathetic activity in the brain, producing a pleasant sedative effect. (help.org)
• Linalool induced a dose dependent increase of motility effects, thus ruling out the confounding influence of a possible sedative effect. (researchgate.net)
• It's likely that its effect is associated with sedative properties. (healthynet.eu)

Orally1

• Clonidine maybe used orally or as patches applied to your skin, it treats high blood pressure. (kuikdose.com)

Inhibitor2

• an antihypertensive drug that is an ACE inhibitor. (absp.org.uk)
• After treatment with the specific If inhibitor ZD 7288, clonidine was no longer able to lower spontaneous beating frequency, suggesting a common site of action. (uni-wuerzburg.de)

Drugs1

• Thus clonidine-like drugs represent novel structures for future HCN channel inhibitors. (uni-wuerzburg.de)

Tablets1

• Do not crush, chew, or break tablets because this will increase the rate of clonidine release. (pillintrip.com)

Mild2

• Clonidine is also a mild sedative and can be used as premedication before surgery. (scopeheal.com)
• Because clonidine has sedative properties and produces a mild sense of euphoria, chronic use increases the risk of tolerance and dependence. (help.org)

Drug3

• an antihypertensive drug. (absp.org.uk)
• a neuroleptic drug used as a sedative and to treat schizophrenia. (absp.org.uk)
• The food and drug administration approved Clonidine in September 1974. (scopeheal.com)

Hypotension1

• The risk of hemodynamic instability, especially hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients. (wikidoc.org)

Substance4

• Although clonidine is effective for these conditions, non-medical use of this substance is a growing concern. (help.org)
• According to a report published by the Substance Abuse and Mental Health Services Administration, approximately 0.2% of Americans aged 12 and older reported that they were current misusers of sedatives - including clonidine in 2016. (help.org)
• Although clonidine isn't a controlled substance as described in the Controlled Substances Act, it does have some potential for abuse. (help.org)
• The Substance Abuse and Mental Health Services Administration reports that another 0.2% of Americans aged 12 and older were current misusers of sedatives in 2016. (help.org)

Anxiety3

• Clonidine also has several non-approved uses and has been prescribed to treat psychiatric disorders, including stress, sleep disorders, and hyperactivity caused by post-traumatic stress disorder, borderline personality disorder, and other anxiety disorders. (scopeheal.com)
• If you suspect that you took too much of Clonidine and your blood pressure first becomes too high (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain) and then followed by low blood pressure (fainting, cold feeling, slow heart rate) seek for immediate medical attention. (kuikdose.com)
• addiction can be difficult to overcome when the individual relies on clonidine to reduce anxiety. (help.org)

Medication2

• This medication has antihypertensive, antianginal and antiarrhythmic action. (medicatione.com)
• Clonidine is a prescription medication that reduces blood pressure by relaxing the blood vessels and reducing the amount of blood the heart pumps each time it beats. (help.org)

Decrease1

• Clonidine can be used to treat Tourette syndrome (precisely to control or decrease tics). (scopeheal.com)

Dosage1

• Usually Clonidine is taken twice daily, dosage depends on individual blood pressure response of a patient. (kuikdose.com)

Blood2

• As with other therapeutically used alpha2-agonists such as moxonidine and rilmenidine, clonidine possesses an imidazoline structure and is believed to lower blood pressure not only via central and peripheral alpha2-receptors, but perhaps even more so by acting on central "imidazoline I1 receptors" in the brain stem. (uni-wuerzburg.de)
• To reduce blood pressure, clonidine activates alpha-2 receptors in the nervous system, relaxing the blood vessels and making it easier for the heart to pump blood throughout the body. (help.org)

Treatment1

• Once a treatment plan has been developed, the individual goes through an initial detoxification period, which is when clonidine is cleared from the body. (help.org)

Beats1

• Clonidine significantly lowered heart rate in anesthetized alpha2ABC-KO and wild-type mice by up to 150 beats/min. (uni-wuerzburg.de)

Overview1

• This guide was written to provide an overview of the clonidine rehabilitation process as well as to offer helpful resources for persons recovering from clonidine addiction. (help.org)

Pain3

• Administering Clonidine to children before surgery may help relieve pain after an operation. (scopeheal.com)
• However, the potential use of Clonidine for postoperative pain relief requires further investigation. (scopeheal.com)
• Clonidine hydrochloride injection (epidural clonidine) is not recommended for obstetrical, postpartum, or perioperative pain management. (wikidoc.org)

Current1

• Furthermore, in HEK293 cells stably transfected with HCN2 and HCN4, it could be shown that clonidine inhibits the If current via blockade of pacemaker channels with similar affinity as in isolated alpha2ABC-KO and wild-type atria. (uni-wuerzburg.de)

Action1

• This inhibition was demonstrated again in isolated sinoatrial node (SAN) cells from alpha2ABC-KO mice and was identical in potency and efficacy to clonidine inhibition observed in isolated wild-type SAN cells, confirming that inhibition of atrial HCN channels constitutes the alpha2-independent bradycardic action of clonidine. (uni-wuerzburg.de)

Result1

• As a result, clonidine misuse is a growing concern in the United States and abroad. (help.org)

Patients2

• Patients receiving epidural clonidine from a continuous infusion device should be closely monitored for the first few days to assess their response. (wikidoc.org)
• There is limited information regarding Off-Label Guideline-Supported Use of Clonidine in adult patients. (wikidoc.org)

Individual1

• Clonidine addiction rehabilitation usually begins with an orientation period that helps the individual adjust to the facility. (help.org)