Secretory role epithelium. Medical search. Frequent questions

Based on the knowledge that the airway epithelium takes the brunt of the stress of cigarette smoke, [ 46 ] we asked this question: does smoking alter the expression of a gene whose product is linked to weight loss? (medscape.com)
We do not have data demonstrating increased levels of AZGP1 in biological fluids, and thus we cannot prove that smoking-induced increases in AZGP1 gene expression in airway epithelium is sufficient to mediate weight loss. (medscape.com)
In the most proximal regions of the conducting zone, including the nasal passage, trachea, and bronchi, the airway epithelium exhibits a columnar, pseudostratified morphology. (stemcell.com)
The major cell types of the large airway epithelium are goblet cells that produce and secrete mucus, ciliated cells that promote mucus motility through coordinated movement of their apical cilia, and basal cells that line the basement membrane and do not contact the apical surface of the epithelium. (stemcell.com)
Myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been shown to play an important role in regulation of airway mucin secretion, as peptides analogous to the amino (N)-terminus of MARCKS attenuate mucin secretion by airway epithelium in vitro and in vivo. (nih.gov)
TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium. (qxmd.com)
Loss of airway expression of TMEM16A induced a massive expansion of the secretory cell population like goblet and club cells, causing differentiation into a secretory airway epithelium. (qxmd.com)
The human basal epithelial cell line BCi-NS1.1 forms a highly differentiated mucociliated airway epithelium when grown in PneumaCult™ media under an air liquid interface. (qxmd.com)
In this article, we review our recent evidence that challenges this concept and discuss the findings that hyaluronan retains certain enzymes important for homeostasis at the apical surface of the airway epithelium, protecting them from removal by mucociliary clearance. (gr.jp)

AZGP1 was first isolated from human plasma [ 33 ] and later found to be expressed in secretory epithelial cells of the lung, liver, breast, GI tract, and sweat glands. (medscape.com)
The type II cell plays an important role in the response of the alveolar epithelium after lung injury through its synthesis and secretion of pulmonary surfactant, and by acting as the stem cell for the replacement of damaged type I epithelial cells. (nih.gov)
The alveolar epithelium is lined with type I and II alveolar epithelial cells (AECs). (stemcell.com)
Here, we show that knockout (KO) of CGNL1, but not of PLEKHA7, results in the loss of junctional CAMSAP3 and its redistribution into a cytoplasmic pool both in cultured epithelial cells in vitro and mouse intestinal epithelium in vivo. (bvsalud.org)
MUC1, also referred to as mammary-type mucin, has a role in the maintenance of the lumina of ductal epithelial cells, and is thought to have an inhibitory role in cell-cell and cell-stroma interactions and in cytotoxic immunity. (bmj.com)
To investigate the effect of estrogen/GPR30 signaling on GMECs proliferation, goat mammary epithelial cells, which expressed cytokeratin 18 and β-casein, were isolated and identified, defining their mammary alveolar epithelium origination. (researchsquare.com)
During a pregnancy/lactation cycle, the mammary epithelial cells proliferate rapidly to form ducts and secretory alveoli through hormonal regulation, resulting in remodeling of the glandular tissue architecture into a milk-secretory organ [2, 3].Estrogen (mainly 17β-estradiol) is a key regulator of mammary gland development, especially for its essential in the epithelial cell proliferation and ductal morphogenesis of the mammary gland [4, 5]. (researchsquare.com)

Among their various functions, semaphorins and their receptors play a key role in the central neuroendocrine regulation of reproduction by controlling the establishment of the neural circuitry responsible for the secretion of gonadotropin-releasing hormone (GnRH), a decapeptide that acts as the 'master molecule' controlling fertility. (karger.com)
Using recently identified selective Clc-2 inhibitor AK-42, we characterized the roles of Clc-2 in Cl - secretion in human intestinal epithelial T84 cells. (aspetjournals.org)
Our findings clarify the roles of Clc-2 in intestinal Cl - secretion and elucidate the mechanism of action of approved-drug lubiprostone. (aspetjournals.org)
Intestinal epithelial Cl - secretion promotes luminal hydration and plays key roles in maintenance of gut health ( Rao, 2019 ). (aspetjournals.org)
Taken together, TMEM16A/F are important for exocytosis, mucus secretion and formation of extracellular vesicles (exosomes or ectosomes) but the present data do no not support a functional role of TMEM16A/F in Notch-mediated differentiation of BCi-NS1.1 cells towards a secretory epithelium. (qxmd.com)
This regulated discharge of stored macromolecules is accompanied by the secretion of solutes and water to the cell exterior to hydrate these protein-rich secretory products. (pancreapedia.org)
The advent of the post-genomic era had raised hopes that - similar to other areas of cell biology - a large number of ZG transport proteins would be identified and their role in pancreatic secretion would be elucidated. (pancreapedia.org)
Moreover, a better understanding of the physiology of pancreatic acinar cell secretion and the role played by ZG in this process seems to be a prerequisite to comprehend the pathogenesis of pancreatic disorders, such as pancreatitis, cystic fibrosis or cancer (65). (pancreapedia.org)
In the following paragraphs, I first review significant advances in the characterization of ZG channels and transporters in the last decade and discuss their putative role in pancreatic acinar secretion ( Figure 1 ). (pancreapedia.org)
Drosophila CrebA facilitates high-level secretion by transcriptional upregulation of the protein components of the core secretory machinery. (johnshopkins.edu)
In CrebA mutant embryos, both salivary gland (SG) morphology and epidermal cuticle secretion are abnormal, phenotypes similar to those observed with mutations in core secretory pathway component genes. (johnshopkins.edu)
Apically localized secretory vesicles are smaller and less abundant, consistent with overall reductions in secretion. (johnshopkins.edu)
In the annelids, this mucous secretion also plays a fundamental role in the formation of the ground substance of tubes, protection from dehydration, absorption of metabolites, and protection against parasites [ 4 ]. (hindawi.com)
In this study, we aimed to understand whether glucose transporter 1 (GLUT1) activity affects the secretion capacity of antiangiogenic factor pigment epithelium-derived factor (PEDF) by the RPE cells, thus explaining the reduction in PEDF levels observed in patients with diabetic retinopathy (DR). (molvis.org)
As the RPE is responsible, among others, for the transport of nutrients, such as glucose, ions, and water, and the secretion of factors crucial for the homeostasis of the neuroretina such as the pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) [ 2 , 10 ], the role of the RPE in DR is worth investigating. (molvis.org)

We focused on breast tissue because, in cattle, BLV DNA and protein have been found to be more abundant in mammary epithelium than in lymphocytes. (cdc.gov)
Cx26 and Cx32 have been co-localized in gap junctions of mouse mammary epithelium during lactation and both homomeric and heteromeric connexins have been identified [ 16 ]. (biomedcentral.com)
The synthetic capacity of milk from the mammary gland relies largely on the quantity and efficiency of functional mammary epithelium [1]. (researchsquare.com)

The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. (lookformedical.com)

Some studies implicate this pathway as having a role in attention deficiency and hyperactive behavior. (wikipedia.org)
To better understand the function of these proteins in the secretory pathway further studies are needed. (pancreapedia.org)
The Figure also describes relevant ion concentrations in mature ZG and emphasizes the decreasing lumen acidity during maturation along the compartments of the secretory pathway that participate in ZG maturation (for further details, see text). (pancreapedia.org)
Whereas mutations in core secretory pathway genes lead to organelle localization defects similar to those of CrebA mutants, they have no effect on SJ-associated membrane. (johnshopkins.edu)
We identified DNA methylation markers possibly associated with clinical and complete asthma remission in nasal brushes and whole blood, and two CpG sites identified from whole blood can be replicated in independent cohorts and may play a role in peroxisome proliferation and Wnt signaling pathway. (biomedcentral.com)
It indicated that estrogen/GPR30 signaling played an important role in GMECs proliferation by affecting cell cycle progression via MEK/Erk&PI3K/Akt signaling pathway. (researchsquare.com)

Chloride channel protein 2 (Clc-2) is proposed as an alternative Cl - channel in intestinal epithelia that can compensate for CFTR loss-of-function. (aspetjournals.org)

Do secretory vesicles from cancer cells modulate DNA damage response to their neighbor? (rgcb.res.in)

Knockout of the Ca2+ -activated Cl- channel TMEM16A or the phospholipid scramblase TMEM16F leads to mucus accumulation in intestinal goblet cells and airway secretory cells. (qxmd.com)
The epithelium has physical, chemical and biological means to maintain the integrity of the defensive barrier against pathogens, such as tigh junctions, layer of mucus, interaction with antimicrobial peptides, immune cells, absortive and secretory cells, which seem to have an important role as presenters of antigens, which could be linked to the presentation of the microflora to generate tolerance state. (edu.pe)
In this context, the different staining patterns observed in epidermal mucous cells hinted at their functional roles with respect to production of mucus with different physical properties. (hindawi.com)
The glandular cells in the surface epithelia secrete mucus that is rich in glycans, glycoproteins, and sialic acid residues [ 5 - 7 ]. (hindawi.com)
In higher eukaryotes, the mucus that coats the epithelium and protects underlying tissue from damage and infection while providing an optimal environment for commensal microbes obtains its protective properties from densely O-glycosylated mucin proteins. (nih.gov)

GC-C, while known mainly for its secretory regulation in the intestinal epithelium, is also expressed in the brain. (wikipedia.org)
I completed my Ph.D. in Neurological Sciences at McGill University in 2006, studying the role of the insulin-like growth factor-II (IGF-II/M6P) receptor in the regulation of cholinergic neurons. (open.ac.uk)
The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. (nih.gov)
Further complexity is added because the intestinal tract is formed of distinct anatomical regions that develop at different rates and carry out diverse roles in digestion, nutrient absorption, metabolism and immune regulation. (nature.com)
Vitamin D-3 plays a key role in immune regulation and may help protect against the aging process. (dralexrinehart.com)

This review summarizes current knowledge of the role of semaphorins and their receptors on the development, differentiation and plasticity of the GnRH system. (karger.com)
In the ileal epithelium, HDAC7 seems to play an important role in the differentiation process of all specialized epithelial subtypes while it appears to suppress mainly secretory lineages and promote differentiation into absorptive cells in the colon epithelium. (ecco-ibd.eu)
D ) Schematic summarizing the transcription factors known to play an important role in the development and differentiation of the SOX9+progenitors. (elifesciences.org)
This document aims was review the mechanism of development and differentiation of intestinal epithelium (IE) and is participation in the defense of the organism. (edu.pe)

Choroid plexus (ChP), a vascularized secretory epithelium situated in all mind ventricles, performs vital roles in growth, homeostasis and mind restore. (microarrayworld.com)

A molecular switch orchestrates enzyme specificity and secretory granule morphology. (nih.gov)

[ 38 ] Consistent with its production by secretory epithelium, AZGP1 is present in most body secretions. (medscape.com)
Secretory IgA (SIgA) is the predominant class of antibody found in intestinal secretions. (nih.gov)
These secretions contain a variety of antibacterial products, such as lactoperoxidase, lysozyme, lactoferrin, or antiproteases, such as secretory leukoprotease inhibitor (SLPI) and tissue inhibitors of metalloproteases (TIMPs) that work in concert to maintain airway sterility and homeostasis. (gr.jp)

The GI tract is a highly complex organ composed of microorganisms, the intestinal epithelium, and the mucosal immune system. (biomedcentral.com)

Mucosal defence against pathogens consists of both innate barriers, such as mucous, epithelium, and innate immune mechanisms, and adaptive host immunity. (clinicaleducation.org)

chioloalveolar tumors, as well as degeneration and atrophy of nasal olfactory epithelium. (cdc.gov)
Numerous studies have demonstrated marked differ- fects on terminal bronchioles are seen, but effects in ences in toxicity between rats and mice to styrene ex- the nasal olfactory epithelium do occur, although to posure, especially by inhalation. (cdc.gov)
minal bronchioles and nasal olfactory epithelium. (cdc.gov)

Secretagogues bind to their receptors at the basolateral membrane of acinar cells and trigger the activation of intracellular signaling pathways to elicit fusion of secretory granules with the apical plasma membrane that is followed by exocytosis of digestive pro-enzymes (the "zymogens") into the lumen. (pancreapedia.org)

Once the enamel layer reaches its full thickness, the tall columnar secretory-stage ameloblasts shorten, and a portion of these maturation-stage ameloblasts become apoptotic. (uthscsa.edu)

In the bronchioles, the cuboidal epithelium contains secretory club cells and fewer ciliated cells than in more proximal airway regions. (stemcell.com)

The present review summarizes the current understanding of how SIgA functions to prevent microbial pathogens and toxins from gaining access to the intestinal epithelium. (nih.gov)
The latter consists predominately, at mucosal surfaces of specialised thymic derived cells called CD4 + T cells, secretory immunoglobulin A (SIgA), secretory immunoglobulin M (SIgM) and antigen-specific (memory primed) cytotoxic T-lymphocytes (CTLs). (clinicaleducation.org)
These responses are normally accompanied by the synthesis of secretory immunoglobulin A (SIgA) antibodies, which provide an important first line of defence against invasion into deeper tissues by these pathogens. (clinicaleducation.org)

Scanning electron micrographs of guinea pig ileal villus and crypt ( inset ) epithelium. (comprehensivephysiology.com)

The height of this epithelium decreases in more distal regions of the conducting zone and resembles a cuboidal epithelium in the small airway. (stemcell.com)
E-I ) Immunofluoresence microscopy shows high levels of SOX9 staining in the epithelium of the distal lung tips, with a high percentage of Ki67 +proliferating cells early in development. (elifesciences.org)
3 - E16.5 distal epithelium. (elifesciences.org)

The following book chapter will be an updated review on the role of mesenchymal stem cells in various infections and their complications. (intechopen.com)
Mouse models that enable targeted mutagenesis in oviduct epithelium (the equivalent of human FT) via the use of tissue-specific gene promoters (such as Pax8 or Ovgp1 ) have shown the ability of oviductal cells to transform into ovarian tumors 14 , 15 , 16 . (nature.com)
In RPE cells depletion of platelet-derived growth factor (PDGF) receptor (PDGFR)ß suppresses vitreous-induced Akt activation, whereas in fibroblasts Akt activation through indirect activation of PDGFRα by growth factors outside the PDGF family (non-PDGFs) plays an essential role in experimental PVR. (bvsalud.org)
Secretory granules are located at the apex of pancreatic acinar cells. (pancreapedia.org)
The ameloblast cells of the enamel organ epithelium are adjacent to and responsible for the developing enamel layer on unerupted teeth. (uthscsa.edu)
The epidermis of the annelids consists of a monolayered epithelium, which contains glandular, supporting, ciliated, and sensory cells. (hindawi.com)
Thus, the C terminus of lacritin is multifunctional by dose and proteolytic processing and appears to play a key role in the innate protection of the eye, with wider potential benefit elsewhere as lacritin flows from exocrine secretory cells. (biofron.com)
Minor epithelial cell types such as enteroendocrine, tuft, and cup cells may be scattered throughout epithelium but are not well visualized here. (comprehensivephysiology.com)
The gut microbiota residing in the gastrointestinal (GI) tract plays an important role in the health status of the host by regulating the cells in local and distant organs, including the brain. (biomedcentral.com)
2017. Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism. . (oregonstate.edu)
The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. (lookformedical.com)

Indeed, recent studies have combined functional and molecular approaches to characterize ZG channels and transporters and their role in pancreas physiology. (pancreapedia.org)
Functional amyloids play a beneficial role in a variety of physiologic processes (eg, long-term memory formation, gradual release of stored peptide hormones). (medscape.com)

Clara cell secretory protein (CCSP) and interleukin 8 levels were assessed in the bronchoalveolar lavage and plasma at 1, 3, 6, and 12 months after transplantation. (nih.gov)
The nonciliated bronchiolar epithelial (Clara) cell is thought to play a similar role during repair of the bronchiolar epithelium. (nih.gov)
These are accompanied by changes in specific epithelial genes including surfactant protein C and Clara cell secretory protein. (nih.gov)

This review aims to highlight the role of the gut microbiota and microbial metabolites in brain function and development, the proposed mechanisms underlying the communication between the gut microbiota and the brain, and the alterations in the gut microbiota in immune-related neurological disorders. (biomedcentral.com)
The gut microbiota and microbial metabolites not only play a role in the maintenance of gastrointestinal homeostasis, but also provide signals to distant organs in the body, including the brain [ 1 , 2 , 3 , 4 ]. (biomedcentral.com)

Correspondingly, removal of several tetraspanins gives partial rescue of the CrebA SJ phenotype, supporting a role for tetraspanins in SJ organization. (johnshopkins.edu)
2017. Rapamycin and the inhibition of the secretory phenotype. . (oregonstate.edu)

The IE has as main function the absorption of nutrients, it is exposed to a wide variety of microorganisms that come with the food, and could alter the intestinal barrier, for this reason the epithelium has evolutionarily conserved mechanisms dealing with the immediate defense depending on the stage of development of the individual, called innate system, as well as of a specific immune system. (edu.pe)

Biochemical and genetic characterization of Wnt-1 protein as a secretory glycoprotein (11,12) that can function in autocrine or paracrine modes, presumably by interaction with membrane receptor(s). (nih.gov)

MUCs are glycoproteins with various roles in homeostasis and carcinogenesis. (bmj.com)
MUCs are a heterogeneous group of glycoproteins with various roles both in homeostasis and carcinogenesis. (bmj.com)
The gut microbiota plays a role in the maintenance of GI tract homeostasis and is likely to have multiple effects on brain development and function. (biomedcentral.com)
After discovering that hyaluronan is a key regulator of the enzymic activity of a kinin generating enzyme, a concerted effort has been established with Drs.Conner and Matthias Salathe (see profiles below) to determine the role of hyaluronan in the airways and its contribution to airway homeostasis. (gr.jp)

Although SIgA's role in protecting the intestinal epithelium from the enteric pathogens and toxins has long been recognized, surprisingly little is known about the molecular mechanisms by which this is achieved. (nih.gov)
In fact, lumenal spaces-the gut, blood vessels, and other tubules and chambers-are themselves generated by epithelia during organismal development through mechanisms that are only now being understood. (rupress.org)
We concluded that intestinal epithelium presents complex mechanisms that help maintaining the homeostatic balance of the body, through the production of substances that are responsible for regulating the processes of absorption of nutrients and the maintenance of the microflora. (edu.pe)
Mechanisms of Viral Defence, Infection and Recovery - Does supplementation have a role to play? (clinicaleducation.org)

Clc-2 inhibitor AK-42 had minimal (15%) inhibitory effect on secretory short-circuit current (I sc ) induced by cAMP agonists, where subsequently applied CFTR inhibitor (CFTR inh -172) caused 2- to 3-fold greater inhibition. (aspetjournals.org)

They have certain immunomodulatory, immunosuppressive, and antimicrobial properties that enable them to have several therapeutic and clinical applications including: treatment of autoimmune disorders, role in hematopoietic stem cell transplantation and regenerative medicine, as well as treatment of various infections and their associated complications such as septic shock and acute respiratory distress syndrome. (intechopen.com)
Using these cell lines, we will study the role of nucleoporins in nuclear organization and function, mitosis, nuclear transport, transcription and overall nuclear architecture. (nih.gov)
C-D ) Gene enrichment modules 4 and 12 are highly enriched for components of the ciliated and secretory cell epithelium respectively. (elifesciences.org)
epithelia and cell junctions. (manchester.ac.uk)
These findings indicate that GPR30-mediated non-genomic signaling could play a significant role in cell proliferation. (researchsquare.com)
2017. Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors. . (oregonstate.edu)
Collectively, our data show that expression of GLUT1 is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 in the cell membrane that contributes to the impairment of the RPE secretory function of PEDF. (molvis.org)

In recent years, intensive research has shown that not only chronic activation of the immune compartment, but also the integrity of the epithelial barrier plays a central role in disease progression. (ecco-ibd.eu)
A specialized transport barrier, in the EYE, formed by the retinal pigment EPITHELIUM, and the ENDOTHELIUM of the BLOOD VESSELS of the RETINA. (lookformedical.com)

However, the expression of several genes thought to play a role in endolymph production is downregulated, including the sodium-potassium-chloride cotransporter gene nkcc1 ( slc12a2 ) and several Na + /K + -ATPase channel subunit genes. (biologists.com)

Similarly, AK-42 inhibited lubiprostone-induced secretory I sc by 20%, whereas CFTR inh -172 caused 2- to 3-fold greater inhibition. (aspetjournals.org)

Mucosa consists of muscularis mucosa, lamina propria, and epithelium. (comprehensivephysiology.com)

We also demonstrate in vivo that TGF-β1 is expressed in the maturation-stage enamel organ at significantly higher levels than in the earlier secretory-stage enamel organ. (uthscsa.edu)

Expression, transport properties ( Agre, 2004 ), and pharmacological gating ( Soveral and Casini, 2017 ) of AQPs are object of strong interest and intense investigation in all body districts and a number of important roles have been already described, both in health and clinical disorders. (frontiersin.org)
Clinical study results suggest that modulation of fatty acid composition and prostaglandin production with GLA supplementation supports the conjunctival epithelium of the eye. (dralexrinehart.com)

J-M ) Monocle3 lineage analysis was performed on E11.5 FACS-sorted lung epithelium and E16.5 whole lung. (elifesciences.org)
blue - E16.5 lung epithelium). (elifesciences.org)

Hypersecretion of mucin plays an important role in the pathophysiology of many inflammatory airway diseases, including asthma, chronic bronchitis, and cystic fibrosis. (nih.gov)

Here, we investigated the role of HDAC7 in the intestinal epithelium to evaluate its potential as a therapeutic target. (ecco-ibd.eu)

Plant-derived bioactive compounds have protective role for plants but may also modulate several physiological processes of plant consumers. (frontiersin.org)

Studies have shown that cGMP synthesis in cones is about 5-10 times higher than it is in rods, which may play an important role in modulating cone adaption to light. (wikipedia.org)

Dr. Conner s current research interests center on the metabolism of reactive oxygen species in the airway and the role of peroxidase in airway host defense against infection. (gr.jp)

Further research is needed to determine whether BLV may play a direct role in human disease. (cdc.gov)
Light micrograph of epoxy‐embedded lymphoid follicle of human small intestine with overlying follicular dome epithelium. (comprehensivephysiology.com)

Many nucleoporins play additional roles during mitosis, and some sub-complexes localize to kinetochores, where they facilitate chromosome segregation. (nih.gov)
Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. (nih.gov)
We conclude that TGF-β1 may play an important role in ameloblast apoptosis during the maturation stage of enamel development. (uthscsa.edu)
Research has shown that specific essential fatty acids found in certain plants and fish can play a role in helping to support natural tear production and tear film integrity in the eyes. (dralexrinehart.com)

In males, spermatogenesis peaked in autumn, with evidence for increased secretory activity in the epithelium of the ductus deferens during the mating season in both populations. (thebhs.org)
Discovery that the mouse int-1 (now Wnt-1) gene is expressed in a highly restricted manner (only in the embryonic nervous system and during spermatogenesis), implying roles in mammalian development (9,10). (nih.gov)

Much recent research has focused on the role of semaphorins in the development and adult activity of hormone systems and, reciprocally, how circulating reproductive hormones regulate their expression and function. (karger.com)
Channels and Transporters in Zymogen Granule Membranes and their Role in Granule Function: Recent Progress and a Critical Assessment. (pancreapedia.org)
The unique expression patterns of Cx26 and Cx32 suggest distinct and overlapping roles in mammary development and function. (biomedcentral.com)
EPA and DHA also promote healthy prostaglandin and cytokine balance to help protect the secretory function of the lacrimal glands. (dralexrinehart.com)

Recently, a tumour suppressor role has been demonstrated for MUC2, and both MUC1 and MUC2 appear to have important roles in pancreatic neoplasia. (bmj.com)
Domain-specific role of tumor suppressor PTEN in genomic stability: A systematic approach. (rgcb.res.in)

It was postulated previously and confirmed recently that podocalyxin, a sialomucin, plays a major role in maintaining the urinary space open by virtue of the physicochemical properties of its highly negatively charged ectodomain. (embl-heidelberg.de)
Ran is a Ras-family GTPase that plays critical roles in many cellular processes, including nucleo-cytoplasmic transport, nuclear envelope assembly, and mitotic spindle assembly. (nih.gov)
Here we investigate whether TGF-β1 plays a role in apoptosis of the maturation-stage ameloblasts. (uthscsa.edu)
Testosterone plays a highly significant role in the transition from the reproductive activity phase to gonadal regression and gonadal recrudescence [ 21 ]. (hindawi.com)
Furthermore, the gut microbiota plays a major role in the modulation of disease outcomes. (biomedcentral.com)

A Role for Inter-subunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity. (nih.gov)

Here, we examine the cellular defects associated with CrebA loss in the SG epithelium. (johnshopkins.edu)

This review provides an update on the involvement of Aquaporins (AQPs), a family of membrane channel proteins with important role in many body functions, in the beneficial effects imparted by food polyphenols and herbal phytocompounds, both in health and disease. (frontiersin.org)

Anatomy105

Organisms19

Diseases17

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes39

Disciplines and Occupations2

Information Science3

Airway Epithelium9

Epithelial cells7

Secretion15

Mammary epithelium3

Alveolar1

Pathway6

Intestinal epithelia1

Vesicles1

Mucus5

Regulation5

Differentiation4

Choroid plexus1

Morphology1

Secretions3

Mucosal Immune System1

Immunity1

Nasal3

Apical1

Columnar1

Bronchioles1

SIgA3

Ileal1

Distal3

Cells11

Functional2

Clara3

Microbial2

Phenotype2

Immune system1

Protein1

Homeostasis4

Mechanisms4

Inhibitory1

Cell7

Barrier2

Genes1

Inhibition1

Consists1

Vivo1

Clinical2

Lung2

Mucin1

Therapeutic1

Modulate1

Synthesis1

Metabolism1

Human2

Play4

Spermatogenesis2

Function4

Suppressor2

Plays5

Activity1

Cellular1

Important role1