Secretion surfactant collectins. Medical search. Frequent questions

Bar chart demonstrates the composition of lung surfactant. (medscape.com)
It is also the only surface active component of lung surfactant capable of lowering surface tension to near zero levels. (absoluteastronomy.com)

SP-A may also play a role in negative feedback limiting the secretion of pulmonary surfactant. (wikipedia.org)
SP-A is not required for pulmonary surfactant to function but does confer immune effects to the organism. (wikipedia.org)
SP-A is found in the pulmonary surfactant in lungs. (wikipedia.org)
pulmonary surfactant SFTPA1 SFTPA2 Surfactant+Protein+A at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Boron W, Boulpaep E (2012). (wikipedia.org)
Dipalmitoylphosphatidylcholine is a phospholipid consisting of two palmitic acids and is the major constituent of pulmonary surfactant. (absoluteastronomy.com)

Collectins are surfactant proteins that are present in serum, lung secretions, and mucosal surfaces. (brmi.online)
Among the four surfactant apoproteins identified, surfactant protein B (SP-B) and SP-C are two small hydrophobic proteins that make up 2-4% of the surfactant mass and are present in commercially available surfactant preparations. (medscape.com)

Surfactant protein A is an innate immune system collectin. (wikipedia.org)
The role of surfactant protein A (SP-A) in childbirth is indicated in studies with mice. (wikipedia.org)
The presence of surfactant protein A seemed to trigger an inflammatory response in the uterus of the mice, but later studies found an anti-inflammatory response in humans. (wikipedia.org)
2003). "Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A". J. Immunol. (wikipedia.org)
Surfactant recovered by alveolar wash from most mammals contains 70-80% phospholipids, 8-10% protein, and 10% neutral lipids, primarily cholesterol. (medscape.com)
Surfactant protein-D (SP-D) is a hydrophilic protein with multiple crucial anti-inflammatory and immunological functions. (bvsalud.org)
These findings help understanding the role of SP-D early in life and support further investigation about the role of SP-D in developing BPD.NEW & NOTEWORTHY Surfactant protein-D increases with gestational age and is inversely associated with BPD development. (bvsalud.org)
Surfactant protein SP-D, member of the front-line immune defense of the lungs, binds glycosylated structures on invading pathogens such as viruses to induce their clearance from the lungs. (bvsalud.org)

decreases were seen in tissues and mucosal secretions, critically decreasing potential for virus transmission. (cdc.gov)

Surfactant is a complex lipoprotein (see the image below) composed of six phospholipids and four apoproteins. (medscape.com)

Surfactant development - allows lung inflation and decreases the work of breathing and also related to immunology of the lungs. (edu.au)

Lysozyme, which is a hydrolytic enzyme found in tears and mucous secretions, can cleave the peptidoglycan layer of the bacterial cell wall thus lysing the microorganism. (brmi.online)

While the role of surfactant in the alveolar compartment has been intensively elucidated both in health and disease states, the possible role of surfactant in the airways requires further research. (biomedcentral.com)
The following sections review the potential role of surfactant in asthma. (biomedcentral.com)

Bar chart demonstrates the composition of lung surfactant. (medscape.com)
Genome-wide association studies and candidate gene approaches have identified a list of inherited mutations, which likely alter cytokine and interferon secretion, and lung-specific mechanisms of immunity in COVID-19. (nih.gov)
While surfactant was initially thought to be a key player in the biophysical behavior of the lung, today its immunomodulatory properties make surfactant a fascinating compound in innate and adaptive immunity of the lung. (biomedcentral.com)

In this issue of ATVB , Devaraj et al demonstrate that physiological concentrations of adiponectin suppress CRP synthesis and secretion in human aortic endothelial cells under hyperglycemic conditions. (ahajournals.org)

it also reaches terminal conducting airways and is present in upper airway secretions. (biomedcentral.com)
This review summarizes the current knowledge on surfactant functions regarding the airway compartment and highlights the impact of various surfactant components on allergic inflammation in asthma. (biomedcentral.com)
In the past decade, direct and indirect evidence has emerged for surfactant as a factor in the regulation of airway calibers and a modulator of allergic inflammation. (biomedcentral.com)
Electron microscopy has revealed that surfactant material forming monolayers and multilayers can be found at the air-liquid interface of the airway lumen. (biomedcentral.com)

Surfactant is a complex lipoprotein (see the image below) composed of six phospholipids and four apoproteins. (medscape.com)

Chest radiographs in a premature infant with respiratory distress syndrome before and after surfactant treatment. (medscape.com)

The major component of surfactant, dipalmitoyl-phosphatidylcholine (DPPC), is an amphiphatic phospholipid. (biomedcentral.com)

17,18 Adiponectin has also been shown to inhibit agonist-stimulated NF-κB signaling and suppress TNF-α secretion from a number of cell types including macrophages. (ahajournals.org)