• serum
  • Secretion of calcitonin is stimulated by: an increase in serum [Ca2+] gastrin and pentagastrin. (wikipedia.org)
  • Parathyroid hormone regulates serum calcium through its effects on bone, kidney, and the intestine: In bone, PTH enhances the release of calcium from the large reservoir contained in the bones. (wikipedia.org)
  • ovaries
  • Simple cuboidal epithelia are found on the surface of ovaries, the lining of nephrons, the walls of the renal tubules, and parts of the eye and thyroid. (wikipedia.org)
  • antidiuretic hormone
  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is characterized by excessive unsuppressible release of antidiuretic hormone (ADH) either from the posterior pituitary gland, or an abnormal non-pituitary source. (wikipedia.org)
  • increases
  • Appropriate ADH secretion is regulated by osmoreceptors on the hypothalamic cells that synthesize and store ADH: plasma hypertonicity activates these receptors, ADH is released into the blood stream, the kidney increases solute-free water return to the circulation, and the hypertonicity is alleviated. (wikipedia.org)
  • The results are decreased kidney reabsorption of glucose, glucosuria effect increases with higher level of glucose in the blood circulation. (wikipedia.org)
  • Membrane
  • The present study quantitatively evaluated the possible role of the transporters in such drug-drug interactions using human kidney slices and membrane vesicles expressing human ATP-binding cassette (ABC) transporters. (aspetjournals.org)
  • The first step in secretion, uptake of organic anions across the basolateral membrane of tubule cells, is mediated for the polyspecific organic anion transporter 1 (OAT1), which exchanges extracellular organic anions for intracellular α-ketoglutarate or glutarate. (springer.com)
  • uptake
  • The uptake of methotrexate by human kidney slices was saturable with a K m of 45 to 49 μM. (aspetjournals.org)
  • Saturable uptake of methotrexate by human kidney slices was markedly inhibited by p -aminohippurate and benzylpenicillin, but only weakly by 5-methyltetrahydrofolate. (aspetjournals.org)
  • NSAIDs and probenecid inhibited the uptake of methotrexate by human kidney slices, and, in particular, salicylate, indomethacin, phenylbutazone, and probenecid were predicted to exhibit significant inhibition at clinically observed plasma concentrations. (aspetjournals.org)
  • calcitriol
  • A third important effect of PTH on the kidney is its stimulation of the conversion of 25-hydroxy vitamin D into 1,25-dihydroxy vitamin D (calcitriol), which is released into the circulation. (wikipedia.org)
  • liver
  • We hypothesized that this aged flamingo developed articular gout over a period of time which led to severe amyloidosis in the kidney, liver and spleen. (askjpc.org)
  • In addition to liver, GNMT activity has been found in a number of other tissues including pancreas and kidney. (wikipedia.org)
  • Acute loin pain Haematuria Ballotable kidneys Sub arachnoid hemorrhage(berry aneurysm) Hypertension Associated liver cyst Uremia due to renal failure Anemia due to CKD Increase RBC or erythropoeitin secretion In many patients with ADPKD, kidney dysfunction is not clinically apparent until forty or fifty years of life. (wikipedia.org)
  • cells
  • KIDNEY: Multifocally, the renal architecture is disrupted by tubulocentric gouty tophi that are composed of an inner, radiating array of eosinophilic, acellular spicules surrounded by macrophages and multinucleated giant cells with few heterophils. (askjpc.org)
  • K+ is absorbed by the gastrointestinal tract and distributed rapidly, with a small amount taken up by cells and most excreted by the kidneys. (ukessays.com)
  • The presence of GNMT in these cells suggests that this enzyme may play a role in secretion. (wikipedia.org)
  • On these surfaces, the cells perform secretion and absorption. (wikipedia.org)
  • The calcitonin receptor, found on osteoclasts, and in the kidney and regions of the brain, is a G protein-coupled receptor, which is coupled by Gs to adenylate cyclase and thereby to the generation of cAMP in target cells. (wikipedia.org)
  • The enzyme renin is secreted by pericytes (mural cells) (1) in vicinity of the afferent arterioles and similar microvessels of the kidney from specialized cells of the juxtaglomerular apparatus-the juxtaglomerular cells, in response to three stimuli: A decrease in arterial blood pressure (that could be related to a decrease in blood volume) as detected by baroreceptors (pressure-sensitive cells). (wikipedia.org)
  • Renin is secreted from juxtaglomerular kidney cells, which sense changes in renal perfusion pressure, via stretch receptors in the vascular walls. (wikipedia.org)
  • Aldosterone has effects on most or all cells of the body but, clinically, the most important actions are in the kidney, on cells of the late distal convoluted tubule and medullary collecting duct. (wikipedia.org)
  • first with the interstitial fluid outside the tubules, and then into the plasma in the adjacent peritubular capillaries through the endothelial cells lining that capillary. (wikipedia.org)
  • hypothalamus
  • For example, the hormones controlling secretion from the anterior lobe of the pituitary gland are synthesized in the hypothalamus , but they are released into the local blood supply to the anterior pituitary, rather than entering the general circulation. (encyclopedia.com)
  • Mechanism
  • New Approaches to Inhibition of Gastric Acid Secretion: Development and Mechanism of Omeprazole. (ebooks.com)
  • Therefore, dapagliflozin reduces the blood glucose concentration with a mechanism that is independent of insulin secretion and sensitivity, unlike many other antidiabetic drugs. (wikipedia.org)
  • precursor
  • Human renin is secreted by at least 2 cellular pathways: a constitutive pathway for the secretion of the precursor prorenin and a regulated pathway for the secretion of mature renin. (wikipedia.org)
  • endocrine
  • Hormones are also produced by organs or tissues whose function is not primarily an endocrine one: the digestive tract, the heart, and the kidneys all produce hormones. (encyclopedia.com)
  • renin
  • The level of angiotensin II is regulated by angiotensin I, which is in turn regulated by renin, a hormone secreted in the kidneys. (wikipedia.org)
  • Renin (etymology and pronunciation), also known as an angiotensinogenase, is a serine protease protein and enzyme secreted by the kidneys that participates in the body's renin-angiotensin aldosterone system (RAAS)-also known as the renin-angiotensin-aldosterone axis-that mediates the volume of extracellular fluid (blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. (wikipedia.org)
  • This is the most direct causal link between blood pressure and renin secretion (the other two methods operate via longer pathways). (wikipedia.org)
  • Renin secretion is also stimulated by sympathetic nervous stimulation, mainly through beta-1 adrenergic receptor (β1 adrenoreceptor) activation. (wikipedia.org)
  • parathyroid
  • PTH essentially acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor, which is present at high levels in bone and kidney, and the parathyroid hormone 2 receptor, which is present at high levels in the central nervous system, pancreas, testis, and placenta. (wikipedia.org)
  • bone
  • The emphasis is on gastric acid secretion and the role of the H+, K+-ATPase, but molecular and cellular information on other P-, V- and F-type H+-ATPases, in bone, kidney, plants and yeast, as well as other cation ATPases, are included for important comparisons. (ebooks.com)
  • pancreatic
  • A few years later, in 1902, Bayliss and Starling, working in University College London, prepared an extract from the duodenum which stimulated secretion of pancreatic digestive juices when it was injected into the bloodstream. (encyclopedia.com)