Cell ProliferationCell DivisionCells, CulturedSignal TransductionCell Line, TumorApoptosisCell CycleCell DifferentiationRNA, MessengerCell LineBromodeoxyuridineBlotting, WesternImmunohistochemistryCell SurvivalMice, Inbred C57BLCell MovementLymphocyte ActivationReverse Transcriptase Polymerase Chain ReactionPhosphorylationDose-Response Relationship, DrugTumor Cells, CulturedProliferating Cell Nuclear AntigenEpithelial CellsTime FactorsGene Expression RegulationMice, KnockoutRNA, Small InterferingDown-RegulationKi-67 AntigenMolecular Sequence DataTransfectionGene Expression Regulation, NeoplasticGene ExpressionFlow CytometryCell Growth ProcessesT-LymphocytesUp-RegulationMice, TransgenicRats, Sprague-DawleyFibroblastsMice, Inbred BALB CStem CellsCyclin D1Mice, NudeTranscription FactorsRNA InterferenceThymidineEnzyme InhibitorsEnzyme ActivationCell CountProto-Oncogene Proteins c-aktBase SequenceMutationInsulinMuscle, Smooth, VascularBodily SecretionsAmino Acid SequenceModels, BiologicalCyclin-Dependent Kinase Inhibitor p27Secretory RateRecombinant ProteinsDNAHyperplasiaCell Transformation, NeoplasticBacterial Secretion SystemsExtracellular Signal-Regulated MAP KinasesIntestinal SecretionsGrowth InhibitorsCytokinesDNA-Binding ProteinsPhenotypeGene Knockdown TechniquesCell Cycle ProteinsDisease Models, AnimalMyocytes, Smooth MuscleMitogensMAP Kinase Signaling SystemProto-Oncogene ProteinsProtein-Serine-Threonine KinasesMitogen-Activated Protein Kinase 3Interleukin-2Gene Expression Regulation, DevelopmentalAntineoplastic AgentsTransforming Growth Factor betaProto-Oncogene Proteins c-mycRats, WistarMembrane ProteinsCyclin-Dependent Kinase Inhibitor p21EstradiolCell AdhesionProtein BindingMitogen-Activated Protein Kinase 1Growth SubstancesIntestinal MucosaLiverPhosphatidylinositol 3-KinasesEpitheliumBreast NeoplasmsKineticsTranscription, Genetic