Secretion calcium signaling. Medical search. Frequent questions

Most of the other pathways in this list rely on metabolic reactions for their initiation and termination, calcium differs in an important way from these other pathways in that as an inorganic cation, calcium can be neither created nor destroyed. (hstalks.com)
Calcium moves across the plasma membrane through pathways such as the plasma membrane calcium ATPase (PMCA), or the sodium calcium exchanger, these are important in expelling calcium from the cell. (hstalks.com)
Calcium can enter through pathways such as store-operated, voltage-operated, or receptor-operated calcium channels. (hstalks.com)
The molecular components of key Ca2+ signalling pathways have been identified. (hstalks.com)
Consequently our understanding of Ca2+ signalling is now advancing rapidly through experimental approaches that involve the controlled expression, inhibition of expression and use of naturally occurring or engineered mutations of channels, pumps, effectors and other proteins related to Ca2+ signalling pathways. (hstalks.com)
Early steps in this transition are complex, with at least 2 signaling pathways identified: 1 stops yeast growth and another, with a heat shock protein 70-type profile, initiates the assembly of proteins necessary for mycelial growth. (cdc.gov)
Yeast-form-specific genes identified in Histoplasma capsulatum function in calcium/calmodulin signaling pathways and sulphur metabolism. (cdc.gov)
Calcium-dependent signaling pathways and heat shock protein expression regulate dimorphism in Paracoccidioides brasiliensis and have broad implications for other pathogens. (cdc.gov)
Calcium is a major constituent of bones and teeth and also plays an essential role as second messenger in cell-signaling pathways. (oregonstate.edu)
CaR stimulation leads to the activation of multiple signal transduction pathways. (jneurosci.org)
We demonstrated that there is an important interferential crosstalk between the AhR and HIF-1α signaling pathways in murine and human CF, in that HIF-1α induction squelched the normal AhR response through an impaired formation of the AhR: ARNT/HIF-1ß heterodimer. (bvsalud.org)
Thus, our discovery of the role of functional interaction between intracellular signaling pathways mediated by calcium ions (Ca 2+) and cyclic adenosine monophosphate (cAMP) (Ca 2+ /cAMP signaling interaction) in these cellular responses, opened a great avenue for the development of new antitumor therapeutic strategies. (researchgate.net)
All these preliminary studies create a general hypothesis of some essential proteins and molecular pathways that are involved in 20E-regulated secretion. (unlv.edu)
Carsten, "Stimulatory pathways of the calcium-sensing receptor on acid secretion in freshly isolated human gastric glands," Cellular Physiology and Biochemistry, Vol. 19, No. 11, 2007, 33-42. (scirp.org)
However, the roles of Ca 2+ signaling pathways in bradyzoites remain largely unexplored. (wustl.edu)
WNT signal transduction is an elaborate and complex aggregation of signaling pathways that regulate a wide range of cellular functions during development and in adult organisms. (kjpp.net)
We use a number of model systems (pituitary cells, cell lines, transgenic animals) to study signal pathways for a hypothalamic peptide hormone, TRH, which acts via a G protein coupled receptor to increase cytoplasmic calcium and protein kinase C activity. (rochester.edu)
Stimulation of T cells through the T-cell receptor results in the activation of a series of signaling pathways that leads to the secretion of interleukin (IL)-2 and cell proliferation. (cdc.gov)

To put this signaling pathway into perspective, I really like this slide adapted from Sir Michael Berridge, which presents an inventory of the known intracellular signal transduction cascades. (hstalks.com)
In the human adrenal gland, serotonin (5-HT), released by subcapsular mast cells stimulates corticosteroid secretion through activation of type 4 serotonin receptors (5-HT4R) positively coupled to cAMP/proteine kinase A (PKA) signaling pathway and calcium influx. (endocrine-abstracts.org)
The ↑[Ca 2+ ] i activates a signaling cascade that involves, sequentially, calcium-calmodulin, nitric oxide synthase, guanylyl cyclase, and protein kinase G. This signal transduction pathway enables Cl − to pass through vesicular channels and act as a counterion for the transport of H + , so that the vesicles of secretogogue-stimulated cells become acidic. (jneurosci.org)
ROR2 functions primarily through the Wnt signaling pathway [ 12 ]. (oncotarget.com)
describes a novel signaling pathway involving Notch1 and its ligand, Δ-like ligand-4 (DLL4) in driving platelet activation and thrombus formation. (elifesciences.org)
The Wnt signaling pathway is highly conserved and crucial during embryonic development. (lu.se)
Activation of the non-canonical Wnt signaling pathway via Wnt5a has been correlated with increased migration and invasion as well as a poor prognosis in malignant melanoma patients. (lu.se)
These results suggest that Wnta1 increased the secretion of ANP and mechanical dynamics in beating rat atria by activation of PKC-TAK1-ATF2-TCF3/LEF1 and TCF4/LEF1 signaling mainly via the WNT/Ca2+ pathway. (kjpp.net)
After activation by phosphorylated DVL, the WNT/PCP pathway is mediated by signaling through the small GTPases RhoA and Rac and Rho-associated kinase (ROCK) or c-Jun N-terminal kinase. (kjpp.net)
In heart, Ca governs cardiomyocyte contraction, is central in electrophysiological properties, and controls major signaling pathway implicated in gene transcription. (escholarship.org)

This leads to the repetitive firing of action potentials that increases calcium influx and triggers insulin granule exocytosis. (nih.gov)
We also reviewed the literature concerning regulation of insulin secretion by channel activity and constructed a data-based computer model of human β cell function. (nih.gov)
On the basis of this model we employed computational simulations to better understand the behavior of action potentials, calcium handling and insulin secretion in human β cells under a wide range of experimental conditions. (nih.gov)
This computational system approach provides a framework to analyze the mechanisms of human β cell insulin secretion. (nih.gov)
In addition to demonstrating normal cell viability and islet morphology, post-cultured islets exhibited normal insulin secretion kinetics, intracellular calcium signaling, and changes in mitochondrial potentials in response to glucose challenge. (nih.gov)
Ca2+ signaling influences insulin secretion in beta cells so it is possible that these contacts might have an involvement in dysfunctional beta cells like diabetic beta cells. (howest.be)
The role these contacts have in insulin secretion is not known. (howest.be)
Calcium signaling influences insulin secretion among other things. (howest.be)
The insulin secretion of INS1 cells was also studied. (howest.be)
This project shows a tendency for higher insulin secretion when mitochondria are recruited to the endoplasmic reticulum when compared to cells where the mitochondria are not recruited to the ER. (howest.be)
This study shows that the amount of mitochondria-endoplasmic reticulum contacts does affect the calcium signaling and the insulin secretion. (howest.be)
Moreover, it shows that an increase in these contacts causes a decrease in calcium signaling spikes but an increase in its heights and an increase in insulin secretion. (howest.be)
Islet α-cells input is essential for insulin secretion from β-cells. (researchsquare.com)
Deficiency of 25(OH)D has been confirmed to affect the synthesis and secretion of insulin in both animal models and human studies 4− [4]. (researchsquare.com)
In vitro, 25(OH)D induces the biosynthesis of insulin and insulin secretion in rat pancreatic islet cells [ 5 , 6 ],[ 7 ] . (researchsquare.com)
Recently some studies reveal that α-cells lacking DBP secrete less glucagon in response to low glucose concentration despite vitamin D sufficiency[10], and glucagon has a physiologic role to activate β-cells and enhance insulin secretion especially in the fed state [ 11 ] . (researchsquare.com)
Similar strategies are being used to ask how insulin secretion by the pancreatic beta cell is controlled. (rochester.edu)
Joan Domingo-Espín J, Lindahl M, Nilsson-Wolanin O, Cushman S W, Stenkula K G, Lagerstedt J O. Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal. (lu.se)

As you can see, the calcium ion is highly represented, and in fact, this messenger is recycled for many different purposes to mediate the actions (for example) of G protein-coupled receptors, receptor tyrosine kinases, voltage-operated calcium channels, among others. (hstalks.com)
Considering vitamin D-binding proteins (DBP), which could bind and transport vitamin D to vitamin D receptor (VDR) in the nucleus, was highly present in human islet α-cells and also seen in islet β-cells, 25(OH)D may also contribute to glucagon secretion from α-cells. (researchsquare.com)
CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. (thermofisher.com)
In addition, we use biochemical and genetic approaches to identify proteins that interact with the receptor during biosynthesis, signaling and desensitization. (rochester.edu)
Hypoparathyroidism results from defective synthesis or secretion of parathyroid hormone (PTH), end-organ resistance, or inappropriate regulations that result from the activated or antibody-stimulated calcium-sensing receptor (CaSR). (medscape.com)
Production and secretion of PTH are regulated by a G protein-coupled calcium-sensing receptor. (medscape.com)
Genetically inherited forms arise from defects of parathyroid gland development, defects in the parathyroid hormone (PTH) gene, defects in the calcium-sensing receptor gene, defects in PTH action, defects in the autoimmune regulator gene, and genetic syndromes. (medscape.com)

More recently I have collaborated with collegues in the Physics and Engineering departments (Lancaster University and Warwick Uinversity) to investigate the role of transmembrane voltage in signal transduction and the physical origins of selectivity of ion channel. (lancs.ac.uk)
Cytosolic Ca 2+ has been established as a ubiquitous intracellular signal molecule, essential for the transduction of a wide variety of environmental stimuli in eukaryotic cells. (lancs.ac.uk)
However, despite a strong body of evidence showing key roles for Ca 2+ signal transduction in filamentous fungi, our understanding of Ca 2+ signalling in these organisms is not well developed. (lancs.ac.uk)
The long-term goal is to understand signal transduction in endocrine cells at a molecular and cellular level. (rochester.edu)

read more keep the cytoplasmic calcium ([Ca2+]c) low and then allow selective increases in [Ca2+]c by stimulating either Ca2+ release from the cells' internal Ca2+ stores or the influx of Ca2+ from the extracellular environment. (hstalks.com)
Calcium efflux from the endoplasmic reticulum as well as influx from the extracellular medium gets triggered when the plasma membrane of the cell is depolarized. (howest.be)
One popular model for the activation of store-operated Ca2+ influx is the secretion-like coupling mechanism, in which peripheral endoplasmic reticulum moves to the plasma membrane upon store depletion thereby enabling inositol 1,4,5-trisphosphate (InsP3) receptors on the stores to bind to, and thus activate, store-operated Ca2+ channels. (ox.ac.uk)
Our findings demonstrate that the cytoskeleton does not seem to regulate calcium influx and that functional InsP3 receptors are not required for activation of I(CRAC). (ox.ac.uk)
The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates. (thermofisher.com)
Influx of calcium (Ca2+) from the extracellular environment, following internal Ca2+ store depletion, provides the elevated and sustained intracellular calcium concentration ([Ca2+](i)) critical for optimal T-cell activation. (cdc.gov)

Calcium: Eating cheese supplies plenty of calcium which supports bone health, muscle contraction, nerve signaling, and hormone secretion. (eatforlonger.com)

Also, significant discoveries including new embryological molecular genetic transcription factors, the role of active placental mineral transport, and hormone regulation factors have changed the understanding of calcium and phosphate homeostasis in the fetus and the newborn. (frontiersin.org)
Current available data suggest that adequate calcium intakes may play a role in body weight regulation and have therapeutic benefits in the management of moderate-to-severe premenstrual symptoms. (oregonstate.edu)
Mitochondrial-endoplasmic reticulum contacts are connections between mitochondria and the endoplasmic reticulum that play a key role in the regulation of lipid synthesis, Ca2+ signaling, intracellular trafficking and the control of mitochondrial biogenesis. (howest.be)
The effect of WNT signaling on regulation of atrial natriuretic peptide (ANP) secretion is unclear. (kjpp.net)
Calcium (Ca) is a universal second messenger involved in the regulation of various cellular processes, including electrical signaling, contraction, secretion, memory, gene transcription, and cell death. (escholarship.org)
In this review, we summarize recent findings on nuclear Ca regulation and its downstream signaling in cardiomyocytes. (escholarship.org)

So in response to high glucose level or in type 2 diabetes, how 25(OH)D impact glucagon secretion from islet α-cells as well as the islet function homeostasis between islet α-cells and β-cells should be elucidated, which can provide new strategies for treating glucose metabolism disorders. (researchsquare.com)

We monitor intracellular calcium in the cytoplasm and the endoplasmic reticulum using several fluorescence imaging techniques. (rochester.edu)

Although both the synthesis and secretion of glue is regulated by the major steroid hormone in insects, 20-hydroxyecdysone (20E), my work is mostly focused on the 20E stimulated secretion of that glue that occurs at the end of the instar. (unlv.edu)

Dr. Brandon Berry studied mitochondrial bioenergetics and hypoxic signaling in the laboratory of Dr. Andrew Wojtovich. (rochester.edu)

However, an interesting corollary of these plasma membrane fluxes is that they can potentially lead to significant alterations in local calcium concentration at the extracellular face of the cell. (hstalks.com)
Ca2+ signals are attenuated by sequestration of Ca2+ into intracellular organelles that function as Ca2+ stores or by the expulsion of Ca2+ back across the plasma membrane. (hstalks.com)
A 30mM potassium buffer is used to depolarize the plasma membrane and thus induce calcium signaling. (howest.be)

Also inhibits the secretion of pancreatic polypeptide . (wikipedia.org)
In contrast, the phorbol downregulation-resistant component of secretion was abolished by pseudoZ, which inhibits the atypical PKCζ. (jneurosci.org)
3,4-Dichloropropionanilide (DCPA) inhibits T-cell activation by altering the intracellular calcium concentration following store depletion. (cdc.gov)
Our laboratory has documented that exposure to the herbicide 3,4-dichloropropionanilide (DCPA) inhibits intracellular signaling events that have one or more Ca2+ dependent steps. (cdc.gov)

The Wnt family encodes a large group of signaling molecules that are involved in cell proliferation, differentiation, migration and apoptosis [ 13 , 14 ]. (oncotarget.com)
New antitumor strategies using drugs targeted to intracellular signaling involved in cell proliferation and survival, angiogenesis, and metastasis have become promising in recent years. (researchgate.net)

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) involves the continued secretion or action of arginine vasopressin (AVP) despite normal or increased plasma volume. (medscape.com)
Circulating calcium concentrations are tightly controlled by the parathyroid hormone (PTH) and vitamin D at the expense of the skeleton when dietary calcium intakes are inadequate. (oregonstate.edu)
A slight drop in blood calcium concentration (e.g., in the case of inadequate calcium intake) is sensed by the parathyroid glands , resulting in their increased secretion of parathyroid hormone (PTH). (oregonstate.edu)
It is also involved in muscle function, nerve transmission, and hormone secretion. (total-health-care.com)
Calcium also plays a role in hormone secretion, helping to regulate various physiological processes. (total-health-care.com)
Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. (bvsalud.org)

How cardiomyocytes decode Ca signal to regulate gene expression without interfering with, or being controlled by, "contractile" Ca that floods the entire cytosol during each heartbeat is still elusive. (escholarship.org)
In addition to supporting bone health, calcium helps regulate blood pressure and prevent conditions like osteoporosis. (total-health-care.com)
This vitamin helps regulate the absorption of calcium and phosphorus, ensuring that they can be properly utilized for bone health. (total-health-care.com)

The major function of the larval salivary gland is the production and eventual secretion of a mix of highly glycosylated mucin proteins called glue. (unlv.edu)
To create a solid foundation for examining exocrine secretion in the salivary gland, I began by characterizing the structure and organization of the wild type salivary gland during its response to 20E. (unlv.edu)

A similar reduction of ↑[Ca 2+ ] e -evoked secretion was produced by inhibitors of conventional and/or novel PKCs (Gö6976, calphostin C, and pseudoA), and these compounds did not inhibit secretion at all when applied to phorbol-downregulated cells. (jneurosci.org)
Functional studies show that SFRP3 can inhibit Wnt5a signaling and induce a decrease in migration and invasion. (lu.se)
PTH acts directly on the kidney to decrease calcium clearance and to inhibit phosphate reabsorption. (medscape.com)

Excerpt: "Our findings that DCs primarily express the RyR1 channel complex and that this complex is uncoupled by very low levels of THI with dysregulated IL-6 secretion raise intriguing questions about a molecular basis for immune dyregulation and the possible role of the RyR1 complex in genetic susceptibility of the immune system to mercury. (blogspot.com)
The application of molecular biology to Ca2+ signalling research has also opened new avenues of investigation. (hstalks.com)
I chose to further focus on three well-known molecular families that drive secretory events: Rab GTPases, myosin motor proteins, and calcium transporters. (unlv.edu)
Lastly, I explored, to a lesser extent, the role of other molecular families suspected to be involved in exocrine secretion. (unlv.edu)
The Rajan lab (Basic Sciences Division) is interested in the molecular mechanisms underlying this hormonal signaling between fat cells and the brain using the fruit fly as a model organism. (fredhutch.org)
In previous work, the Rajan lab discovered how fat cells secrete the appropriate amount of fat hormones depending on nutrient state and uncovered a molecular mechanism that links dysfunctional calcium homeostasis to obesity. (fredhutch.org)
Using behavioral analysis of mice, we aim to characterize molecular signaling cascades underlying hippocampus-dependent spatial learning (Morris water maze, novel object recognition tests) and amygdala-, hippocampus- and cortex- dependent fear learning as well as fear extinction. (circprot.eu)

It is described as a housekeeping enzyme, being responsible for cell-to-cell signaling, tissue homeostasis, and cytoprotection. (medscape.com)

One of the main reasons for this is our current ignorance of Ca 2+ -permeable channel activity (which is responsible for mediating cytosolic Ca 2+ signalling events) in filamentous fungi. (lancs.ac.uk)

All of this transport activity is, of course, exceedingly important in shaping the intracellular calcium signal. (hstalks.com)

ABSTRACT: Background: Among anti-hypertension drugs, calcium (Ca2+) antagonists cause gingival overgrowth as a side effect. (scirp.org)

So it's powerful signaling actions can only be controlled by moving the calcium ion about in different locations inside and outside the cell, or by temporarily buffering it. (hstalks.com)
In today's talk, I'm going to discuss the emerging idea that these calcium fluctuations outside the cell may serve as signals in their own right. (hstalks.com)
Calcium (Ca2+) plays a major role in controlling cell function. (hstalks.com)
Ca2+ signals can be complex with some involving periodic oscillations of varying frequencies or responses that are restricted to specific regions of the cell. (hstalks.com)
In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of the cell cycle and cell growth . (wikipedia.org)
Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. (elifesciences.org)
IP3 receptors play an important role in intracellular Ca2+ signaling in a variety of cell types. (novusbio.com)
His work involved developing a mathematical model to understand how cell calcium signalling drives saliva secretion in parotid epithelia. (systems-mechanobiology.com)
Activation of Wnt5a signaling in melanoma cell lines resulted in a pro-tumorigenic effect by favoring aerobic glycolysis. (lu.se)
Calcium ion (Ca 2+ ) signaling tightly regulates the lytic cycle of tachyzoites by controlling microneme secretion and motility to drive egress and cell invasion. (wustl.edu)
For example, we can 'tag' signaling proteins with green fluorescent protein (GFP) and then follow their movements in the cell during hormonal stimulation in real time. (rochester.edu)

This homeostatic behavior is coordinated by adipokines, signaling molecules released by fat cells to energy-store responsive neurons. (fredhutch.org)

Evidences suggest that Ca 2+ channels TRP and Orai participate in the intracellular Ca 2+ signaling involved the physiological angiogenesis processes [17]. (researchgate.net)
This work is taking advantage of recent developments in fungal genomics, initially leading to the identification of a number of candidate genes that are likely to encode Ca 2+ permeable ion channels (and thus play key roles in Ca 2+ signalling) in the model filamentous fungus, Aspergillus nidulans. (lancs.ac.uk)

RANK Ligand, a TNF family member produced by both T cells and osteoblasts, is a differentiation and activation signal for osteoclasts. (ouhsc.edu)

Welcome to this lecture on extracellular calcium signaling. (hstalks.com)
Calcium concentrations in the blood and fluid surrounding the cells ( extracellular fluid ) must be maintained within a narrow concentration range for normal physiological functioning. (oregonstate.edu)

Passive and active transport of bone-minerals occurs across the placenta to achieve higher fetal concentration of calcium, phosphate, and magnesium compared to maternal levels. (frontiersin.org)
A spiking pattern can be seen because the concentration of calcium changes rapidly. (howest.be)
We previously discovered that this side effect was due to elevation of the calcium concentration in the cytosol ([Ca2+]i). (scirp.org)
PTH secretion by the parathyroid glands (prime regulators of serum calcium concentration) maintains serum calcium within a strict range. (medscape.com)

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) are benign adrenocortical disease responsible for benign tumors and cortisol autonomous secretion. (endocrine-abstracts.org)
Excess levels of calcium can increase the risk for heart disease, kidney stones, and possibly colon cancer. (betternutrition.com)
Aberrant Wnt signaling is important in several different disease processes. (lu.se)
Elevated levels of the transaminases can signal myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. (cdc.gov)
Calcium measurements are used in the diagnosis and treatment of parathyroid disease, bone diseases, chronic renal disease and tetany. (cdc.gov)

Growing evidence has suggested a possible relationship between dietary calcium intake and metabolic syndrome (MetS) risk. (nature.com)
The nocturnal plasma melatonin signal is conserved in essentially all vertebrates and is accessed not just for reproductive rhythms, but for seasonal cycles of metabolic activities, immune functions, and behavioral expression. (frontiersin.org)

Development of dual-reporter parasites revealed dampened Ca 2+ responses and minimal microneme secretion by bradyzoites induced in vitro or harvested from infected mice and tested ex vivo. (wustl.edu)
Differential responses of murine alveolar macrophages to elongate mineral particles of asbestiform and non-asbestiform varieties: Cytotoxicity, cytokine secretion and transcriptional changes. (cdc.gov)

The bone minerals calcium, phosphate and magnesium are all maintained at higher concentrations in utero to achieve adequate bone accretion. (frontiersin.org)
This article will guide clinicians through an updated review of calcium and phosphate physiology, then review specific conditions pertinent to successful neonatal care. (frontiersin.org)
4. A thorough understanding of the topic is essential to correct diagnosis and treatment of disorders of calcium and phosphate in the newborn. (frontiersin.org)
The net effects of PTH activity are an increase in serum calcium and a decrease in serum phosphate. (medscape.com)
PTH acts directly on bone to stimulate bone resorption and cause calcium and phosphate release. (medscape.com)
By stimulating renal 1-alpha-hydroxylase activity, PTH increases serum concentrations of 1,25-dihydroxyvitamin D, the active form of vitamin D and, thus, indirectly stimulates calcium and phosphate absorption by the gut through the actions of vitamin D. The phosphaturic effect of PTH offsets the increases of serum phosphate driven by increased bone resorption and GI absorption. (medscape.com)
Calcium and phosphate release from bone is impaired, calcium absorption from the gut is limited, calciuria develops despite hypocalcemia, and retention of phosphate from the urine causes increased plasma phosphate levels. (medscape.com)

Specifically, they identified a mechanism coupling systemic energy sensing to adipokine secretion via intracellular calcium (Ca 2+ ) signaling and found it to be evolutionarily conserved between Drosophila and humans. (fredhutch.org)

There is a reciprocal relationship between serum calcium and inorganic phosphorus. (cdc.gov)
Any increase in the level of inorganic phosphorus causes a decrease in the calcium level by a mechanism not clearly understood. (cdc.gov)

Platelet aggregation, granule secretion and platelet-leukocyte interaction were analyzed by lumi-aggregometry and flow cytometry. (elifesciences.org)

Gottschalk M, Troprès I, Lamalle L, Grand S, Le Bas JF, Segebarth C. Refined modelling of the short-T2 signal component and ensuing detection of glutamate and glutamine in short-TE, localised, (1) H MR spectra of human glioma measured at 3 T. NMR Biomed. (lu.se)

serum calcium concentrations decrease rapidly, and PTH secretion is triggered. (medscape.com)
Histamine also helps signal the body to produce stomach acid, which is why a certain type of antihistamine, called a histamine-2 blocker, is used to decrease stomach acid. (msdmanuals.com)

The skeleton is a reserve of calcium drawn upon to maintain normal serum calcium in case of inadequate dietary calcium. (oregonstate.edu)
Unlike other protein hormones, its production and secretion are stimulated by decreased intracellular calcium concentrations, which reflect serum calcium concentrations. (medscape.com)

Existence of functional Notch signaling in enucleate platelets remains elusive. (elifesciences.org)

Collectively, our findings indicate that intracellular bradyzoites exhibit dampened Ca 2+ signaling and lower energy levels that restrict egress, and yet upon release they rapidly respond to changes in the environment to regain motility. (wustl.edu)

We tested the hypothesis that protein kinase C (PKC) participates in stimulus-secretion coupling. (jneurosci.org)
moreover, PI3′-kinase inhibitors (wortmannin and LY294002) antagonized secretion. (jneurosci.org)
these effects were blocked by U73122, an antagonist of phospholipase C. U73122 also abolished the effects of Wnta1-mediated upregulation of protein kinase C (PKC) β and γ expression, and the PKC antagonist Go 6983 eliminated Wnta1-induced secretion of ANP. (kjpp.net)

This discovery provided new insight as to why fetal PTH levels were so low, yet fetal calcium levels were maintained higher than and independent of maternal calcium concentrations. (frontiersin.org)
Fetal blood calcium concentrations are maintained ~0.3-0.5 mmol/L higher than in maternal circulation, with the placenta transporting 100-150 mg/kg/day of calcium during the third trimester ( 4 - 6 ). (frontiersin.org)
High concentrations of calcium and oxalate in the urine are major risk factors for the formation of calcium oxalate stones in the kidneys. (oregonstate.edu)
Hypercalcemia, a condition of abnormally high concentrations of calcium in blood, is usually due to malignancy or primary hyperparathyroidism . (oregonstate.edu)
The physiological functions of calcium are so vital to survival that the body will stimulate bone resorption (demineralization) to maintain normal blood calcium concentrations when calcium intake is inadequate. (oregonstate.edu)
Calcium concentrations in the blood and fluid that surround cells are tightly controlled in order to preserve normal physiological function. (oregonstate.edu)

This thesis highlights the complexity of Wnt signaling in general and Wnt5a signaling in melanoma in particular and extends our knowledge of the mechanisms behind progression of malignant melanoma. (lu.se)

These two nutrients play crucial roles in supporting various bodily functions, including bone health, immune system function, and nerve signaling. (total-health-care.com)

Calcium is not only important for bone health but also for several other bodily functions. (total-health-care.com)

whereas, calcium transporters are required for the rapid Ca2+ elevations needed to sustain the response. (unlv.edu)
These protein families contain a large number of members, so the purpose of this study is to identify and define the function of the Rab GTPase(s), myosin motor(s), and calcium transporters that are regulated by 20E and are needed for the secretion of glue. (unlv.edu)

Taken together these data suggests that, in melanoma, an altered Wnt5a signal can induce different pro-tumorigenic effects. (lu.se)

In 2001, we first visualized postsynaptic secretion of BDNF in response to synaptic stimulation. (circprot.eu)
Since then, our lab was strongly involved in investigating the role that synaptic BDNF secretion plays in regulating synaptic plasticity and memory formation. (circprot.eu)

It is also suggested that WNT-ANP signaling is implicated in cardiac physiology and pathophysiology. (kjpp.net)

Organic acid secretion from higher plant roots and fungi into the soil solution plays an important role in nutrient acquisition and metal ion detoxification. (lancs.ac.uk)
WNT signaling plays an important role in cardiac development, but abnormal activity is often associated with cardiac hypertrophy, myocardial infarction, remodeling, and heart failure. (kjpp.net)
Calcium is an essential mineral that plays a crucial role in maintaining strong and healthy bones. (total-health-care.com)

Lumenal ER calcium depletion caused rapid oligomerization of mammalian BiP and a coincidental diminution in substrate binding, pointing to the relative inertness of the oligomers. (elifesciences.org)
DCPA did not alter the depletion of internal Ca2+ stores when stimulated by anti-CD3 or thapsigargin demonstrating that early inositol 1,4,5-triphosphate-mediated signaling and depletion of Ca2+ stores were unaffected. (cdc.gov)

Using the stress-induced dry-eye model mice, it was confirmed that acetylcholine with three fatty acids (10-hydroxydecanoic acid, 8-hydroxyoctanoic acid, and (R)-3,10-dihydroxydecanoic acid) was essential for tear secretion. (inrae.fr)

Signaling is induced through binding of five independent ligands, Delta-like ligands (DLL)-1, 3, 4 and Jagged (Jag)-1 and -2 ( Kopan and Ilagan, 2009 ), to four isoforms of cognate Notch receptors, Notch1 to Notch4, on surface of adjacent cells. (elifesciences.org)
Furthermore, we discovered that calcium-sensing receptors (CaSRs) participate in nifedipine-induced [Ca2+]i elevation. (scirp.org)

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