• PilQ
  • The secretin complex of Thermus thermophilus is an oligomer of the 757-residue PilQ protein, essential for DNA uptake and pilus extrusion. (elifesciences.org)
  • showed the overall structure of the secretin domain of PilQ from Pseudomonas aeruginosa at intermediate resolution. (elifesciences.org)
  • A crown-like density outside the OM was unaccounted for by the molecular model of PilQ and represents an unidentified DNA translocator component essential for the function of the secretin in natural transformation. (elifesciences.org)
  • physiological
  • An intravenous infusion of highly purified secretin caused a release of insulin when the serum secretin levels were within the physiological range.Infusion of hydrochloric acid into the duodenum caused an elevation of serum secretin and serum insulin levels in normal subjects. (garvan.org.au)
  • serum
  • Serum secretin levels rose rapidly after the oral ingestion of glucose or protein and preceded the elevation of serum insulin. (garvan.org.au)
  • Autism
  • The purpose of the study is to determine whether multiple doses of secretin are safe and effective in the treatment of children with autism. (clinicaltrials.gov)
  • Horvath originally became interested in the possible link between secretin and autism after being contacted by Victoria Beck, who brought in her autistic son, Parker, to see Horvath in April 1996. (wikipedia.org)
  • Nevertheless, Mrs. Beck then became convinced that secretin was an effective autism treatment, and therefore contacted Bernard Rimland to tell him about her experience. (wikipedia.org)
  • Sokolski had become intrigued by watching videotapes of Parker seemingly showing his behavior improving greatly after receiving secretin, and persuaded a California gastroenterologist to administer some to his own son, Aaron (who had autism). (wikipedia.org)
  • As a result of this research, the University of Maryland (where Horvath was working at the time) filed a patent application for the use of secretin to treat autism, but ended up giving the rights to the patent to Beck, since she was the first to suspect that secretin might be an effective autism treatment. (wikipedia.org)
  • That same year, researchers from the University of North Carolina, led by Adrian Sandler, published a randomized trial in which they reported that secretin was no more effective as an autism treatment than a placebo. (wikipedia.org)
  • However, a study by researchers from the University of Chicago also concluded that secretin was not an effective autism treatment, and a total of 15 studies, performed after Sandler's study, arrived at the same conclusion. (wikipedia.org)
  • In addition to his research on secretin and autism, Horvath is well known for his research into, and advocacy for awareness of, celiac disease. (wikipedia.org)
  • Mutations
  • Mutations in the secretin domain disrupted the crown and abolished DNA uptake, suggesting a central role of the crown in natural transformation. (elifesciences.org)
  • By contrast, a form of the secretin receptor containing a pair of mutations on the lipid-facing side of transmembrane domain IV was almost entirely monomeric. (biochemj.org)
  • pentagastrin
  • Exogenous secretin inhibited pentagastrin-stimulated acid and pepsin output from both the main stomach and Heidenhain pouch in infected as well as in the uninfected dogs. (ajtmh.org)
  • A similar response of secretin and insulin was seen after intravenous infusion of pentagastrin even when the acid stimulus to the duodenum was prevented. (garvan.org.au)
  • Diagnosis
  • The preliminary diagnosis results based on standard investigations with and without inclusion of secretin MRCP will be compared to the true diagnosis. (clinicaltrials.gov)
  • protein
  • The OM-embedded C-terminal secretin domain likely provides an aperture for DNA and protein translocation through the OM, connecting the periplasm to the extracellular environment. (elifesciences.org)
  • Previous studies have indicated that the G protein-coupled secretin receptor is present as a homo-dimer, organized through symmetrical contacts in transmembrane domain IV, and that receptor dimerization is critical for high potency signalling by secretin. (biochemj.org)
  • We used measures of quantal brightness of the secretin receptor tagged with monomeric enhanced green fluorescent protein (mEGFP) and Spatial Intensity Distribution Analysis to assess this. (biochemj.org)
  • Down-regulation of the secretin receptor-interacting G protein Gα s did not alter receptor organization, indicating that dimerization is defined specifically by direct protein-protein interactions between copies of the receptor polypeptide, whilst short term treatment with secretin had no effect on organization of the wild type receptor but increased the dimeric proportion of the mutated receptor variant. (biochemj.org)
  • namely
  • Dr. Sokolski came to a similar conclusion with regard to his son as Mrs. Beck had with regard to hers, namely that while, prior to Aaron receiving secretin, "You couldn't get Aaron to look at you at all," that after just one dose, "[Aaron] looked right in the therapist's eyes. (wikipedia.org)
  • sequence
  • The sequence of amino acids in secretin is H- His - Ser - Asp - Gly - Thr - Phe - Thr - Ser - Glu - Leu - Ser - Arg - Leu - Arg - Asp - Ser - Ala - Arg - Leu - Gln - Arg - Leu - Leu - Gln - Gly - Leu - Val -NH 2 . (wikipedia.org)
  • equivalent
  • Equivalent studies showed that at moderate expression levels the secretin receptor exists as a mixture of monomeric and dimeric forms, with little evidence of higher-order complexity. (biochemj.org)
  • study
  • 100 patients suspected with AIP will be consented to participate in the study to undergo secretin MRCP in addition to their other standard investigations. (clinicaltrials.gov)