• synthetic
  • The patients will be subjected to MRI and MRCP with the MRCP performed in two stages namely before injection of secretin and after intravenous injection of 0.4mcg/Kg of synthetic human secretin (CHIROSTIM, Human Secretin, CHIRHOCLIN Inc., Burtonsville, MD). All the subjects will be given 3 cups (approximately 500-600cc) of pineapple juice 5-10 minutes before the imaging procedure. (clinicaltrials.gov)
  • To examine the effect of a single dose of human synthetic secretin (HSS) on behaviour and communication in children with autism spectrum disorder (ASD) using an objective measure of communication and social reciprocity and standardised rating scales. (bmj.com)
  • Randomised, crossover, double blind, and placebo controlled trial of a single intravenous dose of human synthetic secretin (HSS) 2 CU/kg. (bmj.com)
  • Autism
  • The purpose of the study is to determine whether multiple doses of secretin are safe and effective in the treatment of children with autism. (clinicaltrials.gov)
  • He is best known for proposing a link between secretin, gastrointestinal disorders and autism and for, as a result, proposing that secretin might be an effective treatment for autism. (wikipedia.org)
  • Horvath originally became interested in the possible link between secretin and autism after being contacted by Victoria Beck, who brought in her autistic son, Parker, to see Horvath in April 1996. (wikipedia.org)
  • Nevertheless, Mrs. Beck then became convinced that secretin was an effective autism treatment, and therefore contacted Bernard Rimland to tell him about her experience. (wikipedia.org)
  • Sokolski had become intrigued by watching videotapes of Parker seemingly showing his behavior improving greatly after receiving secretin, and persuaded a California gastroenterologist to administer some to his own son, Aaron (who had autism). (wikipedia.org)
  • As a result of this research, the University of Maryland (where Horvath was working at the time) filed a patent application for the use of secretin to treat autism, but ended up giving the rights to the patent to Beck, since she was the first to suspect that secretin might be an effective autism treatment. (wikipedia.org)
  • That same year, researchers from the University of North Carolina, led by Adrian Sandler, published a randomized trial in which they reported that secretin was no more effective as an autism treatment than a placebo. (wikipedia.org)
  • However, a study by researchers from the University of Chicago also concluded that secretin was not an effective autism treatment, and a total of 15 studies, performed after Sandler's study, arrived at the same conclusion. (wikipedia.org)
  • In addition to his research on secretin and autism, Horvath is well known for his research into, and advocacy for awareness of, celiac disease. (wikipedia.org)
  • 1905
  • They called this substance secretin and Starling proposed that the body produces many secretin-like molecules, and in 1905 proposed that these substances should be called hormones. (wikipedia.org)
  • gastrointestinal
  • The paper stated that these three children had undergone upper gastrointestinal endoscopy with intravenous secretin administration, and that, subsequently, the children's gastrointestinal and behavioral symptoms had both improved significantly. (wikipedia.org)
  • acid
  • Secretin is initially synthesized as a 120 amino acid precursor protein known as prosecretin. (wikipedia.org)
  • This precursor contains an N-terminal signal peptide, spacer, secretin itself (residues 28-54), and a 72-amino acid C-terminal peptide. (wikipedia.org)
  • Secretin also has an amidated carboxyl-terminal amino acid which is valine. (wikipedia.org)
  • Exogenous secretin inhibited pentagastrin-stimulated acid and pepsin output from both the main stomach and Heidenhain pouch in infected as well as in the uninfected dogs. (ajtmh.org)
  • Johnson LR, Grossman MI: Secretin: The enterogastrone released by acid in the duodenum. (springer.com)
  • Diagnosis
  • The preliminary diagnosis results based on standard investigations with and without inclusion of secretin MRCP will be compared to the true diagnosis. (clinicaltrials.gov)
  • namely
  • Dr. Sokolski came to a similar conclusion with regard to his son as Mrs. Beck had with regard to hers, namely that while, prior to Aaron receiving secretin, "You couldn't get Aaron to look at you at all," that after just one dose, "[Aaron] looked right in the therapist's eyes. (wikipedia.org)
  • protein
  • Previous studies have indicated that the G protein-coupled secretin receptor is present as a homo-dimer, organized through symmetrical contacts in transmembrane domain IV, and that receptor dimerization is critical for high potency signalling by secretin. (biochemj.org)
  • We used measures of quantal brightness of the secretin receptor tagged with monomeric enhanced green fluorescent protein (mEGFP) and Spatial Intensity Distribution Analysis to assess this. (biochemj.org)
  • Down-regulation of the secretin receptor-interacting G protein Gα s did not alter receptor organization, indicating that dimerization is defined specifically by direct protein-protein interactions between copies of the receptor polypeptide, whilst short term treatment with secretin had no effect on organization of the wild type receptor but increased the dimeric proportion of the mutated receptor variant. (biochemj.org)
  • equivalent
  • Equivalent studies showed that at moderate expression levels the secretin receptor exists as a mixture of monomeric and dimeric forms, with little evidence of higher-order complexity. (biochemj.org)
  • Treatment
  • Compared with placebo, secretin treatment was not associated with significant improvement of CSBS standard scores from baseline to 2 or 4 weeks post-infusion. (bmj.com)
  • sequence
  • The sequence of amino acids in secretin is H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2. (wikipedia.org)
  • study
  • 100 patients suspected with AIP will be consented to participate in the study to undergo secretin MRCP in addition to their other standard investigations. (clinicaltrials.gov)