Secrete host parasite interactions. Medical search. Frequent questions

Every year up to 500 million people around the world are infected with Plasmodium falciparum - the parasite that causes malaria - and around 1/2 million people will die from the disease. (gulbenkian.pt)
Toxoplasma and Plasmodium falciparum are two distantly related eukaryotic, single cell parasites of humans and animals that live and replicate in cells of their eukaryotic host. (gulbenkian.pt)
Despite its epidemiological importance, few antigens from this parasite species have been characterized to date compared to Plasmodium falciparum , due in part to the difficulties of maintaining an in vitro culture of P. vivax . (biomedcentral.com)
Given that cholesterol is an important nutrient for malaria parasites, we examined whether APOE Ɛ4 was a risk factor for Plasmodium infection, in terms of prevalence or parasite density. (edu.au)
Median parasite densities were significantly higher in APOE Ɛ4 children for Plasmodium spp. (edu.au)
These findings have significance for understanding host determinants of regulation of malaria parasite density, the design of clinical trials as well as studies of co-infection with Plasmodium and other pathogens. (edu.au)
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
This work identifies Drosophila S2 cells as a clinically-relevant platform suited for the production of 'difficult-to-make' proteins from Plasmodium parasites, and identifies a PfRH5 sequence variant that can be used for clinical production of a non-glycosylated, soluble full-length protein vaccine immunogen. (nature.com)
Plasmodium falciparum parasites are the causative agent of the most severe form of human malaria, and the development of an effective vaccine remains a key strategic goal to aid the control, local elimination and eventual eradication of this disease. (nature.com)
Malaria is caused by infections with the parasite Plasmodium that undergoes a complex life cycle within its hosts. (elifesciences.org)
The parasites we work with, Plasmodium falciparum and Toxoplasma gondii both evolved to excel at infecting and modifying host cells and a huge proportion of the proteins important for these processes are poorly characterized. (treecklab.org)
Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver stages and the disease-causing blood stages of the human malaria parasite Plasmodium falciparum . (nature.com)

These results show that the APOE Ɛ4 allele is associated with higher median malaria parasite densities in children likely due to the importance of cholesterol availability to parasite growth and replication. (edu.au)
I spent my PhD thesis at the Bernhard-Nocht Institute for Tropical Medicine in Hamburg, Germany, studying protein trafficking and invasion of red blood cells by the malaria parasite. (treecklab.org)
Stephanie completed her PhD in David Baker's lab at the London School of Hygiene & Tropical Medicine, where she worked on cyclic nucleotide signalling and molecular motor function in the malaria parasite. (treecklab.org)

Pra1 is a cell surface protein with a single N-terminal TMS involved in the host-parasite interaction during candidal infection. (tcdb.org)
For the host species Gammarus balcanicus, we also analyzed whether parasites were in excess in females to test for sex ratio distortion in relation with Nosema infection. (bvsalud.org)
Infection with another parasite, Toxoplasma gondii , is less dangerous but more widespread, infecting up to a third of the world's population. (gulbenkian.pt)
The group is using a range of lab techniques to identify and study the genes and molecules in parasites and in human cells, so that it can build a detailed picture of how they interact together during infection. (gulbenkian.pt)
By knowing more about the intricate details of parasite infection, the lab hopes to find new approaches for tackling these devastating and widespread diseases. (gulbenkian.pt)
Infection of the host is dependent on the secretion of a specific set of these peptidases. (biomedcentral.com)
In this study we explore the possibility that host phenotypic changes are triggered by the production of mimicry proteins from the parasite by using an ecological model system consisting of the infection of the threespine stickleback (Gasterosteus aculeatus) by the cestode Schistocephalus solidus. (aber.ac.uk)
You can have a person riddled with infection who never realized there's a 2-centimeter-long worm in their eye and thousands of parasites in their blood. (news-medical.net)
Dillman is focused specifically on the proteins that nematode spit releases into hosts during an infection. (news-medical.net)
Our understanding of the immune system stems, in great part, from studying the host response to infection, which in most individuals leads to the absence of clinical disease and establishment of highly apt immunological memory. (frontiersin.org)
Chronic infections, particularly those which are primarily characterized by an asymptomatic intracellular life cycle, e.g., latent Mycobacterium tuberculosis infection (LTBI), hepatitis B virus (HBV) infection, Chlamydia trachomatis infection, cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infections, present a unique premise to decipher the fine balance between protective host immune responses, immunopathology and full-fledged clinical disease. (frontiersin.org)
Although overt inflammatory responses play a major role in malignant transformation of host cells following an infection, it is a disbalanced immune responses, which contribute to drive malignant transformation. (frontiersin.org)
The second part of the review discusses potential host-directed interventional strategies based on existing translational and clinical knowledge of infection-induced inflammation, as well as cancer initiation/progression models. (frontiersin.org)
For a long time, the preventive strategy for this parasitic infection has been the regular use of antiparasitic drugs to reduce parasite burden in the short term. (scielo.org.co)
Understanding host-pathogen interactions and virulence of DWV in honey bees is slowed by the lack of cost-effective high-throughput screening methods for viral infection. (authorea.com)
Previous microarray data also indicated that many serine peptidase genes in Bd are highly expressed in the sporangia stage, which is associated with the infection of keratinized host tissue [ 14 ]. (biomedcentral.com)
Is a condition caused by infection with the scabies mite, a microscopic parasite. (iconic-elements.com)
MBL Grenoble's researchers focus mainly on RNA biology and infection biology, in particular on the structural molecular biology of protein-RNA complexes involved in cellular gene expression and host-pathogen interactions. (embl.org)
Only when a microorganism has successfully established a site of infection in the host does disease occur, and little damage will be caused unless the agent is able to spread from the original site of infection or can secrete toxins that can spread to other parts of the body. (nih.gov)
They establish a site of infection on the epithelial surface in the lumen of the gut and cause no direct pathology themselves, but they secrete toxins that cause damage either in situ or after crossing the epithelial barrier and entering the circulation. (nih.gov)
An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen, Fasciola hepatica: proteins associated with invasion and infection of the mammalian host -- 4. (edu.au)
Collectively, they may help limit tissue injury, enhance host resistance to infection, and promote tissue repair and resolution of inflammation. (msdmanuals.com)

In this study, we report for the first time a comprehensive transcriptomic/secretome description of expressed genes and proteins secreted by the adult stage of Eudiplozoon nipponicum (Goto, 1891) Khotenovsky, 1985, an obligate sanguivorous monogenean which parasitises the gills of the common carp (Cyprinus carpio). (muni.cz)

Secreted phospholipase A2 (sPLA2) is a protein secreted by Clonorchis sinensis and is a component of excretory and secretory products ( Cs ESPs). (biomedcentral.com)
Apolipoprotein E is a monomeric protein secreted by the liver and responsible for the transport of plasma cholesterol and triglycerides. (edu.au)

By doing so we hope to learn i) basic principles of pathogen evolution, ii) what makes one parasite strain more lethal than another, iii) how pathogens achieve tolerance in a host which is ultimately required for success, iv) learn about the immune response and v) identify therapeutic entry points that may allow development of intervention strategies. (gulbenkian.pt)
Helminths are complex pathogens that ensure their long-term survival by influencing the immune responses of their host. (mpg.de)
Because of this, the definition has been expanded to how known pathogens survive within their host, whether they cause disease or not. (omicsonline.org)
Nevertheless, while a chronic host immune response driven by pathogens may be protective against clinical disease, it may also elevate the risk of inflammation-induced dysplasia. (frontiersin.org)
The primary function of antimicrobial molecules is the interaction with pathogens to clear infections. (benthamscience.com)
Using multiple reporters, it is also possible to visualize competition, differential virulence, and host tissue targeting by co-occuring pathogens. (authorea.com)
The latter includes work on important human viral, parasite and bacterial pathogens. (embl.org)

Thus, the local immunological milieu in tissue compartments forms the nature and magnitude of the host responses, i.e., frequencies of regulatory T cells (Tregs) vs. T-helper 17 (Th17) cells, amount of pro-inflammatory cytokines vs. anti-inflammatory cytokines, extent of neutrophilia and antigen-presenting-cell (APC) activation, among others. (frontiersin.org)
Detection of secreted cysticercal antigen: a useful tool in the diagnosis of inflammatory neurocysticercosis. (medscape.com)
and, in response to antigen, are subsequently secreted by plasma cells. (msdmanuals.com)

It enabled us to report the essential physiological pathways and protein molecules involved in their interactions with the fish hosts. (muni.cz)
Four of these candidates correspond to secreted or membrane proteins that could be produced by the parasite and eventually be released in or be in contact with the host to modulate physiological pathways involved in various phenotypes (e.g. behaviors). (aber.ac.uk)
One of these candidates belongs to the Wnt family, a large group of signaling molecules involved in cell-to-cell interactions and various developmental pathways. (aber.ac.uk)
Despite their potential role in modulating host pathways that could lead to parasite-induced phenotypic changes and despite our confirmation that they are expressed in the developmental stage corresponding to the altered host behavior, further investigations will be needed to confirm their mechanistic role in the molecular cross-talk taking place between S. solidus and the threespine stickleback. (aber.ac.uk)
We discuss personalized immunological therapies which, directly or indirectly, target host biological pathways modulated by antimicrobial immune responses. (frontiersin.org)
Toxoplasma secretes a large number of proteins that mediate adhesion and invasion, establishment and defence of the parasitophorous vacuole, and influence various host cell pathways. (treecklab.org)
The pipeline accepts ESTs, quality values, protein sequences and short reads as input and provides as output, assembled contigs and singletons and their annotations including Gene Ontologies, secretory proteins, mapping to protein domains, motifs, metabolic pathways and interaction databases. (edu.au)
ESPs are predicted by a combination of computational approaches to effectively identity proteins secreted by classical and nonclassical pathways. (edu.au)
Different pathways regulate different immune cells to help the body differentiate the bodies own healthy cells from disease-causing agents including bacteria, viruses, fungi, parasites, cancerous cells, and many more. (medscape.com)

Of these, members of the serine peptidase family have been implicated as virulence effectors in Bd because of their potential role in degrading host antimicrobial peptides [ 14 ]. (biomedcentral.com)
However, the parasite effectors responsible for these critical remodelling events remain to be identified. (treecklab.org)
I am currently investigating how exported parasite effectors are responsible for subverting the host cell. (treecklab.org)
These include global regulation of chlamydial gene expression via histone-like proteins, vesicular trafficking, cytoskeletal interactions, cell signaling, chlamydial modification of the inclusion membrane, and interactions mediated by Type III secreted protein effectors, which control entry and subsequent events. (nih.gov)

Most classes of glycans are exposed on the surface of cellular and secreted macromolecules, and thus are in an optimal position to modulate or mediate a variety of events in cell-cell and cell-matrix interactions. (ucsd.edu)
Information concerning the biochemical and molecular nature of physiological processes involved in host-parasite interaction, such as evasion of the immune system and its regulation, digestion of macromolecules, suppression of blood coagulation and inflammation, and effect on host tissue and physiology, is lacking. (muni.cz)
LC-MS/MS spectrometry analysis identified 721 proteins secreted by E. nipponicum with predominantly immunomodulatory and anti-inflammatory functions (peptidyl-prolyl cis-trans isomerase, homolog to SmKK7, tetraspanin) and ability to digest host macromolecules (cathepsins B, D, L1). (muni.cz)

Cysticerci are able to survive in the human brain by disarming host defenses. (medscape.com)

Receives Zn 2+ from the secreted, extracellular zincophore protein, Pra1 for uptake of the metal. (tcdb.org)
Glycans play crucial roles in constructing complex multicellular organs and organisms, a process that requires interactions of cells with one another and with the surrounding extracellular matrix. (ucsd.edu)
This interaction can be mediated by several mechanisms including extracellular vesicle (EV) transfer. (conicet.gov.ar)

Parasites and Vectors , 8 (1), [225]. (aber.ac.uk)
However, the understanding of these symbiotic relationships has mainly been limited to phytophagous insects, while the role of host-associated microbiota in haematophagous insect vectors remains largely unexplored. (biomedcentral.com)

Johnson studies the molecular and cell biology of Trichomonas vaginalis, a parasite that causes trichomoniasis, one of the most prevalent sexually transmitted infections worldwide. (wikipedia.org)
Exploration of E. nipponicum transcriptome-related nucleotide sequences and translated and secreted proteins offer a better understanding of molecular biology and biochemistry of these, often neglected, organisms. (muni.cz)
These values are at least 1000-fold lower than those K i obtained for human cathepsin L (HsCL) and human cathepsin K (HsCK) demonstrating the selectivity of the ppFhCL3 for parasite cathepsins L. By exploiting 3-D structural data we identified key molecular interactions in the specific binding between the ppFhCL3 and FhCL3 mature domain. (biomedcentral.com)
On the molecular and cellular level, microbes can infect the host and divide rapidly, causing disease by being there and causing a homeostatic imbalance in the body, or by secreting toxins which cause symptoms to appear. (omicsonline.org)
Based on a previously published method, we built two complementary analysis pipelines to i) establish a general classification of protein similarity among various species (pipeline A) and ii) identify candidate mimicry proteins showing specific host-parasite similarities (pipeline B), a key feature underlying the possibility of molecular mimicry. (aber.ac.uk)
However, there is still little evidence on the role of microbiota in haematophagous insects of medical importance (pathogen transmission to humans and/or animals) as well as the molecular mechanisms underlying their interactions with the host. (biomedcentral.com)
Collectively our data imply that the CRMP complex acts as a host-molecular sensor to ensure that rhoptry exocytosis occurs when the parasite contacts the host cell. (stanford.edu)
The findings are of interest in understanding molecular processes involved in regulating erythropoiesis, as well as the potential to develop host-directed therapies for malarial parasites that target human reticulocytes. (elifesciences.org)
The present study laid the foundation for further revealing the molecular mechanism of sheep's neural-immune interaction network perceiving the colacobiosis of parasites. (biomedcentral.com)
An in-depth understanding of parasite genomes, host-parasite relationships, the molecular biology of parasites and their functional annotation can help identify therapeutic molecular targets in helminths, from the discovery of novel genes for parasite control with minimum host side effects. (edu.au)
The Host-Parasite Interactions Section studies the basic molecular and cellular biology of chlamydiae and other obligate intracellular parasites. (nih.gov)

Phenazines are secreted metabolites that microbes use in diverse ways, from quorum sensing to antimicrobial warfare to energy conservation. (stanford.edu)

Infectious Diseases are disorders caused by organisms such as bacteria, viruses, fungi, or parasites. (omicsonline.org)
These may be different molecules within the cells like proteins, polysaccharides, or nucleoproteins and may also be the whole cell, like a tumor cell or organisms like bacteria, viruses, fungi, parasites, or agents containing genetic material such as nucleic acids or lipids. (medscape.com)

The gene encoding PvTRAMP was identified through an extensive search of the databases hosting the genome sequence of P. vivax . (biomedcentral.com)

It turns out that a rat parasite, Toxoplasma gondii , needs to be eaten by a cat to complete its lifestyle. (discovermagazine.com)

This suggests a linked pathway of regulation of parasite density involving expression of these genes. (edu.au)
Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
Based on the benchmarking results, a robust transcriptome analysis pipeline (TranSeqAnnotator) has been developed, with contig generation from ESTs and short reads, updated pathway analysis, non-classically secreted protein identification and extensive annotation. (edu.au)
Whereas the majority of intracellular parasites are thought to block maturation of the endocytic vesicle to a lysosome, chlamydiae rapidly dissociate themselves from this pathway and establish a functional interaction with an exocytic pathway that delivers sphingolipids and cholesterol from the Golgi apparatus to the plasma membrane. (nih.gov)
Interaction with this secretory pathway is thought to constitute a novel pathogenic mechanism whereby chlamydiae establish themselves in a site not destined to fuse with lysosomes. (nih.gov)

The microsporidian genus Nosema is primarily known to infect insects of economic importance stimulating high research interest, while other hosts remain understudied. (bvsalud.org)
Nosema granulosis is one of the formally described Nosema species infecting amphipod crustaceans, being known to infect only two host species. (bvsalud.org)
The research group is investigating how parasites such as those that cause human malaria manage to hide from the immune system, spread within the body and emerge to infect others. (gulbenkian.pt)
The Cell Biology of Host - Pathogen Interaction Lab wants to find out how these parasites manage to infect human cells, how they evade the immune system, how they move through the body, and how they emerge to infect other people. (gulbenkian.pt)
The parasite has the widest latitudinal and longitudinal distribution of any worm parasite, largely because of its ability to infect and complete its life cycle in a wide range of mammalian hosts. (biomedcentral.com)
Viruses can also infect the host with virulent DNA, which can affect normal cell processes (transcription, translation, etc.), protein folding, or evading the immune response. (omicsonline.org)

Moreover, in malaria-endemic areas, where immunity to malaria is progressively acquired, detecting peripheral P. falciparum parasitemia in sick children does not necessarily prove that malaria is the cause of the severe pathology observed, given that many persons may carry parasites without expressing clinical malarial disease ( 2 ). (cdc.gov)
Sequestration of P. falciparum -infected erythrocytes (iEs) ( 3 ) in vital organs is considered a key pathogenic event leading to SM, as has been shown in postmortem parasite counts in patients who died with cerebral malaria ( 4 , 5 ). (cdc.gov)
Analysis following immunization of rabbits identified quantitative and qualitative differences in terms of the functional IgG antibody response against the P. falciparum parasite. (nature.com)
How do P. falciparum gametocytes remodel their host cell? (treecklab.org)
P. falciparum exports a large number of proteins out into its host red blood cell. (treecklab.org)

Blood-stage vaccines seek to induce antibodies against the merozoite form of the parasite that invades erythrocytes 2 , and could complement pre-erythrocytic immunity afforded by RTS,S/AS01, protect against disease severity and/or reduce transmission by accelerating the control and clearance of blood-stage parasitemia. (nature.com)
Anti-merozoite vaccine studies have long relied on the standardized in vitro assay of growth inhibition activity (GIA) 12 , whereby purified IgG antibodies are tested against parasites cultured in human red blood cells (RBC) in the absence of other cell types. (nature.com)

MicroRNAs (miRNAs), which are rapidly released from damaged tissues into the host fluids, constitute a promising biomarker for the prognosis of SM. (cdc.gov)
Little is known, however, about the mechanism by which the propeptide of FhCL3, a cathepsin L peptidase secreted by the infective newly excysted juveniles (NEJs), regulates the inhibition and activation of the mature enzyme before it is secreted into host tissues. (biomedcentral.com)
The cysticerci suppress the host inflammatory response and can survive in tissues for months to years. (medscape.com)

Host specificity seemed to be variable with some clades being restricted to single hosts, and some that could be found in several host species. (bvsalud.org)
Nosema ceranae infects midgut epithelial cells of the Apis species and has jumped from its original host A. cerana to A. mellifera worldwide, raising questions about the response of the new host. (bvsalud.org)
Depending on the species, the parasites favor different RBC maturation stages for their intraerythrocytic development. (elifesciences.org)
Even in The Origin of Species , Darwin refers to parasites as regressive instead of progressive. (discovermagazine.com)
No matter how complex or how impressive any other species may be, it has parasites. (discovermagazine.com)
Every species we might hold as a masterpiece of evolutionary complexity cannot out maneuver their parasites. (discovermagazine.com)
However, biologists define it according to the original, comprehensive concept of de Bary: the living together of members of two or more species in all the various forms, whether the interaction is beneficial, harmful, or neutral to one or both organisms. (newworldencyclopedia.org)
Most infectious agents show a significant degree of host specificity , causing disease only in one or a few related species. (nih.gov)

They are also in a position to mediate interactions between organisms, e.g., between host and parasite. (ucsd.edu)
If parasites can not only break into and survive the most complex assortments of systems available, even with modern medicine fighting against them, and manipulate those complex organisms to slave to their bidding, how can we not credit them as masters at what they do? (discovermagazine.com)
These organisms are able to overcome the sophisticated host immune response mechanisms to colonize, mature and reproduce within the host. (edu.au)
All the components of the immune system have to continuously modify to keep the bodies defense up against the ever-evolving organisms that constantly are on a quest to find a new way to attack the host. (medscape.com)

EV secretion by parasites has been reported in protozoans, trematodes and nematodes. (conicet.gov.ar)
Nematodes are devastating parasites of humans, capable of modulating our biology in numerous ways, including suppressing our immune systems,' Dillman said. (news-medical.net)
One such 'arms race' is between parasitic nematodes and their molluscan hosts. (canal-u.tv)

I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
Adherence and invasive properties of Corynebacterium diphtheriae strains correlates with the predicted membrane-associated and secreted proteome. (cdc.gov)

To prevent clearance by the host immune system, they remodel their host cells by secreting proteins that co-opt, or interfere with host cell functions. (gulbenkian.pt)

In future work she aims to explore tolerance mechanisms of parasites to host immune responses. (treecklab.org)

The zoonotic worm parasite Fasciola hepatica secretes an abundance of cathepsin L peptidases that are associated with virulence, invasiveness, feeding and migration. (biomedcentral.com)
Ape parasite origins of human malaria virulence genes. (cdc.gov)

Johnson studies different aspects of trichomonad biology, including drug resistance, organelle biogenesis, gene expression, genomics and host-parasite interactions. (wikipedia.org)

How do obligate intracellular parasites remodel your host cells to survive in a host? (gulbenkian.pt)
Many instances of endosymbioses are obligate, where neither the endosymbiont nor the host can survive without the other, such as "gutless marine worms" that get nutrition from endosymbiotic bacteria. (newworldencyclopedia.org)
R. rickettsii is a small, obligate, intracellular, Gram-negative organism maintained in its tick host through transovarial transmission. (nih.gov)

Liver stage vaccines have the advantage of targeting the parasite from the moment it is transmitted by the bite of an Anopheline mosquito until the parasite has completed its development in hepatocytes 9 . (nature.com)
As a consequence, any parasite leaving the liver will likely escape the pre-erythrocytic vaccine cover and may cause symptomatic, life-threatening disease if left untreated. (nature.com)

In 2014 she found that Trichomonas vaginalis secreted a protein that can invade benign cancerous prostate cells. (wikipedia.org)
In the mammalian host, plasmodia invade red blood cells (RBCs) for their asexual propagation. (elifesciences.org)

Galectins represent a widespread group of β-galactoside-binding proteins which are involved in a multitude of biological processes operative in parasite-host interaction. (mpg.de)

By a combination of forward mechanical pressure and hydrolytic tissue degradation the parasite rapidly traverses the intestinal wall to enter the peritoneum. (biomedcentral.com)
Furthermore, translocation of immune cells from one anatomical compartment to another, i.e., the gut-lung axis via the lymphatics or blood has been identified as an important factor in perpetrating systemic inflammation, tissue destruction, as well as modulating host-protective immune responses. (frontiersin.org)
In endosymbiosis, symbionts occur inside the cells or the tissue (intercellular space) of the host. (newworldencyclopedia.org)

For that project, Dillman is working toward a pesticide based on nematode venom, and on modifying crops to secrete a version of the toxin in the venom, which would give them natural resistance to insect attacks. (news-medical.net)
As part of evaluating the pipeline, I carried out an in-depth analysis of transcriptome from a nematode parasite, Ascaris lumbricoides. (edu.au)

By integrating transcriptomic data with proteomic analysis emphasizing on proteases, I have been able to understand the complexities involved in the ability of a developing parasite to sustain itself within the mammalian host. (edu.au)

In the lab we use a combination of unbiased genetic screens and reverse genetics to uncover the function of the secreted proteins in host-pathogen interaction. (gulbenkian.pt)
Host-pathogen Interactions in the Infectious diseases. (omicsonline.org)
This call for papers on the theme of "Host-pathogen Interactions in the Infectious diseases" is intended to indicate insights and viewpoints from scholars regarding risk and resilience analytics for policy making and operations of large-scale systems on this epidemic. (omicsonline.org)
The discussion includes recent findings on the microbiota functional roles and underlines their interactions with the host biology and pathogen transmission. (biomedcentral.com)
Broadly speaking, I am really interested to understand how host- pathogen interaction works on multiple levels. (treecklab.org)
I very much enjoy working with a team of talented and enthusiastic individuals in the lab to unravel the complexity of host pathogen interaction. (treecklab.org)

Parasitic worms are just the coolest things you could study because there are so many strange interactions, both positive and negative, that occur between the worms and their hosts. (news-medical.net)

And in vitro experiments confirmed that ILC2s could be activated rapidly by NMU and proliferated in vitro, and then the type 2 cytokines IL-5, IL-9 and IL-13 were produced and secreted, which depended on the expression of NMUR1 and Gαq in ILC2s. (biomedcentral.com)

Immunolocalisation/immunoblotting studies show that the FhCL3 zymogen is produced and secreted by gastrodermal cells of the NEJs gut. (biomedcentral.com)
Our results confirm the importance of these carbohydrate-binding proteins in host-parasite-interaction by indicating possible interaction with the host mucosa-associated cells. (mpg.de)
Mechanistically, we identified dysregulated erythropoiesis with reduced numbers of reticulocytes, the preferred host cells of P. yoelii , in Ac-deficient mice. (elifesciences.org)
These proteins drive the transformation of red blood cells from oxygen-transporting cells with no nucleus and little of a typical cell's internal machinery into a parasite-production facility that causes all of malaria's most severe symptoms. (treecklab.org)
After crawling onto their hosts, they inject digestive enzymes into the skin that break down skin cells. (mediadrumworld.com)
These innate immune responses use a variety of germline-encoded receptors to discriminate between microbial and host cell surfaces, or infected and normal cells. (nih.gov)
However, their larvae feed on the skin cells of living hosts. (titanpestandwildlife.com)
Once the organism gains access to the host, it is able to replicate within the host vascular endothelial cells and spread from cell to cell by polymerizing host cell actin. (nih.gov)

The engineered S. alvi induces RNA interference and represses parasite gene expression, thereby inhibits the parasitism significantly. (bvsalud.org)

We then determined the protein cargo in the EV-enriched secreted fractions of T. crassiceps and M. corti conditioned media by LC-MS/MS. Among the identified proteins, eukaryotic vesicle-enriched proteins were identified as expected, but also proteins used for cestode disease diagnosis, proteins related to neurotransmission, lipid binding proteins as well as host immunoglobulins and complement factors. (conicet.gov.ar)
This is the first report of EV secretion in cestode parasites and of an RNA secretion mechanism. (conicet.gov.ar)
We further confirmed that these four candidates are expressed in three different developmental stages of the cestode by RT-PCR, including the stages found in the host. (aber.ac.uk)
Conclusion: In this study, we identified mimicry candidate peptides from a behavior-altering cestode showing specific sequence similarity with host proteins. (aber.ac.uk)

Studies on insect-associated microbial communities have produced strong evidence that symbiotic bacteria play a major role in host biology. (biomedcentral.com)

It significantly reduces the spore load, confirming the importance of the antioxidant mechanism for the intracellular invasion of the N. ceranae parasite. (bvsalud.org)
Recent highlights include: the structure and function of long non-coding RNAs , the structure of the integrator complex , the determination of the mechanism of action of secreted Legionella effector proteins , and the structural and mechanistic analysis of the transcription/replication machines of influenza virus and lassa virus . (embl.org)

Changes in microorganism diversity and abundance may have a direct impact on the holobiont's evolution by modifying the multipartite interaction dynamics. (biomedcentral.com)

They have evolved amazing abilities to survive host defense systems, manipulate host behavior and boost heir own reproductive success. (discovermagazine.com)

Moreover, the kinetic constraints imposed by such rapid erythrocyte invasion mean that extremely high concentrations of functional antibody are required to neutralize the parasite 6 . (nature.com)

The FhCL3 peptidase involved in host invasion by F. hepatica is produced as a zymogen in the NEJs gut. (biomedcentral.com)
The apical organelle complex of merozoites (the parasite's blood stage responsible for RBC invasion) plays an important role in parasite entry into RBCs. (biomedcentral.com)

When one attaches to a person's skin, it secretes a digestive enzyme irritating it. (titanpestandwildlife.com)

We use cell-biological and biochemical approaches to study protein function and aim to put it all into context of the co-evolution of the parasite and the host. (gulbenkian.pt)

According to its transcription and expression profile, PvTRAMP is initially located at the parasite's apical end and later on the parasite surface. (biomedcentral.com)
Host phenotypes that increase the parasite's transmission rate to the next host have been extensively described, but few mechanistic explanations have been proposed to describe their proximate causes. (aber.ac.uk)

This special issue will glance at recent trends and updates that aim to further insight to tackle the Host Pathogenic infections. (omicsonline.org)

This organism is unique among plants in that it secretes copious amounts of oil that is chemically analogous to petroleum. (stanford.edu)

We had earlier identified seven galectins in Strongyloides ratti, four of them detected in the ESP of distinct developmental stages of the parasite. (mpg.de)

Here, using laboratory-generated bees mono-associated with gut members, we find that Snodgrassella alvi inhibit microsporidia proliferation, potentially via the stimulation of host oxidant-mediated immune response. (bvsalud.org)
This defense phenotype varies greatly depending on, (1)the host physiology, its immune response and its microbiota, (2) the pathogenvirulence and its capacity to modulate shell fluid pH, and (3) theenvironmental conditions. (canal-u.tv)

CRMPs and their partners contain putative host cell-binding domains, and CRMPa shares similarities with GPCR proteins. (stanford.edu)

According to the holobiont concept, an arthropod vector should no longer be considered as an isolated organism but rather as a complex system in which the different partners (host and microbiota) interact. (biomedcentral.com)
However, the development of an efficacious malaria vaccine has turned out to be complicated, partly because of the complex life cycle of the parasite and a long history of co-evolutionary adaptation with the human host. (nature.com)

Organisms1

Phenomena and Processes1

Plasmodium12

Malaria parasite3

Infection22

Expressed genes1

Protein secreted2

Pathogens7

Antigen3

Pathways9

Effectors4

Macromolecules3

Disarming host defenses1

Extracellular3

Vectors2

Molecular11

Metabolites1

Fungi2

Genome1

Toxoplasma1

Pathway5

Infect6

Falciparum5

Antibodies2

Tissues3

Species8

Organisms4

Nematodes3

Membrane2

Remodel their host1

Mechanisms1

Virulence2

Genomics1

Obligate3

Liver2

Invade2

Widespread1

Tissue3

Nematode2

Mammalian host1

Pathogen6

Parasitic1

Rapidly1

Cells8

Gene expression1

Cestode4

Bacteria1

Mechanism2

Abundance1

Behavior1

Functional1

Invasion2

Digestive1

Biological1

Parasite's2

Pathogenic1

Amounts1

Stages1

Immune response2

Similarities1

Complex2