• Common signs and symptoms may stem from decreased hepatic synthetic function (eg, coagulopathy), portal hypertension (eg, variceal bleeding), or decreased detoxification capabilities of the liver (eg, hepatic encephalopathy). (medscape.com)
  • Prophylactic endoscopic band ligation (EBL) is used to prevent variceal bleeding in patients with liver cirrhosis. (springer.com)
  • Patients with non-cirrhotic portal hypertension receiving EBL, other than EBL endoscopic treatment, previous transjugular intrahepatic portosystemic shunt (TIPS) implantation or orthotopic liver transplantation, occlusive portal vein thrombosis, patients with fundal varices only, patients with acute and/or uncontrolled variceal bleeding at baseline and insufficient medical/endoscopic records were excluded from this study. (springer.com)
  • Patients who present with upper gastrointestinal (GI) bleeding can be approached as whether the bleeding is variceal or nonvariceal. (medscape.com)
  • Not all upper GI bleeding in cirrhotic patients are from variceal hemorrhage. (medscape.com)
  • Gastric varices are the source of bleeding in 5-10% of patients with variceal hemorrhage. (medscape.com)
  • Clinically, measurement of HVPG is indicated (i) to establish the diagnosis of sinusoidal portal hypertension, (ii) to identify patients at risk for hepatic decompensation by diagnosing CSPH (HVPG ≥10 mm Hg), (iii) to guide pharmacological therapy in primary or secondary prophylaxis of variceal bleeding, and (iv) to assess the risk of hepatic failure after partial hepatectomy 2 , 4 . (jove.com)
  • Transjugular intrahepatic portosystemic shunts (TIPS) can alleviate complications of portal hypertension such as ascites and variceal bleeding by decreasing the portosystemic gradient. (wjgnet.com)
  • In limited clinical situations, parallel TIPS may be only solution to alleviate either variceal bleeding or ascites secondary to portal hypertension when the primary TIPS fails to do so. (wjgnet.com)
  • LAUSANNE, Switzerland, June 1 (Healthcare Sales & Marketing Network) - The Debiopharm Group, a global independent biopharmaceutical development company specialising in oncology and serious medical conditions, announced today its initiation of a confirmatory Phase III study for Sanvar(R) in the United States (US), for the treatment of acute esophageal variceal bleeding (EVB) secondary to portal hypertension. (salesandmarketingnetwork.com)
  • For select patients with little success from traditional medical therapies and previously failed TIPS procedures, a direct transhepatic approach to restoring blood flow and resolving variceal bleeding may be appropriate. (amjcaserep.com)
  • Restoration of flow through the occluded segment of the main portal vein and cessation of variceal bleeding was successfully resolved through the combination of portal vein reconstruction and massive volume embolization of the large coronary vein using a direct, percutaneous approach. (amjcaserep.com)
  • Secondary prevention of portal hypertension is the sum of measures adopted after the first variceal bleeding. (skp-casopis.sk)
  • Transjugular intrahepatic portosystemic shunt (TIPS) offers an effective treatment for patients with complications of portal hypertension, specifically prevention of variceal rebleeding and recurrent or refractory ascites. (emjreviews.com)
  • 1 These sequelae, variceal bleeding and refractory ascites, are associated with poor patient prognosis. (emjreviews.com)
  • Here, we present a protocol for measurement of hepatic venous pressure gradient (HVPG),the gold standard to diagnose clinically significant portal hypertension. (jove.com)
  • The difference between FHVP and WHVP is referred to as HVPG, with values ≥10 mm Hg indicating clinically significant portal hypertension (CSPH). (jove.com)
  • 2. Severe chronic liver disease (Child Pugh C-grade), liver parenchymal disease with significant portal hypertension, and acute liver failure. (who.int)
  • The images below depict esophageal varices, which are responsible for the main complication of portal hypertension, upper gastrointestinal (GI) hemorrhage. (medscape.com)
  • Patients undergoing endoscopic band ligation (EBL) for esophageal varices (EV) were included between January 2000 and May 2020. (springer.com)
  • Patients with cirrhosis are at risk for developing complications mostly related to portal hypertension (PHT), such as ascites or bleeding from gastric or esophageal varices 1 , 2 , 3 . (jove.com)
  • 24 h esophageal pH monitoring has been carried out in many hospitals among healthy Chinese adults and peptic ulcer patients. (wjgnet.com)
  • Recently, an esophageal manometric study was conducted in asymptomatic esophageal diabetic patients that showed the following abnormalities: Diminution of resting LES pressure and amplitude of contraction of the lower segment of the esophageal body, increase of tertiary and segmental contractions and frequent double peak and multi peak contractions[ 3 ]. (wjgnet.com)
  • Thus, increased portal pressure causes increased filtration of vascular fluid with the formation of ascites and the development of collaterals through alternating veins leading to esophageal, gastric, and rectal varices. (fortunejournals.com)
  • Most adult patients present a mild anemia or a totally compensated hemolysis, with fatigue, icterus, splenomegaly and risks of secondary complications including cholelithiasis. (orpha.net)
  • Thrombotic complications (arterial and venous events, including portal vein thrombosis (see this term) and pulmonary hypertension) have been described at a high rate after splenectomy. (orpha.net)
  • Secondary complications are low, except for left ventricular hypertrophy, which requires long-term follow-up. (bvsalud.org)
  • Women with Budd Chiari Syndrome (BCS) and/or portal hypertension are at high risk of pregnancy complications and adverse outcomes. (isth.org)
  • Secondary outcomes included maternal, fetal and obstetrical complications. (isth.org)
  • This review focusses on the optimisation of the use of a covered TIPS endoprosthesis in patients with portal hypertension-related complications, with consideration of evolving practices, patient selection, and multidisciplinary co-operation. (emjreviews.com)
  • 2 Elevated portal pressure increases cardiac output and reduces systemic vascular resistance, increasing blood flow and leading to serious complications. (emjreviews.com)
  • Treatment of portal hypertension focusses on preventing or managing complications and, at first-line, is dependent largely on pharmacological approaches, which include non-selective beta-blockers (NSBB). (emjreviews.com)
  • Paraesophageal varices are not uncommon and are secondary to portal hypertension in patients with hepatic cirrhosis. (myebr.org)
  • A 31-year-old man with a past medical history of portal hypertension, refractory ascites, gastroesophageal varices, and decompensated cirrhosis secondary to alcohol abuse had previously undergone an unsuccessful TIPS placement. (amjcaserep.com)
  • Preprocedural imaging demonstrated a cirrhotic liver, splenomegaly, and gastroesophageal varices compatible with portal hypertension. (amjcaserep.com)
  • We report a case of chronic PVT and main portal vein reconstruction in the presence of a massive coronary vein and actively bleeding gastroesophageal varices. (amjcaserep.com)
  • [ 49 ] It most often occurs in patients with an underlying thrombotic diathesis, including in those who are pregnant or who have a tumor, a chronic inflammatory disease, a clotting disorder, an infection, or a myeloproliferative disorder , such as polycythemia vera or paroxysmal nocturnal hemoglobinuria . (medscape.com)
  • Here we provide a detailed protocol describing the clinical procedure of hepatic venous pressure gradient (HVPG) measurement in patients with advanced chronic liver disease followed by an instruction for transjugular biopsy. (jove.com)
  • Objectives: To assess the efficacy of Pegylated Interferon in clinical practice in patients with chronic viral hepatitis B and C and determine the hematologic side effects. (scirp.org)
  • Patients and Methods: A descriptive retrospective study from January 2012 to November 2013 on a cohort of patients chronic carriers of hepatitis B virus (n = 11) treated with Pegylated Interferon to 180 mcg per week and hepatitis C virus (n = 30) treated with a combination therapy associating pegylated Interferon to 180 mcg per week and Ribavirin assayed according to the genotype. (scirp.org)
  • Following "the Dakar Appeal" [3] , the Ivorian government, through the National Program of the Fight against Viral Hepatitis (NPFVH) has made freely available to patients of the 3 Teaching Hospitals of Abidjan, Pegylated Interferon (PEG-IFN) from February 2012 to November 2013 for the treatment of chronic hepatitis B and C. The pre, per and post therapeutic biological, radiological and histological tests remain the responsibility of patients. (scirp.org)
  • We carried out a study on the results of treatment with PEG-IFN, in patients with chronic hepatitis during this period at the Teaching Hospital of Yopougon in Abidjan in the Ivory Coast. (scirp.org)
  • The aims of our work were to assess the effectiveness of treatment with PEG-INF alone or in combination with Ribavirin (RBV) in clinical practice in patients with chronic hepatitis B or C and to determine the hematologic side effects. (scirp.org)
  • In the previous reports of abdominal ENV, it was hypothesized that the massiveness of the panniculus caused increased interstitial and intravascular pressure predisposing the patients to chronic low-grade cellulitis and lymphangitis [ 5 , 6 ]. (cdlib.org)
  • Also noted were focal calcifications in the region of the diminutive main portal vein, medial splenic vein, and superior mesenteric vein, compatible with sequalae of chronic thrombosis. (amjcaserep.com)
  • Chronic pulmonary hypertension 31. (muni.cz)
  • Chronic lesions due to S. haematobium: hematuria, hydronephrosis, renal insufficiency, genital lesions, right heart decompensation due to pulmonary hypertension secondary to lung fibrosis. (wikitropica.org)
  • The population of the occupied Palestinian territory is facing the socioeconomic consequences of the growing prevalence of invalidity related to noncommunicable diseases and the economic burden of the growing number of patients suffering from chronic diseases who require medical care. (who.int)
  • For patients with prior chronic organ insufficiency (SOFA score should be based on baseline): SOFA increased by = 2 points between 48 hours and 24 hours after diagnosis of infection. (who.int)
  • Genetic Predictors of Ibrutinib-Related Cardiovascular Side Effects in Patients with Chronic Lymphocytic Leukemia. (cdc.gov)
  • An elevated arterial or free venous serum ammonia level is the classic laboratory abnormality reported in patients with hepatic encephalopathy. (medscape.com)
  • In the first group (pulmonary arterial hypertension [PAH]), the primary disorder affects the small pulmonary arterioles. (msdmanuals.com)
  • Resumen Objetivo: Establecer la prevalencia de hipertensión arterial (HTA) en los pacientes pediátricos hospitalizados en un centro hospitalario de tercer nivel de Medellín, Colombia, durante seis años. (bvsalud.org)
  • Abstract Objective: To establish the prevalence of arterial hypertension in pediatric patients hospitalized in a tertiary hospital center in Medellin, Colombia for 6 years. (bvsalud.org)
  • Primary pulmonary hypertension (PPH) is a disorder characterised by lesions of pulmonary arterioles, which increase vascular resistance and lead to elevated pulmonary arterial pressure. (ersjournals.com)
  • Treatment of arterial hypertension 13. (muni.cz)
  • Pharmacogenetic markers of development of angioneurotic edema as a secondary side effect to enalapril in patients with essential arterial hypertension. (cdc.gov)
  • Identification of potential susceptibility genes in patients with primary Sjögren's syndrome-associated pulmonary arterial hypertension through whole exome sequencing. (cdc.gov)
  • We analyzed real-life data of cirrhotic patients undergoing elective EBL at two large Viennese centers between Q1/2000-Q1/2018. (springer.com)
  • It should also be noted that peptic ulcer disease is present more frequently in cirrhotic patients than noncirrhotic patients. (medscape.com)
  • Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators. (medscape.com)
  • Assessment of the agreement between wedge hepatic vein pressure and portal vein pressure in cirrhotic patients. (medscape.com)
  • When enlarged, they are visible as a lower middle mediastinal mass in about 8% of chest radiographs of cirrhotic patients. (myebr.org)
  • Portal hypertensive polyps (PHP) are a recent entity, described in cirrhotic patients with portal hypertension, portal venous obstruction or antral vascular ectasia. (isciii.es)
  • How can you screen HCC in cirrhotic patients? (rimikri.com)
  • The patient had cirrhosis secondary to alcohol abuse. (medscape.com)
  • Unlike the few previously reported cases of intrasinusoidal spread of breast cancer, our patient was palliated with a transjugular intrahepatic portosystemic shunt along with salvage chemohormonal therapy. (biomedcentral.com)
  • The patient underwent palliative transjugular intrahepatic portosystemic shunt and transhepatic venous liver biopsy, which revealed the presence of rapidly progressive and uncontrolled metastatic breast cancer. (biomedcentral.com)
  • Most of the patients previously reported were not treated with transjugular intrahepatic portosystemic shunt (TIPS). (biomedcentral.com)
  • During this multicenter, single-arm, open-label study in the US, Sanvar(R) will be administered for five days in 85 patients with acute EVB due to portal hypertension. (salesandmarketingnetwork.com)
  • Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • When there is acute overt hemorrhage in the unstable patient, angiography should be performed emergently. (medscape.com)
  • We report the case of a 52-year-old Caucasian woman who developed radiological signs of portal hypertension without radiological evidence of hepatic metastasis five years after being diagnosed with metastatic breast cancer. (biomedcentral.com)
  • During salvage therapy with high-dose estradiol (Estradiol valerate), vinorelbine (Navelbine) and bevacizumab (Avastin), she suddenly developed signs of portal hypertension confirmed on computed tomography and by portal and systemic venous pressure measurements. (biomedcentral.com)
  • This study was done to describe the etiology, presentation and outcome of patients with pancytopenia presenting in a general medical ward. (unboundmedicine.com)
  • Patients who had undergone HCC surveillance were compared to those who had not (but had an obvious indication for surveillance, ie, liver cirrhosis or hepatic porphyria and an age of ≥ 50 years) regarding etiology, tumor burden, presence of extrahepatic spread, treatment and lead-time adjusted overall survival. (cbinsights.com)
  • 2 The risk of HCC is elevated for all patients with liver cirrhosis, but the etiology behind cirrhosis has an impact on the risk increase, where hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are associated with a higher risk increase. (cbinsights.com)
  • Hypersplenism secondary to portal hypertension (cirrhosis) was the second most common diagnosis (n = 19). (unboundmedicine.com)
  • The prognosis is poor in patients with Budd-Chiari syndrome who remain untreated, with death resulting from progressive liver failure in 3 months to 3 years from the time of the diagnosis. (medscape.com)
  • Conclusion: Surveillance for HCC in at-risk patients is associated with diagnosis at an earlier tumor stage, treatment with curative intent and with improved lead-time adjusted overall survival. (cbinsights.com)
  • We compared patients who had performed regular examinations to those who had not and concluded that the screening group had less advanced disease at diagnosis, as well as a better survival. (cbinsights.com)
  • The authors concluded by remarking that the identification of the SERPINA1 Z allele as the first marker for the development of severe liver disease in CF illustrates the possibility of identifying CF risk factors early in life, conceptually as a secondary component of neonatal screening after the diagnosis of CF is confirmed. (healthjockey.com)
  • A registry for persons treated with bedaquiline is being implemented by Janssen Therapeutics to track patient outcomes, adverse reactions, laboratory testing results (e.g., diagnosis, drug susceptibility, and development of drug resistance), use of concomitant medications, and presence of other comorbid conditions. (cdc.gov)
  • Contrast-enhanced computed tomography (CT) did not demonstrate metastatic liver disease, although it did show advanced portal hypertension. (biomedcentral.com)
  • A 31-year-old man with decompensated cirrhosis (model for end-stage liver disease of 17) secondary to alcohol abuse was referred to interventional radiology for TIPS placement. (amjcaserep.com)
  • The advantage of carvedilol is a greater beta-blocking effect in patients with a more advanced liver disease, and its 24-hour effect. (skp-casopis.sk)
  • A genetic analysis now points out that a particular gene variation in patients suffering from cystic fibrosis could considerably add to their possibility of developing severe liver disease. (healthjockey.com)
  • Severe liver disease distinguished by cirrhosis with portal hypertension may be developed by a small fraction about 3 - 5 percent with cystic fibrosis (CF). Prior study has claimed that genetic variability that is not related with the cystic fibrosis transmembrane conductance regulator (CFTR) gene may add to the danger for severe liver disease. (healthjockey.com)
  • It is uncommon that patients with uncomplicated hemorrhoid manifest any anal pain. (hemorrhoidstalk.com)
  • Bleeding from the small intestine remains a relatively uncommon event, accounting for ~5-10% of all patients presenting with gastrointestinal (GI) bleeding. (medscape.com)
  • Anlotinib in patients with recurrent platinum resistant/refractory ovarian cancer: a prospective, single arm, phase II study. (cdc.gov)
  • Clinical and experimental data suggest that coliforms may then result in portal bacteremia by bacterial translocation as a result of this epithelial damage. (medscape.com)
  • This retrospective study was conducted in two tertiary clinical centers (Vienna General Hospital of the Medical University of Vienna and Klinik Landstrasse in Vienna) including patients with liver cirrhosis and portal hypertension. (springer.com)
  • Methods: A descriptive cross-sectional study was carried out that reviewed retrospective information obtained from the clinical records of patients under 18 years of age hospitalized at the Pablo Tobón Uribe Hospital in Medellín. (bvsalud.org)
  • Maintains clinical and professional competency as appropriate to the age, culture, developmental stages, and special needs of the patients served. (atriumhealth.org)
  • This study aims to report a clinical case of Budd-Chiari syndrome secondary to an antiphospholipid syndrome, a rather unusual association in literature. (scielo.edu.uy)
  • Review of the clinical history discovered that the patient had cirrhosis of the liver. (myebr.org)
  • Immunotherapy can safely downstage patients and achieve durable systemic disease control to improve clinical outcomes in HCC patients undergoing liver transplant. (clincosm.com)
  • ESR-20-21010 is a single-arm, open-label, Phase II, multicenter clinical trial designed to evaluate the safety and efficacy of durvalumab and tremelimumab for the treatment of hepatocellular carcinoma (HCC) patients who have cirrhosis or portal hypertension and are listed for a liver transplant. (clincosm.com)
  • for example, in high-risk patients TIPS may offer clinical benefits when performed early in the disease course. (emjreviews.com)
  • Her main clinical interests are focused on paediatric liver transplantation and patterns of portal hypertension in young adults requiring a liver transplant, as well as machine perfusion and DCD liver transplantation. (kcl.ac.uk)
  • Herein, our authors present a case of a 40-year-old female patient with Budd-Chiari syndrome in whom the right atrium myxoma was manifested with worsening of clinical symptoms despite medical treatment therapy. (fortunejournals.com)
  • Clinical hypertension 2023 9 29 (1): 26. (cdc.gov)
  • We conducted a secondary analysis of existing clinical and administrative data for this descriptive, correlational study. (cdc.gov)
  • Repeated portal bacteremia, in turn, results in the cascade of events characterized by biliary stasis, obstruction, and stone formation, which consequently result as recurrent pyogenic cholangitis (RPC). (medscape.com)
  • Computed tomographic enterography should be performed in patients with suspected obstruction before VCE or after negative VCE examinations. (medscape.com)
  • The use of salicylates as a tonic against thrombosis in PV patients is not only potentially harmful if the red cell mass is not controlled by phlebotomy, but is also an unproven remedy. (basicmedicalkey.com)
  • Our patient was chronically bed-ridden and had several co-morbid factors including congestive cardiac failure, hypothyroidism, and morbid obesity with a massive apron of panniculus almost reaching up to the mid-thigh. (cdlib.org)
  • Portal hypertensive polyps, a new entity? (isciii.es)
  • Portal hypertensive polyp - what is in a name? (isciii.es)
  • Portal hypertensive polyps: Distinct entity. (isciii.es)
  • Relationship between the methylenetetrahydrofolate reductase (MTHFR) rs1801133 SNP and serum homocysteine levels of Zhuang hypertensive patients in the central region of Guangxi. (cdc.gov)
  • Prognosis is poor overall if a treatable secondary cause is not found. (msdmanuals.com)
  • Plain Language Summary: In this research article, we aimed to evaluate whether patients who have a known risk to develop liver cancer have a better prognosis if they undergo regular screening examinations with ultrasound every sixth months. (cbinsights.com)
  • To develop a support environment, to raise awareness and make behaviour changes for each citizen so that they would reduce salt intake in their daily diet to prevent and control hypertension, stroke and cardiovascular diseases and other non-communicable diseases, contributing to people's health protection, care and promotion. (who.int)
  • a) Efficiently use the information and communication system from the central to local levels to perform information, education and communication activities on low-salt consumption for prevention and control of hypertension, stroke, cardiovascular diseases and other non-communicable diseases. (who.int)
  • Conduct advocacy communications on mass media, develop a column in newspapers, and hold television talks on the topic of salt consumption reduction for prevention and control of hypertension, stroke, cardiovascular diseases and other non-communicable diseases. (who.int)
  • Conduct a national communication campaign annually on the topic of universal salt consumption reduction for prevention of hypertension, stroke, cardiovascular diseases and other non-communicable diseases. (who.int)
  • Similarly, disparities in prevalence of cardiovascular diseases, including hypertension and dyslipidemia, have not been determined in the military population. (cdc.gov)
  • METHODS: Hundred patients with pancytopenia were included in the study from October 2001 to October 2002. (unboundmedicine.com)
  • METHODS AND RESULTS: Twenty ECM plasma proteins were analysed with proximity extension assay in 20 controls and 26 HF patients pre-HT and 1 year post-HT. (lu.se)
  • Our aim was to identify plasma ECM proteins associated to end-stage HF and secondary PH in relation to haemodynamics, before and after heart transplantation (HT).METHODS AND RESULTS: Twenty ECM plasma proteins were analysed with proximity extension assay in 20 controls and 26 HF patients pre-HT and 1 year post-HT. (lu.se)
  • Patients and Methods: Data on patients diagnosed with HCC between 2009 and 2019 were collected from the nationwide Swedish National Registry for Tumors of the Liver and Bile Ducts (SweLiv). (cbinsights.com)
  • Introduction: Renal transplantation is considered the treatment of choice for patients with end-stage renal disease (ESRD) and is associated with decreased mortality when compared to dialysis methods. (unifesp.br)
  • Because secondary lesions contraindicate cystectomy and require aggressive chemotherapy, we performed further investigations. (cdc.gov)
  • All patients with advanced breast cancer developing unexpected portal hypertension should be considered candidates for liver biopsy despite normal computed tomography of the liver imaging results. (biomedcentral.com)
  • A hypodense mass obstructed hepatic flow suggested thrombus formation in the hepatic and portal veins and suprahepatic part of the inferior vena cava on computed tomography. (fortunejournals.com)
  • In patients with occult hemorrhage or stable patients with active overt bleeding, multiphasic computed tomography should be performed after VCE or CTE to identify the source of bleeding and to guide further management. (medscape.com)
  • The guideline will provide a review of diagnostic modalities for patients with small bowel hemorrhage including VCE, endoscopic evaluation with push and/or deep enteroscopy, and radiographic modalities including cross-sectional imaging (computed tomography (CT) and magnetic resonance (MR)) enterography, angiography, and scintigraphy. (medscape.com)
  • Persons exposed only to methyl mercaptan pose little risk of secondary contamination to personnel outside the Hot Zone. (cdc.gov)
  • Persons exposed only to vinyl chloride gas pose no risk of secondary contamination. (cdc.gov)
  • Results: Out of 1860 patients seen in hepatogastroenterology consultation 422 had viral hepatitis B or C that is a prevalence of 22.7% and 41 patients were treated (9.7%) by Pegylated Interferon. (scirp.org)
  • Results: From a total of 382 pediatric patients hospitalized in the studied period, a prevalence of hypertension of 30.6% was found. (bvsalud.org)
  • Conclusions: In children the frequency of hypertension in hospitalized patients is higher than the prevalence reported in outpatients. (bvsalud.org)
  • Multivariate logistic regression models were used to determine the prevalence of hypertension, dyslipidemia, type 2 diabetes, and asthma by race/ethnicity, controlling for rank and sex. (cdc.gov)
  • The purpose of this study was to determine whether disparities exist in the prevalence of hypertension, dylipidemia, diabetes, and asthma among active-duty USAF members. (cdc.gov)
  • Of course, in patients with associated acid-peptic disease, occult gastrointestinal bleeding may lead to a presentation with hypochromic, microcytic anemia, masking the presence of PV. (basicmedicalkey.com)
  • Because cirrhosis is a feature only of advanced disease, a change of its name to "primary biliary cholangitis" was proposed by patient advocacy groups in 2014. (wikipedia.org)
  • The authors report the first description of a case of primary pulmonary hypertension (PPH) in patient with APECED, caused by R257X mutation in AIRE. (ersjournals.com)
  • The findings from this study, provided that other similar cases are reported, suggest that immune deregulation plays a role in the pathogenesis of primary pulmonary hypertension. (ersjournals.com)
  • The primary endpoint is proportion of patients experiencing post-transplant rejection (within 30 days of transplant). (clincosm.com)
  • A total of 30 patients are to be enrolled, to allow at least 20 transplants for adequate primary endpoint analysis. (clincosm.com)
  • Since cirrhosis occurs only in the later stage of PBC, the name primary biliary cirrhosis is actually a misnomer for patients in the earlier stages of the illness. (emedicinehealth.com)
  • A 40-year-old female patient presented with abdominal pain, distension, and dyspnea. (fortunejournals.com)
  • Severe pulmonary hypertension leads to right ventricular overload and failure. (msdmanuals.com)
  • In fact, severe anal pain in patient with hemorrhoids is more likely due to anal fissure and anorectal abscess. (hemorrhoidstalk.com)
  • Patients can also be referred for unexplained hemochromatosis, since iron overload is frequently associated with the disease. (orpha.net)
  • A recent study demonstrated an absence of mutations in BMPR‐II in patients with PPH and connective tissue disease, thus suggesting that PPH associated with immune deregulation may have a different pathogenesis from the familial form 13 . (ersjournals.com)
  • On December 28, 2012, on the basis of data from two Phase IIb trials (i.e., well-controlled trials to evaluate the efficacy and safety of drugs in patients with a disease or condition to be treated, diagnosed, or prevented), the Food and Drug Administration (FDA) approved use of bedaquiline under the provisions of the accelerated approval regulations for "serious or life-threatening illnesses" (21CFR314.500) (Cox EM. (cdc.gov)
  • The bile ducts of patients with cholangiohepatitis are thought to be increasingly susceptible to bacterial seeding as a result of helminthic infections or as a consequence of malnutrition. (medscape.com)
  • The branching bile ducts course through special tissue in the liver called portal tracts, which act as conduits for the ducts. (emedicinehealth.com)
  • In fact, the branching portal tracts containing the bile ducts also contain the blood vessels that enter and leave the liver. (emedicinehealth.com)
  • The inflammation in PBC starts in the liver's portal tracts and involves the small bile ducts in these areas. (emedicinehealth.com)
  • To evaluate management and outcomes of pregnancies in women with BCS and/or portal hypertension. (isth.org)
  • Women with confirmed BCS and/or portal hypertension who conceived at least once were enrolled and study outcomes were assessed up to 12 weeks after delivery or 6 weeks after pregnancy loss. (isth.org)
  • Adverse pregnancy outcomes in women with BCS and portal hypertension are common. (isth.org)
  • Hamulyák EN, Wiegers HMG, van Duuren JR, Middeldorp S, Ganzevoort W. Pregnancy Outcomes in Women with Budd Chiari Syndrome or Portal Hypertension [abstract]. (isth.org)
  • Association between Human Leukocyte Antigen (HLA) DQB1*06 and HLA DQB1*03 and adverse outcomes in a group of critically ill patients with COVID-19 in Tunisia: a cross-sectional study. (cdc.gov)