• Approximately 30% of patients develop secondary Sjogren's syndrome that is associated with another underlying autoimmune disease such as rheumatoid arthritis, lupus, or scleroderma. (medifocus.com)
  • These genes are also implicated in related autoimmune diseases, often seen in patients and their families, e.g. celiac disease, rheumatoid arthritis, scleroderma. (pbc-society.ca)
  • From rheumatoid arthritis and lupus to multiple sclerosis and Crohn's disease, these conditions can have a significant impact on a person's quality of life. (brainboost.blog)
  • There are more than 80 recognized autoimmune diseases, ranging from common ones like rheumatoid arthritis and multiple sclerosis to rarer conditions such as lupus and scleroderma. (brainboost.blog)
  • Sometimes it just affects an individual organ system ( rheumatoid arthritis, Addison's disease, type 1 diabetes, Sjogren's, thyroiditis, scleroderma) and in SLE many organ systems are involved. (drgeraldlewis.com)
  • Multiples sclerosis (MS) most of the time presented as isolated autoimmune disease but lately multiple sclerosis has been increasingly reported to be associated with other autoimmune diseases not affecting the central nervous system such as rheumatic diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, Hashimoto's thyroiditis, primary Sjogren's syndrome, and ankylosing spondylitis [ 3 - 6 ]. (jrmds.in)
  • Rheumatoid Arthritis- a disease process that is systemic. (premierphysiotherapy.ie)
  • These include smoking, working at a job that uses strong chemicals and fumes on a regular basis, having gastroesophageal reflux disease , or having an autoimmune disease like rheumatoid arthritis, lupus, or scleroderma. (ildcollaborative.org)
  • It can occur alone or with rheumatoid arthritis, scleroderma, or systemic lupus erythematosus. (wikidoc.org)
  • Case studies have been reported of persons with alopecia areata who have developed other autoimmune diseases such as lupus erythematosus, rheumatoid arthritis, pernicious anemia, scleroderma and ulcerative colitis. (dermatology.org)
  • Probably due to autoimmune mechanisms, RA can be directly associated with respiratory system damage not only with ILD, but also with bronchiectasis, pleural effusion, rheumatoid parenchymal nodules and, rarely, vascular disease. (biomedcentral.com)
  • This type of corneal ulcer is usually associated with a connective tissue disease, such as rheumatoid arthritis (RA), Sjögren syndrome, Mooren ulcer, or a systemic vasculitic disorder (eg, systemic lupus erythematosus [SLE], Wegener granulomatosis, polyarteritis nodosa). (medscape.com)
  • Hashimoto's is a serious disease, and if left untreated can put you at a higher risk of thyroid cancer, as well as developing additional autoimmune diseases like Lupus, Rheumatoid Arthritis, Celiac Disease, Scleroderma, and Sjogren's Disease to name a few. (yourwellnesscenter.com)
  • Prominent examples include Coeliac disease , diabetes mellitus type 1 (IDDM), systemic lupus erythematosus (SLE), Sjögren's syndrome , multiple sclerosis (MS), Hashimoto's thyroiditis , Graves' disease , idiopathic thrombocytopenic purpura , and rheumatoid arthritis (RA). (wikidoc.org)
  • The severity of these symptoms varies greatly among patients: Some having scleroderma of only a limited area of the skin (such as the fingers) and little involvement of the underlying tissue, while others have progressive skin involvement. (wikipedia.org)
  • Musculoskeletal The first joint symptoms that patients with scleroderma have are typically nonspecific joint pains, which can lead to arthritis, or cause discomfort in tendons or muscles. (wikipedia.org)
  • Lungs Some impairment in lung function is almost universally seen in patients with diffuse scleroderma on pulmonary function testing, but it does not necessarily cause symptoms, such as shortness of breath. (wikipedia.org)
  • Primary biliary cholangitis (PBC) may progress slowly, and many people do not have symptoms, particularly in the early stages of the disease. (healthywomen.org)
  • Because many people with PBC have no symptoms, the disease is often discovered from abnormal results on routine liver blood tests (elevated alkaline phosphatase). (healthywomen.org)
  • Explore the signs and symptoms, genetic cause, and inheritance pattern of various health conditions. (medlineplus.gov)
  • Sjogren's syndrome is difficult to diagnose in part because patients present with a wide range of symptoms that can overlap with many other diseases and conditions. (medifocus.com)
  • The causes of autoimmune diseases are still unknown, and their symptoms can be difficult to manage. (brainboost.blog)
  • The impact of autoimmune diseases can vary widely, with symptoms ranging from mild to debilitating. (brainboost.blog)
  • Because these symptoms can be nonspecific and overlap with other conditions, diagnosing autoimmune diseases can be challenging and may require a comprehensive evaluation by a healthcare professional. (brainboost.blog)
  • Each autoimmune disease presents with its own unique set of symptoms, affecting different organs and systems within the body. (brainboost.blog)
  • Symptoms of Scleroderma vary depending on the type and extent of the disease. (top10intripura.com)
  • Scleroderma, a chronic autoimmune disease, may present with a range of early symptoms that vary based on the subtype and affected organs. (top10intripura.com)
  • Scleroderma treatment aims to manage symptoms, slow disease progression, and improve quality of life. (top10intripura.com)
  • Signs and symptoms of sickle cell disease usually starts appearing from early childhood like dactylitis frequently presenting as earliest sign in many cases around age of 6mnths with dactilitis usually being the very early symptoms. (atomictherapy.org)
  • If you have general, lingering symptoms, you may be suffering from an autoimmune disease -- which means your immune system is attacking healthy tissue. (webmd.com)
  • Your first symptoms of an autoimmune disease may be general, such as fatigue , low-grade fever, and difficulty concentrating, making autoimmune diseases difficult to diagnose at first. (webmd.com)
  • As the disease develops -- or more than one, as Rose points out -- vague symptoms start to appear, such as joint and muscle pain (very common), general muscle weakness, possible rashes or low-grade fever, trouble concentrating, or weight loss. (webmd.com)
  • Systemic lupus erythematosus (SLE or lupus) is an autoimmune disease that can cause joint pain and inflammation, among other symptoms. (ranjithospital.in)
  • Multiple sclerosis is one of the common chronic inflammatory demyelinating disease of the central nervous system (CNS), affecting more than 2 million people worldwide. (jrmds.in)
  • Multiple sclerosis (MS) has been increasingly reported to be associated with other autoimmune diseases not affecting the central nervous system especially connective tissue disease. (jrmds.in)
  • Patient seen and after detailed clinical evaluation we considered demyelinating disease MRI showed (showing features of demyelinating disease) and lumbar puncture (showing oligoclonal band), a diagnosis of multiple sclerosis (MS) was established. (jrmds.in)
  • Detailed history and systemic examination followed by laboratory and radiological investigation should be performed whenever there is a suspicion of Multiple sclerosis, especially if it occurs along with other connective tissue diseases. (jrmds.in)
  • Optic neuritis is one of most common clinical features of multiple sclerosis, may represent the first sign of the disease [ 2 ]. (jrmds.in)
  • Scleroderma, or systemic sclerosis, is an autoimmune connective tissue disorder characterized by excessive collagen production, leading to skin thickening and fibrosis. (alliedacademies.org)
  • Scleroderma is a long-lasting rheumatic disease or connective tissue disorder characterized by consequent tightening and hardening of the skin followed by other tissues and internal organs which play a crucial role in the sustenance of human life. (medimush.co.uk)
  • Scleroderma is a connective tissue disorder characterized by extreme skin tautness, resulting in vascular insufficiency, vasospasm, and Raynaud phenomenon. (medscape.com)
  • Similarly, interstitial lung diseases (ILDs) are a heterogeneous group of lung disorders-characterized by parenchymal lung injury as a consequence of systemic autoimmunity-classified on the basis of their radiologic as well as histopathologic features. (medscape.com)
  • Many acute and chronic lung disorders with variable degrees of pulmonary inflammation and fibrosis are collectively referred to as interstitial lung diseases (ILDs) or diffuse parenchymal lung diseases. (atsjournals.org)
  • Most of these are classified as interstitial lung diseases . (iiab.me)
  • SSc, a chronic disease with multisystemic involvement, is characterized by widespread collagen deposition. (medscape.com)
  • Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a slowly progressive bile duct disease, which results from chronic inflammation of the small intrahepatic bile ducts, the system of small tubes in the liver that helps drain bile. (pbc-society.ca)
  • Primary biliary cirrhosis (PBC) is a chronic disease characterized by progressive inflammation and destruction of the small bile ducts within the liver. (emedicinehealth.com)
  • Sjögren's syndrome - also called Sjögren's disease, is a chronic, slowly progressing inability to secrete saliva and tears. (wikidoc.org)
  • Primary biliary cholangitis (PBC) is the most common liver disease associated with chronic cholestasis in adults. (msdmanuals.com)
  • Systemic Sclerosis Systemic sclerosis is a rare chronic disease of unknown cause characterized by diffuse fibrosis and vascular abnormalities in the skin, joints, and internal organs (especially the esophagus. (msdmanuals.com)
  • Unlike obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), which show a normal or increased total lung capacity (TLC), restrictive disease are associated with a decreased TLC. (medscape.com)
  • SSc is a chronic inflammatory disease that affects vascular connective tissue and accompanies localised or generalised dermal fibrosis. (springeropen.com)
  • As scleroderma progresses, esophageal involvement from abnormalities in decreased motility may worsen due to progressive fibrosis (scarring). (wikipedia.org)
  • It is characterized by microcirculation abnormalities and scleroderma and/or visceral sclerosis. (scirp.org)
  • The term systemic sclerosis is used to describe a systemic autoimmune disease of unknown origin characterized by excessive deposition of collagen and other connective tissue macromolecules in skin and multiple internal organs, prominent and often severe fibroproliferative alterations in the microvasculature, and numerous humoral and cellular immunologic abnormalities. (medscape.com)
  • Collagen vascular disease is a somewhat antiquated term used to describe diseases of the connective tissues that typically include diseases which can be (but are not necessarily) associated with blood vessel abnormalities. (wikidoc.org)
  • However, each of these diseases can evolve slowly or rapidly from very subtle abnormalities before demonstrating the classic features which help in the diagnosis. (wikidoc.org)
  • The mnemonic "PAINT" has been used to divide the causes of restrictive lung disease into pleural, alveolar, interstitial, neuromuscular, and thoracic cage abnormalities. (medscape.com)
  • Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. (scirp.org)
  • The present clinical case is that of a man with the renal complications of scleroderma and the difficulties of the treatment even in the developed countries like France. (scirp.org)
  • In the present case, the management of this disease required a high dose of corticosteroid therapy and extra-renal purification. (scirp.org)
  • This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. (jrheum.org)
  • Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. (wikipedia.org)
  • BackgroundPatients suffering from systemic autoimmune rheumatic disease (SARD) display poor antibody development after two doses of mRNA vaccinations leaving these patients with only limited humoral protection against severe SARS-CoV-2 disease courses. (bvsalud.org)
  • Digestive tract Diffuse scleroderma can affect any part of the gastrointestinal tract. (wikipedia.org)
  • Systemic sclerosis is a complex and heterogeneous disease with clinical forms ranging from limited skin involvement (limited cutaneous systemic sclerosis) to forms with diffuse skin sclerosis and severe and often progressive internal organ involvement (diffuse cutaneous systemic sclerosis), and occasionally a fulminant course (fulminant systemic sclerosis). (medscape.com)
  • In cases of intrinsic lung disease, the physiological effects of diffuse parenchymal disorders reduce all lung volumes by the excessive elastic recoil of the lungs, relative to the outward recoil forces of the chest wall. (medscape.com)
  • Limited systemic scleroderma (ISSc) can be differentiated from diffuse systemic scleroderma (dSSc) as two fundamental clinical subgroups. (springeropen.com)
  • Currently, researchers believe that the condition occurs as a result of a combination of factors involving autoimmunity, viral infections, and genetic predisposition to the disease. (medifocus.com)
  • Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. (osu.cz)
  • Many connective tissue diseases feature abnormal immune system activity with inflammation in tissues as a result of an immune system that is directed against one's own body tissues (autoimmunity). (wikidoc.org)
  • The pathogenesis of the disease is currently not fully understood, but the lung seems to be a possible source of autoimmunity. (biomedcentral.com)
  • Autoimmune diseases are a group of disorders characterized by an aberrant immune response, wherein the body's immune system mistakenly attacks healthy cells and tissues. (alliedacademies.org)
  • Autoimmune diseases are a complex and perplexing group of disorders that continue to baffle medical professionals and researchers alike. (brainboost.blog)
  • Additionally, a family history of autoimmune disorders and certain environmental factors may contribute to an increased risk of the disease. (top10intripura.com)
  • If caused by parenchymal lung disease, restrictive lung disorders are accompanied by reduced gas transfer, which may be marked clinically by desaturation after exercise. (medscape.com)
  • The second is extrinsic disorders or extrapulmonary diseases. (medscape.com)
  • Diseases of these structures result in lung restriction, impaired ventilatory function, and respiratory failure (eg, nonmuscular diseases of the chest wall, neuromuscular disorders). (medscape.com)
  • PFTs are able to highlight a RA-ILD before its clinical onset and to drive follow up of patients with Forced Vital Capacity (FVC) and Carbon Monoxide Diffusing Capacity (DL CO ). In the course of Scleroderma Spectrum Disorders (SSDs) and Idiopathic Inflammatory Myopathies (IIMs), DL CO appears to be more sensitive than FVC in highlighting an ILD, but it can be compromised by the presence of PAH. (biomedcentral.com)
  • Sjögren syndrome is a particular multisystem disease that commonly occurs in middle-aged women, but it can be seen in both sexes and all ages in association with other autoimmune disorders. (medscape.com)
  • Autoimmune diseases such as Parkinson's disease, Hashimoto's and Celiac disease are all on the rise in the United States and throughout much of the world. (helpmychronicpain.com)
  • A week ago, when someone asked me about how often I see Hashimoto's Disease (Autoimmune Thyroiditis), my usual answer was about 1 in 15 women and about 1 in 100 men in my office. (yourwellnesscenter.com)
  • Hashimoto's Disease is when antibodies attack the structure of the thyroid. (yourwellnesscenter.com)
  • Other cause for idiopathic subglottic stenosis, though not proved, includes genetic factors, a subtle manifestation of collagen vascular disease, an anatomic predisposition of the smaller female subglottis, mechanical trauma from coughing, as well as gastroesophageal reflux disease (GERD), etc. (drsanu.com)
  • Idiopathic pulmonary fibrosis (IPF) is a lung disease that causes scar tissue to build up in the lungs. (ildcollaborative.org)
  • They include idiopathic fibrotic diseases, connective-tissue diseases, drug-induced lung disease, environmental exposures (inorganic and organic dusts), and primary diseases of the lungs (including sarcoidosis). (medscape.com)
  • Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease characterized by elevated pulmonary artery pressure with no apparent cause. (medscape.com)
  • In some cases the specific cause of the disease can be diagnosed, but in others the probable cause cannot be determined, a condition called idiopathic pulmonary fibrosis . (iiab.me)
  • PBC is a disease that disproportionately affects women, with 10 women for every man having the disease. (healthywomen.org)
  • Localized Scleroderma primarily affects the skin and underlying tissues, with limited impact on internal organs. (top10intripura.com)
  • Systemic Scleroderma: It is more severe as it affects the blood circulation and the internal organs thus proving fatal to life. (medimush.co.uk)
  • Pachydermia that affects the hands and extends proximal from the metacarpophalangeal joint is deemed to suffice for the classification of a patient as a scleroderma patient. (springeropen.com)
  • The exact cause of Scleroderma is not fully understood, but it is believed to involve a combination of genetic predisposition and environmental triggers. (top10intripura.com)
  • Researchers think that this increase is due to a combination of genetic predisposition and environmental factors. (helpmychronicpain.com)
  • In patients with lupus and rheumatic diseases, there are two dangerous autoantibodies-the antiphospholipid antibody, which can end up killing a fetus (usually in the second trimester), and the anti-Sjögren's syndrome, which can damage the baby's heart. (integrativetelemedicine.com)
  • These associations indicate a possible role for TGFβ3, TGFβ2 and TIMP1 in genetic susceptibility to SSc and for TGFβ3 in determining the degree of cutaneous fibrosis. (bath.ac.uk)
  • 1 - 3 Acute kidney injury is a common prominent feature of the disease, owing to the susceptibility of the glomerular circulation to endothelial damage. (jrheum.org)
  • Possibilities include immunologic responses to unknown antigens and genetic susceptibility, such as genetic predisposition to the development of defective suppressor T-lymphocyte function, production of autoantibodies (eg, antinuclear antibodies), and activation of the complement pathway. (medscape.com)
  • Polyarteritis nodosa, Wegener granulomatosis, and scleroderma are other vasculitides that also may result in a corneal ulcer. (medscape.com)
  • Polyarteritis nodosa is a vasculitis of small- and medium-sized arteries, which leads to multiple organ disease. (medscape.com)
  • The pathogenesis of polyarteritis nodosa is not clear, but, in some patients, it may be related to hepatitis B antigen-associated immune complex disease or other immune complexes. (medscape.com)
  • As the disease progresses over time, however, it can also produce so-called "extraglandular manifestations" that reflect damage to other vital body organs such as the kidneys, lungs, joints, and peripheral nerves. (medifocus.com)
  • It is worth mentioning that autoimmune diseases often have a multifactorial etiology, involving genetic predisposition, environmental triggers, and dysregulation of the immune system. (alliedacademies.org)
  • PBC is an autoimmune disease where a person's own immune system may attack his or her liver. (pbc-society.ca)
  • Because the immune system is generally "overactive", it is common for people with PBC or their family members to have other autoimmune diseases. (pbc-society.ca)
  • At their core, autoimmune diseases occur when the immune system, which is designed to protect the body from harmful invaders like bacteria and viruses, goes awry. (brainboost.blog)
  • These diseases occur when the immune system, which is designed to protect the body from harmful invaders like bacteria and viruses, mistakenly attacks its own healthy cells and tissues. (brainboost.blog)
  • When this balance is disrupted, either by genetic or environmental factors, the immune system can go haywire, launching an attack on the body's own tissues. (brainboost.blog)
  • SLE is one of the autoimmune diseases, where the body's defence immune system, instead of fighting bacteria and invading viruses, starts attacking the normal body tissues. (drgeraldlewis.com)
  • RA is an autoimmune disease in which the body's immune system mistakenly attacks the synovium, the lining of the membranes that surround the joints. (ranjithospital.in)
  • The short answer is, 'Autoimmune inner ear disease (AIED) results when your body's out-of-control immune system attacks your inner ear tissues. (saywhatclub.org)
  • One study indicated that immune system dysfunction was responsible for 16% of people with bilateral Meniere's disease and 6% of all people with any variety of Meniere's disease. (saywhatclub.org)
  • In yet another study, specific immune system antibodies were detected in 47% of people with Meniere's disease. (saywhatclub.org)
  • This all shows that a large percentage of the people with Meniere's disease have an underlying immune system problem. (saywhatclub.org)
  • Pulmonary Artery Hypertension (PAH, a potentially lethal condition characterized by high blood pressure in lung arteries) and Obstructive Lung Diseases (OLDs, an airway obstruction with airflow limitation) can also occur. (biomedcentral.com)
  • PBC is thought to have an autoimmune basis, probably triggered by an environmental factor in a person with a subtle genetic predisposition. (pbc-society.ca)
  • Some individuals may have a genetic predisposition to developing autoimmune diseases, which can be triggered by certain environmental factors like infections, toxins, or even stress. (brainboost.blog)
  • Environmental factors, such as infections, hormonal imbalances, exposure to certain chemicals, and even psychological stress, are believed to interact with genetic factors, contributing to the development of autoimmune diseases. (brainboost.blog)
  • Pathogenesis of autoimmune conditions is complex and includes not only genetic factors, but also environmental influence, which is considered to be the reason for the rise of incidence of autoimmune diseases. (bvsalud.org)
  • Even with a genetic tendency, a person may not develop an autoimmune disease without an environmental influence to set it off. (webmd.com)
  • However, genetic predisposition and environmental factors certainly play a key role in leading to its manifestation. (medimush.co.uk)
  • Connective tissue diseases can have strong or weak inheritance risks, and can also be caused by environmental factors. (wikidoc.org)
  • These are the autoimmune CTDs, where the cause is unknown but may have both genetic and environmental links. (wikidoc.org)
  • Genetic and environmental factors are associated with SLE. (medscape.com)
  • Causal factors include an unhealthy lifestyle (stress), dietary habits, exposure to environmental pollutants, and genetic predisposition. (med-vetacupuncture.org)
  • citation needed] Other pulmonary complications in more advanced disease include aspiration pneumonia, pulmonary hemorrhage and pneumothorax. (wikipedia.org)
  • Panel members are experts in adult pulmonary diseases. (atsjournals.org)
  • This usually takes the form of Interstitial Lung Disease (ILD), but Obstructive Lung Disease (OLD) and Pulmonary Artery Hypertension (PAH) can also occur. (biomedcentral.com)
  • Connective Tissue Diseases (CTDs) are often characterized by pulmonary involvement. (biomedcentral.com)
  • Pulmonary fibrosis (literally "scarring and damage of the lungs ") is a respiratory disease in which scars are formed in the lung tissues, leading to serious breathing problems. (iiab.me)
  • Pulmonary fibrosis may be a secondary effect of other diseases. (iiab.me)
  • In severe cases, it impacts the muscles and tissues which is called subcutaneous localized scleroderma. (medimush.co.uk)
  • A connective tissue disease is any disease that has the connective tissues of the body as a primary target of pathology. (wikidoc.org)
  • Second, since AIED often occurs in conjunction with other autoimmune diseases, it follows logically that more women than men would develop AIED. (saywhatclub.org)
  • Secondary Raynaud´s disease occurs frequently as a result of circulatory disturbances and is found in almost 90% of all cases. (springeropen.com)
  • Prognosis is determined by the form of the disease and the extent of visceral involvement. (wikipedia.org)
  • Skin involvement in scleroderma can have significant functional and cosmetic implications [ 3 ]. (alliedacademies.org)
  • Diagnosis is based on clinical manifestations, but tests and procedures may be used initiallly to exclude alternative diagnoses, and later for assessment of organ involvement and monitoring of disease progression (see Presentation and Workup ). (medscape.com)
  • 10 This review aims to provide an assessment of the nature and extent of complement involvement in the underlying pathophysiology of TMA associated with autoimmune diseases that will help to stratify patients for targeted therapy. (jrheum.org)
  • Connective Tissue Diseases (CTDs) are systemic autoimmune conditions characterized by frequent lung involvement. (biomedcentral.com)
  • The main clinical presentation is Interstitial Lung Disease (ILD), characterized by an involvement of the lung interstitium with inflammatory cells and/or exaggerated deposition of extracellular matrix by myofibroblasts. (biomedcentral.com)
  • If this is left untreated, acid from the stomach can back up into the esophagus, causing esophagitis and gastroesophageal reflux disease. (wikipedia.org)
  • Many more people than that have gastroesophageal reflux disease or an autoimmune disease. (ildcollaborative.org)
  • The roles and contributions of the complement system in the pathophysiology of autoimmune diseases / Wilhelm J. Schwaeble, Youssif M. Ali, and Robert B. Sim. (osu.cz)
  • In either case, there is a growing body of evidence which points to a genetic predisposition in a subset of patients. (iiab.me)
  • Marfan syndrome - a genetic disease causing abnormal fibrillin . (wikidoc.org)
  • Thus, any autoimmune response was perceived to be abnormal and postulated to be connected with human disease. (wikidoc.org)
  • Although the distinct cause of interstitial lung disease (ILD) in connective disease tissue (CTD) is not known, the underlying pathogenesis is thought to be secondary to varying degrees inflammation, alveolar injury, dysregulated tissue repair, and fibroproliferation. (medscape.com)
  • LS pathogenesis involves factors such as a genetic predisposition and an immune-mediated Th1-specific IFNγ-induced phenotype. (bvsalud.org)
  • Systemic scleroderma and Raynaud's can cause painful ulcers on the fingers or toes, which are known as digital ulcers. (wikipedia.org)
  • Researchers led by Professor Claudia Langenberg and Professor Maik Pietzner, working across PHURI and the BIH, carried out the largest genetic study of Raynaud's phenomenon. (focustechnica.com)
  • The team used electronic health records from the UK Biobank, a large-scale biomedical database and research resource containing genetic and health information from half a million UK participants, to identify more than 5,000 people affected by Raynaud's. (focustechnica.com)
  • This process can be damaged over time or due to genetic dysfunction. (myvivaa.com)
  • Current research supports that it is caused by a combination of a dysfunction of the immunological system and genetic factors. (rarediseases.org)
  • Excluding left-sided heart disease, including diastolic dysfunction, is especially important in these patients because of major treatment implications. (medscape.com)
  • The precise mechanisms underlying the development of dermatological manifestations in autoimmune diseases are not fully understood, but it is believed that immune-mediated inflammation and tissue damage play significant roles [ 4 ]. (alliedacademies.org)
  • The diseases cause inflammation or scarring of the lung tissue (interstitial lung disease) or result in filling of the air spaces with exudate and debris (pneumonitis). (medscape.com)
  • If the disease is severe, even minor abrasions or chaffing can cause bleeding, tearing, and blistering. (rarediseases.org)
  • These diseases lead to increased mortality and persistent reduction in quality of life of the patients, posing a severe medical burden. (bvsalud.org)
  • Systemic Scleroderma, also known as systemic sclerosis, is more severe and can affect various organs such as the heart, lungs, kidneys, and digestive system. (top10intripura.com)
  • The other patient had severe heart disease, and I doubted whether she'd be able to withstand pregnancy. (integrativetelemedicine.com)
  • Hormonal status, frequent trauma and autoimmune diseases are well-known associations for LS, yet infections do not seem to be clear risk factors. (bvsalud.org)
  • Risk factors for developing Scleroderma include gender, as it is more common in women, and age, with onset typically occurring between 30 and 50 years old. (top10intripura.com)
  • Genetic factors are also thought to play a role in functional constipation, but linkage studies, association studies, and direct gene sequencing have yet to find associated gene mutations. (medicalhomeportal.org)
  • It may be associated with an injury, there may be some genetic predisposition or other factors may come into play. (premierphysiotherapy.ie)
  • Weaker genetic factors may create a predisposition towards developing these autoimmune diseases. (wikidoc.org)
  • These diseases can be characterized according to etiological factors. (medscape.com)
  • Alopecia can be temporary, or it can be permanent - which may be affected by genetic factors. (dermareading.co.uk)
  • Certain genetic factors can make individuals more susceptible to hair loss. (drmichaelwald.com)
  • The term systemic sclerosis (SSc) is assigned to a complex of inflammatory and fibrotic diseases referred to as collagenoses. (springeropen.com)
  • Scleroderma is an aspect of systemic sclerosis , a systemic connective tissue disease that also involves subcutaneous tissue, muscles, and internal organs. (medscape.com)
  • Scleroderma - an activation of immune cells which produces scar tissue in the skin, internal organs, and small blood vessels. (wikidoc.org)
  • For children with lichen sclerosus affecting the perianal region, constipation may be among the first signs of the presence of the disease. (rarediseases.org)
  • A: Antibody titers measured 6 months after two doses of mRNA vaccination in patients with connective tissue disease, vasculitis and healthy controls. (bvsalud.org)
  • While PBC is rare, it is the most common cholestatic (bile build-up) liver disease. (healthywomen.org)
  • Liver transplantation is considered when medical treatment no longer sufficiently controls the disease and a person develops end-stage liver disease as a result. (healthywomen.org)
  • PBC is the most common autoimmune liver disease, affecting 1 in 1,000 women over the age of 40. (pbc-society.ca)
  • There is a correlation between alopecia areata and thyroid disease. (dermatology.org)
  • But even though there is a correlation between alopecia areata and thyroid disease, treating the thyroid disease does not remedy the alopecia areata. (dermatology.org)
  • Certain types of illness, including thyroid disease, can make conception particularly difficult. (integrativetelemedicine.com)
  • This article provides an overview of the dermatological manifestations seen in autoimmune diseases, highlighting their clinical features and significance. (alliedacademies.org)
  • Dr. Brenner focuses his clinical and research pursuits on a wide range of motility topics including IBS, constipation, opioid related constipation, fecal incontinence, gastroparesis and scleroderma. (gastrogirl.com)
  • While scleroderma itself does not typically require emergency treatment, certain complications associated with the disease may necessitate immediate medical attention. (top10intripura.com)
  • Treatment is directed principally toward managing complications and providing symptomatic relief, but disease-modifying agents are under investigation (see Treatment and Medication ). (medscape.com)
  • Treatment of autoimmune diseases is often based on unspecific immune suppression, increasing the risk of infectious diseases as well as cancer manifestation. (bvsalud.org)
  • Fifty percent of patients with SSc go on to develop clinically significant lung disease (SSc-ILD). (medscape.com)
  • Restrictive lung diseases are characterized by reduced lung volumes, either because of an alteration in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus. (medscape.com)
  • The first is intrinsic lung diseases or diseases of the lung parenchyma. (medscape.com)
  • Restrictive lung diseases are characterized by a reduction in FRC and other lung volumes because of pathology in the lungs, pleura, or structures of the thoracic cage. (medscape.com)
  • Panel members were selected because of an interest and expertise in the interstitial lung disease and to provide a range of opinions, expertise, and geography. (atsjournals.org)
  • In view of this, PFTs can also represent a useful, inexpensive and safe tool for the diagnosis of lung disease in CTDs and its management in the early stages, in which the disease could be more responsive to treatment. (biomedcentral.com)
  • In very rare situations, this could be a symptom of dermatological or systemic disease. (myvivaa.com)