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Heterogeneous-Nuclear Ribonucleoprotein UMatrix Attachment Region Binding ProteinsProtein Inhibitors of Activated STATNuclear Matrix-Associated ProteinsNuclear MatrixMatrix Attachment RegionsTissue ScaffoldsChromomycinsSTAT3 Transcription FactorHeterogeneous-Nuclear RibonucleoproteinsTwo-Hybrid System TechniquesSTAT1 Transcription FactorMolecular Sequence DataSTAT5 Transcription FactorDNA-Binding Proteins5-Lipoxygenase-Activating Protein InhibitorsBinding SitesCell LineBase SequenceCell NucleusNuclear ProteinsObject AttachmentDNARNA-Binding ProteinsDictionaries as TopicSTAT6 Transcription FactorProteinsTissue EngineeringSUMO-1 ProteinSteatorrheaSignal TransductionSmall Ubiquitin-Related Modifier ProteinsProtein BindingAmino Acid SequenceSumoylationSTAT2 Transcription FactorSTAT4 Transcription FactorBiocompatible MaterialsPorosityTrans-ActivatorsCells, CulturedEleusineDatabases, GeneticMEDLINEPolyestersSTAT Transcription FactorsAbstracting and Indexing as TopicPubMedNanofibersGene Expression RegulationNatural Language ProcessingTerminology as TopicCholesterol Ester Transfer ProteinsQuinolinesProtein Interaction MappingTranscription, GeneticInformation Storage and RetrievalCarrier ProteinsBlotting, WesternGenesProtein Structure, TertiaryPhosphorylationCell Line, TumorTransfectionReceptors, ComplementRNA, MessengerData MiningModels, MolecularTenebrioSoftwareInternetComputational BiologyMilk ProteinsMicroscopy, Electron, ScanningGene Expression ProfilingEnzyme InhibitorsTranscription FactorsMaterials TestingMutationImmunohistochemistryCystatinsStreptomycetaceaePolyglycolic AcidAbsorbable ImplantsProtease InhibitorsDatabases, ProteinDecanoatesCell AdhesionKineticsGene ExpressionVirus AttachmentReactive Attachment DisorderPolymersTrypsin InhibitorsVocabulary, ControlledMice, Inbred C57BLReverse Transcriptase Polymerase Chain ReactionIntracellular Signaling Peptides and ProteinsOvomucinGene Regulatory Networks
Peptides and proteinsTranscriptionProliferationSynthesisExpressionCellsTransforming growAbilityCellComplexActivityPIASEukaryoticTransmembraneDegradationMRNAsResiduesCleavageMotifsInteractsChromatinBindsActivatorLysineRegulateIntracellularRegulatoryMammalsModifierYeastSUMO1TranslationSimilarityContrastEnzymeCatalyzesUltimatelyFactorsTissueComplexesModificationPrecursorStructuralActivationResults suggestFormStructureLossDomain
Peptides and proteins2
  • The peptidomimetic based drugs are designed with the aim of overcoming the shortcomings of natural peptides and proteins. (ijpsr.com)
  • Therefore, from a past few decades there have been extensive research in designing synthetic peptides and proteins for health care 4- 5 . (ijpsr.com)
Transcription3
  • This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. (wikipedia.org)
  • β-catenin then translocates to the nucleus where it forms a complex with TCF/LEF transcription factors and activates Wnt target gene expression 28 , 29 . (nature.com)
  • For the quantification of cellular differentiation at the molecular level, osteogenic differentiation of MSCs is controlled by the interaction of hormones and transcription factors: runt-related transcription factor-2 (RUNX2) effectuates the expression of bone-specific genes, e.g. osterix (OSX), collagen type 1 alpha-1 (COL1A1), osteocalcin (OC), and bone sialoprotein (BSP) by binding to the promoters of these genes. (biomedcentral.com)
Proliferation2
  • Because of their capacity for ex vivo proliferation and differentiation they provide a good source of osteoprogenitor cells within custom-shaped scaffolds for implantable autologous bone tissue thus allowing the generation of a large transplantable cell population from a small biopsy [ 5 - 11 ]. (biomedcentral.com)
  • Subsequently, the protein adsorption capacity, simulated degradation, cell adhesion and proliferation capacity of the composite microcarriers were investigated. (bvsalud.org)
Synthesis1
  • The greatest impediment to this scientific endeavor is the complexity in the structure of Proteins and thus, its synthesis 6 . (ijpsr.com)
Expression5
  • Gene expression profiling was performed after silencing of key components of Wnt signaling pathway and an iterative signature algorithm was applied to predict pathway-dependent gene signatures. (nature.com)
  • Depending on the cultivation technique we found significant differences in both gen and protein expression. (biomedcentral.com)
  • Protein expression was examined using immunoblotting with or without the treatment of GW9662. (medchemexpress.com)
  • OE-Con and OE cells are treated with GW9662 (10 μM), and protein expression levels are determined by western blot. (medchemexpress.com)
  • The effect of GW9662 on the protein expression of PPARγ. (medchemexpress.com)
Cells4
  • Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. (nature.com)
  • Independent experiments confirmed several target genes, including PLOD2 , HADH , LCOR and REEP1 as non-canonical target genes in various colon cancer cells. (nature.com)
  • Bone grafting is a common procedure in orthopaedic surgery and the implantation of autologous bone grafts supplying osteoinductive growth factors, osteogenic cells, and a structural scaffold, has become the gold standard for the surgical treatment of bone defects caused by trauma, tumor, infection or congenital abnormalities. (biomedcentral.com)
  • Electrospun polyurethane/poly (ɛ-caprolactone) nanofibers promoted the attachment and progress of human endothelial cells in static and dynamic tradition situations On this examine, the angiogenic capability of human endothelial cells was studied after being plated on the floor of polyurethane-poly caprolactone (PU/PCL) scaffolds for 72 hours. (wildpalm.net)
Transforming grow1
  • Generally, alkaline phosphatase (ALP), COL1A1, BSP, RUNX2, transforming growth factor-beta 1 (TGFB1), osteonectin (ON), and bone morphogenetic protein-2 (BMP2) are known to be early markers of osteoblastic differentiation, whereas OC and osteopontin (OPN) are expressed later in the differentiation process [ 20 ]. (biomedcentral.com)
Ability1
  • defined Peptidomimetics as "compounds whose essential elements (pharmacophore) mimic a natural peptide or protein in 3D space and which retain the ability to interact with the biological target and produce the same biological effect" 14 . (ijpsr.com)
Cell1
  • Proteins, along with the nucleic acids in a cell form the molecular basis of life itself 1 . (ijpsr.com)
Complex1
  • In alphaviruses, this process is thought to be mediated, at least in part, by the viral protease (nsP2) which is responsible for processing the nonstructural polyproteins (P123 and P1234) into individual proteins (nsP1-nsP4), forming the viral replication complex. (bvsalud.org)
Activity1
  • It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). (wikipedia.org)
PIAS3
  • E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. (wikipedia.org)
  • The SAP motif is a 35-residue motif, which has been named after SAF-A/B, Acinus and PIAS, three proteins known to contain it. (expasy.org)
  • Eukaryotic proteins of the PIAS (protein inhibitor of activated STAT) family. (expasy.org)
Eukaryotic1
  • A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordered regions of proteins. (biomedcentral.com)
Transmembrane1
  • HN - 2017 MH - ADAM12 Protein UI - D000072199 MN - D8.811.277.656.675.374.102.125 MN - D9.400.430.500.125 MN - D12.776.395.33.125 MS - A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS. (nih.gov)
Degradation5
  • The SAP motif is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. (expasy.org)
  • Ubiquitin is best known for its role in redirecting the proteins towards degradation via proteasomal or lysosomal pathways by binding to the target protein in a polymer fashion (also known as poly-ubiquitin tags), but it is also involved in regulating nuclear localization and DNA repair pathways [ 65 ]. (biomedcentral.com)
  • Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
  • We observe that each gene and its products have a unique set of DNA, RNA or protein motifs that encode a regulatory program to define the logical circuitry that guides the life cycle of these biomolecules, from transcription to degradation. (biomedcentral.com)
  • The life of a gene product, from transcription to degradation, is controlled by a series of regulatory decisions. (biomedcentral.com)
MRNAs1
  • Finally, we contrast the regulatory properties of protein motifs and the regulatory elements of DNA and (pre-)mRNAs, advocating that co-regulation, co-operativity, and motif-driven regulatory programs are common mechanisms that emerge from the use of simple, evolutionarily plastic regulatory modules. (biomedcentral.com)
Residues1
  • This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Cleavage2
  • Mammalian Acinus, a protein which induces apoptotic chromatin condensation after cleavage by caspase-3 [ 6 ]. (expasy.org)
  • Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site. (expasy.org)
Motifs2
  • HN - 2017 MH - ADAMTS1 Protein UI - D000071097 MN - D8.811.277.656.675.374.102.500.500 MN - D9.400.430.500.500.500 MN - D12.776.395.33.500.500 MN - D12.776.860.300.85.500 MS - An ADAMTS protease that contains two disintegrin loops and three C-terminal thrombospondin (TS) motifs. (nih.gov)
  • HN - 2017 MH - ADAMTS13 Protein UI - D000071120 MN - D8.811.277.656.675.374.102.500.813 MN - D9.400.430.500.500.813 MN - D12.776.395.33.500.813 MN - D12.776.860.300.85.813 MS - An ADAMTS protease that contains eight thrombospondin (TS) motifs. (nih.gov)
Interacts1
  • SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. (asm.org)
Chromatin6
  • Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. (expasy.org)
  • Nuclear matrix attachment regions (MARs) are regulatory DNA sequences that are important for higher-order chromatin organization, long-range enhancer function, and extension of chromatin modifications. (nih.gov)
  • Here, we show that MATR3, a nuclear matrix protein, interplays with antisense LINE1 (AS L1) RNAs to form a meshwork via phase separation, providing a dynamic platform for chromatin spatial organization. (bvsalud.org)
  • HDAC inhibition diminishes NUP98's chromatin binding and dysregulates NUP98 and RAE1's target gene expression. (bvsalud.org)
  • We report that a broadly used rabbit monoclonal antibody raised against human EZH2, a catalytic subunit of PRC2, cross-reacts with an RNA-binding protein called Scaffold Attachment Factor B (SAFB) in mouse embryonic stem cells (ESCs) under buffer conditions that are commonly used for chromatin immunoprecipitation (ChIP). (bvsalud.org)
  • SARS-CoV-2 ORF8 encoded protein contains a histone mimic, disrupts chromatin regulation, and enhances replication. (asm.org)
Binds2
  • Here we characterize a novel cell type-specific MAR-binding protein, SATB2, which binds to the MARs of the endogenous immunoglobulin micro locus in pre-B cells and enhances gene expression. (nih.gov)
  • The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)
Activator2
  • Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. (expasy.org)
  • The overall results suggest that some activating mechanism for the progeny virus of wild-type Sendai virus exists in the lung of mice and the principle (activator) responsible for this phenomenon has a character similar to trypsin. (nih.gov)
Lysine2
  • The Polycomb Repressive Complex 2 (PRC2) is a conserved enzyme that tri-methylates Lysine 27 on Histone 3 (H3K27me3) to promote gene silencing. (bvsalud.org)
  • Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 16.8 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Regulate1
  • Each of these processes such as growth, molecule and ion transport or cell division involves molecular pathways with an array of intermediates which ultimately converge on a gene or a group of genes getting modulated, which further regulate a cascade of more such pathways. (biomedcentral.com)
Intracellular1
  • Soluble HB-EGF is a diffusible factor that can be captured by the receptors to activate the intracellular EGF receptor signaling cascade. (pharmaceuticalintelligence.com)
Regulatory1
  • The gene regulatory network maintaining progenitor function remains incompletely understood. (bvsalud.org)
Mammals1
  • SUMO is a conserved family of proteins that has one member in yeast, around eight in plants and four in mammals. (biomedcentral.com)
Modifier2
  • We found that SATB2 differs from the closely related thymocyte-specific protein SATB1 by modifications of two lysines with the small ubiquitive related modifier (SUMO), which are augmented specifically by the SUMO E3 ligase PIAS1. (nih.gov)
  • Small Ubiquitin like Modifier (SUMO) proteins have been recognized as one of the key PTMs modulating the function and half-life of many proteins, thereby serving as master switches in multiple molecular signalling pathways. (biomedcentral.com)
Yeast3
  • Yeast THO1 protein. (expasy.org)
  • Yeast RAD18, a protein involved in DNA repair. (expasy.org)
  • A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. (expasy.org)
SUMO12
  • Mutations of the SUMO conjugation sites of SATB2 enhance its activation potential and association with endogenous MARs in vivo, whereas N-terminal fusions with SUMO1 or SUMO3 decrease SATB2-mediated gene activation. (nih.gov)
  • In the late 90s, a single protein, now called SUMO1, was reported by several researchers with different names with differing functions. (biomedcentral.com)
Translation2
  • After translation, where is a protein localised, and what complexes should it join? (biomedcentral.com)
  • The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation. (asm.org)
Similarity1
  • Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
Contrast1
Enzyme2
  • It is also known as protein inhibitor of activated STAT protein gamma (PIASg or PIASy), and is an enzyme that in humans is encoded by the PIAS4 gene. (wikipedia.org)
  • Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. (nih.gov)
Catalyzes1
  • PARP is a nuclear protein that catalyzes the poly(ADP-ribosyl)ation of proteins. (expasy.org)
Ultimately1
Factors1
  • Vertebrate scaffold attachment factors A and B (SAF-A/B). These two proteins are heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind to AT-rich chromosomal region. (expasy.org)
Tissue1
  • It functions as an ANGIOGENESIS INHIBITOR as well as in normal tissue growth and fertility. (nih.gov)
Complexes1
  • A novel hnRNP protein (HAP/SAF-B) enters a subset of hnRNP complexes and relocates in nuclear granules in response to heat shock. (expasy.org)
Modification2
  • Sumoylation is also involved in targeting SATB2 to the nuclear periphery, raising the possibility that this reversible modification of a MAR-binding protein may contribute to the modulation of subnuclear DNA localization. (nih.gov)
  • SUMO modification changes the function and/or fate of the protein especially under stress conditions, and the consequences of this conjugation can be appreciated from development to diverse disease processes. (biomedcentral.com)
Precursor1
  • HN - 2017 (1997) MH - ADAM17 Protein UI - D000072198 MN - D8.811.277.656.675.374.102.375 MN - D9.400.430.500.375 MN - D12.776.395.33.375 MN - D23.50.301.264.35.57 MN - D23.101.100.110.57 MS - A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. (nih.gov)
Structural1
  • Structural impact on SARS-CoV-2 spike protein by D614G substitution. (asm.org)
Activation1
  • These proteins interact with phosphorylated STAT dimers and inhibit STAT mediated gene activation. (expasy.org)
Results suggest1
  • These results suggest that MC delivery via microvesicles can mediate gene transfer to an extent that enables effective prodrug conversion and tumor cell death such that it comprises a promising approach to cancer therapy. (regenerativemedicine.net)
Form1
  • In this case, the progeny virus was produced in the activated form and multiple-cycle replication occurred successively. (nih.gov)
Structure1
  • SARS-CoV-2 Omicron Variant: ACE2 Binding, Cryo-EM Structure of Spike Protein-ACE2 Complex and Antibody Evasion. (asm.org)
Loss1
  • Thus, HB-EGF acts as an autocrine and local paracrine cardiac growth factor that leads to loss of gap junction proteins within a spatially confined microenvironment. (pharmaceuticalintelligence.com)
Domain1
  • HN - 2017 MH - ADAM10 Protein UI - D000072197 MN - D8.811.277.656.675.374.102.250 MN - D9.400.430.500.250 MN - D12.776.395.33.250 MN - D23.50.301.264.35.48 MN - D23.101.100.110.48 MS - A disintegrin and metalloproteinase domain-containing protein. (nih.gov)