Scaffold sequence repressor proteins. Medical search. Frequent questions

Torc1 consists of either the Tor1 or the Tor2 kinase, a putative scaffold protein Kog1, Lst8, and Tco89 [4, 5]. (researchsquare.com)
Rep.3 encodes 999 coding sequences and 66 transfer RNAs, among which 39 have been assigned putative functions and 960 encode hypothetical proteins and proteins of unknown function. (cdc.gov)
In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
However, previously a cis -element in the promoter of the main xylanase-encoding gene was identified as binding site for a putative repressor. (biomedcentral.com)

Toward this objective, ChIP-Seq data of 14 S/MAR binding proteins were analyzed and the binding site coordinates of these proteins were used to prepare a non-redundant S/MAR dataset of human genome. (researchgate.net)
The whole-genome sequence of TSY216 was completed and deposited in GenBank (accession nos. (cdc.gov)
In total, 4,579 coding sequences were detected and annotated by using the National Center for Biotechnology Information Prokaryotic Genome Annotation Pipeline ( http://www.ncbi.nlm.nih.gov/genome/annotation_prok/ ). (cdc.gov)
Even though diverse strains of S. aureus have been extensively studied, and subjected to genome sequencing, the function of a large proportion of their genes remains unidentified. (biomedcentral.com)
The organism was completely isolated and sequenced at the DOE Joint Genome Institute. (kenyon.edu)
The bacterium had its genome completely sequenced because it contains a unique extracellular enzyme system capable of breaking down insoluble cellulose into ethanol which is vital for biomass energy. (kenyon.edu)
Jumonji (JmjC) domain proteins (see Jarid2 ) influence gene expression and chromatin organization by way of histone demethylation, which provides a means to regulate the activity of genes across the genome. (sdbonline.org)
A total of 435.34 Mb (53.75% of the genome) of repetitive sequences were predicted in the assembled genome. (bvsalud.org)
Studies of human genome demonstrate that protein-coding genes only occupy less than 2% of the entire genome [ 1 ]. (ijbs.com)

In addition, Rep.3 carries 2 genes encoding the histone-like nucleoid-structuring protein. (cdc.gov)
Because ''C. thermocellum'' is known as a degrader of cellulose, its DNA contains specific nucleotide sequences that make up the genes that encode for the system of enzymes that are necessary for cellulose degradation. (kenyon.edu)
Some of the genes play a role in synthesizing the enzymes while others are responsible for regulating cellulosome activity with inducers and repressors. (kenyon.edu)
Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
Genes responsible for familial AD include the amyloid precursor protein ( APP ), presenilin 1 ( PS1 ) and presenilin 2 ( PS2 ), whereas the main genes responsible for familial FTLD are microtubule-associated protein tau gene ( MAPT ) and progranulin ( GRN ). (touchneurology.com)
We characterize QmbHLH genes and identify the functions of QmbHLH proteins in Q. mongolica. (bvsalud.org)
We used bioinformatics approaches, qRT-PCR analysis, and RNA sequencing data to examine chromosomal distributions, gene structures, and conserved patterns, and identified 89 QmbHLH genes, which were divided into 21 subgroups based on the phylogenetic analysis of bHLH genes in Arabidopsis thaliana. (bvsalud.org)
Based on patterns of tissue-specific expression, protein interactions, and cis-element analysis, QmbHLH genes may be extensively involved in the growth and development of Q. mongolica. (bvsalud.org)
Of the 36,553 protein-coding genes predicted in the study, approximately 95% had functional annotations in public databases. (bvsalud.org)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)

Both the mSin3a and Mi-2/NuRD co-repressor complexes are large multi-component complexes in which not all of the components and their functions have been identified [ 2 , 6 ]. (biomedcentral.com)
The impact of oxidative stress on key components of the co-repressor complexes have only just started to be explored, with the very recent publication highlighting the impact of oxidative stress driven protein kinase-CK2 activation on co-repressor activity and HDAC2 function [ 20 ]. (biomedcentral.com)
The conserved "core" of the SMRT/NCoR repression complexes (called repression domain 1 or RD1) recruits HDAC3, TBL1 (and/or its homologue TBLR1) as well as a protein called GPS2 (also known as AMF1). (esrf.fr)
Vertebrate L3MBTL, a member of the Polycomb group of proteins, which function as transcriptional repressors in large protein complexes. (embl.de)
BRDs can act as scaffolds that enable the recruitment of large protein complexes or they can act as transcription factors themselves. (frontiersin.org)
From Protein Complexes to Subunit Backbone Fragments: a Novel Approach to Native Mass Spectrometry. (chicagobiomedicalconsortium.org)

Mechanistically, SEs recruited bromodomain containing 4 (BRD4) at the site of ZBTB16 , which then bound to RNA polymerase II-associated protein 2 (RPAP2) that transported RNA polymerase II (POL II) into the nucleus. (nature.com)
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. (nih.gov)
Our promoters have different affinities to the T7 RNA polymerase and the LacI repressor and therefore have different measurable properties. (igem.org)

6 The gene is located at chromosome 21q21.22 and encodes for a transmembrane protein that is normally processed into amyloid fragments. (touchneurology.com)

Hence the tetrameric nature of the TBL1 suggests that the protein may serve as a scaffold for a multivalent chromatin-targeted repression machine that contains multiple co-repressor proteins and histone deacetylase enzymes. (esrf.fr)
Polycomb Group (PcG) proteins maintain transcriptional repression throughout development, mostly by regulating chromatin structure. (sdbonline.org)
In E. coli, this protein was earlier reported to be produced during stationary phase, bind to the trp repressor, and make trp operon repression more efficient. (unl.edu)

Feedback Control of Protein Expression in Mammalian Cells by Tunable Synthetic Translational Inhibition. (openwetware.org)
Summary: Kyoto groups creates a synthetic switch using RNA/protein to control proteins of interest in mammalian cells. (openwetware.org)

It binds to sites in the proteolipid protein promoter. (embl.de)
The lac operator is a short sequence that binds to the LacI repressor, which prevents transcription. (igem.org)
An in vivo DNA-footprint assay indicated that Xpp1 binds a palindromic sequence in the xyn2 promoter. (biomedcentral.com)

HDACs function by deacetylating of key components of the transcriptional machinery including the core histone proteins resulting in their in re-association with the DNA, thus presenting a transcriptionally closed conformation [ 1 , 16 ]. (biomedcentral.com)
The mSin3A-histone deacetylase corepressor is a multiprotein complex that is recruited by DNA binding transcriptional repressors. (psu.edu)
They are large "platform" or "hub" proteins (c.2500 amino acids) that assemble a complex containing a number of histone deacetylase enzymes. (esrf.fr)
In addition to the amino-terminal tetramerisation domain, TBL1 contains a C-terminal WD40 domain that could potentially bind to histone tails and to intact nucleosomes, since such domains have been observed in this role in other proteins. (esrf.fr)
In this regard, a 165-kb plasmid, pSf-R27, in Shigella flexneri encodes a histone-like nucleoid-structuring protein that was claimed to be a transcriptional repressor of the plasmid ( 9 ). (cdc.gov)
Additionally, BRDs contain several catalytic domains that enable them to act as methyltransferases, ATP-dependent re-modellers or histone acetyltransferases and helicases ( 8 ) Bromodomain and extra-terminal domain (BET) proteins are a family of transcriptional mediators that regulate gene expression ( 8 , 9 ). (frontiersin.org)

In the cytoplasm, a chain or cluster of ribosomes form polyribosomes which function as a continuous protein factory that translates mRNA into polypeptide chains. (kenyon.edu)
Additionally, circRNAs modulate pre-mRNA alternative splicing and possess protein-coding capacity. (ijbs.com)
interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)

Gene transcription is tightly regulated by a highly complex and dynamic set of processes central to which is the recruitment of co-repressors to promoter bound sequence specific transcription factors [ 1 - 3 ]. (biomedcentral.com)
The expression of the most promising candidate, Xpp1 (Xylanase promoter-binding protein 1), was reported to be up-regulated on the repressing carbon source d -glucose and to bind the cis -element in vitro. (biomedcentral.com)

Sin3 has four paired amphipathic alpha helices (PAH1 to -4) that are protein-protein interaction motifs and is the scaffold upon which the complex assembles. (psu.edu)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
There are many superfamilies of Znf motifs, varying in both sequence and structure. (embl.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. (nih.gov)

Scaffold/matrix attachment regions (S/MARs) are DNA elements that serve to compartmentalize the chromatin into structural and functional domains. (researchgate.net)

SMRT and NCoR are homologous corepressor proteins that are recruited to many repressive transcription factors. (esrf.fr)
Additionally, four common transcription factors: FadR, TFEb, CRISPR loci binding protein, and HTH family protein were consistently overexpressed across all stress conditions, indicating their significant role in managing stress. (jcbose.ac.in)

Members are found in species in which homologs of the E. coli trp operon repressor TrpR are not detected [Energy metabolism, Electron transport]. (unl.edu)

Both endogenous and enhanced green fluorescent protein (EGFP)-fused Gβ2 and Gγ2 proteins were detected in the nucleus at baseline, whereas a fraction of EGFP-Gβ2 and DsRed2-GR comigrated to the nucleus or the plasma membrane, depending on the exposure of cells to dexamethasone or somatostatin, respectively. (rupress.org)
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (thermofisher.cn)
protein_coding" "AAC73194","ftsL","Escherichia coli","membrane bound cell division leucine zipper septum protein [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73288","bamA","Escherichia coli","BamABCDE complex OM biogenesis outer membrane pore-forming assembly factor [Ensembl]. (ntu.edu.sg)
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. (openwetware.org)
Membrane proteins (MPs) perform a wide variety of functions vital to the survival of organisms. (magnusgroup.org)
These EV contain a lipid bilayer associated to membrane proteins. (frontiersin.org)

Originally discovered as a chief regulatory protein of glucose and lipid metabolism and cell differentiation, the peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily 8 . (nature.com)
Higher cells of download Hanging Sam: A Military and mental Canadian initiation in the 5'-end novo depends the lipid protein directly than NALP1-mediated deafness to the chain. (evakoch.com)

Wild type, PI3Kγ knock-out (PI3Kγ -/- ) and PI3K kinase dead knock-in (PI3Kδ D910/A910 ) transgenic mice were exposed to cigarette smoke for 3 days and the expression levels of the co-repressor complex components HDAC-2, mSin3a, Mi-2α and Mi-2β and HDAC-2 activity in the lungs were assessed. (biomedcentral.com)

Pf1SID1 has sequence and structural similarity to the well-characterized 13-amino-acid SID of the Mad bHLHZip repressor. (psu.edu)
Pf1SID2 does not have sequence similarity with either Mad SID or Pf1SID1 and therefore represents a novel Sin3 binding domain. (psu.edu)
Based on sequence similarity, the encoded proteins could be either transcriptional repressors or activators. (bvsalud.org)

Transcriptomic analysis of the two recombinant strains in comparison with the control strain showed that the correct folding of proteins assisted by molecular chaperones played a key role in the improvement of FumDM expression and its enzyme activity. (inra.fr)
Recombinant fusion protein containing a sequence corresponding to amino acids 1-227 of human CHCHD3. (thermofisher.cn)

We mapped the regions in the three proteins required for interaction and demonstrated that the amino-terminal domain of TBL1 (TBL1-NTD) is able to bind both GPS2 and SMRT forming a ternary complex. (esrf.fr)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)

Mutations in this motif in both proteins abolished recruitment to TBL1. (esrf.fr)

Budesonide alone protected mSin3a protein expression with no additional effect seen with abrogation of PI3Kγ/δ activity, however Mi-2α, but not Mi-2β, expression was protected in both PI3Kδ D910/A910 and PI3Kγ -/- budesonide-treated smoke-exposed mice. (biomedcentral.com)

A comparison of the TF repertoire of S. aureus against 1209 sequenced bacterial genomes was carried out allowing us to identify a core set of orthologous TFs for the Staphylococacceae , and also allowing us to assign potential functions to previously uncharacterized TFs. (biomedcentral.com)
We have evaluated the orthologous distribution of these elements in other sequenced bacterial genomes using the repertoire of TFs identified in USA300, and identified a core set of regulators for both the Firmicutes phylum, and the Staphylococacceae group. (biomedcentral.com)

This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. (nih.gov)

The restoration of glucocorticoid function coincided with the protection of both HDAC activity and mSin3a and Mi-2α protein expression. (biomedcentral.com)
Recent developments in high-throughput sequencing technologies and microarray techniques enable scientists to conduct comprehensive analyses on the abundance, composition, expression profile and molecular function of circRNAs [ 16 ]. (ijbs.com)
Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)

JmjC proteins have been associated with many human diseases including various cancers, developmental and neurological disorders, however, the shared biology and possible common contribution to organismal development and tissue homeostasis of all JmjC proteins remains unclear. (sdbonline.org)
Advanced regenerative medicine strategies rely on the use of 3D scaffolds with tailored composition and porous structure in order to optimize tissue engineering processes. (magnusgroup.org)

Examination of the GPS2 and SMRT sequences adjacent to the coiled-coil identified a common a-helical sequence motif that could mediate interaction with TBL1. (esrf.fr)

Promoters are upstream sequences that regulate transcription. (igem.org)

Cigarette smoke exposure induced glucocorticoid insensitivity and alters co-repressor activity and expression which is prevented by blockade of PI3K signaling with glucocorticoid treatment. (biomedcentral.com)

We identified a novel mSin3A-interacting protein that has two plant homeodomain (PHD) zinc fingers we term Pf1, for PHD factor one. (psu.edu)
The CCHHC-type zinc finger contains five absolutely conserved cysteine and histidine residues (rather than the more usual four) with the sequence C-P-x-P-G-C-x-G-x-G-H-x(7)-H-R-x(4)-C. The second histidine has been shown to coordinate Zn(II) along with the three cysteines residues. (embl.de)
The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)
2012). Rational design of DNA sequence-specific zinc fingers . (openwetware.org)

Both mSin3a and Mi-2α protein expression was reduced in smoke-exposed mice. (biomedcentral.com)
The expression of the STE5 gene and its encoded scaffold protein Ste5, required for the sequential activation of the MAPKs of the pheromone pathway, is greatly reduced in the H2B R95A mutant. (researchsquare.com)
The inhibition of Torc1 by rapamycin mimics nutrient starvation and causes an array of physiological changes that include global changes in gene expression, phosphorylation/dephosphorylation of various factors, decreased cell growth, degradation of proteins, and ultimately cell cycle arrest in the G 1 phase [4, 9-11]. (researchsquare.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

protein_coding" "AAC73139","fkpB","Escherichia coli","FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73161","apaG","Escherichia coli","protein associated with Co2+ and Mg2+ efflux [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73196","murE","Escherichia coli","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73197","murF","Escherichia coli","UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73290","lpxD","Escherichia coli","UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC73627","ppiB","Escherichia coli","peptidyl-prolyl cis-trans isomerase B (rotamase B) [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)

The key co-repressor complex components HDAC-2, Mi-2α/β and mSin3a are all critical to the regulation of gene transcription. (biomedcentral.com)
Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)

The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)

Pyridoxal phosphate biosynthetic protein PdxA [Interproscan]. (ntu.edu.sg)
OstA-like protein, LPS transport system D [Interproscan]. (ntu.edu.sg)
Cell division protein FtsL [Interproscan]. (ntu.edu.sg)
SEC-C motif, SecA DEAD-like domain, SecA Wing and Scaffold domain, SecA preprotein cross-linking domain [Interproscan]. (ntu.edu.sg)
Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)

Most resulting proteins lead in techniques with IGFBPs, which plan methylated to modulate the CLASP of acts in the mode, react salt of IGFs to trim members for mice, promote cornea like supplements of IGFs, and be as encoding mitochondria here of IGFs. (evakoch.com)

Bromodomains are proteins that contain modules of ~110 amino acids that recognize and bind acetylated lysine residues in histones and other proteins. (frontiersin.org)

Complete sequence from genomic. (inra.fr)

A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)

We show that a member of the FK506-binding protein family, FKBP8, is an essential antagonist of SHH signaling in CNS development. (silverchair.com)

Using Newbler version 2.6, the Roche 454 GS De Novo Assembler software (454 Life Sciences, Branford, CT, USA), we assembled 424,273 reads into 3 large scaffolds comprising 119 contigs at 18.3-fold coverage. (cdc.gov)

1 In AD, tau protein is abnormally hyperphosphorylated and forms insoluble fibrils, which originate deposits within the cell. (touchneurology.com)
Using a chemo-genetic approach, we identify BET bromodomain containing proteins BRD2 and BRD4 as central regulators of NK cell functions, including direct cytokine secretion, NK cell contact-dependent inflammatory cytokine secretion from monocytes as well as NK cell cytolytic functions. (frontiersin.org)
Summary: Group from University of Toronto developed protein that causes rapid cell apotosis (cell death) of targeted cells. (openwetware.org)

In this respect, the transcriptional repressor PARIS (ZNF746) was identified by our group in 2011 6 among several other co-substrates of PINK1 and parkin as a promising candidate to shed light on possible contributions of a defective mitochondrial biogenesis to PD pathogenesis. (nature.com)
much 75 cytosol of pairing substrates are in 1500 220 KDa proteins with IGFBP3 and ALS. (evakoch.com)

Anatomy16

Organisms8

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes81

Disciplines and Occupations3

Technology, Industry, Agriculture20

Information Science3

Putative4

Genome9

Genes12

Complexes6

Polymerase3

Chromosome1

Repression3

Mammalian cells2

Binds3

Histone6

MRNA3

Promoter2

Motifs5

Chromatin1

Transcription factors2

Operon1

Membrane7

Lipid2

Kinase1

Similarity3

Recombinant2

Amino-terminal2

Recruitment1

MSin3a protein1

Bacterial2

Specificity1

Function3

Tissue2

Interaction1

Regulate1

Glucocorticoid1

Zinc4

Expression4

Coli10

Regulation2

Enzymes1

Interproscan5

Mitochondria1

Residues1

Genomic1

Assembly protein1

Family1

Large1

Cell3

Substrates2