Scaffold cells chromosomes. Medical search. Frequent questions

These scaffold proteins are responsible for the condensation of chromatin during mitosis. (wikipedia.org)
In mitosis, it is concentrated at the centromeres and the axis along the chromosome arms. (wikipedia.org)
The removal of this protein causes a dramatic loss of the chromosome structure in mitosis, and the cell cycle comes to a stop. (wikipedia.org)
Condensin I regulates the timing of chromosome condensation and is essential for changing the chromatin organization at the beginning of mitosis, from TADs to an array of loops around the chromosome axis. (wikipedia.org)
KIF4A, a chromokinesin, is implicated in the shaping of chromosomes during mitosis. (wikipedia.org)
As each chromosome contains a single centromere, it remains unclear how acentric fragments derived from shattered chromosomes are inherited between daughter cells during mitosis 6 . (nature.com)
Here we tracked micronucleated chromosomes with live-cell imaging and show that acentric fragments cluster in close spatial proximity throughout mitosis for asymmetric inheritance by a single daughter cell. (nature.com)
Here we show that pulverized chromosomes from micronuclei spatially cluster throughout mitosis and identify the CIP2A-TOPBP1 complex as an essential regulator of this process. (nature.com)
Consistent with this hypothesis, we discovered a protein Rif1 that enters the nucleus right after mitosis and its knockout has a profound disruptive effect on RT in both mouse and human cells. (fsu.edu)
During the course of development, the cells grow in size and divide to give rise to daughter cells through a process called mitosis. (hastakshepnews.com)
The study provides several new leads for a candidate-based approach to understand how the nuclear architecture dismantled during mitosis is re-organized to reproduce a cell that is structurally and functionally similar to the mother cell. (hastakshepnews.com)
on chromosomes are important for successful mitosis and implicate histone tail Atropine posttranslational modifications Pgf in regulating Topo II? (immune-source.com)
mitosis → produces genetically identical daughter cells. (mindmeister.com)

It is composed of a group of non-histone proteins that are essential in the structure and maintenance of eukaryotic chromosomes throughout the cell cycle. (wikipedia.org)
In the late 1970s, Ulrich K. Laemmli and colleagues discovered a backbone structure in eukaryotic chromosomes after they depleted the histone proteins. (wikipedia.org)
In eukaryotic organisms, the DNA of each cell is organized into separated chromosomes, which are composed of chromatin, a mixture of DNA and many different groups of proteins. (wikipedia.org)
Among them, the structural proteins (that are not histones) bind the chromatin fiber around themselves forming a long, continuous axis or backbone that gives the chromosomes their shape. (wikipedia.org)
When these proteins are removed, the chromosome shape does not appear and the chromatin fibers spread out. (wikipedia.org)
Condensin complexes, formed from the union of SMC2 and SMC4 (among other proteins), are responsible for the condensation of chromosomes. (wikipedia.org)
2004). Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells . (up.pt)
reveal that a scaffold formed by the proteins centrosomin and PLP is required to maintain the activity of interphase centrosomes, which is essential for nuclear spacing and proper chromosome segregation. (scivee.tv)
Crowding of asymmetric proteins results in an asymmetric lateral pressure across the membrane which can be used by cells in a number of biological processes involving membrane remodeling. (portlandpress.com)
In the placenta, an additional mechanism comes into play: In this tissue, some genes are deactivated by chemically modifying the proteins that serve as a structural scaffold for the DNA. (eurekalert.org)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)
Cells establish their shape and movement through the cytoskeleton, which is composed of polymers (microtubules) made up of proteins such as tubulin. (farmhouseflaredesigns.com)
New Delhi, February 26: Researchers from the Centre for Cellular and Molecular Biology ( CSIR-CCMB ) have identified the proteins that make up the interphase nuclear scaffold called the Nuclear Matrix (NuMat) and the Mitotic Chromosome Scaffold (MiCS). (hastakshepnews.com)
This means, during the process of condensing the genetic material for cell division, the proteins of the nuclear matrix are packaged and passed on to the daughter cells in the form of a mitotic chromosome, which now serves as a form of mitotic memory for the precise re-establishment of mitotic memory," researchers point out. (hastakshepnews.com)
The researchers compared the qualitative and quantitative protein compositions of the interphase nucleus and the mitotic chromosomes from fruit fly cell lines using techniques such as Liquid Chromatography with tandem mass spectrometry (LC-MS/MS). The data analysis using bioinformatic approaches to identify the proteins in the NuMat and MiCS revealed a two-thirds overlap between them. (hastakshepnews.com)
Our hypothesis states that the proteins that make the nuclear matrix of the interphase nucleus, during cell division are disassembled and packaged into the mitotic chromosomes and these serve as mitotic memory to guide the re-establishment of nuclear architecture in daughter cells," researchers explain. (hastakshepnews.com)

However, during cell division, the nuclear envelope and matrix essential for the structural and architectural integrity of the interphase nucleus are disassembled, and chromosome territories are condensed into mitotic chromosomes, only to be reassembled and re-established in the daughter nucleus. (hastakshepnews.com)
Intro In preparation for chromosome segregation materials of interphase chromatin are remodeled to form rod-shaped chromonemas of mitotic chromosomes (Swedlow and Hirano 2003 Eltsov et al. (immune-source.com)
is definitely targeted to mitotic chromosomes but core enrichment is definitely abolished (Coelho et al. (immune-source.com)

The maintenance of a single centromere per chromosome is critical for establishing bipolar microtubule attachments to the mitotic spindle and achieving high-fidelity genome segregation 17 . (nature.com)
The draft genome of the moss model, Physcomitrella patens, comprised approximately 2000 unordered scaffolds. (doe.gov)
In order to enable analyses of genome structure and evolution we generated a chromosome-scale genome assembly using genetic linkage as well as (end) sequencing of long DNA fragments. (doe.gov)
Such a global approach had previously been described only for chromosomes 21 and 22, which together account for 2.2% of the genome. (biomedcentral.com)
As of late 2000, the public human sequence was primarily based on approximately 24,000 accessioned bacterial artificial chromosome (BAC) clones covering 97% of the euchromatic portion of the genome [ 6 ]. (biomedcentral.com)
Thirty percent of the genome is in finished form, including the entire sequence of chromosomes 21 and 22 [ 7 ]. (biomedcentral.com)
Using a combination of various cutting-edge tools, including Hi-C for genome-wide chromatin conformation, the authors generated the near-chromosomal de novo genome assembly for the Indian cobra, and assigned portions of the genome, called scaffolds, to chromosomes. (activemotif.jp)
Collectively, the generated assembly allowed for gene mapping of the chromosomes, analysis of genomic features like GC content, and comparisons of the Indian cobra genome with other species for evolutionary studies by a process called whole-genome synteny comparison. (activemotif.jp)
Flexible design -We can design your probes from any genome reference sequence(s), and can accommodate any cytogenetics use case, such as chromosome painting or barcoding, RNA-FISH, and much more. (arborbiosci.com)
De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds. (cdc.gov)

Three protein groups have been identified as the main components of the scaffold: DNA topoisomerase IIα, condensins, and the KIF4A kinesin. (wikipedia.org)
It is thought that the protein has a role in untangling the DNA as the loops become more concentrated along the axis during the condensation of the chromosomes. (wikipedia.org)
The expression levels of dentin sialo-phosphoprotein (DSPP), dentin matrix protein-1 (DMP1), enamelysin/matrix metalloproteinase 20 (MMP20) and phosphate-regulating gene with homologies to endopeptidases on X chromosome (PHEX) were analysed using RT-PCR. (scielo.br)
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. (nih.gov)
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. (nih.gov)
This protein is a molecular chaperone with specific function in cell signal transduction. (nih.gov)
The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and cell cycle regulation. (portlandpress.com)
107 3e-22 UniRef50_Q4Y788 Cluster: Cell division cycle protein 48 homologu. (u-tokyo.ac.jp)
40 0.076 UniRef50_Q4MZM6 Cluster: Cell division cycle protein 48, putativ. (u-tokyo.ac.jp)
39 0.10 UniRef50_A7AVE1 Cluster: Cell division cycle protein ATPase, put. (u-tokyo.ac.jp)
34 3.8 UniRef50_Q0W6B6 Cluster: Putative cell division cycle protein 48. (u-tokyo.ac.jp)
In 1944 it was realized that genetic transformation in bacteria was due to DNA and not protein and that DNA was the molecule responsible for heredity in genes and chromosomes [ 8 ]. (biomedcentral.com)
Each chromatid is a single molecule of DNA attached to protein matrix fibres that forms its scaffold or axial filament [ 14 ]. (biomedcentral.com)
EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)
Microtubules are a protein scaffold that gives cells their shape and structure. (prettechengineering.com)
The drug works by disrupting the formation of microtubules, a protein scaffold that helps establish the shape and structure of cells. (prettechengineering.com)
While textbook depictions of cells show them to float in amorphous bags of liquid, the fact is that they are established through the cytoskeleton, which comprises protein structures called microtubules. (prettechengineering.com)
Sequence similarities and secondary structure predictions indicate that Pds5 consists of tandemly repeated HEAT repeats, and might therefore function as a protein-protein interaction scaffold, possibly in the cohesin-DNA complex assembly. (nih.gov)
It works by interfering with the formation of microtubules, a protein scaffold in cells that provides structure and shape. (farmhouseflaredesigns.com)
This protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. (medlineplus.gov)
The menin protein is present in the nucleus of many different types of cells and appears to be active in all stages of development. (medlineplus.gov)
As a result of these mutations, one copy of the MEN1 gene in each cell makes no functional protein. (medlineplus.gov)
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. (nih.gov)
The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. (nih.gov)
Dystrophin (encoded by DMD ) is a protein in muscle cells that transmits contractile force to extracellular protein scaffolds. (cd-genomics.com)

Another important technique implemented was Chrom-seq (Single-chromosome sequencing) which involves sequencing of individual chromosomes that are isolated by a method called laser capture microdissection. (activemotif.jp)

We now recognize that, following DNA replication, the metaphase chromosome consists of two chromatids held together by a centromere and by cohesin. (biomedcentral.com)
Both panels include myTags human chromosome 17 centromere probes [ATTO 647N] and chromosomes [stained with Hoescht 33342] pseudo-colored gray. (arborbiosci.com)

This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. (nih.gov)
The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. (nih.gov)
Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex in a Cohort of Sporadic Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia. (nih.gov)
CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells. (nih.gov)
The results could be significant for X-chromosome-related disease because reactivation of the silent gene could compensate for the malfunctioning active gene. (eurekalert.org)
CF27-specific gene clusters which have been analyzed were expressed by both ferrous iron-grown and sulfur-attached cells, indicating that they are not pseudogenes and may play a role in both situations. (frontiersin.org)
The first suggests that disruption of the inner nuclear membrane and the nuclear lamina causes disorganization of nuclear chromatin and gene expression, while the second proposes that the mechanical strength of the cell nucleus is disrupted when the nuclear lamina is weakened leading to structural and signaling defects in mechanically stressed tissue such as muscle and heart. (medscape.com)
If the second copy of the MEN1 gene is also altered, the cell has no working copies of the gene and does not produce any functional menin. (medlineplus.gov)
Some gene mutations are acquired during a person's lifetime and are present only in certain cells. (medlineplus.gov)
The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. (nih.gov)

Although some reference genomes are available for this clade, few are at the chromosome level, inhibiting high-resolution genomic studies. (biorxiv.org)

Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. (scielo.br)
Mesenchymal stromal cells (MSCs) can regulate macrophage activation, dampens inflammation and improves wound healing. (care-graduateschool.fr)
These factors can cause damage to stromal cells in the fibrous framework of the ventricular wall, and followed by gradual degeneration, necrosis, extracellular edema of cardiomyocytes, finally whole-heart enlargement, cardiac function decline and heart failure. (cd-genomics.com)

Condensin II drives the compaction of the chromosome loops along the axis. (wikipedia.org)
In particular, SMC2 (present in condensin I and II) is detected in the interior of the chromosome as part of the scaffold. (wikipedia.org)
It is known that KIF4A regulates the behavior of condensin I, because in absence of KIF4A the chromosome axis does not become enriched with condensin I. Poonperm R, Takata H, Hamano T, et al. (wikipedia.org)
Could condensin scaffold the mitotic chromosome? (up.pt)
In either or chicken cells depleted of condensin Topo II? (immune-source.com)
2008 It is not known if the chromosome core region is definitely enriched with DNA inside a positively supercoiled topological state but Atropine this can be inferred from the fact that condensin localization is mostly restricted to the core region of chromosomes (Maeshima and Laemmli 2003 Ono et al. (immune-source.com)

Inactivation of CIP2A-TOPBP1 caused acentric fragments to disperse throughout the mitotic cytoplasm, stochastically partition into the nucleus of both daughter cells and aberrantly misaccumulate as cytoplasmic DNA. (nature.com)
What makes the two daughter cells identical to the mother cell is not only their physical organization and function but also the organization of their genetic material in the control room of the cell, the nucleus. (hastakshepnews.com)
Nuclear Matrix (NuMat) is supposed to be the underlying biomolecular scaffold that provides structural organization and functional compartmentalization of the nucleus. (hastakshepnews.com)
The residual framework structure of the CELL NUCLEUS that maintains many of the overall architectural features of the cell nucleus including the nuclear lamina with NUCLEAR PORE complex structures, residual CELL NUCLEOLI and an extensive fibrogranular structure in the nuclear interior. (bvsalud.org)

Journal of Cell Biology. (wikipedia.org)
from the July 6th, 2015, issue of The Journal of Cell Biology and includes an interview with two of the. (scivee.tv)
from the May 25, 2015, issue of The Journal of Cell Biology and. (scivee.tv)

A proteinaceous scaffold found between homologous chromosomes during meiosis. (mcw.edu)

1995 and resolution of the two sisters within the pair (Sumner 1991 The intense fidelity with which cells carry out this process of mitotic chromosome formation is essential for avoiding chromosome segregation errors. (immune-source.com)
is essential for chromosome condensation and segregation whereas Topo II? (immune-source.com)

All the cells contain the same genetic information, but depending on the organ, different genes are active. (eurekalert.org)
Some of these genes likely play a role in cell growth and division. (medlineplus.gov)
Lighter bands on chromosomes called euchromatin where genes are expressed. (mindmeister.com)

This shows that interphase chromatin structure is not sufficient to dictate RT and lead us to hypothesize that the chromatin structure set-up during early G1 may act as a scaffold to seed the assembly of some factor capable of setting replication initiation thresholds. (fsu.edu)

Cyril Darlington pioneered plant cytogenetics in 1920-30 and made important advances in our understanding of mechanisms of chiasma formation and the behavior of sex chromosomes in meiosis [ 7 ]. (biomedcentral.com)
meiosis → produces genetically different daughter cells. (mindmeister.com)

Scaffold/matrix attachment regions (S/MARs) are DNA elements that serve to compartmentalize the chromatin into structural and functional domains. (researchgate.net)
In summary, the work descried in this thesis uncovers a model where replication-timing is regulated at the unit of chromatin structure called TADs, which are generally stable across cell-types, but the compartment that they reside in corresponds to the time of their replication. (fsu.edu)
Interphase chromatin structure is established along with the establishment of RT and may act as scaffold for replication regulation factors like Rif1. (fsu.edu)
Finally, replication timing and its association with chromatin structure are highly conserved and are observed even at the single chromosome level. (fsu.edu)
2012 This dramatic transformation of interphase chromatin to a set of actually tractable condensed chromosomes is definitely complete within minutes yet must achieve not just linear compaction but also individualization of each chromosome (Giménez-Abián et al. (immune-source.com)

Cell Cycle, 3 (5), 538 - 540. (up.pt)
Cell Cycle, 6 (11), 1367 - 1378. (up.pt)
Due to its abundance and versatile function, VCP participates in many cellular pathways including ERAD, endolysosomal trafficking, selective autophagy, cell cycle regulation, and DNA damage signaling [ 1 ]. (portlandpress.com)
39 0.10 UniRef50_Q4UBT9 Cluster: Cell divison cycle CDC48 homologue, put. (u-tokyo.ac.jp)
They have been shown to bind mitochondrial DNA, induce necroptosis and apoptosis, and arrest cell cycle progression in colorectal cancer cells. (prettechengineering.com)
It binds to beta-tubulin and disrupts microtubules, causing cell cycle arrest and apoptosis. (prettechengineering.com)
But the dynamics of this relationship during differentiation and cell cycle have been poorly understood. (fsu.edu)
Microtubules are involved in many important cellular processes, such as cell cycle progression (i.e., separating chromosomes during cell division). (farmhouseflaredesigns.com)

We also show that Pds5 co-localizes with cohesin on chromosomes, that the chromosomal association of Pds5 and cohesin is interdependent, that Scc1 recruits Pds5 to chromosomes in G1 and that its cleavage causes dissociation of Pds5 from chromosomes at the metaphase-to-anaphase transition. (nih.gov)
Our myTags probes can be easily integrated into your existing workflows to enable (F)ISH research on chromosomal material or whole cells. (arborbiosci.com)

Nature Reviews Molecular Cell Biology. (wikipedia.org)
Molecular Biology of the Cell, 18 (3), 850 - 863. (up.pt)
T cells have been recently identified by using key molecular markers such as CD4 and CD8 ( 4 , 5 ). (aai.org)
The future of molecular cytogenetics is likely to depend on a better knowledge of chromosome structure and function. (biomedcentral.com)
One of the purposes of this review is to encourage research into chromosome structure as this could help advance molecular cytogenetics. (biomedcentral.com)
To assess the molecular mechanisms of MSCs-macrophages interactions within the 3D-biomaterial scaffold. (care-graduateschool.fr)

2013). Aurora B and Cyclin B have opposite effects on the timing of cytokinesis abscission in drosophila germ cells and in vertebrate somatic cells . (up.pt)
The primary cilium is a highly conserved microtubule-based organelle present in most vertebrate cell types. (bvsalud.org)

Since the genetic code was deciphered much has been learnt about the chromosome structure shared by all organisms from yeast to human. (biomedcentral.com)
The life of all complex organisms , like humans, originates from a single cell called the zygote. (hastakshepnews.com)
myTags Custom probes from Daicel Arbor Biosciences have been used successfully in (F)ISH experiments with a wide range of organisms such as animals, plants, and microbes - and for a variety of research applications such as 3D DNA-FISH, RNA-FISH, chromosome painting and barcoding, and much more. (arborbiosci.com)

Comparing to a chromosome doubled number of colchicine and loq were also work. (myjuicecup.com)

In biology, the chromosome scaffold is the backbone that supports the structure of the chromosomes. (wikipedia.org)
Cell Biology (3rd ed. (wikipedia.org)

The enzyme DNA topoisomerase IIα prominently appears along the chromosome axis as part of the scaffold. (wikipedia.org)
We discovered that the enzyme PRC2 plays an important role in the inactivation of the X chromosome, at least in the placenta," says Andergassen. (eurekalert.org)
Once we remove this enzyme, the silent X chromosome is reactivated. (eurekalert.org)
is the target of an important class of anticancer medicines but tumor cells can become resistant by reducing the association of the enzyme with chromosomes. (immune-source.com)
to chromosomes and it is not known if the highly dynamic property of the enzyme is definitely biologically important. (immune-source.com)

1985 Gasser and Laemmli 1987 enzymes that function in mitotic chromosome formation. (immune-source.com)

Moreover, they have been shown to inhibit the RAS-related signaling pathway in lung cancer cells with a KRAS mutation. (prettechengineering.com)

Here, we assemble genomes from three members of the genus, the tiger ( Panthera tigris ), the snow leopard ( Panthera uncia ), and the African leopard ( Panthera pardus pardus ), at chromosome or near-chromosome level. (biorxiv.org)

Clinical significance of L1CAM expression and its biological role in the progression of oral squamous cell carcinoma. (nih.gov)
The idiosyncratic relationship between diagnostic delay and stage of oral squamous cell carcinoma. (tractorgallery.net)

Stains used by pathologists to identify bacteria also served to identify chromosomes. (biomedcentral.com)

The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
RPA enhances in vitro melting, FAN1 excision, and repair of slipped-CAGs and protects against CAG expansions in human cells. (bvsalud.org)
HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro. (nih.gov)

However, most fragments derived from pulverized chromosomes are acentric and cannot directly bind to spindle microtubules 14 . (nature.com)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)

When SMC2 is inhibited, the structure of the mitotic chromosome suffers grave defects. (wikipedia.org)
Centrosomes undergo dramatic changes in size and structure during the rapid cell cycles of early Drosophila embryos. (scivee.tv)
The review provides a brief account of the structure of somatic and meiotic chromosomes, stressing the high conservation of structure in plants and animals, with emphasis on aspects that require further research. (biomedcentral.com)
These studies reaffirmed that chromosome structure and behavior in somatic and germ cell divisions were common to all plants and animals. (biomedcentral.com)
This cellular structure is made of microtubules, which are also used to pull and separate the chromosomes during cell division. (prettechengineering.com)

The stochastic inheritance of chromosome fragments by both newly formed daughter cells could in part contribute to the alternating DNA copy-number states that are characteristic of chromothripsis 2 . (nature.com)
Lastly, we explored the conservation of replication timing at single cell level that revealed a highly conserved yet stochastic regulation of replication timing. (fsu.edu)
This is consistent with a model of replication timing regulation where the timing is the outcome of stochastic origin firing and is not affected by the precise environment within a cell. (fsu.edu)

These microtubules form a network of filaments that allow the cell to change shape and transport organelles and cargo around the body. (prettechengineering.com)

Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation]. (nih.gov)
Fugu B7-H1/DC inhibited T cell proliferation concomitant with increasing levels of both IL-10 and IFN-γ expression, whereas both B7-H3 and B7-H4 promoted T cell growth following IL-2 induction and the suppression of IL-10. (aai.org)

Sirtuins do things like fix broken DNA, ensure the structural integrity of chromosomes, control how cells reproduce themselves and whether they become senescent. (xtend-life.com)

The sites of DNA attachment to the scaffold have not been sequenced although repetitive elements are said to be involved. (biomedcentral.com)

Dendritic cells (DCs), 4 monocytes/macrophages, and B cells have been identified as major professional APCs ( 1 , 2 ). (aai.org)
A novel cell therapy product will be developed by embedding MSCs and macrophages within a 3D biocompatible scaffold, and its efficacy in wound healing will be assessed. (care-graduateschool.fr)

The mechanisms of transmission of both discontinuous and continuous characteristics across the generations were unknown before Mendel's laws were explained at the turn of the 20th Century by the behavior of chromosomes in germ cells [ 2 , 3 ]. (biomedcentral.com)

This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. (scielo.br)
To determine the in vivo efficacy of this new cell therapy as a treatment of chronic wound healing. (care-graduateschool.fr)

In a follow-up project at TUM, Andergassen will study whether heart diseases might also be associated with epigenetics and especially with the inactive X chromosome in women. (eurekalert.org)
Because our epigenetics change as we get old, it is conceivable that the X chromosome becomes active again and that the duplicate genetic activity has a negative influence," says the researcher. (eurekalert.org)

2022). Image analysis workflows to reveal the spatial organization of cell nuclei and chromosomes. (arborbiosci.com)

Mitotic clustering drives the unequal inheritance of acentric fragments by a single daughter cell, providing an explanation for the origins of distinct patterns of chromothripsis found across diverse cancer types and congenital disorders. (nature.com)
There are four genetic modes: autosomal dominant inheritance, autosomal recessive inheritance, sex chromosome linkage inheritance and mitochondrial inheritance. (cd-genomics.com)

Sequencing of daughter cell pairs derived from micronucleated mother cells demonstrated that complex rearrangements are indeed a common outcome of micronucleus formation. (nature.com)
The authors determined that the Indian cobra has two complete sets of chromosomes from each parent totaling 19 pairs, among which 1 pair contains the sex chromosomes. (activemotif.jp)

Although different stem cells, morphogens and scaffolds can be combined to simulate natural odontogenic regeneration, it is crucial to determine which options most closely replicate the characteristics of human dental tissues. (scielo.br)
editors Culture of human stem cells. (scielo.br)
We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)

Broad range of probeset sizes -Our optimized design and synthesis technologies can accommodate any size target, from a single locus to a full chromosome. (arborbiosci.com)

Replication Timing (RT) is a stable epigenetic property that is cell type specific and is extensively regulated during differentiation in units that range from 400-800kb called replication domains. (fsu.edu)

Thus, distinct patterns of chromothripsis can be explained by the spatial clustering of pulverized chromosomes from micronuclei. (nature.com)

The results showed that fenbendazole reduced the viability of the tumor cells by modulating their redox status. (prettechengineering.com)
Without menin, these cells can divide too frequently and form a tumor. (medlineplus.gov)

These studies implicate a potential mechanism suppressing the loss of genetic material after chromosome pulverization, although how distinct patterns of rearrangements arise in cancer and germline disorders remains unclear. (nature.com)
When a cell divides, the entire genetic material of the cell is replicated to make two copies and equally distributed to the daughter cells. (hastakshepnews.com)

In our study, fenbendazole induced autophagy via Beclin-1 expression and apoptosis in both 5-FU-sensitive and -resistant colorectal cancer cells. (prettechengineering.com)
They believe that this is because of its interference with glucose metabolism, which leads to apoptosis and other cell death pathways. (prettechengineering.com)
They also noticed that fenbendazole triggered apoptosis in 5-fluorouracil-resistant SNU-C5/5-FUR cells without activating p53. (prettechengineering.com)
The induction of apoptosis caused by fenbendazole has been shown to halt the growth of cancerous cells and inhibit their spread. (prettechengineering.com)
For example, it may play a role in copying and repairing DNA and regulating the controlled self-destruction of cells (apoptosis). (medlineplus.gov)

Genetic regulation takes place in every cell in the body. (eurekalert.org)

While undergoing division, the cell must remember the mother cell's organization in order to reorganize the daughter cells in the same fashion. (hastakshepnews.com)

Anatomy66

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