Scaffold brain tumor suppressor proteins. Medical search. Frequent questions

In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
Low AKAP12 expression in a larger cohort of patients (75) characterized tumor invasiveness, recurrence, and progression, indicating its potential as a prognostic biomarker. (nature.com)
It may function in tumor progression and in lymphomagenesis. (nih.gov)
Meanwhile, the DOC-2/DAB2 interacting protein DAB2IP was previously identified as a member of the Ras-GTPase activating protein family, and functions as a tumor suppressor in cancer progression 7 , 8 . (nature.com)
Elevated AEG-1 expression is seen in nearly all tumor types, and in most cases AEG-1 positively correlates with tumor progression and poorer patient survival. (biomedcentral.com)
Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are currently the focus of anticancer drug development. (spandidos-publications.com)

Recent studies, including publications from the Penn group, have identified lncRNAs with tumor suppressive and oncogenic activities in cancers. (sciencedaily.com)
DNA DSB repair E3 ligase genes are involved in tumor suppressive or oncogenic functions, such as RNF168 and FBXW7, by assisting the functionality of these genomic alterations. (bmbreports.org)
Here, we have demonstrated that activation of the tumor suppressor protein phosphatase 2A (PP2A), a negative regulator of multiple oncogenic signaling proteins, is a promising therapeutic approach for the treatment of cancers. (mssm.edu)

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene. (wikipedia.org)
From Protein Complexes to Subunit Backbone Fragments: a Novel Approach to Native Mass Spectrometry. (chicagobiomedicalconsortium.org)
According to ELISA, Western blotting (WB) and reverse transcriptase polymerase chain reaction (RT-PCR), TFH significantly downregulates expression levels of diglyceride (DAG)-activated protein kinase C (PRKCA), mitogen activated protein kinase 10 (MAPK10), human nuclear factor κB subunit p65 (NF-κB p65) and tumor necrosis factor-α (TNF-α) in pancreas of STZ-induced rats. (bvsalud.org)
This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. (nih.gov)
G protein subunit gamma 2 [Sourc. (gsea-msigdb.org)
Mechanistically, we found that SMAPs act by binding to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. (mssm.edu)

The NHEJ pathway, which repairs double-strand breaks in DNA, is one of the major pathways in tumor cells that respond to radiation treatment and chemotherapeutic agents. (sciencedaily.com)
Conclusion: For the protection of stem cells against apoptosis, different pathways, namely Phosphoinositide 3-Kinase (PI3K/AKT), Hypoxia-Inducible Factor (HIF1), Mitogen-Activated Protein Kinases (MAPK) and Hippo, are discussed. (benthamscience.com)
This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. (assaygenie.com)
Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway , regulate synaptic development in vertebrates and invertebrates. (sdbonline.org)
Both proteins are known to negatively control the bone morphogenetic protein (BMP) and the transforming growth factor beta ( TGF-β ) signaling pathways. (bio-rad-antibodies.com)
What pathways are this gene/protein implicaed in? (cancer-genetics.org)
Stiffened tumor stroma is a hallmark of cancer and understanding mechanosensitive pathways involved in the onset of cancer is key in identifying strategies for cancer treatment. (5dok.org)

They found that PML limits breast cancer metastasis by inhibiting cancer stem cell survival, tumor cell migration and blood vessel formation. (forth.gr)
Invasion and metastasis are key features that distinguish malignant tumors-cancer proper-from benign growths. (bbvaopenmind.com)
In 2002 and 2004, several groups, under different experimental settings, reported identification of the gene, first named as astrocyte elevated gene 1 (AEG-1), now having the GenBank symbol as MTDH, which stands for metadherin, for its involvement in tumor metastasis and adhesion. (biomedcentral.com)

Our aim was to establish a live cell culture to enable the understanding of the cellular processes driving the non-malignant growth of these tumors. (frontiersin.org)
Although these tumors are considered to be non-malignant, they have a high rate of proliferation and can reach large sizes before being diagnosed. (frontiersin.org)
A further conversion of the malignant tumor leads to the formation of highly motile and invasive cancer cells, and the recruitment of normal cells that act as helpers in tumor dissemination. (bbvaopenmind.com)
Glioblastoma multiforme (GBM) is the most prevalent primary malignant brain tumor and, remains one of the most lethal cancers, with a median survival of only 15 months upon diagnosis 1 . (nature.com)
As a multifunctional oncoprotein, AEG-1 has been shown to overexpress in multiple types of human cancer, and the elevation of AEG-1 in tumor cells leads to enhanced phenotypes characteristic of malignant aggressiveness, including increased abilities to proliferate robustly, to invade surrounding tissues, to migrate, to induce neovascularization, and to enhance chemoresistance. (biomedcentral.com)

The fact that RELA can be modified by a collection of kinases via phosphorylation at different sites/regions within the protein under different stimulations might suggest a synergistic effect of these modifications. (wikipedia.org)
This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)
MPZL1 is a main receptor for concanavalin-A (ConA) and it is involved in cellular signaling induced by ConA, which most likely includes Src family tyrosine-protein kinases. (assaygenie.com)
In Drosophila, Hpo and Warts kinases are core components of this pathway and function as tumor suppressors by inhibiting Yorkie (Yki) . (sdbonline.org)
Arencibia JM, Pastor-Flores D, Bauer AF, Schulze JO and Biondi RM: AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases. (spandidos-publications.com)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)

ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)
In earlier studies, researchers at the Technion took a stem cell, removed its contents, and then shaped a piece of the cell's outer membrane into a vehicle to deliver treatments into the brain. (nyulangone.org)
As a fragment of the former stem cell's membrane, the nanoghost encompasses particular mechanisms that slow it enough to traverse the barrier that filters blood flowing into the brain, and which keeps most drugs from entering. (nyulangone.org)
The first lysosome-targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to the cation-independent mannose-6-phosphate receptor (CI-M6PR). (stanford.edu)
Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)

This study shows that Schip1 , a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. (sdbonline.org)

Biomarkers for identification of these histologically identical WHO II tumors do not exist. (nature.com)

Huang L , Kang J , Chen G , Ye W , Meng X , Du Q , Feng Z , . Low-intensity focused ultrasound attenuates early traumatic brain injury by OX-A/NF-κB/NLRP3 signaling pathway. (aging-us.com)
Recent study at IMBB, published in Cell Death and Disease revealed that CISD-1, an iron sulfur cluster binding protein implicated in the pathogenesis of the neurodegenerative disorder Wolfram Syndrome type 2, modulates longevity and proteostasis by engaging autophagy and the mitochondrial intrinsic apoptosis pathway. (forth.gr)
These results suggest that the ERK1/2 pathway, and other neurotransmitter systems that stimulate protein synthesis via ERK1/2, represent additional therapeutic targets for FXS. (jneurosci.org)
MYD88: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (assaygenie.com)
The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. (nih.gov)
Neuronal loss of the serine-threonine protein kinase Tao , a regulator of the Hippo signaling pathway, results in supernumerary boutons, each of which contain a normal number of active zones. (sdbonline.org)

Using a clinically guided genetic screening approach, researchers identified a non-coding RNA that is overexpressed in triple-negative breast cancer cells and regulated by the tumor suppressor p53 and the activated cell surface protein, EGFR. (sciencedaily.com)
This lncRNA is overexpressed in triple-negative breast cancer cells and regulated by the tumor suppressor p53 and the activated cell surface protein, EGFR. (sciencedaily.com)
In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
In the first joint collaboration, NYU Langone and Technion researchers will test the ability of a nanotechnology based on stem cell "nanoghosts" to deliver to the brain a promising treatment for metastatic melanoma, skin cancer that has spread or metastasized, and is often incurable. (nyulangone.org)
Our studies should provide important information on nanoghosts' general value as drug and gene carriers to the brain, and create potential for new treatment approaches against brain tumors and metastases," says Professor Marcelle Machluf, PhD, head of the Laboratory for Cancer Drug Delivery and Cell Based Technologies at the Technion, and inventor of the nanoghost with her colleagues there. (nyulangone.org)
It is much harder to secure funding for this type of high risk, high reward research," says Eva Hernando-Monge, PhD , associate professor in the Department of Pathology at NYU Langone, a member of the Perlmutter Cancer Center, and leader of the NYU team that first identified miR-124 as a suppressor of the growth of brain metastases . (nyulangone.org)
We demonstrate that systemic delivery of PIP-CpG induces tumor regression and enhances therapeutic efficacy compared with untargeted CpG in aggressive murine breast and pancreatic cancer models. (stanford.edu)
This review focuses on an up-to-date understanding of the functions of E3 ligases in cancers and debates the perspectives of cancer cells that rely on inhibition or activation of ubiquitylation of target proteins. (bmbreports.org)
Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells. (nih.gov)
After they enter distant organs such as the bone marrow, the lungs, the liver, or the brain, cancer cells are able to survive, adapt, and eventually overtake these new environments, leading to the formation of lethal metastases. (bbvaopenmind.com)
In cancer treatment this phenomenon can be exploited to selectively kill tumour cells that have specific genetic mutations. (hrb.ie)
Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer. (cancer-genetics.org)
Protein kinase B, also known as Akt, plays a central role in many types of cancer and has been validated as a therapeutic target nearly two decades ago. (spandidos-publications.com)

DUSP6/MKP3 is a dual-specific phosphatase that regulates extracellular regulated kinase ERK1/2 and ERK5 activity, with an increasingly recognized role as tumor suppressor. (cancer-genetics.org)

The World Health Organization (WHO) histologically classifies tumors into three grades: benign (I), atypical (II) and anaplastic (III) 2 . (nature.com)
Molecular characterization of these benign yet rapidly proliferating tumors has been limited to evaluating a few mutations in few genes. (frontiersin.org)

Furthermore, PIP-CpG transforms the immune-suppressive TME dominated by myeloid-derived suppressor cells into a lymphocyte-rich TME infiltrated with activated CD8+ T cells, CD4+ T cells, and B cells. (stanford.edu)

Promoting immune activation within the tumor microenvironment (TME) is a promising therapeutic strategy to reverse tumor immunosuppression and elicit anti-tumor immunity. (stanford.edu)

Neurobehavioral examination, Nissl staining, hematoxylin and eosin staining of the brain tissue, and brain water content, were performed 3 days later. (aging-us.com)
Results: LIFUS improved tissue damage, neurological deficits, and brain edema. (aging-us.com)
Tissue extracts of Mouse Testis (Lane 6) and Mouse Kidney (Lane 7) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). (thermofisher.com)
In the discovery set of fresh-frozen tissue specimens (14), the A-kinase anchor protein 12 (AKAP12) protein was found downregulated across the grades. (nature.com)
Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
Tumor tissue from a rare non-infantile 8-year-old female DIG patient was dissociated and digested using collagenase to establish live cultures. (frontiersin.org)
Using immunohistochemistry, the 3D cultures were shown to express markers as in the original DIG tumor tissue indicating that the spheroid cultures were able to maintain the heterogeneity found in the original tumor. (frontiersin.org)
The tumor is heterogeneous with meningeal tumor cells, mainly a mixture of fibroblast like cells, and neuroepithelial cells in a background of connective tissue. (frontiersin.org)
RAPTOR is mostly found in the skeletal muscle and to a lesser extent in brain, lung, small intestine, kidney, and placenta tissue. (bio-rad-antibodies.com)

Phosphorylation of serine 311 by protein kinase C zeta type (PKCζ) serves the same purpose. (wikipedia.org)
In vivo studies revealed that RELA is also under acetylation modification in the nucleus, which is just as important as phosphorylation as a post-translational modification of proteins. (wikipedia.org)
To map the mechanisms of aggressiveness we aimed to investigate changes in protein phosphorylation across WHO grades of human meningiomas. (nature.com)
One source of confusion may be that proxy measures of protein synthesis, such as mGluR-LTD or phosphorylation of signaling molecules, have been used in intact hippocampal slice preparations, whereas metabolic labeling experiments have been performed in synaptoneurosome preparations of cortex that are not easily related to altered hippocampal synaptic plasticity. (jneurosci.org)

Escherichia coli is widely used host for the intracellular expression of many proteins. (sharif.edu)
Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development. (uchicago.edu)
Scope includes mutations and abnormal protein expression. (cancer-genetics.org)
Methods We established new patient-derived PA cell lines that preserve molecular features of the primary tumors and can be studied in OIS and proliferation depending on expression or repression of the SV40 large T antigen. (ibecbarcelona.eu)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)

For example, it can inhibit the transcription of the tumor suppressor gene ARF. (bio-rad-antibodies.com)
SMURF1 works as an oncogene, while SMURF2 has a dual role and can both promote or inhibit tumors. (bio-rad-antibodies.com)
A set of twenty-five thioxanthene-9-one and xanthene-9-one derivatives, that were previously shown to inhibit cholinesterases (ChEs) and amyloid β (Aβ40) aggregation, were evaluated for the inhibition of tau protein aggregation. (ibecbarcelona.eu)

Results: To increase the viability of stem cells, techniques like scaffolds of stem cells with hydrogel or alginate, pre-conditioning, different routes of administration and encapsulation, are implemented. (benthamscience.com)

In cases where multiple other mutations, in genes such as TP53, ATRX, and others, recurrence of the tumor is a possibility. (frontiersin.org)

This gene encodes a multi-domain scaffolding protein that is required for normal development. (thermofisher.com)
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. (assaygenie.com)
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)

By regulating filamentous actin, Cdc42 and Rac exert a profound effect on cell shape, polarity, migration, cell:cell and cell:matrix adhesion, protein traffic, and cytokinesis. (biomedcentral.com)
adhesion G protein-coupled recep. (gsea-msigdb.org)

To enable tumor-localized immunotherapy following intravenous administration, we chemically conjugated a polyspecific integrin-binding peptide (PIP) to an immunostimulant (Toll-like receptor 9 [TLR9] agonist: CpG) to generate a tumor-targeted immunomodulatory agent, referred to as PIP-CpG. (stanford.edu)

In mammalian cells, as many as twenty types of protein have been reported to bind to activated Cdc42 [ 2 ]. (biomedcentral.com)
Importantly, the team found that blocking LINP1 significantly increases sensitivity by the tumor cells to radiation therapy. (sciencedaily.com)
Finally, we show that T cells are required for therapeutic efficacy and that PIP-CpG treatment generates tumor-specific CD8+ T cells. (stanford.edu)
Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. (uchicago.edu)
Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. (uchicago.edu)
Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair. (uchicago.edu)
LIGHT delivery to tumors by mesenchymal stem cells mobilizes an effective antitumor immune response. (uchicago.edu)
Comparative effects of bone morphogenetic proteins and sox9 overexpression on extracellular matrix metabolism of bovine nucleus pulposus cells. (uchicago.edu)
Genes down-regulated in myeloid-derived suppressor cells from colon tumors: wildtype versus HDC [GeneID=3067] knockout. (gsea-msigdb.org)
Differentially expressed genes of CD11b+Gr-1+ immature myeloid cells (IMCs) in the bone marrow and colonic tumor setting of histidine decarboxylase (HDC)-KO mice were examined by microarray (Affymetrix Mouse 430.2 array). (gsea-msigdb.org)
A spontaneous cell line-like cell culture with high percentage of stem cells has been established from a DIG tumor for the first time. (frontiersin.org)
Solid tumors such as carcinomas of the lung, colon, breast, or prostate start in epithelial cells that line the surface of the bronchia, the intestinal mucosa, or the alveoli of fl uid secretion in the breast and prostate. (bbvaopenmind.com)
They smurf on tumor cells. (bio-rad-antibodies.com)
Conclusions Our data demonstrate that BCL-XL is critical for survival of senescent PA tumor cells and provides proof-of-principle for the use of clinically available BCL-XL-dependent senolytics. (ibecbarcelona.eu)

PML is a protein that regulates important cellular decisions about life or death. (forth.gr)
An unusual cellular factor potentiates protein-DNA complex assembly between Oct-1 and Vmw65. (mcmaster.ca)
at the same time developing protein and peptide-based tools that will allow us to manipulate cellular processes on a molecular level. (stanford.edu)
Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)

Here, we use an in vitro assay of protein synthesis in the hippocampus of male Fmr1 knock-out (KO) mice to explore the molecular mechanisms involved in this core biochemical phenotype under conditions where aberrant synaptic physiology has been observed. (jneurosci.org)
A strong rationale for taking this approach is that slice has been shown to accurately reproduce the in vivo phenotype of elevated basal protein synthesis in the Fmr1 KO hippocampus (cf. (jneurosci.org)

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. (stanford.edu)

Dendrites are complex neuronal structures with a key role in information processing in the brain. (forth.gr)

This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. (thermofisher.com)
Myelin Protein Zero-Like 1 (MPZL1) is a cell surface receptor, which is involved in signal transduction processes. (assaygenie.com)

This cytoplasmic protein is also known as protein ced-12 homolog. (bio-rad-antibodies.com)

RELA protein has four isoforms, the longest and the predominant one being 551 amino acids. (wikipedia.org)
4 isoforms of the human protein are produced by alternative splicing. (assaygenie.com)

Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
In contrast to the profound benefit observed in heterotopic tumors, only two of seven intrinsically sensitive PDXs were responsive to Depatux-M as intracranial tumors. (stanford.edu)

Improvement of both intracellular and extracellular production of recombinant protein in E. coli is an attractive goal in order to reduce production cost and increase process efficiency and economics. (sharif.edu)

Soluble suppressor activity obtained from allopregnant mouse decidua that blocks the cytolytic effector response to IL-2 is related to transforming growth factor-beta. (mcmaster.ca)
It may sound like it recognizes little blue people, but in this case our Rabbit Anti-Human SMURF1 Antibody binds to the E3 ubiquitin-protein ligase SMURF1 (SMAD ubiquitination regulatory factor). (bio-rad-antibodies.com)

PZR: an immunoglobulin superfamily cell surface protein. (assaygenie.com)
Aifantis, I. Regulation of stem cell function by protein ubiquitylation. (benthamscience.com)
With a name reminiscent of a red TV puppet, the Goat Anti-Human ELMO1 Antibody binds to human ELMO1 (engulfment and cell motility protein 1). (bio-rad-antibodies.com)
The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)

these proteins are also important in regulating gene transcription. (biomedcentral.com)

The E3 ubiquitination step determines the overall specificity for ubiquitination of the target protein, and the activated ubiquitin is usually transferred to a lysine residue in the substrate. (bmbreports.org)

The analysis of Cdc42 and Rac function in evolutionarily distant organisms is useful as a tool to uncover the basic activities of these proteins. (biomedcentral.com)
This activity is strongly conserved and probably represents a primordial function of these proteins. (biomedcentral.com)
Genomic studies of TNBC to crack its tough-to-treat status have mainly focused on protein-coding genes and the function of non-coding genes is still largely unknown. (sciencedaily.com)
Such models advance our understanding of brain function and lead to new artificial intelligence systems. (forth.gr)
Post-translational modifications change function of most proteins. (bmbreports.org)
Although it is now clear that mGluR5 participates in the pathogenesis of FXS, at least in animal models, it is still poorly understood how Gp1 mGluRs trigger protein synthesis and how this process is altered in the absence of FMRP to disrupt synaptic function. (jneurosci.org)

Understanding the mechanisms of failure for this promising strategy is critically important.METHODS: PDX models were employed to study efficacy of systemic vs intracranial delivery of Depatux-M. Immunofluorescence and MALDI-MSI were performed to detect drug levels in the brain. (stanford.edu)
For biomedical applications, we are combining rational design and combinatorial methods to create designer protein therapeutics and diagnostic agents. (stanford.edu)

Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. (uchicago.edu)

Since heat shock proteins in E. coli were reported to be helpful for protein refolding and hindering aggregation, in this work different types of single and periodic heat shocks were tested on lab scale to enhance intracellular and extracellular protein production. (sharif.edu)

The covalent attachment of ubiquitin to a target protein is catalyzed by the sequential action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin ligase (E3). (bmbreports.org)
SMURF1 is a ubiquitin ligase specific for SMAD proteins associated to receptors (R-SMADs). (bio-rad-antibodies.com)

and proteins that interact with members of the Arp2/3 complex and hence the actin cytoskeleton (Table 1 ). (biomedcentral.com)
In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. (thermofisher.com)

Activated protein C resistance and low molecular weight lipoprotein (a): dual pathogens for atherothrombosis? (mcmaster.ca)

PA1-044 detects synapse-associated protein 97 (SAP97) from rat and human tissues. (thermofisher.com)

Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma. (stanford.edu)

Can you find any other proteins with interesting names that we have antibodies for? (bio-rad-antibodies.com)

We find that elevated basal protein synthesis in Fmr1 KO mice is selectively reduced to wild-type levels by acute inhibition of mGluR5 or ERK1/2, but not by inhibition of mTOR (mammalian target of rapamycin). (jneurosci.org)

Mutations in this gene have been found in somatic sebaceous tumors. (cancer-genetics.org)

According to the metabotropic glutamate receptor (mGluR) theory of FXS, excessive protein synthesis downstream of mGluR5 activation causes the synaptic pathophysiology that underlies multiple aspects of FXS. (jneurosci.org)
The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. (assaygenie.com)

Compound 20 showed outstanding biological data, inhibiting tau protein and Aβ40 aggregation with IC50 = 1.8 and 1.3 μM, respectively. (ibecbarcelona.eu)

These data demonstrate that conjugation to a synthetic tumor-targeted peptide can improve the efficacy of systemically administered immunostimulants and lead to durable anti-tumor immune responses. (stanford.edu)
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of mouse iNOS. (genetex.com)

Background Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and a mitogen-activated protein kinase (MAPK)-driven disease. (ibecbarcelona.eu)

In human, AEG-1 represents a protein of 582 amino acids, and the amino acid sequences are highly conserved across vertebrates. (biomedcentral.com)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)

Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. (biomedcentral.com)
Our data suggest that elevated protein synthesis in the Fmr1 KO is due to saturation of mRNA translation downstream of the MAP kinase ERK1/2 which is basally activated by mGluR5. (jneurosci.org)

By Western blot, this antibody detects an ~140 kDa protein representing SAP97 from rat brain homogenate. (thermofisher.com)
iNOS antibody detects iNOS protein at cytoplasm by immunohistochemical analysis. (genetex.com)
iNOS antibody detects iNOS protein by immunofluorescent analysis. (genetex.com)

The nanoghost's cargo is a microRNA (miR), a stretch of genetic material that fine-tunes genetic messages by blocking the conversion of genes into proteins. (nyulangone.org)

Selective protein degradation platforms have afforded new development opportunities for therapeutics and tools for biological inquiry. (stanford.edu)
The mechanism behind malignancy and tumor genesis is unknown, limiting development of alternative therapies. (nature.com)
The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma. (nih.gov)
Our strategy of reactivating endogenous PP2A may be applicable to the treatment of other diseases and represents an advancement toward the development of small molecule activators of tumor suppressor proteins. (mssm.edu)
Temozolomide (TMZ) is widely used for treating glioblastoma multiforme (GBM), however, the treatment of such brain tumors remains a challenge due to the development of resistance. (nature.com)
Dr. Cochran's translational interests span protein-based drug discovery and development for applications in oncology and regenerative medicine, and the development of new technologies for high-throughput protein analysis and engineering. (stanford.edu)
The review outlines the development of several promising drug candidates emphasizing the importance of each chemical scaffold. (spandidos-publications.com)

DIG is a grade I tumor involving superficial cerebral cortex and leptomeninges, often attached to dura, with a large mass composed of both solid and cystic areas. (frontiersin.org)

Anatomy18

Organisms8

Diseases37

Chemicals and Drugs87

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes71

Disciplines and Occupations1

Technology, Industry, Agriculture4

Information Science3

Health Care1

Progression6

Oncogenic3

Subunit6

Pathways7

Metastasis3

Malignant5

Kinases5

Adaptor protein1

Membrane5

Drosophila1

Biomarkers1

Pathway6

Cancer13

Phosphatase1

Benign2

Suppressive1

Microenvironment1

Tissue9

Phosphorylation4

Expression5

Inhibit3

Hydrogel1

Recurrence1

Gene encodes3

Adhesion2

Immunotherapy1

Cells15

Cellular4

Phenotype2

Targeted protein degradation1

Neuronal1

Signal transduction2

Homolog1

Isoforms2

Intrinsically2

Recombinant protein1

Factor2

Cell4

Transcription1

Ubiquitination1

Function6

Methods2

Osteogenic1

Extracellular1

Ubiquitin ligase2

Actin cytoskeleton2

Molecular1

Tissues1

EGFR1

Antibodies1

Inhibition1

Mutations1

Receptor2

Aggregation1

Peptide2

MAPK1

Amino2

Downstream2

Detects3

Genetic1

Development7

Cerebral1