• Kaposi's sarcoma is a condition in which a person has bluish-red or purple cancerous spots (arising from connective tissue cells) on the skin and on some sites inside the body. (healthtap.com)
  • Kaposi's sarcoma is due to the combination of HIV virus, human herpes #8 virus, and immunosuppression, so the cancer is seen AIDs patients. (healthtap.com)
  • In 1995, studies published in Nature and The Lancet reported that clinical grade hCG extracted from pregnant women's urine was effective at shrinking Kaposi's sarcomas . (cancertherapyadvisor.com)
  • Kaposi's sarcoma in the acquired immune deficiency syndrome: a proposal for uniform evaluation, response, and staging criteria. (medscape.com)
  • Kaposi's sarcoma is a neoplasm of vascular endothelium that is characterized by proliferation of spindle cells, neoangiogenesis, inflammation and edema 17 . (bvsalud.org)
  • The endemic form of Kaposi's sarcoma, present in Africa (mainly in the south of the Sahara Desert), is relatively rare, but more aggressive. (bvsalud.org)
  • Thus, an "oncodrug" hypothesis has been proposed, specifically with regard to quinine and its derivatives for African Kaposi sarcoma. (medscape.com)
  • The breakthrough came in 1994, when the Kaposi sarcoma-associated herpes virus (human herpesvirus type 8 [HHV-8]) was identified using representational difference analysis. (medscape.com)
  • Kaposi sarcoma and its causative agent, Karposi sarcoma-associated herpesvirus, have distinctive largely unexplained geographic distributions. (medscape.com)
  • Kaposi sarcoma (KS) is a rare angioproliferative disorder, which is usually associated with human herpesvirus‑8 infection. (spandidos-publications.com)
  • Until recently, scientists have not been able to effectively study Kaposi sarcoma-associated herpesvirus (KSHV) since KSHV-infected cells die before becoming cancer cells. (cancertherapyadvisor.com)
  • Curatolo P, Quaglino P, Marenco F, Mancini M, Nardò T, Mortera C, Rotunno R, Calvieri S and Bernengo MG: Electrochemotherapy in the treatment of Kaposi sarcoma cutaneous lesions: A two-center prospective phase II trial. (spandidos-publications.com)
  • Background: Classical Kaposi sarcoma is a rare complication of Kaposi sarcoma-associated herpes virus (KSHV) infection. (aacrjournals.org)
  • Using SAS-callable SUDAAN, we compared the characteristics of classical Kaposi sarcoma cases and KSHV-seropositive controls. (aacrjournals.org)
  • Results: In total, 142 classical Kaposi sarcoma cases and 123 KSHV-seropositive controls were recruited. (aacrjournals.org)
  • Evaluation for Kaposi sarcoma should include a complete physical examination and a biopsy of suspected lesions including lymph nodes. (medscape.com)
  • Solitary Kaposi sarcoma lesions may be excised surgically or removed using laser surgery. (medscape.com)
  • Kaposi sarcoma-associated paradoxical immune reconstitution inflammatory syndrome (KS-IRIS) in antiretroviral (ART)-naïve HIV-infected patients is a major contributor to KS-associated mortality in Africa. (medscape.com)
  • Quinine and its derivatives might better explain the epidemiology of Kaposi sarcoma in Africa than oncoweeds. (medscape.com)
  • Those staging schemes may or may not correlate well with the presentation and outcomes in the many HIV-infected children in sub-Saharan Africa who have Kaposi sarcoma. (medscape.com)
  • HHV-8 has been linked closely with all 4 types of Kaposi sarcoma, ie, classic (traditional), endemic (African), epidemic (AIDS related), and iatrogenic (related to immunosuppression). (medscape.com)
  • Most reports on the epidemic of Kaposi sarcoma has been described in homosexual men and very few cases have been reported among heterosexual men. (bvsalud.org)
  • The purpose of this paper is to present two cases of Kaposi sarcoma in its epidemic form in HIV positive patients. (bvsalud.org)
  • Management modalities for Kaposi sarcoma include nonintervention, surgical removal of skin nodules or severely affected areas (eg, areas of the extremities, intussuscepted bowel), laser surgery, conventional and megavoltage radiotherapy, chemotherapy, immunotherapy, antiviral drugs, and cessation of immunosuppressive therapy in iatrogenically immunosuppressed patients. (medscape.com)
  • Although the authors prefer intralesional vinblastine, intralesional vincristine as first-line therapy for nodules in classic Kaposi sarcoma has also been recommended. (medscape.com)
  • Kaposi sarcoma (KS) is a rare cancer that starts in cells that line the lymph or blood vessels. (cancer.ca)
  • A three-arm, open-label, randomized, non-inferiority trial found that paclitaxel plus ART was superior to both oral etoposide plus ART and bleomycin and vincristine plus ART, supporting its use for advanced AIDS-associated Kaposi sarcoma in resource-limited settings. (medscape.com)
  • In 1981, Kaposi sarcoma seen in AIDS (KS-AIDS) in America was identified in 3 reports of Kaposi sarcoma as an original defining element of what later became known as AIDS (plus an important editorial and a Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report bulletin). (medscape.com)
  • [ 2 ] For some time, Kaposi sarcoma was seen in 30-40% of patients with AIDS, often as the presenting sign. (medscape.com)
  • The challenge remained to explain the reason male patients who have sex with males and have AIDS exhibited Kaposi sarcoma much more commonly than did patients with AIDS unassociated with homosexuality, with the exception of small foci of this group in isolated midwestern communities. (medscape.com)
  • Patients with HIV/AIDS are also at increased risk of developing Kaposi sarcoma. (bvsalud.org)
  • The aim of this article is to present two cases of Kaposi sarcoma in the hard palate of HIV/AIDS male patients. (bvsalud.org)
  • Kaposi sarcoma should be considered in the differential diagnosis of any AIDS patient who presents with bluish, smooth, firm, nonpulsatile macule or nodule in the region of the hard palate. (bvsalud.org)
  • About 15% of all diagnosed cases of AIDS have associated Kaposi sarcoma 4 . (bvsalud.org)
  • Kaposi sarcoma is one of the first recognized opportunistic diseases in HIV infection and is still the most common malignancy associated with AIDS 32 . (bvsalud.org)
  • Elderly American man of Armenian origin with characteristic violaceous plaques of the legs, a good example of classic Kaposi sarcoma. (medscape.com)
  • Although sarcomas are rare, representing only 1% of cancer types, at West Cancer Center & Research Institute, we have a team that specializes in treating this form of cancer. (westcancercenter.org)
  • Kaposi sarcoma is rare in HIV negative patients and it is associated with HHV-8 infection. (bvsalud.org)
  • In his original article entitled "Idiopathic multiple sarcoma of the skin", Moritz Kaposi described the indolent and rare disease that is known as classic or sporadic Kaposi sarcoma. (bvsalud.org)
  • We conducted a population-based, frequency-matched case-control study in Sicily to further investigate the reported inverse relationship between smoking and classical Kaposi sarcoma and to identify other factors associated with altered risk. (aacrjournals.org)
  • Development of Kaposi sarcoma in the oral cavity also has prognostic implications for untreated HIV patients, who are found to have higher death rates than patients affected only by cutaneous disease. (bvsalud.org)
  • Studies in 1995 reported that the pregnancy hormone human chorionic gonadotropin (hCG) could shrink Kaposi sarcomas, but the data was later retracted. (cancertherapyadvisor.com)
  • [ 3 ] Since then, much research has shown that HHV-8 appears to be necessary to, but not sufficient for, the development of Kaposi sarcoma. (medscape.com)
  • It differs from other sarcomas because it can appear in several parts of the body at the same time. (cancer.ca)
  • Tony Antakly, PhD, and his team at the University of Montreal found that purified hCG had no cancer-fighting effects against Kaposi sarcoma cells. (cancertherapyadvisor.com)
  • Because the natural history of Kaposi sarcoma (KS) is variable, assessment of therapy may be difficult. (medscape.com)