• Methods: We developed a Markov model to assess the costs and benefits of sodium oxybate plus antidepressants and stimulants or current standard treatment based on their effects on the quality of life of patients. (omicsonline.org)
  • Methods-- We implemented a pragmatic cluster randomized controlled trial to test the effectiveness of an automated interactive voice response tool designed to provide physicians with real-time patient-reported data about responses to newly prescribed diabetic peripheral neuropathy medicines. (cdc.gov)
  • The objective of this document is to outline the available methods and tools for screening and sequencing patient specimens for the detection of VOC or VOI, with a focus on those that offer a rapid turn-around time so as to support rapid implementation of public health actions for COVID 19 control. (who.int)
  • Methods: As a retrospective quantitative research design was used, 173 maternal records of pregnant teenagers from 13 to 19 years were sampled from six district hospitals and Community Health Centres (CHCs) between 01 January 2017 and 31 December 2019 to undergo systematic random sampling. (bvsalud.org)
  • Despite these efforts to disassociate the use of substances and pregnancy, there was still a lack of response using the traditional methods of recruitment (newspaper advertisements and craigslist posts). (cdc.gov)
  • The use of nutritional ERPs may enhance short-term and long-term recovery and mitigate frailty progression while improving patient-reported outcomes. (bmj.com)
  • Data gathered from the PROTein to Enhance outComes of (pre)frail paTients undergoing Cardiac Surgery Study will be published in peer-reviewed journals and presented at national and international conferences. (bmj.com)
  • The primary outcome will be the response rate, determined by the Children's Depression Rating Scale-Revised (CDRS-R). Secondary outcomes include the change in scores on the Beck Depression Inventory (BDI), the Screen for Child Anxiety-Related Emotional Disorders (SCARED) and the Safe Assessment. (biomedcentral.com)
  • A secondary analysis of the 24-week TORDIA [ 12 ] outcomes suggest a potential advantage of early augmentation using an atypical antipsychotic or mood stabilizer, but the sample size used was small. (biomedcentral.com)
  • As confirmed by previous studies, the brief multifamily program (consisting of six sessions over a period of 1.5 months) was found to be effective in improving outcomes for caregivers (e.g., burden, depression, knowledge) and patients (e.g., preventing relapse) in the context of routine care. (frontiersin.org)
  • For patients, family psychoeducation has been effective in improving outcomes in schizophrenia with a better level of global functioning, medication adherence, and a reduction in the use of healthcare resources and the frequency of relapse ( 6 - 8 ). (frontiersin.org)
  • Success will mean we realise our vision to improve outcomes for patients with aggressive cancers. (cosmosmagazine.com)
  • The reduction of harm through an ineffective treatment, the possibility of individualized dosing, the reduction of sample size, and the possible evaluation of the influence of the placebo effect on efficacy outcomes justify this design for a single-centered placebo-controlled investigator-initiated trial of nabilone. (springer.com)
  • Primary study outcomes were measurement of daily steps (over 14 consecutive days, using an activity monitor), assessment of activity time by activity intensity (using metabolic equivalents [METs]), and evaluation of correlation between PA and patient characteristics. (dovepress.com)
  • Secondary outcomes included further investigation of the influence of patient characteristics on PA. (dovepress.com)
  • I blog about therapist variables leading to poor outcomes, aspects of the therapeutic relationship and outcomes, and psychological therapies and patient quality of life. (uottawa.ca)
  • Would implementing the studied intervention or procedure (if found successful) result in improved outcomes for the patients/clients/population group? (andeal.org)
  • identified program characteristics (eg, leadership support, well-defined staff roles, use of support and maintenance sessions) associated with successful program implementation (9,11,12) and better patient weight-loss outcomes (13). (cdc.gov)
  • Three treatment outcomes weremeasured: Adequate trial, six-week response and two months sustainedrecovery. (findmedarticle.com)
  • Les participants ont été interrogés à la sélection puis à la fin du traitement pour connaître leur opinion en matière d'accès aux soins et de qualité de ceux-ci. (who.int)
  • T0 features among dropout, stable and healed participants were compared. (biomedcentral.com)
  • PARTICIPANTS: Patients aged ≥18 years with a minimum follow-up of 12 months. (bvsalud.org)
  • Eighteen (18) participants were purposively sampled. (bvsalud.org)
  • Although data exist on the prevalence of some immunosuppressive conditions, the total burden of these conditions in the United States remains unknown, particularly when considering patients who are receiving emerging immunosuppressive therapies ( 6 - 8 ). (cdc.gov)
  • Disallowing background maintenance therapies contributed to this high dropout rate in this challenging, heterogenous patient group. (wikipedia.org)
  • This then means we test the samples simultaneously for responses to numerous therapies and identify which drugs destroy the tumours. (cosmosmagazine.com)
  • There are no clearly effective therapies for lupus membranous nephropathy (LMN), and controlled trials in patients with LMN are lacking. (bmj.com)
  • A post hoc meta-analysis of individual data of 200 patients from four phase 2 studies evaluating nightly alicaforsen 240 mg enema for six weeks showed that alicaforsen is effective in patients with active, distal, moderate to severe UC. (wikipedia.org)
  • Was the number, characteristics of withdrawals (i.e., dropouts, lost to follow up, attrition rate) and/or response rate (cross-sectional studies) described for each group? (andeal.org)
  • Morphologic characteristics in P- and F-samples were comparable but genetic alterations were evident in microsatellite analysis strengthening the assumption of a clonal selection. (europdxworkshop.eu)
  • The study was undertaken to evaluate patient characteristics, (Age and sex distribution) long term sequelae of CNS prophylaxis (growth retardation) and the treatment outcome in these 66 paediatric patients who were treated and followed up at Cancer Institute, Maharagama, Sri Lanka during the period between 1st May 1982 and 27th September 1993. (who.int)
  • Establishing a case definition for and quantifying the burden of immunosuppressive conditions might facilitate evaluation and use of influenza vaccines to enhance immune response in this high-risk target group. (cdc.gov)
  • A large body of proof suggests that renal sodium retention in patients with the initial evaluation of a affected person with ascites should cirrhosis is secondary to arterial splanchnic vasodilation diabetes mellitus type 2 epidemiology in the philippines [url=http://brcp-1.gov.bd/pharmacy/Losartan/]buy discount losartan 25 mg line[/url]. (ehd.org)
  • Tissue and blood samples will be collected prior to randomisation and on the last day of the intervention/observation-only period (end of 4 months). (biomedcentral.com)
  • For patients, the family psychoeducation intervention significantly reduced the risk of relapse with a significant effect found at 12 months follow-up ( p = 0.014). (frontiersin.org)
  • Therefore, family intervention should be developed to reduce the burden of caregivers and enhance patients' prognosis. (frontiersin.org)
  • INTERVENTION: Hospitals were randomised (1:1) to patient management by standard care or according to the GRS and associated guidelines. (bvsalud.org)
  • Exercise training improves exercise capacity and symptoms in patients with ILD, but these benefits are not sustained 6 months following intervention. (bmj.com)
  • Patients assigned to physicians in the intervention group receive three brief interactive calls every 2 months after a medication is prescribed to alleviate diabetic peripheral neuropathy symptoms. (cdc.gov)
  • We plan to Author Manuscript compare changes in self-reported quality of life between the intervention group and patients in the control group who receive three non-interactive automated educational phone calls. (cdc.gov)
  • Patients who reported highmaternal protection (maternal overprotection) on the PBI had poorer treatmentresponse in the short-term at six weeks, and longer term, for two months ofsustained recovery. (findmedarticle.com)
  • A pretested structured checklist was used to record data from sampled maternal records. (bvsalud.org)
  • However the co-primary endpoints (an adaptation of the Mayo Score of improvement in endoscopic remission and bowel frequency) were not met, perhaps due to the high discontinuation rate of 35% that compromised the sample size available for statistical analysis. (wikipedia.org)
  • 16 In addition, by using the structured clinical interview for the DSM-III-R ( Diagnostic and Statistical Manual of Mental Disorders , third edition, revised) 17 we excluded patients who also had a current psychiatric disorder or symptomatic insomnia because of the separate effects of these conditions on fatigue. (bmj.com)
  • Conclusion The number of patients treated in this study was small, and only limited conclusions can be drawn. (bmj.com)
  • Conclusions: The experience ofhaving a neglectful father or an overprotective mother was more predictiveof response to treatment for depression than abuse, suggesting that the quality ofongoing intra-familial relationships has a greater impact on treatmentoutcomes for depression than experiences of discrete abuse in childhood. (findmedarticle.com)
  • Conclusions-- Innovative strategies are needed to guide improvements in healthcare delivery for patients with symptomatic diabetic peripheral neuropathy. (cdc.gov)
  • The goals were to 1) explore the ways in which respondents interpreted the call-back questions, 2) understand how they formulated answers based on those interpretations, 3) draw conclusions about the concepts measured in each question and 4) describe how each question functions and performs in the context of the purposive sample drawn for this study. (cdc.gov)
  • SETTING: Patients presenting with suspected non-ST elevation acute coronary syndrome to 42 hospitals in England between 9 March 2017 and 30 December 2019. (bvsalud.org)
  • A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals with phosphodiesterase-5 inhibitors (PDE5i). (ersjournals.com)
  • 32 patients (52%) experienced study drug-related adverse events and 10 (16%) experienced serious adverse events (2 (3%) study drug-related, none during the PDE5i treatment-free period). (ersjournals.com)
  • Given the positive results from an open-label trial and one case series in patients with chronic refractory pouchitis, US FDA has agreed to a rolling submission for a license application for the treatment of pouchitis. (wikipedia.org)
  • Cytotoxic chemotherapy drugs have become the main treatment in recent decades, especially in patients with NSCLC without EGFR, ALK, and ROS gene mutations. (biomedcentral.com)
  • This study explores the combination of intestinal microecological regulation and chemotherapy to provide new treatment strategies and basis for lung cancer patients. (biomedcentral.com)
  • As an exploratory aim, we examined whether brain-derived neurotrophic factor (BDNF) and fatty acid amide hydrolase (FAAH) moderated treatment response. (nature.com)
  • Four patients receiving exercise and three receiving flexibility treatment dropped out before completion. (bmj.com)
  • 16 of 29 patients rated themselves as better after completing exercise treatment compared with eight of 30 patients who completed flexibility treatment. (bmj.com)
  • 12 of 22 patients who crossed over to exercise after flexibility treatment rated themselves as better after completing exercise treatment. (bmj.com)
  • 32 of 47 patients rated themselves as better three months after completing supervised exercise treatment. (bmj.com)
  • 35 of 47 patients rated themselves as better one year after completing supervised exercise treatment. (bmj.com)
  • 2017) have further argued that the treatment and care for the patients with AMI who are admitted in the emergency department is not solely dependent on the role and performance of the doctors. (myassignmenthelp.com)
  • If a patient gets the right treatment, it's a gamechanger. (cosmosmagazine.com)
  • The idea behind this is to tailor treatment for individual patients so that potentially effective drugs are used, while ineffective, often toxic, agents are avoided. (cosmosmagazine.com)
  • We can look forward to a whole level of data analysis and prediction analysis to try and find the right treatment for the right patient and doing it in a rapid way. (cosmosmagazine.com)
  • Ultimately, we want to translate this to the clinic and identify the right treatment for the right patient in a clinically relevant time frame. (cosmosmagazine.com)
  • A total of 38 patients will have 80% power to detect a probability of 0.231 that an observation in the treatment group is less than an observation in the placebo group using a Wilcoxon rank-sum test with a 0.050 two-sided significance level assuming a true difference of 2.5 points between nabilone and placebo in the primary outcome measure and a standard deviation of the change of 2.4 points. (springer.com)
  • This prospective randomized controlled trial examined 91 patients whose serum HBV DNA levels were greater than 60 IU/mL after at least 24 weeks of treatment with LAM/LdT+ADV for LAM-resistant HBV. (e-cmh.org)
  • Patients were randomized to receive a new treatment (ETV+TDF, n=45) or maintained on the same treatment (LAM/LdT+ADV, n=46) for 48 weeks. (e-cmh.org)
  • ETV+TDF combination treatment led to a significantly higher rate of virologic response compared to LAM/LdT+ADV combination treatment in patients with LAM-resistant HBV who had suboptimal responses to LAM/LdT+ADV regardless of HBV genotypic resistance profile (NCT01597934). (e-cmh.org)
  • The widespread use of antiviral agents with low genetic barriers to resistance, such as lamivudine (LAM), adefovir (ADV), telbivudine (LdT), and clevudine (approved in South Korea), as initial treatment is one of the main causes of the high prevalence of genotypic resistance to NUCs among patients with CHB in Asian countries [ 10 ]. (e-cmh.org)
  • The overall response rate (50% reduction in symptoms) was 41% for psychotherapy and 16% for no treatment. (uottawa.ca)
  • Remission from depression (no clinically elevated depressive symptoms) at post-treatment was about 33%, whereas about 10% of patients in control conditions (no treatment or treatment as usual) remitted after therapy. (uottawa.ca)
  • Overall, time-limited psychotherapy is modestly to moderately better than no treatment, with about one-third of treated patients no longer being depressed after time-limited psychotherapy. (uottawa.ca)
  • Results in more severely depressed patients are better with combined treatment of pharmacotherapy plus psychotherapy. (uottawa.ca)
  • Fill in the details of the treatment trial, noting that sample size and sample design are required fields. (stanleyresearch.org)
  • There may be a therapeutic benefit with filgotinib treatment, which may support future investigations with filgotinib or other JAK inhibitors in patients with LMN. (bmj.com)
  • Our study demonstrates that 16 weeks of treatment with the Janus kinase 1 (JAK1) inhibitor filgotinib reduced proteinuria in a small number of patients with LMN. (bmj.com)
  • Currently the most common treatment (standard care) is to use antidepressants as anti-cataleptics and stimulants for daytime sleepiness symptoms, but this combination of treatments has been observed to be inadequate for some patients [ 5 ]. (omicsonline.org)
  • Further clinical data permitted a change in the licence to "the treatment of narcolepsy with cataplexy in adult patients" in 2008 [ 6 ]. (omicsonline.org)
  • 1 - 3 Treatment options are often limited and patients suffer increasing exercise limitation as their disease progresses. (bmj.com)
  • Ropinirole treatment also decreased the expression of 29 genes related to cholesterol synthesis which were elevated in neurons from ALS patients. (technologynetworks.com)
  • F.R.S.N.Z. F.R.A.N.Z.C.P.1 Background: Childhood neglect and abuse are recognized as risk factors fordepression, but are not often studied as predictors of treatment response indepression. (findmedarticle.com)
  • The Ocular Hypertension Treatment Study (OHTS) is a multicenter, prospective, randomized, controlled clinical trial studying more than 1800 research subjects, evaluating the safety and efficacy of medical treatment in preventing or delaying the onset of visual-field loss and/or optic nerve damage in patients with ocular hypertension who are at moderate risk for developing primary open-angle glaucoma (POAG). (medscape.com)
  • Telephone Study, a randomized trial designed to improve medication treatment, titration and quality of life among patients with symptomatic diabetic peripheral neuropathy. (cdc.gov)
  • These calls provide patients with the opportunity to report on symptoms, side effects, self-titration of medication dose and overall satisfaction with treatment. (cdc.gov)
  • This trial aims to assess whether real-time collection and clinical feedback of patient treatment experiences can reduce patient symptom burden. (cdc.gov)
  • These findings should encourage clinicians to use medication protocols, and these important results come at a time when communities are struggling to link a growing number of patients with the most effective individualized treatment," NIDA Director Nora D. Volkow, MD, said in a statement. (medscape.com)
  • What the study did confirm is that there are a lot of challenges to getting on the extended-release naltrexone and that makes it difficult for both patients and physicians to use that medication," said Dr Saxon, who ran one of the study's treatment sites in Seattle but did not participate in the designing the study or analyzing or reporting the results. (medscape.com)
  • patients generally either initiated treatment early, during a methadone or buprenorphine taper while undergoing detoxification, or later, after detoxification was completed. (medscape.com)
  • This study was performed on 56 patients with leprosy: 28 under treatment and 28 treated for the disease. (bvsalud.org)
  • The treatment group had more women (Pearson ÷2=12.47, p=0.0004) and younger patients (Pearson ÷2=9.688, p=0.0079) than the healed group. (bvsalud.org)
  • The sample consisted of 56 patients of both genders with a history of leprosy: 28 under treatment and 28 were already treated for the disease. (bvsalud.org)
  • For a 6% non-inferiority margin and considering a 5% withdrawal rate, 284 patients will be included. (bmj.com)
  • Inclusion requirements had been type 2 diabetes, age group 40C75 years, energetic diabetic nephropathy (UAE 15C300 mg/24 h or comparable albumin-to-creatinine proportion [men 1.25C25, females 1.75C35 mg/mmol] in two of three samples within 2C6 weeks) despite ACE-Is and/or ARBs in unchanged dose for at least three months, glycated hemoglobin (A1C) 8.5%, and around glomerular filtration rate of 30 ml/min. (ampkpathway.com)
  • The average response rate (50% reduction in symptoms) was 29% for psychotherapy or pharmacotherapy alone, but combining treatments resulted in 12% to 16% higher response rate. (uottawa.ca)
  • The normalized protein catabolic rate is a flawed marker of nutrition in CAPD patients. (andeal.org)
  • As the response rate of this onsite-survey proved to be rather low, the AGOF commissioned YouGovPsychonomics with the conduction of a market research study. (websm.org)
  • The aim of this study was to identify possibilities for increasing the response rate and minimising the total dropout rate. (websm.org)
  • The study's results also proved of value in practice, as they contributed to increase the response rate to the internet facts significantly. (websm.org)
  • Extended-release naltrexone (XR-NTX) ( Vivitrol , Alkermes) and buprenorphine/naloxone (BUP-NX) ( Suboxone , Indivior) were similarly efficacious in preventing relapse for patients with opioid use disorder, although naltrexone therapy was more difficult to initiate, new research shows. (medscape.com)
  • When patients could not follow the study protocol, results favored BUP-NX, with lower relapse rates, better relapse-free survival, and more opioid-abstinent days. (medscape.com)
  • A use-week was further defined as at least 1 day of nonstudy opioid use, having a urine sample that tested positive for nonstudy opioids, refusing to provide a urine sample, or missing an appointment for collecting a urine sample. (medscape.com)
  • Patients with opioid use disorders frequently relapse and present with intoxication. (medscape.com)
  • CAPD patients who are clinically stable and has no history of infection or hospital admission in the month prior to assessment. (andeal.org)
  • We conducted a KAP study among 70 CL patients attending 4 clinics in Aleppo. (who.int)
  • Six patients (10%) experienced clinical worsening, including death in two (not study drug-related). (ersjournals.com)
  • The TORDIA study previously reported that in adolescents with no improvement in depression after one appropriate trial of a selective serotonin reuptake inhibitor (SSRI), there were similar response rates between switching to another SSRI or switching to the norepinephrine reuptake inhibitor (SNRI) venlafaxine. (biomedcentral.com)
  • Clinical effectiveness data are sparse, but a recent observational study demonstrated lower vaccine effectiveness against influenza illness (≈20%) in patients with cancer compared with the general population (≈42%) ( 12 , 13 ). (cdc.gov)
  • The main objective of this study was to determine whether the psychophysiological stress response during a social-evaluative speaking task differs in inpatients participating in the MSC or the Progressive Muscle Relaxation (PMR) program at the end of their 6-week psychiatric rehabilitation stay (i.e., post-test only design). (frontiersin.org)
  • The study included 613 methadone patients between April 1, 2003 and March 31, 2004. (biomedcentral.com)
  • This study will seek to investigate the efficacy of "Microbiota modulation of the Gut-Lung Axis" combined with chemotherapy in patients with advanced NSCLC. (biomedcentral.com)
  • A qualitative sub-study will explore patient experience and perception of the trial. (biomedcentral.com)
  • 14 A similar training programme improved symptoms and physiological findings in an open study of patients with the "effort syndrome. (bmj.com)
  • This study should be the basis for further evaluations of long-term efficacy and safety of the use of cannabinoids in PD patients. (springer.com)
  • This study investigated (1) the validity of a 2-question screen and the 9-item Patient Health Questionnaire (PHQ-9) for identifying postpartum depression and (2) the feasibility of screening for postpartum depression during well-child visits. (annfammed.org)
  • Another study in patients with type 2 diabetes compared apple cider vinegar with water. (elixirnews.com)
  • 2002: (HRC) A study of the dose response association between infant iron status and later cognitive functioning (D Richards, E Wells, L Toop et al. (otago.ac.nz)
  • This large-scale, multicenter, non-interventional, cross-sectional study examined the activity status of COPD patients in Japan and explored factors related to PA. (dovepress.com)
  • Did the authors study an outcome (dependent variable) or topic that the patients/clients/population group would care about? (andeal.org)
  • Was the selection of study subjects/patients free from bias? (andeal.org)
  • Now, researchers in the current study report the findings from a clinical trial of ropinirole in a small number of ALS patients, with its findings suggesting ropinirole slowed disease progression over a six-month period. (technologynetworks.com)
  • The study was double-blinded for an initial 24-week period where patients and researchers did not know who received ropinirole and who received a placebo. (technologynetworks.com)
  • An Internet-based Study on Coping with Illness and Attitudes towards Online Health Care in Cancer Patients. (websm.org)
  • The protocol for the randomized, controlled, multisite study required that patients achieve complete withdrawal from opioids before beginning therapy with XR-NTX. (medscape.com)
  • The study authors determined that almost all patients who had failed to begin therapy with a study drug experienced an early relapse. (medscape.com)
  • In the study, 570 patients were randomly assigned to receive either XR-NTX or BUP-NX. (medscape.com)
  • Thus, the present study aimed to evaluate the oral health status of patients with leprosy in relation to the presence of associated lesions, prevalence of caries and plaque accumulation. (bvsalud.org)
  • MAIN OUTCOME MEASURES: The primary outcome measure was patient reported score on the Sino-Nasal Outcome Test-22 (SNOT-22) at six months, with 9 points defined as the minimal clinically important difference. (bvsalud.org)
  • One-hundred and fifty CS patients will be randomised to receive either a leucine-rich protein supplement or a placebo with no supplemented protein. (bmj.com)
  • In a Phase III randomised clinical trial with 299 patients with steroid dependent Crohn's disease, clinical response was correlated with drug exposure, with significant efficacy versus placebo being observed in the subgroup with greatest area under the curve, hence pharmacodynamic modelling suggests that alicaforsen (ISIS 2302) may be an effective therapy at adequate dose levels. (wikipedia.org)
  • Empiric evidence shows that it consistently lowers placebo response and variability, and offers improved power and predictivity at lower sample sizes, in comparison to parallel arm designs with or without placebo lead-in, in a wide range of therapeutic indications and interventions. (stanleyresearch.org)
  • In recent years, 2 enhanced IIVs, MF59-adjuvanted standard-dose IIV and a high-dose IIV that contains 4 times the hemagglutinin antigen of each virus compared with the standard-dose IIV, have been developed to improve the immune responses to and efficacy of standard-dose IIVs ( 15 , 16 ). (cdc.gov)
  • The efficacy of alicaforsen was durable in these sub-groups, with significantly improved duration of clinical response with no maintenance therapy, suggesting a disease-modifying effect. (wikipedia.org)
  • Based on the theoretical basis of "intestinal and lung axis microecological adjustment", combined with traditional platinum-containing two-drug chemotherapy, the efficacy of the new therapy on patients with advanced NSCLC was observed. (biomedcentral.com)
  • In a 12-month follow-up randomized clinical trial, we aimed to measure the efficacy of a brief family psychoeducation program in terms of reducing relapse risk and improving medication adherence in patients, as well as reducing caregiver burden, depression and increasing knowledge of the illness. (frontiersin.org)
  • In phase 1 (at baseline), patients will be recruited and grouped in fluoxetine group or fluoxetine combined with CBT group by patient self-selection. (biomedcentral.com)
  • Sociodemographic, symptom severity (PANSS) and medication adherence (MARS) from patients were assessed at baseline and relapse rates was recorded during the 12 months follow-up period. (frontiersin.org)
  • Patients with baseline ADV resistance were excluded. (e-cmh.org)
  • Multivariate analysis indicated that high baseline HBV DNA level ( P =0.005) and LAM/LdT+ADV maintenance therapy ( P =0.001) were negatively associated with virologic response. (e-cmh.org)
  • The differential response highlights the confounding symptoms of a large subset of subjects whose needs are apparently not being met by the current clinical trial design. (wikipedia.org)
  • A recent systematic review including 11 studies demonstrates consistent improvement in many outcome measures of patients, such as relapse rates and medication adherence, but heterogeneity in symptoms reliefs ( 9 ). (frontiersin.org)
  • Although open-label observations report a positive effect of cannabinoids on non-motor symptoms (NMS) in Parkinson's disease (PD) patients, these effects remain to be investigated in a controlled trial for a broader use in NMS in PD patients. (springer.com)
  • It is widely believed that treatments for major depression (psychotherapy and antidepressant medications) have improved patients' symptoms since the 1980s. (uottawa.ca)
  • Limitations were small sample and no control group. (lu.se)
  • Lower reward dependence and lower cooperativeness characterized the dropout group. (biomedcentral.com)
  • After correction for alpha inflation no differences in the psychophysiological stress response and psychometric parameters between the MSC and PMR group were found. (frontiersin.org)
  • At week 48, additional ADV- or ETV-associated mutations were cleared in ETV+TDF group, but such mutations were present in 4.3% of patients in LAM/LdT+ADV group ( P =0.106). (e-cmh.org)
  • Four patients in the filgotinib group and one patient in the lanraplenib group completed week 16. (bmj.com)
  • The role of exercise training in this diverse patient group is unclear. (bmj.com)
  • Currently, patients with AN, even after receiving individually-tailored therapeutic interventions, often relapse following marginal weight restoration. (lidsen.com)
  • However, more research with clinical randomized controlled trials investigating larger samples are needed to further affirm these initial findings. (frontiersin.org)
  • 66 patients with the chronic fatigue syndrome who had neither a psychiatric disorder nor appreciable sleep disturbance. (bmj.com)
  • These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with the chronic fatigue syndrome. (bmj.com)
  • Patients with the chronic fatigue syndrome perceive greater fatigue than healthy controls taking the same exercise. (bmj.com)
  • 10 Fitness training improved both aerobic capacity and myalgia more than flexibility exercises in patients with the "fibrositis/fibromyalgia syndrome," 13 a condition which overlaps with the chronic fatigue syndrome. (bmj.com)
  • Patients met the Oxford criteria for the chronic fatigue syndrome. (bmj.com)
  • Schizophrenia is a chronic and severe mental disorder which has serious consequences for both the patient and caregivers. (frontiersin.org)
  • Patients with chronic obstructive pulmonary disease (COPD) have decreased physical activity (PA) compared with healthy adults. (dovepress.com)
  • Data from 417 patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I (29.5%), II (43.9%), III (23.5%), and IV (3.1%) were evaluated. (dovepress.com)
  • Patients with chronic hepatitis B (CHB) and continuously high levels of serum hepatitis B virus (HBV) DNA have an increased risk for progression of hepatic fibrosis and development of hepatocellular carcinoma (HCC) [ 1 , 2 ]. (e-cmh.org)
  • Objectives Patients with lupus membranous nephropathy (LMN) are at risk for prolonged proteinuria and progressive chronic kidney disease. (bmj.com)
  • Although exercise training effectively improves exercise capacity and health related quality of life in patients with chronic obstructive pulmonary disease (COPD), 4 its role in patients with ILD is unclear. (bmj.com)
  • Current guidelines for exercise prescription in chronic lung disease are based on evidence from studies of patients with COPD 7 where respiratory mechanics and peripheral muscle dysfunction are major limitations to exercise capacity. (bmj.com)
  • In this cohort of primary care patients with predominantly subacute or chronic ACJ pain of non-traumatic onset, traditional ACJ tests were of limited diagnostic value. (biomedcentral.com)
  • Studies of postpartum depression screening demonstrate that it is feasible in outpatient clinical settings, either during mothers' postpartum visits 7 , 8 or during infants' well-child visits, 9 - 11 with the use of screens such as the Edinburgh Postnatal Depression Scale 7 - 10 or the 2-item Patient Health Questionnaire (PHQ-2). (annfammed.org)
  • Most patients in these studies had moderate to severe depression. (uottawa.ca)
  • Nous avons mené une étude à ce sujet auprès de 70 patients dans quatre centres de santé à Alep. (who.int)
  • Abstract Cutaneous leishmaniasis (CL) is endemic in Aleppo and yet the knowledge, attitudes and practices (KAP) of CL patients in Aleppo has never been studied. (who.int)
  • This analysis suggests that alicaforsen enema could offer an effective, potentially durable response in moderate/severe distal active UC. (wikipedia.org)
  • Schizophrenia is recognized for its severe impact on both patients and caregivers. (frontiersin.org)
  • Psychiatry is seeking interventions that could reliably sustain weight gain and psychosomatic recovery of patients with severe anorexia nervosa (AN). (lidsen.com)
  • The SAVER trial provides an opportunity to investigate the effects of a repurposed, inexpensive and well-tolerated medication as a potential chemopreventive strategy for patients with high-risk OED. (biomedcentral.com)
  • Results: Patients reporting low paternal care (paternal neglect), asmeasured by the Parental Bonding Instrument (PBI), were less likely tocomplete an adequate six-week trial of medication. (findmedarticle.com)
  • However there was a suggestion of a therapeutic response in a sub-population with elevated serum CRP (C-reactive Protein) levels >2mg/dl. (wikipedia.org)
  • Each go to, 24-h urine, CAY10505 place morning hours urine, and bloodstream samples were CAY10505 gathered. (ampkpathway.com)
  • Immunosuppressed patients have a high risk for influenza complications and an impaired immune response to vaccines. (cdc.gov)
  • SAVER is a phase IIb open-label, randomised control trial of VPA as a chemopreventive agent in patients with high-risk oral epithelial dysplasia (OED). (biomedcentral.com)
  • One hundred and ten patients with high-risk OED will be recruited from up to 10 secondary care sites in the UK and randomised into either VPA or observation only for 4 months. (biomedcentral.com)
  • The current management options for patients with high-risk OED are limited and mostly include surgical resection and clinical surveillance. (biomedcentral.com)
  • One key downside of the research is that Cuijpers and colleagues classified only 31% of studies as having a low risk of bias (i.e., high-quality studies with sufficient sample sizes and other state-of-the-art procedures), and the risk of publication bias (suppression of negative findings) was high. (uottawa.ca)
  • We transcribed and descriptively coded interviews and compared responses from high- and low-retention programs. (cdc.gov)
  • 2017) highlighted that the registered nurses in the cardiovascular unit have varying roles in the care process of the patients with MI in the emergency department and this mainly includes nurse-initiated thrombolytic, patient education and adoption and subsequent procurement of the primary health interventions upon admission to the emergency unit. (myassignmenthelp.com)
  • The introduction of nucleotide/nucleoside analogues (NUCs), which block the reverse transcription of HBV polymerase, has markedly improved the prognosis of these patients [ 6 - 9 ]. (e-cmh.org)
  • Of course, conventional therapy such as chemotherapy and radiotherapy are still used and continue to benefit patients. (cosmosmagazine.com)
  • 2010: (CMRF and Genesis Oncology Trust (Bruce Blue Award)) Chemotherapy response in an obese mouse model with colorectal cancer. (otago.ac.nz)
  • will allow obtaining results with 194 patients recruited. (bmj.com)
  • Analysis by intention to treat gave similar results (17/33 v 9/33 patients better). (bmj.com)
  • Results Nine patients were randomised to receive filgotinib (n=5) or lanraplenib (n=4). (bmj.com)
  • Found in two independent samples of Swedish adults, these results pointed towards the continued existence of micronutrient dilution for over two decades. (lu.se)
  • It can help prolong the survival time of lung cancer patients and improve the quality of life, thereby generating huge economic and social benefits. (biomedcentral.com)
  • VLU patients have a worse quality of life than non-affected persons of the same age due to the pain, malodour and loss of independence that it causes [ 2 ]. (biomedcentral.com)
  • In the USA, VLUs have been estimated to cost a billion dollars a year, representing an average cost of over 40,000 dollars during the lifetime of each patient [ 1 ], without taking into account the financial effects of impaired quality of life, sick leave and frequent hospitalization. (biomedcentral.com)
  • You can't do that if you're getting the variability of manually producing these patient tumours or if you are growing them in an environment that differs substantially to that found in the body. (cosmosmagazine.com)
  • Introduction In the past 20 years, the increasing burden of heart disease in an ageing population has resulted in cardiac surgery (CS) being offered to more frail and older patients with multiple comorbidities. (bmj.com)
  • In recent years, an increasing number of patients are receiving biologic or immune-modulating agents with immunosuppressive potential ( 4 , 5 ). (cdc.gov)
  • Data from 50 inpatients (25 MSC, 25 PMR, 35 female) aged 19 to 76 years ( M = 47.22, SD = 12.44) were analyzed in terms of psychophysiological stress response. (frontiersin.org)
  • On the 25 patients included, the mean age was 33.3 years (SD = 9.7) with a mean duration of disease of 7.48 years (SD = 7.1). (frontiersin.org)
  • These are delivered in different therapeutic settings encompassing inpatient, day hospital (DH), or outpatient services, with different rates of remission according to the heterogeneity of the sample selection [ 16 ]. (biomedcentral.com)
  • Data from well-characterized clinical samples constitute an important scientific resource. (stanleyresearch.org)
  • Controlled studies with larger samples should replicate these promising preliminary findings. (lu.se)
  • Enhanced recovery protocols (ERPs), such as prehabilitation, have been associated with a reduction in complications after CS in vulnerable patients. (bmj.com)
  • Cocaine use in methadone patients may be associated with heroin use, which indicates the importance of prescribing appropriate methadone dosages in order to indirectly reduce cocaine use. (biomedcentral.com)
  • The review documents that although acceleromyography is widely used in research, it cannot be used interchangeably with mechanomyography and electromyography for construction of dose-response curves or for recording different pharmacodynamic variables after injection of a neuromuscular blocking agent. (silverchair.com)
  • A cohort of older patients with bilateral cataract was assessed one week before and one to three months after first eye or both eye cataract surgery. (biomedcentral.com)
  • Eligible patients were randomised 1:1 to receive either filgotinib or lanraplenib in a blinded fashion for up to 52 weeks. (bmj.com)
  • Reduced PA was observed in the Japanese COPD patients with the majority of them being GOLD stage I/II. (dovepress.com)
  • 8 , 9 The applicability of such guidelines to patients with ILD is unclear as the physiological basis of exercise limitation differs substantially from COPD. (bmj.com)
  • This trial assessed the preferential Janus kinase 1 (JAK1) inhibitor filgotinib and the spleen tyrosine kinase inhibitor lanraplenib in patients with LMN. (bmj.com)
  • 17 , 18 Whether it is safe and efficacious to apply standard exercise training principles to all patients with ILD is unknown. (bmj.com)
  • Our laboratory focuses on discovery, cloning, sequencing, and creating gene therapy approaches for patients with hereditary forms of epidermolysis bullosa, a serious (potentially lethal) skin disease. (stanford.edu)
  • In previous PRAMS studies, associating substance use with pregnancy tended to elicit negative responses from mothers who felt judged about such behaviors. (cdc.gov)
  • Patients who received ropinirole during both phases of the trial gained the most benefit. (technologynetworks.com)
  • A total of 25 days of patients with schizophrenia (DSM-IV-TR) and family primary caregivers were recruited in a single regional psychiatric outpatient facility located in Bordeaux. (frontiersin.org)
  • However, a review of immunogenicity studies suggests that antibody responses to inactivated influenza vaccines (IIVs) in persons who are immunocompromised could be suboptimal compared with persons without immunosuppression ( 11 ). (cdc.gov)
  • Despite the oral examination being part of the comprehensive examination of a patient with leprosy, there are few studies describing the oral health and dental care of these patients. (bvsalud.org)
  • Therefore, as part of my doctoral thesis, I have conducted four studies on sugar consumption, with different factors connected to disease development in a large sample of the adult Swedish population. (lu.se)
  • There were no significant differences in response between those with and without IPF. (bmj.com)
  • What we're now missing is a way to predict which patients will benefit the most from which treatments. (cosmosmagazine.com)
  • Our idea is to get patient samples and grow these as a mini tumour in the laboratory, then put these mini tumours through testing using a battery of drugs and potential treatments, find the best ones, and feed that back. (cosmosmagazine.com)