• Imatinib mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. (medkoo.com)
  • Novartis, a Swiss pharmaceutical conglomerate, filed a patent application in 1997 for Glivec, an anticancer drug used to treat Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST), claiming that it invented the beta crystalline salt form (imatinib mesylate) of the free base, imatinib. (legalserviceindia.com)
  • The beta-crystalline form of imatinib mesylate was deemed unique and creative by IPAB, but the drug of Novartis was denied a patent due to Section 3(d) of the Act. (legalserviceindia.com)
  • On 20/7/2002, NATCO Pharma applied for an Indian patent on what is known as the A2 form of Imatinib Mesylate. (legalserviceindia.com)
  • Natco Pharma has again applied for a patent on novel crystalline forms I and II of Imatinib Mesylate and has also accepted that they exist in alpha and beta forms in NOVATIS Patent. (legalserviceindia.com)
  • Both parties challenging the application of Novartis themselves applied for the patenting of the crystalline forms of Imatinib Mesylate as novel inventions. (legalserviceindia.com)
  • The main issue before the court was whether the beta crystalline form of Imatinib Mesylate constitutes an innovation under section 2(j) and (j)(a), and if so, how does it affect section 3? (legalserviceindia.com)
  • The appellant claimed that imatinib Mesylate in beta crystalline form is a brand-new product. (legalserviceindia.com)
  • No crystalline form of Imatinib Mesylate was anticipated or disclosed in the Zimmerman patent. (legalserviceindia.com)
  • In the Zimmermann patent, there was no method for converting Imatinib to Imatinib Mesylate that worked. (legalserviceindia.com)
  • Furthermore, the parties opposing Novartis' application have filed for and received patents for crystalline versions of Imatinib Mesylate as a novel innovation. (legalserviceindia.com)
  • The salts Imatinib Mesylate are involved in the preparation of Imicap Capsule. (medibuddy.in)
  • In organosulfur chemistry, a mesylate is any salt or ester of methanesulfonic acid (CH3SO3H). (wikipedia.org)
  • Salts and esters of methanesulfonic acid are known as mesylates. (triownchemie.com)
  • TAGRISSO tablets contain 40 or 80 mg of osimertinib, equivalent to 47.7 and 95.4 mg of osimertinib mesylate, respectively. (mdtodate.com)
  • These highlights do not include all the information needed to use DEFEROXAMINE MESYLATE safely and effectively. (nih.gov)
  • See full prescribing information for DEFEROXAMINE MESYLATE. (nih.gov)
  • Deferoxamine mesylate is not indicated for the treatment of primary hemochromatosis (since phlebotomy is the method of choice for removing excess iron in this disorder). (nih.gov)
  • See Full Prescribing Information for instructions on preparation of Deferoxamine mesylate for administration. (nih.gov)
  • For injection: 500 mg of deferoxamine mesylate as a lyophilized powder in single-dose fliptop vial for reconstitution. (nih.gov)
  • Discontinue Deferoxamine mesylate and initiate appropriate treatment immediately. (nih.gov)
  • Delay Vitamin C for one month after start of Deferoxamine mesylate. (nih.gov)
  • To suppress iron (Fe) interferences with the PAN reagent, the Fe(III) masking agents deferoxamine mesylate (DFO-B) or disodium 4,5-dihydroxy-1,3-benzenedisulfonate (Tiron) were added and their Fe masking efficiencies were investigated. (nature.com)
  • D.H.E. 45 (dihydroergotamine mesylate) is an ergot alkaloid used to treat a migraine or cluster headache attack. (rxlist.com)
  • Our D.H.E. 45 (dihydroergotamine mesylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • D.H.E. 45 (dihydroergotamine) ® is ergotamine hydrogenated in the 9, 10 position as the mesylate salt. (rxlist.com)
  • D.H.E. 45® (dihydroergotamine mesylate) Injection, USP is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. (rxlist.com)
  • D.H.E. 45® (dihydroergotamine mesylate) Injection, USP should be administered in a dose of 1 mL intravenously, intramuscularly or subcutaneously. (rxlist.com)
  • Available as a clear, colorless, sterile solution in single 1 mL sterile ampuls containing 1 mg of dihydroergotamine mesylate per mL, in packages of 10 (NDC 0078-0041-01). (rxlist.com)
  • Serious cardiac events, including some that have been fatal, have occurred following use of D.H.E. 45® (dihydroergotamine mesylate) Injection, USP, but are extremely rare. (rxlist.com)
  • A clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S -alkyl isothiourea salts is simple, environment- and worker-friendly. (organic-chemistry.org)
  • A simple NaClO 2 -mediated oxidative chlorosulfonation of S-alkyl isothiourea salts enables a convenient, safe, and environmentally benign synthesis of diverse sulfonyl chlorides in high yields. (organic-chemistry.org)
  • Structurally diverse sulfonyl chlorides were synthesized via N -chlorosuccinimide chlorosulfonation in good yields from S -alkylisothiourea salts, which can be easily prepared from readily accessible alkyl halides or mesylates and inexpensive thiourea. (organic-chemistry.org)
  • Protein aggregation and unfolding occurred at 10 mol% IL, altering the protein shape, especially for ILs with multiple alkyl chains on the cation, or with a mesylate/nitrate anion. (bvsalud.org)
  • We also offer the methanesulfonate salt form of dabrafenib: Cat. (lclabs.com)
  • The CAS number of the methanesulfonate salt form is 1195768-06-9. (lclabs.com)
  • Mesylate esters are a group of organic compounds that share a common functional group with the general structure CH3SO2O−R, abbreviated MsO−R, where R is an organic substituent. (wikipedia.org)
  • Parlodel (bromocriptine mesylate) is a dopamine receptor agonist used to treat certain conditions caused by a hormone imbalance in which there is too much prolactin in the blood (hyperprolactinemia), and to treat these disorders when they are caused by brain tumors that can produce prolactin. (rxlist.com)
  • Our Parlodel (bromocriptine mesylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Parlodel® (bromocriptine mesylate) is an ergot derivative with potent dopamine receptor agonist activity. (rxlist.com)
  • Each Parlodel® (bromocriptine mesylate) SnapTabs® tablet for oral administration contains 2½ mg and each capsule contains 5 mg bromocriptine (as the mesylate). (rxlist.com)
  • Bromocriptine mesylate is chemically designated as Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'α)-monomethanesulfonate (salt). (rxlist.com)
  • Parlodel (bromocriptine mesylate) is indicated for the treatment of dysfunctions associated with hyperprolactinemia including amenorrhea with or without galactorrhea, infertility or hypogonadism . (rxlist.com)
  • Tricaprin is used to construct solid lipid nanoparticles (SLNs) as delivery system for bromocriptine (B682600, Mesylate salt). (chemicalbook.com)
  • b As the hydrochloride salt. (medscape.com)
  • Phenethylamine is strongly basic and forms a stable crystalline hydrochloride salt with a melting point of 217 °C. Phenethylamine is also a skin irritant and possible sensitizer. (hmdb.ca)
  • The hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. (medindex.am)
  • The active ingredient of Eprosartan MESYLATE is eprosartan. (imedix.com)
  • In salts, the mesylate is present as the CH3SO−3 anion. (wikipedia.org)
  • When modifying the international nonproprietary name of a pharmaceutical substance containing the group or anion, the spelling used is sometimes mesilate (as in imatinib mesilate, the mesylate salt of imatinib). (wikipedia.org)
  • The salts Phentolamine Mesylate are involved in the preparation of Fentosol Injection. (medibuddy.in)
  • The present invention is a novel haloalkyl sulfone anilide compound or a salt thereof, an herbicide composition including said compound or salt thereof, an herbicide method including a step for applying the herbicide composition, and a m. (sumobrain.com)
  • Eprosartan mesylate is a medication used for treating hypertension (high blood pressure). (imedix.com)
  • a Listed salts supply approximately 200 mg of elemental iron daily. (medscape.com)
  • Please note the dose is based on the weight of elemental iron, not of iron salts. (medscape.com)
  • Mesylates are generally prepared by treating an alcohol and methanesulfonyl chloride in the presence of a base, such as triethylamine. (wikipedia.org)
  • PEG-halide (chloride, bromide, iodide, tosylate and mesylate) reacts with deprotonated carboxyl groups i.e. (creativepegworks.com)
  • The present invention provides compounds which inhibit the activity of TRPC6, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. (justia.com)
  • Provided is a compound able to activate Nrf2 and represented by formula (1), a salt thereof, or a solvate of these. (sumobrain.com)
  • Oral solutions of ferrous iron salts are available for use in pediatric populations. (medscape.com)
  • Cocaine and Benztropine Mesylate also react inside the liver to form a chemical known as cocaethylene, which is toxic to the heart, liver, and other organs. (worldsbest.rehab)
  • The fumarate salt form of ibutilide, a class III antiarrhythmic agent. (medindex.am)
  • Even taking Cocaine without Benztropine Mesylate has a negative effect on the heart, and then taking Benztropine Mesylate with it increases the risk exponentially. (worldsbest.rehab)
  • While common, combining cocaine and Benztropine Mesylate together or even hours apart can be extremely risky because it increases heart rate and blood pressure, further increasing the risk of a heart attack. (worldsbest.rehab)
  • Taking Cocaine and Benztropine Mesylate actually increases the risk of a heart attack. (worldsbest.rehab)
  • Most ILs increased HEWL size compared to buffer, while the nitrate and mesylate anions induced the most significant size increases. (bvsalud.org)
  • Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. (csnpharm.com)
  • Tenofovir disoproxil fumarate (TDF) is the salt of tenofovir disoproxil with fumaric acid. (who.int)
  • Related to mesylate is the mesyl (Ms) or methanesulfonyl (CH3SO2) functional group. (wikipedia.org)
  • Common salts exhibited specific ion effects, while the IL effect varied with concentration due to complex ion-pairing. (bvsalud.org)
  • Related: 1218779-75-9 (Apatinib mesylate salt) 811803-05-1 (Apatinib free base). (medkoo.com)
  • WCK 771 is an arginine salt of levonadifloxacin, a broad-spectrum benzoquinolizine sub-class of fluoroquinolone with a potent activity against Staphylococcus aureus including MRSA, quinolone-resistant S. aureus and vancomycin-non-susceptible strains (VISA and VRSA). (wockhardt.com)
  • Over the past 60 years, due to the advancement of hemo- the Work Group and tasked it with planning, developing, dialysis (HD) technology and the introduction of medical reviewing, and disseminating appropriate HD treatment insurance, dialysis treatment has become widespread, en- guidelines in accordance with international standards. (bvsalud.org)
  • PEG reagents react with carboxylic acid in the presence of coupling agents such as DCC (N,N'-dicyclohexylcarbodiimide) and EDIC (N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide, HCl salt). (creativepegworks.com)
  • As an alternative to water pills, Dr. Rackley recommends restricting salt in your diet and exercising for weight loss. (clevelandclinic.org)
  • When mixed with Benztropine Mesylate, Cocaine can affect the body's ability to keep the correct temperature and heart function. (worldsbest.rehab)
  • Upon exposure to air, it forms a solid carbonate salt with carbon dioxide. (hmdb.ca)
  • Whereas mesylates are often hydrolytically labile, mesyl groups, when attached to nitrogen, are resistant to hydrolysis. (wikipedia.org)