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  • Genome
  • CRISPR/Cas9 and related genome editing techniques are already revolutionising scientific research, through use in the development of new cell and animal models. (phgfoundation.org)
  • gene
  • And now that a powerful gene-editing technique has been used on human embryos, it's fine to get a little freaked out. (wired.com)
  • Some think gene editing for therapeutic purposes will inevitably lead to the creation of genetic classism. (wired.com)
  • Added world-recognized neurobiologist, Dr. Evan Y. Snyder, head of the FDA's Cellular, Tissue and Gene Therapies Advisory Committee, Director of the Stem Cells and Regenerative Biology Program at Sanford Burnham Medical Research Institute, as an non-compensated member of our Board of Advisors. (marketwired.com)
  • In recent attempts to alleviate the symptoms of t hese d iseases, research has turned to the capabilities of gene therapy as a tool for treatment . (issuu.com)
  • viable
  • Research is needed to determine the most viable stem cell lines and reliable ways to promote the differentiation of pluripotent stem cells into specific cell types (neurons, muscle cells, etc. (jci.org)
  • widespread
  • While we acknowledge that it is still vitally important to continue public discussions for new applications of this kind, we also think that a challenge lies ahead in terms of managing the increased workload involved in research oversight that will result from the widespread use of a more accessible technology. (phgfoundation.org)
  • The safety, efficacy, and widespread use of VZV vaccines suggest that they may also be effective as recombinant vaccines against other infectious diseases that affect the young and the elderly. (hindawi.com)
  • somatic
  • The Committee recommends that cryopreserved embryos be the preferred source for research but believes that the promise of somatic cell nuclear transfer is such that research in this area is justified. (docplayer.net)
  • federally-funded
  • More than 60 existing stem cell lines from genetically diverse populations around the world are expected to be available for federally-funded research. (archives.gov)
  • In August 2010, as part of preliminary motions in Sherley vs Sebelius, Judge Royce C. Lamberth granted an injunction against federally funded embryonic stem cell (ESC) research on the grounds that the guidelines for ESC research "clearly violate" the Dickey-Wicker Amendment. (wikipedia.org)
  • Oak Ridge National Laboratory (ORNL) is an American multiprogram science and technology national laboratory sponsored by the U.S. Department of Energy (DOE) and administered, managed, and operated by UT-Battelle as a federally funded research and development center (FFRDC) under a contract with the DOE. (wikipedia.org)
  • pluripotent
  • In contrast to multipotent stem cells (including mesenchymal stem cells or MSCs), pluripotent stem cells (PSCs) are intrinsically able to self-renew indefinitely and to give rise to virtually all cell types in the body, features that provide distinct advantages in relation to regenerative medicine applications and for which PSCs have been the subject of intense research over the past 30 years. (frontiersin.org)
  • clinical
  • IVF pioneer and stem-cell researcher Professor Alan Trounson of the Monash Institute of Reproduction and Development recently told The Sydney Morning Herald that he would like Australia to be the first to conduct clinical trials within two years, and that this would require access to new lines of stem cells from 'spare' IVF embryos. (abc.net.au)
  • Additionally, the safety and efficacy of the treatment must be tested before the therapy can begin to make its way towards clinical development, Turnbull said. (the-scientist.com)
  • Subsequent to the quarter end, in July, 2015, the Company completed a nine month safety study of the hpNSCs demonstrating safety elements for regulatory approval of the upcoming Parkinson's disease clinical trial, and submitted the results to the Australian TGA. (marketwired.com)
  • As with all forms of clinical treatment, the medical community looked to basic science research to improve the safety and efficacy of IVF for mothers and babies. (wikipedia.org)
  • The latest research achievements in the field of stem cells led in 2016 to the publication of "Guidelines for Stem Cell Research and Clinical Translation" by the International Society for Stem Cell Research (ISSCR). (hindawi.com)
  • Under the common principles of research integrity, protection of patient's welfare, respect for the research subjects, transparency and social justice, the centrality of good clinical practice, and informed consent in research and translational medicine is supported. (hindawi.com)
  • According to this view, it is also recommended the need for registration of all clinical trials in progress or carried out in public databases, along with the transparency of the results, in order to ensure a research that is not burdened by fraud attempts. (hindawi.com)
  • Before a clinical use can be envisioned, however, significant challenges will need to be addressed in relation to the robust derivation, long-term culture, differentiation, and clinical safety of equine iPSCs. (frontiersin.org)
  • It is recommended only as a third line treatment in graft versus host disease in adults, based on lack of efficacy and side effects observed in clinical trials. (wikipedia.org)
  • Michigan Medicine has nearly 26,000 employees, including about 2,700 faculty, more than 5,000 nurses and nearly 1,200 residents and clinical fellows known as house officers as well as other clinical, research, education and administrative staff. (wikipedia.org)
  • nuclear
  • The laboratory is home to several of the world's top supercomputers including the world's fifth most powerful supercomputer ranked by the TOP500, Titan, and is a leading neutron science and nuclear energy research facility that includes the Spallation Neutron Source and High Flux Isotope Reactor. (wikipedia.org)
  • After the end of World War II the demand for weapons-grade plutonium fell and the reactor and the laboratory's 1000 employees were no longer involved in nuclear weapons, instead it was used for scientific research. (wikipedia.org)
  • treatments
  • With heart failure leading the cause of death in the USA (Hunt), biomedical research is fundamental to advance medical treatments for cardiovascular diseases. (jove.com)
  • Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
  • pregnancy
  • The embryos will be donated by couples undergoing IVF, and current legal restrictions remain in place: the embryos must be destroyed before they are 14 days old, and it will be illegal to use them to achieve a pregnancy. (phgfoundation.org)
  • biomedical
  • Stable increase in revenues from our biomedical businesses, ability to generate net income as a parent company and progress in demonstrating the safety and efficacy of our stem cells for the treatment of Parkinson's disease and stroke position us as a leader in regenerative medicine field," stated Andrey Semechkin, Ph.D., CEO and Co-Chairman of ISCO. (marketwired.com)
  • Given the wide range of exciting applications they could have, it is hoped future research will make the biomedical promise of iPSCs a reality not only for humans but also horses. (frontiersin.org)
  • diseases
  • Dr McCullagh said there was much misinformation around about the potential for stem cell research to help cure diseases. (abc.net.au)
  • This review summarizes research to develop and evaluate VZV vectors as recombinant vaccines against other diseases. (hindawi.com)
  • Several studies on stem cells produced increasingly important findings, with considerable implications on the quality of human life, as in the case of the therapies for intractable diseases, the assessment of efficacy and toxicity of new drugs and transplants. (hindawi.com)
  • demonstrate
  • While the primary endpoint of the trial is to demonstrate safety, doctors are also testing whether the cells restore sensation and movement. (cellmedicine.com)
  • Published the results of two proof of concept studies that demonstrate the safety and efficacy of the Company's stem cell treatment of Parkinson's disease in both non-human primate and rodent animal models in the journal " Cell Transplantation" . (marketwired.com)
  • development
  • The embryos from which the existing stem cell lines were created have already been destroyed and no longer have the possibility of further development as human beings. (archives.gov)
  • This position has resulted in the 14‐day rule that permits research on human embryos to the point where the primitive streak appears, the point in development after which embryos cannot split into twins or fuse together anymore (Hyun et al , 2016 ). (cloudfront.net)
  • Development expenses decreased by 8% to $3.65 million due primarily to reductions in cost of sales and consulting expenses relating to our research and development projects, partially offset by an increase in sales and marketing spending. (marketwired.com)
  • Net loss from development activities was $9.81 million, compared to $11.36 million in 2011 reflecting a reduction of $1.55 million or 14% primarily due to favorable reductions in cost of sales, research and development and general and administrative expenses. (marketwired.com)
  • We expect our net operating loss to continue declining quarter over quarter through 2015 year-end as our research and development expenses are expected to continue decreasing due to the completion of multiple preclinical studies during the three months ended June 30, 2015. (marketwired.com)
  • This is partly attributed to the relative lack of knowledge of early embryo development in domestic species, which precludes the use of optimal conditions to stably maintain embryonic cells in an undifferentiated state. (frontiersin.org)
  • The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease. (wikipedia.org)
  • advances
  • Responding to advances in research and translational medicine, in May 2016, the International Society for Stem Cell Research (ISSCR) published an update of the existing guidelines [ 1 , 2 ]. (hindawi.com)
  • As a non-profit entity, Michigan Medicine uses positive operating margins to fund continued advances in patient care, education, research, and the facilities needed to support these functions. (wikipedia.org)
  • study
  • Drug high-throughput screening Cerebral organoids can be used as simple models of complex brain tissues to study the effects of drugs and to screen them for initial safety and efficacy. (wikipedia.org)
  • cell lines
  • Federal funding of research using existing embryonic stem cell lines is consistent with the President's belief in the fundamental value and sanctity of human life. (archives.gov)
  • Today's decision relates only to the use of federal funds for research on existing stem cell lines derived in accordance with the criteria set forth above. (archives.gov)
  • The Australian Academy of Science 's Professor John White argues that the decision is urgent, because existing stem cell lines are insufficient or unacceptable for research to continue. (abc.net.au)
  • cells
  • The creation of embryonic stem cells. (archives.gov)
  • Most recently, research has targeted the stem cells derived from embryos because stem cell *Update of Preembryo Research in Ethics in Obstetrics and Gynecology, Second Edition, 2004 Terms defined in the glossary appear in bold type. (docplayer.net)
  • Received a key patent issued by the USPTO covering the creation of liver and pancreas precursor cells. (marketwired.com)
  • He said that diabetes, Parkinson's, and spinal cord lesions were the most likely candidates for a cure, but that alternatives such as xenotransplantation, which had been researched for several decades, were being ignored in the current hype over embryonic stem cells. (abc.net.au)
  • The leader of the field of embryonic stem cells is Geron, the company that funded the research that lead to the discovery of human embryonic stem cells, as well as the company that has the exclusive license for their commercial use. (cellmedicine.com)
  • In the 2-1 opinion of April 29, 2011, the appeals panel said that the Dickey-Wicker Amendment was "ambiguous" and that the National Institutes of Health had "reasonably concluded" that although federal funds could not be used to directly destroy an embryo, the amendment does not prohibit funding a research project using embryonic stem cells. (wikipedia.org)
  • The research on this type of cell is subjected to minor limitations because, despite being very similar to embryonic cells, the IPSC are produced from specialized adult cells (such as skin cells) and cannot therefore be considered as embryonic. (hindawi.com)
  • Research has been conducted on the effects of stem cells on animal models of brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease. (wikipedia.org)
  • already
  • The guidelines are inspired by the values already enshrined in key international documents regarding scientific research and experimentation, such as research rigor and integrity, supervision and transparency, patient welfare, and social justice [ 5 - 7 ]. (hindawi.com)
  • however does not affect already implanted embryos. (wikipedia.org)
  • The University of Chicago re-assumed responsibility, until in December 1947 Union Carbide and Carbon Co., which already operated two other facilities at Oak Ridge, took control of the laboratory and Alvin Weinberg was named Director of Research ORNL, and in 1955 Director of the Laboratory. (wikipedia.org)
  • therapy
  • The Committee recognizes that the science of this field, especially the science of stem cell research and therapy, is changing rapidly and anticipates that future changes will require revisiting past issues and either modifying previous guidelines or creating new ones in order to address formerly unimagined possibilities. (docplayer.net)
  • effectiveness
  • The proven safety and effectiveness of the varicella and shingles vaccines provide support for recombinant VZV (rVZV) vaccines to induce immunity against not only VZV but also against other pathogens. (hindawi.com)
  • Evidence supports effectiveness and safety in adolescents and those who have and have not previously had children. (wikipedia.org)
  • proven
  • The most relevant topics consist of research fairness, based on proven evidence studies and transparency, and patient involvement through effective and truthful communication. (hindawi.com)
  • long
  • The long term impact of this on medical research will be difficult to calculate, but it is likely that research in certain areas will become quicker and easier to carry out. (phgfoundation.org)
  • fundamental
  • The President's decision reflects his fundamental commitment to preserving the value and sanctity of human life and his desire to promote vital medical research. (archives.gov)
  • medical
  • Nonetheless, the results are "very promising," said neurogeneticist linkurl:Carolyn Sue;http://www.kolling.usyd.edu.au/research/neurogenetics-group/csue.php of the Kolling Institute of Medical Research at the University of Sydney in Australia, who was also not directly involved in the research. (the-scientist.com)
  • In 1950, Richard Doll published research in the British Medical Journal showing a close link between smoking and lung cancer. (wikipedia.org)