DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
MethotrexatePolyglutamic AcidAntirheumatic AgentsFolic Acid AntagonistsTetrahydrofolate DehydrogenaseArthritis, RheumatoidAminopterinAntimetabolites, AntineoplasticLeukemia L1210Reduced Folate Carrier ProteinTrimetrexateFolic Acidgamma-Glutamyl HydrolaseDrug Therapy, CombinationLeucovorinTetrahydrofolatesAbortifacient Agents, NonsteroidalCyclophosphamideDrug ResistanceTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsImmunosuppressive AgentsSulfasalazineVincristineDeoxyuridinePrecursor Cell Lymphoblastic Leukemia-LymphomaDrug Administration Schedule6-MercaptopurineDermatologic AgentsPregnancy, EctopicFluorouracilFormyltetrahydrofolatesFolate Receptors, GPI-AnchoredDoxorubicinPhosphoribosylaminoimidazolecarboxamide FormyltransferaseOsteosarcomaInjections, SpinalPrednisoneDose-Response Relationship, DrugCytarabineThymidylate SynthaseLeukemia, LymphoidHydroxychloroquineCentral Nervous System NeoplasmsPregnancy, TubalSarcoma 180Pteroylpolyglutamic AcidsIsoxazolesPsoriasisAsparaginaseGestational Trophoblastic DiseaseRemission InductionBiological TransportHydroxymethyl and Formyl TransferasesProbenecidMucositisNucleotide DeaminasesCarcinoma, Ehrlich TumorDouble-Blind MethodVinblastineAntibodies, MonoclonalArthritis, JuvenileCombined Modality TherapyArthritis, PsoriaticTrophoblastic NeoplasmsTime FactorsAdministration, OralLeukemia L5178CisplatinHypoxanthines
Treat ectopic pregnanciesPsoriasisPharmacieBiologicFarmacie Online CialisPregnancyDiscontinuation of methotrexateInjectionReceiving low-dose methotrexateRheumatoid arthritis patientsToxicityDoseLigneDrugsChemotherapyStop taking methoBiologicsDosesNSAIDsSilagraSkin rashesPlus methotrexateTake methotrexate2016ViagraMedicationsFarmaciaRisksDosageCorticosteroidsTHERAPYDiscontinueTreatmentDISEASESDMARDMedicationHydroxychloroquineReactionsComplicationsInfliximabSide effectsSuppressNauseaSymptomsImmune systemRemissionKidneysLupusLiver damageTreatmentsElimination
Treat ectopic pregnancies3
  • Methotrexate is an abortifacient and is used to treat ectopic pregnancies, provided the fallopian tube has not ruptured. (wikipedia.org)
  • While the standard Mifepristone-Misoprostol combination is not used to treat ectopic pregnancies, Methotrexate is the most common and safest way to end one - by stopping the cells from growing, which ends the pregnancy. (wonkette.com)
  • In some cases, Methotrexate may be used to treat ectopic pregnancies, where a fertilized egg implants outside the uterus. (prescriptiongiant.com)
Psoriasis11
Pharmacie29
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Biologic6
  • There's a strong emphasis on maximizing methotrexate using various means before switching to a biologic or JAK [Janus kinase] inhibitor," she said in a press conference at ACR Convergence 2020. (medscape.com)
  • Results of a systematic review exploring the comparative effectiveness of treatments of early rheumatoid arthritis show that treatment efficacy can be improved with combination therapy with anti-TNF or other biologic medications, compared with methotrexate monotherapy. (wikipedia.org)
  • You might start with a biologic if you can't take methotrexate. (webmd.com)
  • Your doctor will choose a biologic drug that's safe for any other health conditions you have and that fits the kind of treatment you prefer. (webmd.com)
  • What is the safest biologic for rheumatoid arthritis? (scienceoxygen.com)
  • It is recommended by the American College of Rheumatology and the European League Against Rheumatism that, when methotrexate treatment fails in rheumatoid arthritis, a biologic disease modifying ant-rheumatic drug such as a Janus kinase inhibitor should be started. (hcplive.com)
Farmacie Online Cialis2
Pregnancy24
  • Methotrexate with dilation and curettage is used to treat molar pregnancy. (wikipedia.org)
  • Methotrexate (MTX) is a potent teratogen when used in high doses for cancer or termination of tubal pregnancy. (nih.gov)
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  • Methotrexate can harm a developing fetus, so it should be avoided during pregnancy. (prescriptiongiant.com)
  • However, some topical treatments may not be safe to use during pregnancy. (healthline.com)
  • However, you can have a safe pregnancy despite your condition. (upmc.com)
  • Many medications for Crohn's and ulcerative colitis are safe during pregnancy. (upmc.com)
  • Methotrexate is not safe during pregnancy. (upmc.com)
  • For the safest pregnancy, he should talk to his doctor about alternative medications while you are attempting to get pregnant. (upmc.com)
  • Aminosalicylates are considered safe during pregnancy and while breastfeeding. (upmc.com)
  • Overall, you can feel comfortable having a safe pregnancy despite your IBD, especially when in remission. (upmc.com)
  • They may need to make important changes to your medication to ensure a safe pregnancy. (vic.gov.au)
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  • Suction and embryo reduction with local methotrexate injection offers an effective, safe and minimally invasive surgical treatment to remove ectopic pregnancy tissue. (bvsalud.org)
Discontinuation of methotrexate3
  • Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration. (nih.gov)
  • Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration (see section 5.2 and 4.4). (medicines.org.uk)
  • Furthermore, they may be used to inform treatment guidelines regarding optimal approaches to treatment tapering or discontinuation of methotrexate in patients with rheumatoid arthritis," the authors wrote. (hcplive.com)
Injection15
  • Methotrexate can be given by mouth or by injection (intramuscular, intravenous, subcutaneous, or intrathecal). (wikipedia.org)
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  • Treatments included suction curettage (n=12), embryo reduction with local methotrexate injection (n=12), laparoscopic excision (n=3) and excision through laparotomy (n=3). (bvsalud.org)
Receiving low-dose methotrexate1
  • Malignant lymphomas, which may regress following withdrawal of methotrexate, may occur in patients receiving low-dose methotrexate and, thus, may not require cytotoxic treatment. (nih.gov)
Rheumatoid arthritis patients3
  • Studies and reviews have found that most rheumatoid arthritis patients treated with methotrexate for up to one year had less pain, functioned better, had fewer swollen and tender joints, and had less disease activity overall as reported by themselves and their doctors[citation needed]. (wikipedia.org)
  • Rheumatoid arthritis patients who achieve low disease activity on tofacitinib in combination with methotrexate, should be able to discontinue methotrexate safely and without significant worsening of disease activity, especially if they are having trouble tolerating it, new research shows. (hcplive.com)
  • The study, which is called ORAL Shift, is also the first-known non-inferiority global clinical trial whose aim was to assess efficacy and safety of a JAK inhibitor after methotrexate withdrawal in rheumatoid arthritis patients who have achieved low disease activity with tofacitinib and methotrexate combination treatment. (hcplive.com)
Toxicity3
  • Rosales A, Madrid A, Muñoz M, Dapena JL, Ariceta G. Charcoal Hemoperfusion for Methotrexate Toxicity: A Safe and Effective Life-Rescue Alternative When Glucarpidase Is Not Available. (gencat.cat)
  • High doses or accidental overdose of Methotrexate can lead to severe toxicity, which can be life-threatening. (prescriptiongiant.com)
  • Although low- dose MTX appears to be a safe medication, acute MTX toxicity can be a life -threatening emergency . (bvsalud.org)
Dose9
  • Your doctor will monitor you more carefully and may need to give you a lower dose of methotrexate or stop your treatment with methotrexate. (medlineplus.gov)
  • In contrast, it has been perceived as safe when used once weekly at low dose for rheumatological conditions. (nih.gov)
  • Background: High dose methotrexate (HDMTX) is used for the treatment of pediatric hemato-oncological diseases. (gencat.cat)
  • This Phase IIb study demonstrated the safety and efficacy of abatacept plus methotrexate (MTX) over 1 year of double-blind (DB) treatment in patients with RA and an inadequate response to MTX 3 , 4 , and confirmed ~10 mg/kg to be the most effective dose. (jrheum.org)
  • The recommended initial dose is 7.5 mg of methotrexate once weekly , administered subcutaneously. (medicines.org.uk)
  • I have had high dose prednisone , Salasoprosyn (excuse spelling) methotrexate,arava and endep,lyrica and neurontin for neuropathy. (cancer.org)
  • This confirms that lowering the dose is safe - and that it can result in major cost savings, say the authors. (creakyjoints.org)
  • This is not the first study to find that it's safe for most RA patients with low disease activity to taper their dose of biologics, but some doctors are reluctant to try this approach. (creakyjoints.org)
  • Methotrexate (MTX) is considered a relatively safe drug when prescribed at low- dose regimens not exceeding 25 mg/week. (bvsalud.org)
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Drugs8
  • Like other cytotoxic drugs, methotrexate may induce "tumor lysis syndrome" in patients with rapidly growing tumors. (nih.gov)
  • Biologics are safe drugs overall. (webmd.com)
  • They include the prescription drugs methotrexate, cyclosporine and oral retinoids. (health.am)
  • The results of this study indicate that withdrawal of methotrexate and continuation of tofacitinib as monotherapy in moderate to severe rheumatoid arthritis after achieving low disease activity was not inferior to staying on both drugs with regards to efficacy. (hcplive.com)
  • Methotrexate can interact with various drugs, so it's crucial to inform your healthcare provider about all the medications you are taking to avoid potential complications. (prescriptiongiant.com)
  • Save Money On Prescription Drugs methotrexate dosage . (deineitloesung.de)
  • Cialis works faster than other ED drugs and methotrexate for skin rashes . (totalcontrol.hu)
  • Although many of the wipe sample analytical results were ND, there is no safe level of exposure when handling hazardous drugs. (cdc.gov)
Chemotherapy4
  • Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. (wikipedia.org)
  • Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents. (wikipedia.org)
  • Although originally designed as a chemotherapy drug, in lower doses methotrexate is a generally safe and well-tolerated drug in the treatment of certain autoimmune diseases. (wikipedia.org)
  • If you do develop lymphoma, it might go away without treatment when you stop taking methotrexate, or it might need to be treated with chemotherapy. (medlineplus.gov)
Stop taking metho2
  • If you experience any of the following symptoms, stop taking methotrexate and call your doctor right away: mouth sores, diarrhea, black, tarry, or bloody stools, or vomit that is bloody or looks like coffee grounds. (medlineplus.gov)
  • It's best that you stop taking methotrexate before trying to conceive. (upmc.com)
Biologics4
Doses5
  • Methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis, is a potentially dangerous lesion, which may occur acutely at any time during therapy and has been reported at low doses. (nih.gov)
  • Severe, occasionally fatal, skin reactions have been reported following single or multiple doses of methotrexate. (nih.gov)
  • Use of low doses of methotrexate together with NSAIDs such as aspirin or analgesics such as paracetamol is relatively safe in people being treated for rheumatoid arthritis, with appropriate monitoring. (wikipedia.org)
  • Methotrexate is used in higher doses to treat certain types of cancer, such as leukemia, lymphoma, and some types of solid tumors. (prescriptiongiant.com)
  • Initial protocols for medical therapy required long-term hospitalization and multiple doses of methotrexate and were associated with significant side effects. (medscape.com)
NSAIDs1
  • Traditional treatment options for JRA -- including NSAIDs, corticosteroids, and DMARDs such as methotrexate -- are not effective in all patients. (medscape.com)
Silagra1
Skin rashes8
Plus methotrexate6
  • To evaluate the safety and efficacy of abatacept plus methotrexate (MTX) over 5 years in patients with rheumatoid arthritis. (jrheum.org)
  • It included 694 patients in the open-label phase and of these, 623 received tofacitinib modified-release 11 mg once daily plus methotrexate for 24 weeks. (hcplive.com)
  • Of these, 267 were assigned to the tofacitinib monotherapy group and 266 were assigned to the tofacitinib plus methotrexate group. (hcplive.com)
  • In terms of adverse events, 107 (41%) of 264 patients in the tofacitinib monotherapy group and 109 (41%) of 266 in the tofacitinib plus methotrexate group had adverse events of which five patients from each group discontinued treatment because of adverse events. (hcplive.com)
  • Most patients with rheumatoid arthritis with moderate-to-high disease activity who received tofacitinib plus methotrexate and achieved low disease activity and who cannot tolerate or prefer not to use methotrexate can consider discontinuing it without significant worsening of disease activity or unexpected safety issues," the authors wrote. (hcplive.com)
  • Methotrexate withdrawal in patients with rheumatoid arthritis who achieve low disease activity with tofacitinib modified-release 11 mg once daily plus methotrexate (ORAL Shift): a randomised, phase 3b/4, non-inferiority trial. (hcplive.com)
Take methotrexate3
  • You should only take methotrexate to treat cancer or certain other conditions that are very severe and that cannot be treated with other medications. (medlineplus.gov)
  • If you drink or have ever drunk large amounts of alcohol or if you have or have ever had liver disease, your doctor may tell you not to take methotrexate unless you have a life-threatening form of cancer because there is a higher risk that you will develop liver damage. (medlineplus.gov)
  • Your doctor may tell you that you should not take methotrexate unless you have life-threatening cancer. (medlineplus.gov)
20163
  • Likewise, a 2016 study found the use of methotrexate, in combination with anti-TNF agents, has been shown to be effective for the treatment of ulcerative colitis. (wikipedia.org)
  • Its slow elimination (half-life of 15 days) and its potentially serious side effects means it is recommended that, until there is more published data on this drug in relation to breastfeeding, safer alternatives are used (Sammaritano 2020, Götestam 2016, Flint 2016, Sammaritano 2014, Weber 2008, Østensen 2006, Temprano 2005) , especially during the neonatal period and in case of prematurity. (e-lactancia.org)
  • D'Andrea and colleagues examined Medicare's database for individuals 65 and older diagnosed with RA from 2008 to 2016 and starting either HCQ or methotrexate for the first time. (medpagetoday.com)
Viagra7
Medications3
  • These conditions and medications may increase the risk that you will develop serious side effects of methotrexate. (medlineplus.gov)
  • That's because these medications have been around for long enough to confirm that they're safe and they work. (webmd.com)
  • Some medications are safe to take while you're pregnant however others, like methotrexate, shouldn't be taken. (vic.gov.au)
Farmacia12
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Risks5
  • Talk to your doctor about the risks of taking methotrexate for your condition. (medlineplus.gov)
  • Methotrexate should only be prescribed by physicians with expertise in the use of methotrexate and a full understanding of the risks of methotrexate therapy. (medicines.org.uk)
  • This drug can also pose risks if the baby's father is taking methotrexate. (upmc.com)
  • Many antibiotics are also safe, but some can pose serious risks, so be sure to let your doctor know if you want to breastfeed. (upmc.com)
  • Some 27,000 HCQ initiators were then matched according to this propensity score with the same number of methotrexate users for the final analysis of cardiovascular risks. (medpagetoday.com)
Dosage2
Corticosteroids1
  • Methotrexate is usually the first medicine given for rheumatoid arthritis, often with another DMARD and a short course of steroids (corticosteroids) to relieve any pain. (scienceoxygen.com)
THERAPY5
  • While methotrexate is considered first-line therapy for rheumatoid arthritis, it is often ineffective by itself and is associated with tolerability issues and adverse events. (hcplive.com)
  • It has been shown that tofacitinib monotherapy is effective for the treatment of rheumatoid arthritis in patients who have never taken methotrexate, however, it was previously unknown if discontinuing methotrexate while on combination therapy with tofacitinib was safe and effective. (hcplive.com)
  • Effective JAK inhibitor therapy in rheumatoid arthritis: can methotrexate be discontinued? (hcplive.com)
  • Is Long-term Etanercept Therapy Safe and Effective in Patients With JRA? (medscape.com)
  • Medicinal plants used by traditional medical practitioners (TMP) to treat cancers are considered safe when used alone or combined with conventional therapy to ensure their effectiveness and eliminate the toxic effects of orthodox medicines. (who.int)
Discontinue1
  • Discontinue methotrexate first and, if the lymphoma does not regress, appropriate treatment should be instituted. (nih.gov)
Treatment11
  • New proposed guidelines for managing rheumatoid arthritis (RA) recommend that methotrexate (MTX) be used aggressively before other treatment options. (medscape.com)
  • Methotrexate is one of the first-line therapies for the treatment of rheumatoid arthritis. (wikipedia.org)
  • Your doctor may order liver biopsies (removal of a small piece of liver tissue to be examined in a laboratory) before and during your treatment with methotrexate. (medlineplus.gov)
  • Glucarpidase is an effective treatment in cases of methotrexate (MTX) delayed elimination, but cost is high and availability is limited. (gencat.cat)
  • Methods: We present three pediatric cases with prolonged exposure to MTX after HDMTX and delayed elimination in which hemoperfusion was performed as rescue treatment for methotrexate intoxication. (gencat.cat)
  • Conclusions: CHP can be considered as a rescue treatment option in MTX intoxication, since it is an effective and safe extracorporeal method for removing MTX, in cases where rescue with leucovorin is insufficient and glucarpidase is not available or while waiting for delivery. (gencat.cat)
  • The question in this study was whether methotrexate could be safely removed from the course of treatment. (hcplive.com)
  • Both men and women taking Methotrexate should use contraception during treatment and for a period afterward. (prescriptiongiant.com)
  • Methotrexate is a common first-line treatment for rheumatoid arthritis (RA), an autoimmune disease that causes joint inflammation and pain. (prescriptiongiant.com)
  • Patients were on combination treatment with RTX and methotrexate (MTX). (the-rheumatologist.org)
  • With evolving experience with methotrexate, the treatment of selected ectopic pregnancies has been revolutionized. (medscape.com)
DISEASES3
  • Chronic diseases, such as rheumatoid arthritis (RA), require treatments that not only provide durable efficacy, but are also safe and well tolerated. (jrheum.org)
  • Vaccines are safe and effective in protecting individuals and populations against infectious diseases. (cdc.gov)
  • Cancer is a notable deadly disease involving such as fluorouracil, methotrexate and several other diseases. (who.int)
DMARD2
  • They most often come in after you've tried a standard disease-modifying antirheumatic drug (DMARD) like methotrexate. (webmd.com)
  • Most patients with rheumatoid arthritis (RA) start out taking the disease-modifying antirheumatic drug (DMARD) methotrexate, but that's not always enough. (creakyjoints.org)
Medication2
  • Methotrexate is available as a generic medication. (wikipedia.org)
  • Methotrexate is also used in medication abortions in combination with Misoprostol. (wonkette.com)
Hydroxychloroquine3
Reactions1
  • Methotrexate may cause serious or life-threatening skin reactions. (medlineplus.gov)
Complications1
Infliximab1
Side effects2
Suppress1
  • Methotrexate can suppress bone marrow function, which may result in anemia and other blood-related issues. (prescriptiongiant.com)
Nausea1
Symptoms1
Immune system3
  • Taking methotrexate may increase the risk that you will develop lymphoma (cancer that begins in the cells of the immune system). (medlineplus.gov)
  • Methotrexate may decrease the activity of your immune system, and you may develop serious infections. (medlineplus.gov)
  • Methotrexate can weaken the immune system, increasing susceptibility to infections. (prescriptiongiant.com)
Remission1
Kidneys2
Lupus1
  • Methotrexate has also been used for multiple sclerosis and is used occasionally in systemic lupus erythematosus, with tentative evidence to support such use. (wikipedia.org)
Liver damage2
  • Methotrexate may cause liver damage, especially when it is taken for a long period of time. (medlineplus.gov)
  • Methotrexate can affect the liver, potentially leading to liver damage or elevated liver enzymes. (prescriptiongiant.com)
Treatments2
  • He said he was glad to see support for exhausting methotrexate options first before trying new treatments. (medscape.com)
  • Methotrexate was first made in 1947 and initially was used to treat cancer, as it was less toxic than the then-current treatments. (wikipedia.org)
Elimination2
  • Methotrexate elimination is reduced in patients with impaired renal functions, ascites, or pleural effusions. (nih.gov)
  • Methotrexate elimination is reduced in patients with a third distribution space (ascites, pleural effusions). (medicines.org.uk)