• natural
  • Lager beer is the most produced fermented beverage: in 2015 the worldwide production reached a global volume of 170 × 10 +9 L. The fermentation workhorse of lager brewing is Saccharomyces pastorianus , a natural interspecific hybrid of Saccharomyces cerevisiae and Saccharomyces eubayanus [ 1 , 2 ] whose domestication is thought to have occurred in central Europe (Bohemia, nowadays Czech republic) in the late Middle Ages. (biomedcentral.com)