• ions
  • Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. (abcam.com)
  • The structure of p11 is classified by a pair of the helix-loop-helix motif, also known as the EF-hand-type that recognizes and binds calcium ions. (wikipedia.org)
  • It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. (wikipedia.org)
  • Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. (wikipedia.org)
  • Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell. (wikipedia.org)
  • The voltage-dependence of current through the channel is mainly due to binding of Mg2+ or Zn2+ ions to the protein as described above. (wikipedia.org)
  • glial fibrill
  • Its potential clinical use in the therapeutic decision making process is substantiated by a vast body of literature validating variations in serum 100B levels with standard modalities for prognosticating the extent of CNS damage: alterations in neuroimaging, cerebrospinal pressure, and other brain molecular markers (neuron specific enolase and glial fibrillary acidic protein). (wikipedia.org)
  • Molecular
  • Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). (genecards.org)
  • Affinity
  • one in the N-terminus and a canonical EF hand in the C-terminus having higher calcium affinity (dissociation constant of roughly 20 micromolar). (wikipedia.org)
  • residues
  • The two EF hand domains neighbor each other in three dimensional space, and are connected to each other through a short beta sheet region (residues 27-29 and 68-70). (wikipedia.org)
  • Human
  • A synthetic peptide corresponding to a sequence at the C-terminus of human S100 beta(64-78aa DGDGECDFQEFMAFV), identical to the related rat and mouse sequences. (bosterbio.com)
  • S_100 Protein, anti_human antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of S_100 Protein, anti_human. (antibody-antibodies.com)
  • S_100 Protein, anti_human Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
  • S100A8
  • Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. (genecards.org)
  • loops
  • The EF-hand types, united by an anti-parallel beta-strand between loops L1 and L3, are located on the same side of the molecule, opposite the N-and C-termini. (wikipedia.org)
  • target
  • Helix 3, 4, and the hinge region are the most divergent areas between individual S100 proteins, and so it is likely that the sequence of these regions is pivotal in fine-tuning calcium-dependent target binding by S100 proteins. (wikipedia.org)
  • In addition, due to its interaction with serotonin-signaling proteins and its correlation with symptoms of mood disorders, p11 is a new potential target for drug therapy. (wikipedia.org)
  • TLR4
  • Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. (genecards.org)
  • regulation
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (wikipedia.org)
  • P11 has been implicated in the transportation of proteins involved in mood regulation, nociception, and cell polarization. (wikipedia.org)
  • Although the exact mechanism is unclear, p11 protein has shown to be essential in the regulation of serotonin signaling in the brain. (wikipedia.org)
  • molecule
  • The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. (wikipedia.org)
  • dependent
  • While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. (wikipedia.org)
  • form
  • The dimerized form of the protein is created by packing between the H1 and H4 helices in an antiparallel arrangement with the hydrophobic regions residing in the core. (wikipedia.org)