• ions
  • Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. (abcam.com)
  • This protein is a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. (mybiosource.com)
  • The structure of p11 is classified by a pair of the helix-loop-helix motif, also known as the EF-hand-type that recognizes and binds calcium ions. (wikipedia.org)
  • It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. (wikipedia.org)
  • Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell. (wikipedia.org)
  • The voltage-dependence of current through the channel is mainly due to binding of Mg2+ or Zn2+ ions to the protein as described above. (wikipedia.org)
  • glial fibrill
  • Its potential clinical use in the therapeutic decision making process is substantiated by a vast body of literature validating variations in serum 100B levels with standard modalities for prognosticating the extent of CNS damage: alterations in neuroimaging, cerebrospinal pressure, and other brain molecular markers (neuron specific enolase and glial fibrillary acidic protein). (wikipedia.org)
  • inhibition
  • This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. (wikipedia.org)
  • This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. (wikipedia.org)
  • This protein may function in the inhibition of casein kinase. (wikipedia.org)
  • kinase
  • Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. (abcam.com)
  • cytosolic
  • This class of proteins has been implicated in the regulation of cytoskeleton assembly, cytosolic enzymes, and membrane dynamics. (wikipedia.org)
  • amino
  • If you wish to use this product in a species other than those specified here and want to determine the amino acid sequence homology between the immunogen and the corresponding protein in that species, simply copy the amino acid sequence for this immunogen and test it on the BLAST database that you can access through the link below. (biosensis.com)
  • The BLAST database can also be used to compare any amino acid sequence between species and between protein. (biosensis.com)
  • You can then search any amino acid sequence in the target protein using the BLAST database. (biosensis.com)
  • Human
  • A synthetic peptide corresponding to a sequence at the C-terminus of human S100 beta(64-78aa DGDGECDFQEFMAFV), identical to the related rat and mouse sequences. (bosterbio.com)
  • S_100 Protein, anti_human antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of S_100 Protein, anti_human. (antibody-antibodies.com)
  • S_100 Protein, anti_human Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
  • Affinity
  • one in the N-terminus and a canonical EF hand in the C-terminus having higher calcium affinity (dissociation constant of roughly 20 micromolar). (wikipedia.org)
  • This antibody is purified through a protein A column, followed by peptide affinity purification. (mybiosource.com)
  • ligand
  • While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. (wikipedia.org)
  • loops
  • The EF-hand types, united by an anti-parallel beta-strand between loops L1 and L3, are located on the same side of the molecule, opposite the N-and C-termini. (wikipedia.org)
  • target
  • In addition, due to its interaction with serotonin-signaling proteins and its correlation with symptoms of mood disorders, p11 is a new potential target for drug therapy. (wikipedia.org)
  • processes
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (wikipedia.org)
  • form
  • The dimerized form of the protein is created by packing between the H1 and H4 helices in an antiparallel arrangement with the hydrophobic regions residing in the core. (wikipedia.org)