Roles macrophage migration inhibitory factors. Medical search. Frequent questions

Phagocytosis of malarial pigment hemozoin (Hz) by monocytes, macrophages, and neutrophils is a central factor for promoting dysregulation in innate inflammatory mediators. (ijbs.com)
The CB subunit induce an inhibitory effect on spreading and phagocytosis in macrophages and decreased the number of circulating blood and lymph lymphocytes. (fapesp.br)
CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. (thermofisher.com)

They originate from blood monocytes which move into the testis then mature into macrophages. (wikipedia.org)
Dysfunctional endothelium is a key factor in atherosclerosis that favors the increase of the expression of chemotactic and adhesion molecules (such as, intercellular adhesion molecule 1, ICAM1, and vascular cell adhesion molecule 1, VCAM1, as well as E-selectin and P-selectin) and enhanced recruitment and accumulation of monocytes [ 6 , 8 , 9 ]. (hindawi.com)
Monocytes in the circulation are precursors to tissue macrophages. (msdmanuals.com)
Monocytes migrate into tissues, where over about 8 hours, they develop into macrophages under the influence of macrophage colony-stimulating factor (M-CSF), secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
Co-incubation of rFg-CaBP4 with concanavalin A-stimulated monocytes increased the transcription levels of interleukin (IL)-2, IL-4, interferon gamma and transforming growth factor-β. (biomedcentral.com)

In this work, we examined the effect of Streptococcus pneumoniae and its major pathogenic factors (the capsule and PLY) on microglial tissue migratory behavior in acute brain slices and in primary cultures. (biomedcentral.com)
Here, we show that MM-derived macrophage migratory inhibitory factor (MIF) stimulates bone marrow stromal cells to produce the disease critical cytokines IL-6 and IL-8, prior to any cell-cell contact. (biomedcentral.com)

Parasitic helminths generally induce strong type 2 immunity that normally controls parasite infection and is characterized by production of type 2 cytokines like interleukin- (IL-) 4, IL-5, and IL-13 by innate cells (group 2 innate lymphoid cells (ILC2s), basophils, eosinophils, neutrophils, and macrophages) and CD4 + T helper 2 (Th2) lymphocytes. (hindawi.com)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)

The INRG classification takes into account several factors, such as tumor stage and differentiation, patient age, histology, MYCN oncogene status, DNA ploidy, and segmental chromosomal anomalies, in particular chromosome 11q aberration [ 6 ] . (encyclopedia.pub)
Ngns (class II bHLH transcription factors) are known as pro-neural factors as they are necessary to initiate differentiation of NSPCs and are important to specify a neuronal subtype[3]. (bartleby.com)
Th cells secrete cytokines that regulate the activation and differentiation of other immune cells such as B cells, macrophages, NK cells, and Tc cells. (stemcelldaily.com)
Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)

Design and Methods The expression of hypoxia-inducible factor protein was examined in patients' bone marrow biopsy specimens using immunohistochemistry. (haematologica.org)
6 , 7 CXCL12 is an important mediator of several aspects of MM biology including transendothelial migration, 8 , 9 MM plasma cell migration and retention within the bone marrow, 10 , 11 angiogenesis, 7 and osteoclastic bone resorption. (haematologica.org)

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that plays a key role in several diseases, including cancer. (encyclopedia.pub)

They also secrete cytokines such as interferon-gamma (IFN-gamma) that enhance the activity of macrophages and other immune cells. (stemcelldaily.com)

Lipopolysaccharide (LPS) treatment was found to trigger BV‑2 cell migration, inflammation and neuronal apoptosis. (spandidos-publications.com)
Lipopolysaccharide (LPS)-activated macrophages can directly permeate into the central nervous system (CNS) to produce an inflammatory response. (spandidos-publications.com)
Macrophages are activated by cytokines (eg, IFN-gamma, interleukin (IL)-4, IL-13) and by various microbial components (eg, lipopolysaccharide). (msdmanuals.com)

In the present study, the mechanistic role of Foxc1 on microglial migration, neuroinflammation and neuronal apoptosis during the occurrence of cognitive dysfunction in SAE was investigated. (spandidos-publications.com)
After Foxc1 was overexpressed, the cognitive dysfunction of mice that underwent CLP surgery was improved, with the expression of IκBα also increased, microglial cell migration, the expression of p65, IL‑1β and TNF‑α and neuronal apoptosis were all decreased in vivo and in vitro , which were in turn reversed by the inhibition of IκBα in vitro . (spandidos-publications.com)
Overall, these results suggest that the overexpression of Foxc1 inhibited microglial migration whilst suppressing the inflammatory response and neuronal apoptosis by regulating the IκBα/NF‑κB pathway, thereby improving cognitive dysfunction during SAE. (spandidos-publications.com)
We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. (degruyter.com)

One study showed that 95% of cells found in the peritoneal fluid of women with endometriosis are macrophages with impaired phagocytic function, which are unable to eat away unwanted cells, molecules, and other targets present in this fluid. (endonews.com)
Macrophages, which are phagocytic cells that can engulf and destroy microbes and also secrete cytokines and chemokines to modulate inflammation and immunity. (stemcelldaily.com)

It includes an investigation of the effects of infection, inflammation and immune factors on testicular function. (wikipedia.org)
Early studies demonstrated the presence of macrophages in the rat testis Testicular macrophages are the largest population of immune cells in the rodent testis. (wikipedia.org)
The potential factors involved in the migration of maternal immune cells to the placenta is still unexplored. (frontiersin.org)
Major histocompatibility complex (MHC) class II genes play important recognition roles in the immune system in vertebrates. (geneticsmr.com)
Macrophages are highly plastic innate immune cells that adopt an important diversity of phenotypes in response to environmental cues. (hindawi.com)
Besides, appropriate immune response is needed to repair tissue damage linked to parasite migration or to avoid damage caused by excessive immune activation. (hindawi.com)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. (mdpi.com)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)

It is likely that most of the adult population of testicular macrophages in adult rats are a result of very rapid proliferation of early precursors that entered the testis during postnatal maturation Testicular macrophages can respond to infectious stimuli and become activated (undergo changes enabling the killing of the invading micro-organism), but do so to a lesser extent than other types of macrophages. (wikipedia.org)
Aside from responding to infectious stimuli, testicular macrophages are also involved in maintaining normal testis function. (wikipedia.org)
Prostanoids are generated widely in response to diverse stimuli and play important roles in normal physiology and disease. (fapesp.br)

An example is production of the inflammatory cytokines TNFα and IL-1β by activated rat testicular macrophages: these macrophages produce significantly less TNFα and IL-1β than activated rat peritoneal macrophages. (wikipedia.org)
As such, the role of P. falciparum -derived Hz ( Pf Hz) in mediating suppression of erythropoiesis through its ability to cause dysregulation in pro- and anti-inflammatory cytokines, growth factors, chemokines, and effector molecules is discussed in detail. (ijbs.com)
Activated macrophages kill intracellular organisms and secrete cytokines (eg, tumor necrosis factor-alpha [TNF-alpha], IL-10). (msdmanuals.com)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)
The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well. (cdc.gov)

However, in the case of injury or infection, ECs control the adhesion and migration of inflammatory cells into the damaged tissue. (fapesp.br)
5 Functional in vitro assays indicate different physiological roles of MSCs related to their heterogeneity and tissue location of origin. (bmj.com)
In brain tissue, primary microglia cells showed an enhanced response towards lysates from bacteria lacking capsules and pneumolysin as they moved rapidly to areas with an abundance of bacterial factors. (biomedcentral.com)
Inflammatory macrophages in the dog contain high amounts of intravesicular ferritin and are associated with pouches of connective tissue fibers. (cdc.gov)

12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
However, a reduction in the expression of IL-10 and no change in the expression of tumor necrosis factor-α were detected. (biomedcentral.com)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

Studies showed that MIF has roles in the growth and progression of endometriosis lesions in mice, and treatment with MIF inhibitor, ISO-1, blocks the development of endometriosis pathology. (endonews.com)
Targeting the hypoxic niche, and more specifically hypoxia-inducible factor-2, may represent a viable strategy to inhibit angiogenesis in multiple myeloma and progression of this disease. (haematologica.org)

Migration assays showed that MAIT cells and EM T cells migrated toward conditioned medium from placental explants. (frontiersin.org)
Blocking of MIF or a combination of MIF, CCL25, and CCL20 in migration assays inhibited MAIT cell migration toward placenta conditioned medium. (frontiersin.org)
The role of hypoxia-inducible factors-1 and -2 in the regulation of CXCL12 expression was examined using over-expression and short hairpin RNA knockdown constructs, electrophoretic mobility shift assays and chromatin immunoprecipitation. (haematologica.org)

The levels of several chemokines were significantly higher in intervillous compared to peripheral blood, including macrophage migration inhibitory factor (MIF), CXCL10, and CCL25, whereas CCL21, CCL27 and CXCL12 were lower. (frontiersin.org)
In addition, LPS can indirectly produce neuroinflammation by peripheral inflammatory factors diffusing into the CNS through the blood-brain barrier, thus leading to CNS inflammatory injury ( 1 ). (spandidos-publications.com)

It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)

MIF was identified as a major regulator of atherogenesis by promoting the recruitment of mononuclear cells, activating inflammatory signaling pathways, and transdifferentiating macrophages into foam cells in the vessel wall as well as by enhancing collagenase expression and matrix degradation, the latter contributing to plaque destabilization [ 18 - 20 ]. (hindawi.com)

Macrophage migration inhibitory factor (MIF) is an important regulator of innate immunity with key roles in neural regeneration and responses to pathogens, amongst a multitude of other functions. (edu.au)

Here, we reviewed the recent advances from the laboratory mouse about macrophage origin, polarization, activation, and effector functions during parasitic helminth infection. (hindawi.com)

Forkhead box C1 (Foxc1) is a member of the forkhead transcription factor family that has been found to regulate in cell migration. (spandidos-publications.com)
PPAR is a nuclear receptor and transcription factor that can be activated by several agonists, however, in ECs the most important and abundant is the PGI2. (fapesp.br)
Furthermore, we provide evidence that this IL-6/8 production is mediated by the transcription factor cMYC. (biomedcentral.com)

With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. (bvsalud.org)
In addition, Bcl-2 family proteins have normal physiological roles in regulating mitochondrial fission/fusion and mitochondrial energetics to facilitate neuronal activity in healthy brains. (hopkinsmedicine.org)

Macrophage Migration Inhibitory Factor Family in Cancer" Encyclopedia , https://encyclopedia.pub/entry/16148 (accessed December 01, 2023). (encyclopedia.pub)
Recently, granulocyte colony-stimulating factor (G-CSF) has been recognized as a useful molecule for the treatment of a wide range of complex ailments, such as cancer, AIDS, H1N1 influenza, cardiac and neurological diseases. (geneticsmr.com)
Roles of NF-κB signaling in the regulation of miRNAs impacting on inflammation in cancer. (ac.ir)
The key factor of cancer associated morbidity and mortality is principally attributable to the development of metastases. (intechopen.com)
Several risk factors and pathologies, including ageing, smoking, obesity and diabetes have been associated with poor prognosis in colorectal cancer patients. (frontiersin.org)
Of particular interest to our group are the mechanisms by which Bcl-2 family proteins and other factors regulate programmed cell death, particularly in the nervous system, in cancer and in virus infections. (hopkinsmedicine.org)

and, (2) some factors which normally lead to inflammation are present at high levels in the testis, where they regulate the development of sperm instead of promoting inflammation. (wikipedia.org)

A French study shows macrophage migration inhibitory factor (MIF) can be a therapeutic target for endometriosis. (endonews.com)

Alternative activation of macrophages by IL-4 in vitro was described as an opposite phenotype of classically activated macrophages, but the in vivo reality is much more complex. (hindawi.com)

Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)

Sebum consists of lactic acid and fatty acids that maintain the pH of the skin between 3 and 5, which is inhibitory to many bacteria. (stemcelldaily.com)

Based on different gene expression profiles, subtypes of macrophages (eg, M1, M2), which have different roles in amplifying or limiting the inflammatory response, have been identified. (msdmanuals.com)
Association of macrophage migration inhibitory factor and mannose-binding lectin-2 gene polymorphisms in acute rheumatic fever. (cdc.gov)

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. (thermofisher.com)

Among the bHLH transcription factors, neurogenins (Ngns) play a significant role to regulate neurogenesis and astrogliogenesis. (bartleby.com)
Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)

Macrophages are directly involved in the fight against invading micro-organisms as well as being antigen-presenting cells which activate lymphocytes. (wikipedia.org)
A multivariate factor analysis indicated that high levels of MIF and CCL25 were associated with high proportions of MAIT cells in intervillous blood. (frontiersin.org)
We also demonstrated that MIF mediated segregation between OECs and J774a.1 cells (a monocyte/macrophage cell line) in co-culture, which suggests that MIF contributes to the fact that macrophages are largely absent from olfactory nerve fascicles. (edu.au)
In this study, we show that CAF EVs promote the migration and invasion abilities of SACC cells. (researchsquare.com)
Results Strong hypoxia-inducible factor-2 protein expression was detected in CD138 + multiple myeloma plasma cells in patients' biopsy specimens. (haematologica.org)
Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
We utilized live imaging and immunostaining of glial cells in dissociated and acute brain slice cultures to study the effect of pneumococcal factors, including the cholesterol-dependent cytolysin pneumolysin and the pneumococcal capsule, on microglial motility and taxis. (biomedcentral.com)
Th9 cells were first identified as a Th2 subpopulation have many important roles. (cdc.gov)

We can take advantage of a variety of helminth models available, each of which have their own feature including life cycle, site of infection, or pathological mechanisms influencing macrophage biology. (hindawi.com)

SNRPN codes for several products, including small nucleolar RNAs, a splicing factor involved in RNA processing, and a polypeptide known as SNURF. (bartleby.com)

While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
Promoter analyses revealed increased hypoxia-inducible factor-2 binding to the CXCL12 promoter under hypoxic conditions. (haematologica.org)

Extracellular vesicles (EVs) play important roles in intercellular communication. (researchsquare.com)
MMP-2 is an important enzyme in the MMP family, and has several essential roles in the skin photo-aging process. (toxicolres.org)
They play important roles in the pain pathway where in concert with proinflammatory factors such as leukotrienes they mediate sensitization and hyperalgesia. (researchgate.net)

These findings provide additional evidence that calcium-binding EF-hand proteins play roles in host-parasite interaction. (biomedcentral.com)

The expression levels of miR-128-3p and transforming growth factor beta receptors II (TGFBR2) were detected by quantitative polymerase chain reaction (qPCR). (degruyter.com)

1. Wu Y, Ding Y, Tanaka Y, Zhang W. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. (ac.ir)

The physiopathological process of ACS is the atherosclerosis, the build-up of an atherosclerotic plaque starts at lesion-prone areas in large- and medium-sized arteries where the endothelium is dysfunctional, induced by cardiovascular risk factors like chronic smoking, hypertension, and permeation of macromolecules such as lipoproteins to the intima layer [ 6 , 7 ]. (hindawi.com)
Therefore, it is essential to understand the causes and risk factors leading to its development. (frontiersin.org)
Because of its magnitude, CRC represents a global health concern and therefore it is essential to understand the causes and risk factors leading to its development. (frontiersin.org)

Our data indicate that microglia possess the capacity for a very agile response towards bacterial pathogens, but key pathogenic factors, such as pneumococcal capsules and pneumolysin, inhibited this response shortly after a bacterial challenge. (biomedcentral.com)

Ageing represents the major risk factor for CRC development. (frontiersin.org)

Anatomy13

Organisms6

Diseases6

Chemicals and Drugs36

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes17

Disciplines and Occupations1

Information Science2

Phagocytosis3

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Induce2

Differentiation5

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Immune8

Stimuli3

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