• As recognition for his scientific activity in the field, Ion Ababii was first elected correspondent member (1993) and then full member (2000) in the Academy of Sciences in the Republic of Moldavia. (wikipedia.org)
  • Nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that include muscle and neuronal nAChRs and receptors for GABA A , glycine, and serotonin. (jneurosci.org)
  • Ions are exchanged * between the intracellular and extracellular environments, and * between the cytosol and the sarcoplasmic reticulum (SR) via * channels and pumps. (nih.gov)
  • Moreover, in conditions of simultaneous intracellular dialysis of the fast Ca 2+ chelator BAPTA (10 m m ) and removal of extracellular Ca 2+ ions, the inhibitory action of BDNF is further prevented. (jneurosci.org)
  • The following presentation aims at discussing the physiological roles and molecular characteristics of Na + -K + -Cl - cotransport in the TALH and those of the individual NKCC2 splice variants more specifically. (nih.gov)
  • She did extensive research on molecular regulation of nuclear hormone receptors from 1994-1997 at Brigham and Women's Hospital, Harvard Medical School. (nih.gov)
  • For ideas and techniques which have opened new frontiers in chemical research and now play major roles in the study, understanding, and use of photoionization and photoelectron spectroscopy in studies of 'hot atom' chemistry and work with multiply charged molecular ions. (ornl.gov)
  • Large clusters of metal ions: the transition from molecular to bulk magnets. (uni-bielefeld.de)
  • Allbritton NL, Meyer T, Stryer L (1992) Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. (yale.edu)
  • Higher cellular concentration of the metal ions may affect metabolic processes, resulting in growth inhibition through cellular toxicity (Zenk 1996). (researchsquare.com)
  • The RYR1 and CACNA1S genes provide instructions for making proteins that play essential roles in muscles used for movement ( skeletal muscles ). (medlineplus.gov)
  • The proteins produced from the RYR1 and CACNA1S genes are involved in the movement of calcium ions within muscle cells. (medlineplus.gov)
  • A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins. (uni-bielefeld.de)
  • Subsequently, ADARs were found to deaminate adenosines site-specifically within the coding sequences of transcripts encoding ion-channel subunits, increasing the diversity of these proteins in the central nervous system. (biomedcentral.com)
  • Berg's research focuses on the structural and functional roles that metal ions, especially zinc, have in proteins. (nih.gov)
  • [25] [26] The enzymatic activity of AdK from different sources show a marked dependence on phosphate (Pi) and/or pentavalent ions and it is a conserved property of the PfkB family of proteins. (wikipedia.org)
  • Therefore, living cells must maintain high concentrations of intracellular ATP by continuously regenerating ATP from its hydrolysis products, adenosine-diphosphate (ADP) and phosphate ion, via energy metabolism that uses chemical energy stored in cellular nutrients, such as glucose. (elifesciences.org)
  • They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis. (nih.gov)
  • Some polyprenoids, such as cholesterol in animals, phytosterols in plants or hopanoids and α,ω-dihydroxylated carotenoids in Bacteria ( Fig. 1) , are of paramount importance in biological membranes, where they act as reinforcers ( Ourisson & Nakatani, 1994 ). (intechopen.com)
  • They are components of cellular membranes that fulfill multiple functional roles, from cell structure and transport to signaling. (michaeljfox.org)
  • P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. (nih.gov)
  • Given the central roles of zinc in cellular growth and differentiation, it is no surprise that the effects of zinc deficiency are pronounced in the rapid turnover of tissues and organs, especially the immune system. (nih.gov)
  • In addition, new and emerging roles of zinc in human health will be discussed. (nih.gov)
  • In the presence of N -acetylglutamate, ammonium ions combine with bicarbonate to form carbamoyl phosphate. (medscape.com)
  • By definition, saline soil displays electrical conductivity superior to 4.0 dS m -1 at 25 °C (approximately 40 mM NaCl) and a concentration of 15% exchangeable sodium (Na + ) ion in the root zone. (scielo.br)
  • The resulting increase in calcium ion concentration inside the cells stimulates muscles to contract. (medlineplus.gov)
  • The abnormal increase in calcium ion concentration within muscle cells activates processes that generate heat (leading to increased body temperature) and produce excess acid (leading to acidosis). (medlineplus.gov)
  • 4. Regulation of avian calbindin-D28K gene expression in primary chick kidney cells: importance of posttranscriptional mechanisms and calcium ion concentration. (nih.gov)
  • Metal ions needed by plants in trace quantity for normal growth and development play roles in nucleic acid metabolism and redox reactions or as structural configuration of many enzyme molecules. (researchsquare.com)
  • My research focuses on the role of metal ions for structural integrity and function of factor VIII. (rochester.edu)
  • Here we decompose functional interactions between brain regions into synergistic and redundant components, revealing their distinct information-processing roles. (nature.com)
  • He is interested in dynamic regulations of synaptic ion channels and metabotropic receptors implicated in neuronal plasticity, excitability and psychiatric disorders with a combination of techniques including Tandem affinity purification-mass spectrometry, biochemistry, imaging and behavior. (nih.gov)
  • The present findings disclose a novel target for rapid actions of BDNF that might play important roles on synaptic transmission and plasticity in the brain. (jneurosci.org)
  • PSA-NCAM plays vital roles in the development of the nervous system and NMDA receptor-dependent synaptic plasticity in the adult. (auburn.edu)
  • A wide range of charged, potentially toxic xenobiotics as well as endogenous organic ions are transported into the lumen by renal tissues of vertebrates and invertebrates. (silverchair.com)
  • Dr. Dax Hoffman received his B.S. in Genetics from the University of Minnesota in 1994 and his Ph.D. from Baylor College of Medicine in 1999, where he studied dendritic K+ channels with Dr. Dan Johnston. (nih.gov)
  • After joined Dr. Hoffman's lab, Ying's current research focuses on the roles of A-type K+ channels subunit Kv4.2 with other ion channels in neuronal plasticity and excitability. (nih.gov)
  • His graduate work spurred a keen interest into enhancing knowledge of the contribution of ion channels in regulation of intrinsic excitability and plasticity in neurons and circuits. (nih.gov)
  • Ion channels, electrical activity and insulin secretion. (ox.ac.uk)
  • The application of the patch-clamp technique, which permits the recordings of the minute currents associated with the opening of individual ion channels, to pancreatic islet cells has revolutionized our understanding of the beta cell electrophysiology. (ox.ac.uk)
  • The properties of functionally important ion channels are described and their possible roles are discussed. (ox.ac.uk)
  • Although the behaviours of single ion channels have * been extensively studied experimentally, ionic current interactions * make it difficult to deduce their individual roles in membrane * excitability. (nih.gov)
  • F) The kinetics of the ultra-slow gates of several * ion channels. (nih.gov)
  • Hawthorn may play a supportive role in cardiovascular health due to several mechanisms, including modulating ion channels. (lifeextension.com)
  • In order to better understand the roles of the * individual ion currents, Satoshi Matsuoka et al. (nih.gov)
  • Metal Ions in Biological Systems, Vol 39. (nih.gov)
  • G. Jones, "The Charge-Shift Reaction in 9-Substituted Acridinium Ions. (grc.org)
  • reaction kinetics diagram * * [[Image file: matsuoka_3_2003.png]] * * A schematic diagram describing the reaction kinetics of the * ion channel gates in the Matsuoka et al. (nih.gov)
  • Linear accelerator 3 (Linac 3) is the starting point for the ions used in experiments at CERN. (cern.ch)
  • It provides lead ions for the Large Hadron Collider (LHC) and for fixed-target experiments. (cern.ch)
  • After Linac 2 was built, Linac 1 was used to deliver ions for experiments at the Super Proton Synchrotron . (cern.ch)
  • In: Molybdenum and Tungsten: Their Roles in Biological Processes (Sigel H, Sigel A, eds). (nih.gov)
  • suspect that we I keeping liberty, wliile biological sur\eys in mind, botanists might nmch more readily have become my expanding of topic to include the roles (plural) natural historians of plants had our collections con- of natural history collections, not oidy in relation tinned to he called, as they were before de Tour- NBS to the but also in relation to society at large, nefoii and Linnaeus (Radford et al. (zlibrary.to)
  • i how those roles have Missions of Biological hveys St changed (or not) over the years. (zlibrary.to)
  • Model Structure * * Different types of ion channel, with their distinct gating and * conductance properties, play a unique role in generating membrane * excitation. (nih.gov)
  • Apoptosis is a form of programmed cell death, with important roles in development, tissue homeostasis, and immunity. (elifesciences.org)
  • Juegan un papel esencial en la homeostasis intracelular del cobre mediante la regulación de la captación, salida y almacenamiento de los iones de cobre, y también en la biosíntesis de las cuproproteínas. (bvsalud.org)
  • AIS Water employs over 60 staff in a range of roles including administration and management, micro-electronics, chemistry, power systems, electrical and mechanical engineering, water system design, assembly, metalworking and plumbing. (ausleisure.com.au)
  • Modelling the Roles of Individual Current Systems in Ventricular * Cells and in the SA Node * * Model Status * * This model has been curated and unit checked by Alan Garny in * collaboration with the model authors and it is known to run * in COR to reproduce the published results. (nih.gov)
  • Muscle contractions are triggered by the flow of certain charged atoms (ions) in muscle cells. (medlineplus.gov)
  • When the RYR1 channel is active, it releases calcium ions from storage into the fluid-filled space inside muscle cells. (medlineplus.gov)
  • As a result, abnormally large amounts of calcium ions are released from storage within muscle cells. (medlineplus.gov)
  • In doing so, and through the involvement of other ion transport systems, it allows this nephron segment to reclaim a large fraction of the ultrafiltered Na + , Cl - , Ca 2+ , Mg 2 + , and HCO 3 - loads. (nih.gov)
  • We then discuss some of the known developmental roles of GABAergic signaling, as well as the development and refinement of GABAergic synapses as a framework for understanding potential causes of mature circuit dysfunction. (karger.com)
  • Starting with the year 1994 he was rector of the State University of Medicine and Pharmacy "Nicolae Testemițanu" in Chișinău. (wikipedia.org)
  • The group's general approach * to modelling was based on the methods used in the Difrancesco-Noble, * 1985 Model and the Luo-Rudy Ventricular Model II (dynamic), * 1994. (nih.gov)
  • There was soon pressure to provide heavier ions to study quark-gluon plasma , so the dedicated Linac 3 was built. (cern.ch)
  • As a recognition for his merits in the field of research of otorhinolaryngology, Ion Ababii was given the following distinctions: Title of "Om Emerit" „Дружба народов" order. (wikipedia.org)
  • Model simulations showed that * ion conductance by the L-type Ca2+ channel (ICaL) dominates * the membrane conductance during the action potential. (nih.gov)
  • It now injects lead ions into the Low Energy Ion Ring , which prepares them for injection into the LHC. (cern.ch)
  • These days scientists must not be smart, but smarter, and for that our materials and technologies must go beyond current knowledge, and occupy multiple-roles. (rsc.org)