• Resveratrol
  • Resveratrol has been claimed to be an activator of Sirtuin 1, but this effect has been disputed based on the fact that the initially used activity assay, using a non-physiological substrate peptide, can produce artificial results. (wikipedia.org)
  • However, resveratrol was later shown to directly activate Sirtuin 1 against non-modified peptide substrates. (wikipedia.org)
  • Another study has emphasized the important role played by resveratrol, a non-flavonoid compound contained in red wine, to induce formation of sirtuins (Sirt) which, in turn, exert potent anti-aging effects ( 4 ). (frontiersin.org)
  • SIRT2
  • Similar to other sirtuin family members, SIRT2 displays a ubiquitous distribution. (wikipedia.org)
  • Several studies in cell and invertebrate models of Parkinson's disease (PD) and Huntington's disease (HD) suggested potential neuroprotective effects of SIRT2 inhibition, in striking contrast with other sirtuin family members. (wikipedia.org)
  • SIRT3
  • Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in mitochondria and have been implicated in regulating metabolic processes. (wikipedia.org)
  • Fasting increases SIRT3 expression in white and brown adipose tissue (WAT and BAT, respectively) and overexpression of SIRT3 in HIB1B brown adipocytes increases the expression of PGC-1α and UCP1, suggesting a role for SIRT3 in adaptive thermogenesis BAT. (wikipedia.org)
  • Furthermore, SIRT3 and AceCS2 are found complexed with one another, suggesting a critical role for control of AceCS2 activity by SIRT3. (wikipedia.org)
  • mitochondria
  • At a higher level, these results suggest that the mitochondrion's role as a major chemical factory in the cell, and not just as the power plant, may also contribute to disease when the mitochondria are broken. (elifesciences.org)
  • metabolic
  • Enteric glial cells (EGCs) exert a critical role in the structural integrity, defense, and metabolic function of enteric neurons. (frontiersin.org)
  • exert
  • Several researches have described that EGCs exert a structural supportive role to the enteric neurons and are also responsible for their survival and maintenance ( 5 ). (frontiersin.org)
  • cellular
  • Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. (wikipedia.org)
  • This function provides a link between sirtuin expression and the cellular response to limited nutrients due to caloric restriction. (wikipedia.org)
  • bacteria
  • In addition, several Gram positive bacteria, including Staphylococcus aureus and Streptococcus pyogenes, as well as several fungi carry macrodomain-linked sirtuins (termed "class M" sirtuins). (wikipedia.org)
  • activity
  • This article will present the members of the human sirtuin family with their respective functions and review the existing druglike inhibitors and activators of sirtuin activity. (eurekaselect.com)
  • Sirtuin activity is inhibited by nicotinamide, which binds to a specific receptor site, so it is thought that drugs that interfere with this binding should increase sirtuin activity. (wikipedia.org)
  • transcription
  • This suggests that SIRT7 plays a crucial role in connecting the function of chromatin remodeling complexes to RNA Pol I machinery during transcription. (wikipedia.org)
  • tissues
  • These functions are necessary in cells in order to divide and regenerate tissues, and play a maintenance role in homeostatic functions. (wikipedia.org)
  • different
  • The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. (springer.com)
  • crucial
  • These cells are known as vascular endothelial cells and vascular smooth muscle cells and both play a crucial role in the construction of blood vessels that are destroyed in the heart in the wake of a myocardial infarction . (fightaging.org)
  • The ΔFosB splice variant has been identified as playing a central, crucial (necessary and sufficient) role in the development and maintenance of pathological behavior and neural plasticity involved in both behavioral addictions (associated with natural rewards) and drug addictions. (wikipedia.org)
  • class
  • Several Gram positive prokaryotes as well as the Gram negative hyperthermophilic bacterium Thermotoga maritima possess sirtuins that are intermediate in sequence between classes and these are placed in the "undifferentiated" or "U" class. (wikipedia.org)
  • expression
  • Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. (wikipedia.org)
  • Mir-132 microRNA has been reported to interact with Sirtuin 1 mRNA, so as to reduce protein expression. (wikipedia.org)
  • The oscillatory nature of Hes1 expression has a role in determining differentiation fate as well. (wikipedia.org)
  • important role
  • ΔFosB also plays an important role in regulating behavioral responses to natural rewards, such as palatable food, sex, and exercise. (wikipedia.org)
  • found
  • They also found that CaMKII was necessary for depolarization-induced HDAC5 phosphorylation in NAc tissue, highlighting its role as a kinase for HDAC5. (wikipedia.org)
  • play a role
  • Many factors and components play a role in the cell cycle of K562 cells in terms of growth, cell differentiation, and apoptosis. (wikipedia.org)
  • These kinases play a role in the formation of spindles, separation of chromosomes, as well as cytokinesis. (wikipedia.org)
  • Epigenetics may play a role in a wide array of vascular complications and in diabetes. (wikipedia.org)
  • It has also been proposed that microtubules play a role in the formation of stress granules, maybe by transporting granule components. (wikipedia.org)