• Resveratrol
  • Another study has emphasized the important role played by resveratrol, a non-flavonoid compound contained in red wine, to induce formation of sirtuins (Sirt) which, in turn, exert potent anti-aging effects ( 4 ). (frontiersin.org)
  • Resveratrol has been claimed to be an activator of Sirtuin 1, but this effect has been disputed based on the fact that the initially used activity assay, using a non-physiological substrate peptide, can produce artificial results. (wikipedia.org)
  • However, resveratrol was later shown to directly activate Sirtuin 1 against non-modified peptide substrates. (wikipedia.org)
  • SIRT2
  • Similar to other sirtuin family members, SIRT2 displays a ubiquitous distribution. (wikipedia.org)
  • Several studies in cell and invertebrate models of Parkinson's disease (PD) and Huntington's disease (HD) suggested potential neuroprotective effects of SIRT2 inhibition, in striking contrast with other sirtuin family members. (wikipedia.org)
  • SIRT3
  • Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in mitochondria and have been implicated in regulating metabolic processes. (wikipedia.org)
  • Fasting increases SIRT3 expression in white and brown adipose tissue (WAT and BAT, respectively) and overexpression of SIRT3 in HIB1B brown adipocytes increases the expression of PGC-1α and UCP1, suggesting a role for SIRT3 in adaptive thermogenesis BAT. (wikipedia.org)
  • Furthermore, SIRT3 and AceCS2 are found complexed with one another, suggesting a critical role for control of AceCS2 activity by SIRT3. (wikipedia.org)
  • epigenetic
  • It has been known that epigenetic regulations, such as the methylation of H3K9, have a key role in the mechanism of addiction. (wikipedia.org)
  • Verdin's laboratory focuses on the role of epigenetic regulators in the aging process. (wikipedia.org)
  • defense
  • Enteric glial cells (EGCs) exert a critical role in the structural integrity, defense, and metabolic function of enteric neurons. (frontiersin.org)
  • exert
  • Several researches have described that EGCs exert a structural supportive role to the enteric neurons and are also responsible for their survival and maintenance ( 5 ). (frontiersin.org)
  • cellular
  • Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. (wikipedia.org)
  • This function provides a link between sirtuin expression and the cellular response to limited nutrients due to caloric restriction. (wikipedia.org)
  • bacteria
  • In addition, several Gram positive bacteria, including Staphylococcus aureus and Streptococcus pyogenes, as well as several fungi carry macrodomain-linked sirtuins (termed "class M" sirtuins). (wikipedia.org)
  • activity
  • Sirtuin activity is inhibited by nicotinamide, which binds to a specific receptor site, so it is thought that drugs that interfere with this binding should increase sirtuin activity. (wikipedia.org)
  • human
  • Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells. (cityofhope.org)
  • play
  • These cells are known as vascular endothelial cells and vascular smooth muscle cells and both play a crucial role in the construction of blood vessels that are destroyed in the heart in the wake of a myocardial infarction . (fightaging.org)
  • Many factors and components play a role in the cell cycle of K562 cells in terms of growth, cell differentiation, and apoptosis. (wikipedia.org)
  • These kinases play a role in the formation of spindles, separation of chromosomes, as well as cytokinesis. (wikipedia.org)
  • These functions are necessary in cells in order to divide and regenerate tissues, and play a maintenance role in homeostatic functions. (wikipedia.org)
  • HES1 has been shown to play a large role in both the nervous, and digestive systems. (wikipedia.org)
  • Epigenetics may play a role in a wide array of vascular complications and in diabetes. (wikipedia.org)
  • It has also been proposed that microtubules play a role in the formation of stress granules, maybe by transporting granule components. (wikipedia.org)
  • crucial
  • The ΔFosB splice variant has been identified as playing a central, crucial (necessary and sufficient) role in the development and maintenance of pathological behavior and neural plasticity involved in both behavioral addictions (associated with natural rewards) and drug addictions. (wikipedia.org)
  • class
  • Several Gram positive prokaryotes as well as the Gram negative hyperthermophilic bacterium Thermotoga maritima possess sirtuins that are intermediate in sequence between classes and these are placed in the "undifferentiated" or "U" class. (wikipedia.org)
  • expression
  • Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. (wikipedia.org)
  • Mir-132 microRNA has been reported to interact with Sirtuin 1 mRNA, so as to reduce protein expression. (wikipedia.org)
  • The oscillatory nature of Hes1 expression has a role in determining differentiation fate as well. (wikipedia.org)
  • important role
  • ΔFosB also plays an important role in regulating behavioral responses to natural rewards, such as palatable food, sex, and exercise. (wikipedia.org)
  • found
  • They also found that CaMKII was necessary for depolarization-induced HDAC5 phosphorylation in NAc tissue, highlighting its role as a kinase for HDAC5. (wikipedia.org)