Following the isolation of neuropeptide Y (NPY) from the porcine hypothalamus in 1982, researchers began to speculate about the involvement of NPY in hypothalamic-mediated functions. (wikipedia.org)
PACAP38 , derived from a 176-amino acid precursor (preproPACAP), is a 38-amino acid peptide discovered as an ovine hypothalamic neuropeptide. (eurogentec.com)
Orexins (or hypocretins) are hypothalamic neuropeptides with a multitude of physiological functions. (researchgate.net)
It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. (stanford.edu)
Receptors5
Some of these receptors are among the most highly conserved neuropeptide receptors[citation needed]. (wikipedia.org)
Neuropeptide Y1 receptors have been found in highest density in the dentate gyrus along with a variety of other brain areas. (wikipedia.org)
Neuropeptide W/B receptors are a family of G protein-coupled receptors (GPCRs) that bind the endogenous ligands neuropeptides B and W. The two receptors in the family are NPBW1 and NPBW2. (multispaninc.com)
NPB/W receptors play a role in the regulation of food intake, pituitary hormone release, corticosterone release, growth hormone release, and inflammatory pain. (multispaninc.com)
Blocking the binding of wake-promoting neuropeptides orexin to receptors OX1R and OX2R is thought to suppress wake drive (Ki values of 8.1 nM and 0.48 nM, respectively). (eisai.com)
Peptides2
Neuropeptides FF (NPFF), AF (NPAF), and SF (NPSF) are homologous amidated peptides that were originally identified on the basis of similarity to the molluscan neuropeptide FMRF-amide. (aspetjournals.org)
Our results support a model for the role of these peptides in pain regulation at the level of the spinal cord. (aspetjournals.org)
Putative role1
Thanks to a new highly specific split-Gal4 line, this study describes LPNs' morphology in fine detail, their synaptic connections, daily bimodal expression of neuropeptides, and a putative role of this cluster in controlling daily activity and sleep patterns is proposed. (sdbonline.org)
PACAP-27 is a neuropeptide originally isolated from bovine hypothalamus but is also found in humans and rats. (eurogentec.com)
Neuropeptides as regulators of the hypothalamus-pituitary-gonadal (HPG) axis activity and their putative roles in stress-induced fertility disorders. (illumina.com)
Precursor2
Portions of this work were previously presented in abbreviated fashion in the following abstracts: Vilim FS and Ziff E (1995) Cloning of the neuropeptide NPFF and NPAF precursor from bovine, rat, mouse, and human. (aspetjournals.org)
Panula P, Nieminen M, Aarnisalo AA, Lintunen M, Karhunen T, Vilim FS, Ziff E and Karlstedt K (1996) Expression of neuropeptide FF precursor in rat CNS. (aspetjournals.org)
It is a member of the tachykinin family of neuropeptides, and is widely distributed in the peripheral and central nervous systems of vertebrates. (enzolifesciences.com)
Behavior2
These findings will increase our mechanistic understanding of how neuropeptide signaling acts on anatomical circuits to modulate chemosensory perception and motivated behavior. (hhs.gov)
The neuropeptide cocaine and amphetamine regulated transcript (CART) was shown to induce anxiety-like behavior in rodents, and mutations in the human CART gene are associated with depression and anxiety. (lu.se)
Recent research also has thrown lights upon a significant role of orexins, especially orexin A, in regulation of male reproductive functions owing to their receptor expressions in vital testicular cells, such as Leydig cells, Sertoli cells as well as spermatozoa at different developmental stages, even in the epididymis and penis. (researchgate.net)
The orexin neuropeptide signaling system plays a role in wakefulness. (eisai.com)
Synaptic1
Investigation of the role of neurohormonal signalling was assessed by analysis of neuropeptide deficient and synaptic protein mutants. (bl.uk)
Regulation2
Both non-peptidergic transmitters and neuropeptides are involved in the control of this adaptive response in a complex manner with the manner of regulation depending on the food context. (bl.uk)
Our results confirm human genetic studies indicating CART as a neurobiological correlate of depression and anxiety, and suggest that its differential regulation in specific brain regions may play a role for the behavioral phenotypes. (lu.se)
Arginine-vasopressin1
Oxytocin (OXT) and arginine-vasopressin (AVP) are two phylogenetically conserved neuropeptides that have been implicated in a wide range of social behaviors. (frontiersin.org)
Sensory1
PACAP in pancreatic islets may play a parasympathetic and sensory neurotransmitter role . (eurogentec.com)
Protein1
The aim of the present study was to investigate the usefulness of multidrug resistance protein 1 (MDR1) and neuropeptide Y (NPY) levels in predicting the efficacy of levetiracetam (LEV) plus oxcarbazepine (OXC) treatment administered to children with epilepsy and to determine their prognosis. (usp.br)
Cellular2
Neuropeptide Y has been identified as being synthesized in GABAergic neurons and to act as a neurotransmitter during cellular communication. (wikipedia.org)
However, the cellular actions neuropeptides elicit to support temperature-robust activity remain unknown. (jneurosci.org)
Rats1
Since mast cells are active during inflammatory responses it becomes crucial to find out if these cells are actually present and play a role in dental pulp under normal and inflammatory conditions either in humans or in rats. (bvsalud.org)
Innate2
PACAP and VIP are two multifunctional neuropeptides modulating innate and adaptive immunity . (eurogentec.com)
Innate behaviors, including blood-feeding and mating, play key roles in vector biology and undergo dramatic changes influenced by environmental factors and internal state but we know little about the physiological changes underlying the behavioral readout. (hhs.gov)
Physiological1
Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. (wikipedia.org)
Cells4
It was then demonstrated that both ROS and TRPA1 are required in a subset of anterior enteroendocrine cells for the release of the DH31 neuropeptide which activates its receptor in the neighboring visceral muscles. (sdbonline.org)
Mast cells play an important role in a variety of biological processes and actively participate in the inflammatory response. (bvsalud.org)
The role of mast cells in the inflammatory dental pulp response is not clear. (bvsalud.org)
Mast cells play an important role in a variety of biological processes including allergic reactions, atherosclerosis and inflammation 7,8 . (bvsalud.org)
Peripheral1
Peripheral cardiac sympathetic hyperactivity in cardiovascular disease: role of neuropeptides. (ox.ac.uk)
Expression1
Our results confirm the evolutionary conservation of NPFF, NPAF, and NPSF neuropeptide expression in mammalian brain. (aspetjournals.org)
Findings1
Our findings demonstrate that a substance-P-related neuropeptide can boost dendritic electrical spread to maintain neuronal activity when perturbed and reveals key neurophysiological components of neuropeptide actions that support pattern generation in temperature-compromised conditions. (jneurosci.org)
Temperature1
Because neuropeptides are commonly implicated in sustaining neuronal activity during perturbation, our results provide a promising mechanism to support temperature-robust activity. (jneurosci.org)
Brain3
Neuropeptide Y has been indicated as playing an important role in neurogenesis in various parts of the brain. (wikipedia.org)
The dentate gyrus is significantly involved in cell proliferation, a process modulated by various internal factors including neuropeptide Y. Reduction or elimination of NPY released by interneurons decreased cell growth in this brain area. (wikipedia.org)
They have key roles in blood vessels in the central nervous system (CNS) including maintaining functional integrity of the blood brain barrier (BBB) and blood spinal barrier (BSB). (s4me.info)
Important role2
This is the case of chronic kidney disease (CKD), for which the medication burden could be a problem, and nutritional therapy plays an important role in the patient's treatment. (mdpi.com)
In pharyngeal and central nervous system, shows no aberrant pumping behaviours, suggesting an important role for the worm's enteric system. (bl.uk)
Immune2
Considering that neuropeptides are known as important mediators between the nervous and immune systems, neurogenic inflammation induced and regulated by neuropeptides secreted from nerve terminals is expected to be involved in the pathogenesis of DED. (annocl.org)
VNs are potent activators of adenylate cyclase and thus also have a key role in cyclic AMP production affecting regulatory T cell and other immune functions. (s4me.info)
Mechanisms1
However, further research is required in this direction to elucidate the mechanisms by which orexins play a role in different testicular functions and effect of orexins on semen quality. (researchgate.net)
Play1
The neurobiological bases of mood disorders remain elusive but both monoamines and neuropeptides may play important roles. (lu.se)
Action2
Recent data demonstrates a direct action of the sympathetic cotransmitters neuropeptide Y (NPY) and galanin on the ability of the vagus to release acetylcholine and control heart rate. (ox.ac.uk)
This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. (stanford.edu)
Suggest1
These results suggest that neuropeptide signalling is required both to maintain the low level of pumping and to reduce it in the absence of food. (bl.uk)
Review2
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man. (medscimonit.com)
For the first time, we present an up-to-date review of all published data regarding interactions between the aforementioned neuropeptide systems. (illumina.com)
Model1
That maps well with ME, of course, but I've never really heard of vasoactive neuropeptides before, so I have no idea where this model fits! (s4me.info)