Role lipids hyperlipidemias. Medical search. Frequent questions

Hyperlipidemias may basically be classified as either familial (also called primary) when caused by specific genetic abnormalities or acquired (also called secondary) when resulting from another underlying disorder that leads to alterations in plasma lipid and lipoprotein metabolism. (wikipedia.org)
Tumor necrosis factor-alpha (TNF-alpha), a pivotal pro-inflammatory cytokine in RA may be involved in the development of the disturbed lipid metabolism. (researchgate.net)
Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)
Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
This review discusses the role of adipokines and PPARs with regard to hepatic energy metabolism and progression of NAFLD. (wjgnet.com)
Hormones produced by adipose tissue play a critical role in the regulation of energy intake, energy expenditure, and lipid and carbohydrate metabolism. (diabetesjournals.org)
Adipose tissue plays a crucial role in the regulation of energy homeostasis, insulin sensitivity, and lipid/carbohydrate metabolism. (diabetesjournals.org)
Adipocytes produce a number of hormones that have wide-ranging effects on energy intake, energy expenditure, and carbohydrate and lipid metabolism, including nutrient partitioning and fuel selection. (diabetesjournals.org)
Thyroid disorders are known to influence lipid metabolism and are common in dyslipidemic patients. (hormones.gr)
These changes in the lipid profile are explained by the regulatory effect of thyroid hormones on the activity of some key enzymes of lipoprotein metabolism. (hormones.gr)
The alterations in the lipid profile observed in different thyroid abnormalities, the effect of treatment of these disturbances on the restoration of lipid metabolism, as well as the potential clinical implications and therapeutic guidelines are briefly discussed. (hormones.gr)
thus, there is an obvious need for an improved hepatocyte model to better understand how TM6SF2 impacts lipid metabolism.To address this need, we present an optimized protocol for the differentiation of inducible pluripotent stem cells (iPSCs) into hepatocyte-like cells (HLCs), created in collaboration with the Leong Lab. (columbia.edu)
To investigate the effect of TM6SF2 variant expression on hepatic lipid metabolism, we produced HLCs derived from 4 homozygous TM6SF2-carrier individuals (KK) and 4 age- and sex-matched unaffected siblings (EE). (columbia.edu)
After extensive confirmation of successful gene editing, we explore the effect of TM6SF2 on lipid metabolism in the edited iPSCs. (columbia.edu)
In summary, we present here methodological approaches for generating multiple cell culture models in which to investigate the function of TM6SF2, as well as novel evidence supporting a role for TM6SF2 in iPSC cholesterol metabolism. (columbia.edu)
In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
2010). Senp2 also regulates fatty acid metabolism in skeletal Downloaded from https://academic.oup.com/jmcb/article-abstract/10/3/258/4763638 by Ed 'DeepDyve' Gillespie user on 26 June 2018 Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1 j 259 muscle (Koo et al. (deepdyve.com)
Centrilobular localization of steatosis results from decreased energy stores caused by relative hypoxia and a shift in lipid metabolism, along with a shift in the redox reaction as a result of preferential oxidation of alcohol in the central zone. (medscape.com)
Advances in the understanding of the pathogenesis of alcoholic steatosis have provided some useful insights, including the role of peroxisome proliferator-activated receptor alpha, which is crucial for the regulation of hepatic fatty acid metabolism. (medscape.com)
The disorder of lipid metabolism and genetic predisposition are major risk factors for coronary artery disease (CAD). (biomedcentral.com)
Abstract The present study was performed to investigate the possible effects of wheat germ supplementation on lipid metabolism in humans. (cryonet.org)
Glucocorticoids, cortisol in humans or corticosterone in rodents, the end product of the HPA axis, is a catabolic hormone with the primary function of increasing availability of energy during a stressed condition by having an effect on the metabolism of carbohydrate and lipids (12, 13). (researchsquare.com)
Chronic high glucose dramatically influences β-cell lipid metabolism via substrate availability, changes in the activity and expression of enzymes of glucose and lipid metabolism, and modifications in the expression level of key transcription factors. (diabetesjournals.org)
Although TNF-α has well-established effects on lipid metabolism, the long-term effects of TNF-α blockade on lipid pattern are still unclear. (bmj.com)
Conversely, whole body and tissue iron stores associate with fat mass and distribution and glucose and lipid metabolism in adipose tissue, liver, and muscle. (ox.ac.uk)
Manipulation of the iron-regulatory proteins erythroferrone and erythropoietin affects glucose and lipid metabolism. (ox.ac.uk)
Several lines of evidence suggest that iron accumulation and metabolism may play a role in the development of metabolic diseases including obesity, type 2 diabetes, hyperlipidaemia and non-alcoholic fatty liver disease. (ox.ac.uk)
Patients who suffer from it, in addition to presenting altered glucose metabolism, also suffer from alterations in lipid metabolism. (jabonline.in)
Xanthomas can develop in the setting of altered systemic lipid metabolism or as a result of local cell dysfunction. (medscape.com)
The biochemical and genetic basis for the inherited disorders of lipid and lipoprotein metabolism differ considerably. (medscape.com)
Disorders of lipid metabolism. (medlineplus.gov)
She has published over 150 peer-reviewed articles in the area of lipids-modifying drugs, cardiovascular risk stratification, and cardiovascular prevention and has lectured widely on preventive cardiology and the diagnosis and treatment of disorders of lipid metabolism. (cdc.gov)

Hyperlipidemia is abnormally high levels of any or all lipids (e.g. fats, triglycerides, cholesterol, phospholipids) or lipoproteins in the blood. (wikipedia.org)
You may have heard that you have high cholesterol, high triglycerides, low HDL cholesterol, or even a high level of lipids in your blood. (healthline.com)
Hyperlipidemia is above normal lipid (fat) levels in the blood, which include several types of lipids, including triglycerides. (healthline.com)
Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
Learn the role that chylomicrons, very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) play in high cholesterol and high triglycerides. (healthcmi.com)
After the influence of hyperlipidemia, the levels of cholesterol and triglycerides in the blood exceed the standard. (growmorehealth.com)
This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors. (warwick.ac.uk)
They discovered that a certain group of lipids, namely the triglycerides (TAG), exhibit circadian behavior, with levels peaking about eight hours after sunrise. (sciencedaily.com)
A lipid profile should include measurement of total cholesterol, HDL cholesterol and triglycerides. (who.int)
When you go to a health care professional to get your cholesterol checked , this test (also called a lipid panel or lipid profile) will usually check the levels of cholesterol and triglycerides in your body. (cdc.gov)

Apart from CVD, hyperlipidemia is also closely associated with diabetes, insulin resistance, and obesity [ 10 ]. (hindawi.com)
Leptin treatment dramatically improves metabolic abnormalities (insulin resistance and hyperlipidemia) in patients with relative leptin deficiency due to lipoatrophy. (diabetesjournals.org)
These hormones, the pathways controlling their production, and their receptors are promising targets for managing obesity, hyperlipidemia, and insulin resistance. (diabetesjournals.org)
A review examining the role of these three hormones in regulating energy homeostasis and insulin action was published in early 2002. (diabetesjournals.org)
Insuf﫿cient adipose lipid storage is asso- ciated with many pathological conditions including hyperlipidemia, insulin resistance, and type 2 diabetes. (deepdyve.com)
Adipocyte Senp2 de﫿ciency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feed- ing. (deepdyve.com)
This mouse also showed an ectopic lipid in﫿ammation indicates that HFD induced adipocyte death would distribution and insulin resistance. (deepdyve.com)
adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)
Consequently, the role of hepatic Reptin in the pathogenesis of insulin resistance (IR) and non-alcoholic fatty liver disease consecutive to a high-fat diet was investigated. (nih.gov)
Metabolic syndrome is a combination of conditions that include insulin resistance/Type II diabetes, HTN, hyperlipidemia, and obesity. (nursingcenter.com)
They come together as a symbiotic relationship, such as obesity coupled with insulin resistance, and with these come HTN and hyperlipidemia. (nursingcenter.com)
There was no effect on plasma lipids or uric acid, but there was a lower glucose and insulin peak concentration after consumption of the FVPD compared with the sugar-matched control. (cambridge.org)
The insulin resistance and the proinflammatory states play a key role in the MS pathogenesis 36 . (bvsalud.org)

Overt and subclinical hypothyroidism have an adverse effect on the serum lipid profile that may predispose to the development of atherosclerotic disease. (hormones.gr)

In addition, kelp is rich in iodine, which can supplement the human body with fibrous alginic acid, inhibit the absorption of cholesterol in the stomach and intestines, reduce the accumulation of fatty substances in the body, and is more conducive to losing weight and stabilizing blood lipids. (growmorehealth.com)
Although specific pathogenic entities contributing to diabetic risk, such as central adiposity, ectopic fat accumulation, hyperlipidaemia and inflammation, are well-characterized, the response of cellular systems to such insults are less well understood. (warwick.ac.uk)
In studying the role of circadian rhythm in the accumulation of lipids in the liver, postdoctoral fellow Yaarit Adamovich and the team in the lab of Dr. Gad Asher of the Weizmann Institute's Biological Chemistry Department, together with scientists from Dr. Xianlin Han's lab in the Sanford-Burnham Medical Research Institute, Orlando, US, quantified hundreds of different lipids present in the mouse liver. (sciencedaily.com)
Yet no currently available drugs have been shown to change lipid accumulation as efficiently and drastically as simply adjusting meal time -- not to mention the possible side effects that may be associated with such drugs. (sciencedaily.com)
Familial lipoprotein lipase deficiency is an example of a primary disorder in which a deficiency of lipoprotein lipase in tissue leads to a type I pattern of hyperlipidemia, with a massive accumulation of chylomicrons in the plasma. (medscape.com)
Familial LDL receptor deficiency and familial defective apoprotein B-100 are examples of primary defects that can lead to the accumulation of LDL, which corresponds to a type IIa pattern of hyperlipidemia. (medscape.com)
Неалкогольна жирова хвороба печінки (НАЖХП) Fatty liver is excessive accumulation of lipid in hepatocytes. (msdmanuals.com)

Hyperlipidemias are also classified according to which types of lipids are elevated, that is hypercholesterolemia, hypertriglyceridemia or both in combined hyperlipidemia. (wikipedia.org)

Lipid and lipoprotein abnormalities are common in the general population and are regarded as modifiable risk factors for cardiovascular disease due to their influence on atherosclerosis. (wikipedia.org)
It plays a key role in the buildup of fatty deposits in arteries, causing them to narrow ( atherosclerosis ). (healthline.com)
Without cholesterol there can be no atherosclerosis" stated Anitchkov in 1915 and the causal role of lipids in this ubiquitous disorder is now indisputable. (bmj.com)
Oxidation of lipids can also create deposits in cartilage which affects affecting blood flow of subchondral bone in the same way that blood vessels are affected by atherosclerosis . (clevelandclinic.org)

Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
The main biological role of leptin appears to be adaptation to reduced energy availability rather than prevention of obesity. (diabetesjournals.org)

This study aimed to evaluate the effect of Prosopis ruscifolia on lipid profile in albino Swiss mice with hyperglycemia and hyperlipidemia. (jabonline.in)

This type of hyperlipidemia is called primary hyperlipidemia, or familial hyperlipidemia . (healthline.com)

Thus, prevention and treatment of hyperlipidemia are effective approaches to reduce the incident rate of chronic diseases. (hindawi.com)
There is a growing interest in TCM treatment of hyperlipidemia. (hindawi.com)
In the last few decades, hundreds of Chinese herbal medicines in the form of compounds, extracts, single herbs, or formulae have been reported to be effective for the prevention and treatment of hyperlipidemia [ 16 ], especially those high-fat diet (HFD) induced cases. (hindawi.com)
List the classes of medications used in the treatment of hyperlipidemia and their basic mechanisms of action. (ashp.org)

Dr. Robert Block specializes in the care of patients with hyperlipidemia. (rochester.edu)
Reasonable diet and exercise in daily life for patients with hyperlipidemia Combined, it can effectively assist and stabilize blood lipids in the body, play a good conditioning role, and reduce physical damage under the action of drugs. (growmorehealth.com)

The likelihood of developing its cardiovascular consequences, especially coronary heart disease (CHD), is enhanced by dyslipidaemia, which manifests itself either as an increase in low-density lipoprotein (LDL), resulting in hypercholesterolaemia, or in very-low-density lipoprotein (VLDL), resulting in either hypertriglyceridaemia or, if VLDL remnants accumulate, mixed hyperlipidaemia. (bmj.com)
Given the pivotal role that lipoproteins play at the juncture of these two conditions, researchers hypothesize that the ER-membrane spanning TM6SF2 protein regulates the degree of lipidation of VLDL particles synthesized in the liver. (columbia.edu)
Thus the lipoprotein pattern was comparable to that obtained with the low fat diet, but the VLDL lipid composition remained altered. (cryonet.org)

Increased risk for venous thrombosis was found among those under 50 having both lipid abnormalities. (who.int)

Mateo-Gallego R, Calmarza P, Jarauta E, Burillo E, Cenarro A and Civeira F (2010) Serum ferritin is a major determinant of lipid phenotype in familial combined hyperlipidemia and familial hypertriglyceridemia. (scielo.br)
Hyperlipidemia and hypertriglyceridemia are common diseases characterized by abnormally elevated levels of lipids in blood and liver cells, which lead to fatty liver and other metabolic diseases. (sciencedaily.com)

Over the years, statins and fibrates evolved to become the foremost widely prescribed agents for the elevated lipid profile even with their side effects. (alliedacademies.org)

You may have also heard of hyperlipidemia and hypercholesterolemia and wondered if these conditions are the same and how they relate to your cholesterol or triglyceride levels. (healthline.com)
A blood test called a lipid panel , or a lipid profile, can determine your cholesterol and triglyceride levels. (healthline.com)
Through the absorption and digestion of the human body, it helps to reduce blood pressure and blood lipids Cholesterol and triglyceride levels in the body, promote the stable development of blood lipids and prevent blood levels from rising. (growmorehealth.com)

Most diabetics are obese and suffering from a syndrome of diabetes, hypertension, and hyperlipidemia. (diabetespakistan.com)

In addition to being the most common lipid abnormality in type 2 diabetes mellitus, hypertriglyceridaemia is also a feature of impaired glucose tolerance and impaired fasting glucose. (who.int)

Hyperlipidemia represents a subset of dyslipidemia and a superset of hypercholesterolemia. (wikipedia.org)
Hyperlipidemia vs. Hypercholesterolemia: What's the Difference? (healthline.com)
What's the Difference Between Hyperlipidemia and Hypercholesterolemia? (healthline.com)
Hypercholesterolemia is a specific type of hyperlipidemia. (healthline.com)
The risk factors, potential causes, and possible health impacts are the same for hypercholesterolemia as they are for hyperlipidemia. (healthline.com)
What are the key differences between hypercholesterolemia and hyperlipidemia? (healthline.com)
Hypercholesterolemia is a type of hyperlipidemia. (healthline.com)
Neither hyperlipidemia nor hypercholesterolemia cause symptoms in most people. (healthline.com)

Advances in research on adipose tissue suggest an integral role played by adipokines in NAFLD. (wjgnet.com)
Under physiological conditions, the main- PPARγ mutation has been shown to link to familial partial lipody- tenance of normal adipose tissue mass is mainly the result of a strophy, a clinical disorder characterized by the loss of adipose balance of lipid storage and lipolysis (Bouchard et al. (deepdyve.com)

Patients with rheumatoid arthritis (RA) frequently display an atherogenic lipid profile which has been linked with inflammation. (researchgate.net)
Short-term effects of anti-TNF on plasma lipid concentrations seemed beneficial and anti-atherogenic. (bmj.com)
We conclude that one-year therapy with infliximab is likely to lead to a more pro-atherogenic pattern of the plasma lipids concentrations. (bmj.com)
1 Among the traditional cardiovascular risk factors, the lipid profile in RA has often been described as "pro-atherogenic", 2 based on decreased HDL-cholesterol (HDL-C) and increased LDL:HDL-C ratio and lipoprotein (a) plasma concentrations in both active and treated RA. (bmj.com)

Hyperlipidemia is a condition where you have a high level of lipids (fats) in your blood. (healthline.com)

We found that Reptin deletion completely rescued pathological phenotypes associated with IR, including glucose intolerance, hyperglycaemia, hyperlipidaemia and hepatic steatosis. (nih.gov)

ASP increases the efficiency of triacylglycerol synthesis in adipocytes leading to enhanced postprandial lipid clearance. (diabetesjournals.org)
2003). Selective Cellular uptake of fatty acids and following storage in the form of disruption of Pparγ2 or adipocyte-speci﫿c Pparγ knockout leads TGs in adipocytes are key steps in lipid storage. (deepdyve.com)
Serum leptin, a cytokine-type peptide hormone mainly produced by adipocytes, may play an important role in the pathogenesis of steatosis. (medscape.com)

Hyperlipidemia is usually chronic and requires ongoing medication to control blood lipid levels. (wikipedia.org)
Elevated levels of Lipoprotein(a) may also be classified as a form of hyperlipidemia. (wikipedia.org)
Because HDL cholesterol plays an important role in getting rid of LDL, you want higher levels of HDL in your blood. (healthline.com)
Various inherited or acquired disorders that cause high lipid levels in the blood fall under this umbrella category. (healthline.com)
Average percentage of abnormal blood lipid levels among Americans at age 20 or above [ 4 ]. (hindawi.com)
This review suggests that a hyperlipidemic treatment regimen along with vitamins may help reduce the high serum lipid levels and thereby reduce the risk in the development of cardiovascular diseases. (alliedacademies.org)
Learn the statistical prevalence, pathophysiology, signs and symptoms, and serum lipid levels relevant to an understanding of hyperlipidemia. (healthcmi.com)
Our findings suggest that TM6SF2 may impact cholesterol localization within ER subdomains, which regulate expression levels of cholesterol synthesis genes and activities of ER lipid-raft associated enzymes. (columbia.edu)
Experimental studies directly support the central role of LDL in atherogenesis, and lowering LDL-C levels is associated with a reduction in CVD risk. (aao.org)
Metabolic speed, burning excess fat in the body, stabilizing blood lipid levels, are beneficial to health. (growmorehealth.com)
a lipid used in the production of hormones, bile salts, and cell membranes that contributes to atherosclerotic plaque formation when levels are high. (ashp.org)
however, more than 50% of American adults have hyperlipidemia or elevated (inappropriately high) levels of lipids in their bloodstreams. (ashp.org)
The associated inflammatory response involves an increase in serum ferritin levels, which provides a defense against the growth of microorganisms by limiting the availability of circulating iron ( Cherayil, 2011 Cherayil BJ (2011) The role of iron in the immune response to bacterial infection. (scielo.br)
They are not only advised dietary changes to lower lipid levels but medicines are also needed sometimes. (diabetespakistan.com)
Ginger , known for its myriad health benefits, might also play a role in modulating cholesterol levels , given its active compounds, such as gingerol. (medicalnewstoday.com)
The scientists were astonished to find, however, that daily fluctuations in this group of lipids persist even in mice lacking a functional biological clock, albeit with levels cresting at a completely different time -- 12 hours later than the natural schedule. (sciencedaily.com)
So what was making the fluctuating lipid levels "tick" if not the clocks? (sciencedaily.com)
An abnormal result may mean you have high lipid (fat) levels in your blood. (medlineplus.gov)
The frequency may be decreased to every other year for patients with optimal lipid levels. (who.int)

In 2013, the American Heart Association reported that proportions of American adults aged 20 or above had abnormal blood lipid serum profile (details are shown in Table 1 ) [ 4 ]. (hindawi.com)
Intervention A 12 month intervention to improve depression, glycaemic control, blood pressure, and lipid control by integrating a "treat to target" programme for diabetes and risk factors for coronary heart disease with collaborative care for depression. (bmj.com)
Elevated blood sugars, as well as elevated cholesterol/lipids, increase free radicals within the body, this oxidative stress exceeds the resilience of cartilage on the cellular level. (clevelandclinic.org)
Some people say that walking more helps lower blood lipids, so is this claim true? (growmorehealth.com)
Can walking reduce blood lipids? (growmorehealth.com)
Long-term exposure to excessive blood lipids will lead to the continuous deposition of fat components in the blood vessels, resulting in blood circulation disorders, which cannot be effectively circulated everywhere and reduce the efficiency of surgery. (growmorehealth.com)
If blood lipids continue to rise, it is easy to lead to high blood pressure. (growmorehealth.com)
This is mainly because the increase in blood lipid concentration will lead to blood viscosity, promote myocardial dysfunction, lead to rapid contraction of blood vessels, activate active enzymes in the body, lead to vasospasm and uncontrolled blood pressure, Even cerebral thrombosis or myocardial infarction. (growmorehealth.com)
Long-term failure to lower blood lipids will lead to reduced coronary blood circulation, myocardial bleeding and acute vasoconstriction, leading to angina pectoris or coronary heart disease. (growmorehealth.com)
When biological potassium enters the blood, it can dissolve the plaque deposited on the inner wall of the blood vessel, and finally excrete it through urination or defecation, so as to achieve the effect of lowering blood lipids. (growmorehealth.com)
reduce blood lipids, prevent diabetes, therefore, people with high blood lipids usually eat more onions. (growmorehealth.com)
Blood serum samples were analyzed for PCB congeners using gas chromatography/mass spectroscopy (GC/MS). Results were reported as concentrations of individual PCB congeners per unit volume of blood serum, and also as lipid-based concentrations. (cdc.gov)
It is extremely clear that low lipid density protein, or "bad," cholesterol (LDL-C), in the blood is a significant risk factor for heart disease and stroke, the leading causes of death among Americans. (cdc.gov)

Although less fat stor- adqcKO pose lipid storage in adipocyte-speci﫿c Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
The role of the early growth response-1 (EGr-1) transcription factor is thought to be essential for ethanol-induced fatty liver injury in mice. (medscape.com)
One thing that came to mind was that, since food is a major source of lipids -- particularly TAG -- the eating habits of these mice might play a role. (sciencedaily.com)

His sub-focus is the role of fatty acids and cardiovascular disease. (rochester.edu)
This higher level of plasma lipids could be a major risk factor associated with various cardiovascular diseases. (alliedacademies.org)
[ 2 ] The investigators speculated that this imbalance could play a role in the risk for cardiovascular disease and liver fibrosis, conditions commonly associated with NAFLD. (medscape.com)
Published January 22, 2018 at 798 × 528 in Role Of Glucose And Lipids In The Atherosclerotic Cardiovascular Disease In Patients With Diabetes . (endotext.org)
One type of lipid, known as a phospholipid, is responsible for making up the cell membranes of nearly every cell in the body, while others, called steroids, are versatile hormones that are integral parts of the reproductive, immune, renal, cardiovascular, and central nervous systems. (ashp.org)
This issue of American Family Physician includes a review of patient-centered evidence supporting the use of lipid-lowering therapy for the prevention of atherosclerotic cardiovascular disease (ASCVD). (aafp.org)

Taken as a whole, the present results obtained in humans are very close to those previously obtained in the rat and point out that wheat germ may play a beneficial role in the dietary management of hyperlipidemia. (cryonet.org)

2 This guideline's unique approach was to shift away from the practice of treating lipid targets to specific goals (i.e., for low-density lipoprotein cholesterol [LDL-C] and non-high-density lipoprotein cholesterol [non-HDL-C]). Instead, the guideline recommended moderate- to high-intensity statin therapy for four groups of patients most likely to achieve maximal net benefit based on their increased risk. (aafp.org)

The term hyperlipidemia refers to the laboratory finding itself and is also used as an umbrella term covering any of various acquired or genetic disorders that result in that finding. (wikipedia.org)
Primary hyperlipidemia is usually due to genetic causes (such as a mutation in a receptor protein), while secondary hyperlipidemia arises due to other underlying causes such as diabetes. (wikipedia.org)
Hyperlipidemia can be genetic, meaning it runs in families and is an inherited condition. (healthline.com)
A nonsynonymous, loss of function variant (rs58542926, E167K) located in the gene encoding TM6SF2 was identified in multiple genetic association studies as significantly correlating with increased risk for non-alcoholic fatty liver disease (NAFLD) and decreased risk for hyperlipidemia. (columbia.edu)
Environmental, genetic, and immunologic factors appear to play a role. (medscape.com)

However, dysregulation of the HPA axis in T2DM has been shown to worsen further the hyperglycaemic state causing hyperlipidemia and dyslipidemia as well as increase the risk of depression in diabetic patients (8, 13-16). (researchsquare.com)

Conclusions Integrated care that covers chronic physical disease and comorbid depression can reduce social role disability and enhance global quality of life. (bmj.com)
Amgen's Repatha (evolocumab) and Sanofi/Regeneron's Praluent (alirocumab) haven't quite broken into diabetes treatment algorithms, but Dr. Farkouh sees a clear niche for these more potent lipid-lowering agents - people with comorbid diabetes and hyperlipidemia despite maximally-tolerated statin therapy. (closeconcerns.com)

Lipids (water-insoluble molecules) are transported in a protein capsule. (wikipedia.org)
Niemann Pick C1 Like1 protein (NPC1L1), ATP citrate lyase (ACL), C-reactive protein (CRP), lanosterol 14 α -demethylase (LDM), squalene synthase (SqS) and farnesiod X-receptor (FXR) known to be implicated in the physiology of hyperlipidemia. (springeropen.com)
a spherical particle made up of hundreds of lipid and protein molecules. (ashp.org)
Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. (medlineplus.gov)

Data from animal studies and clinical studies support the role of proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) in the early stages of fatty liver, as well as in alcoholic steatohepatitis. (medscape.com)
This study aimed to determine the role of Reptin in mammalian adult liver. (nih.gov)
The main role of HDL is to accept cholesterol and to transport it back to the liver (reverse cholesterol transport). (medscape.com)

His expertise includes the diagnosis and treatment of patients with complex lipid disorders and familial cholesterol diseases. (rochester.edu)
What diseases can hyperlipidemia cause? (growmorehealth.com)

ABSTRACT To assess the risk of venous thromboembolism (VTE) associated with hyperhomocystein- aemia (hyper-Hcy) and hyperlipidaemia, we performed a case-control study. (who.int)

Authors Lairon D. Lacombe C. Borel P. Corraze G. Nibbelink M. Chautan M. Chanussot F. Lafont H. Title Beneficial effect of wheat germ on circulating lipoproteins and tissue lipids in rats fed a high fat, cholesterol-containing diet. (cryonet.org)

He is interested in understanding the role of biomarkers, such as fatty acids, for clinical use as well as in helping to understand heart disease pathophysiology. (rochester.edu)

Hyperthyroidism may be the underlying cause for acquired hypocholesterolemia or unexpected improvement of the lipid profile of a previously hyperlipidemic patient. (hormones.gr)
It was observed that the administration of P. ruscifolia in hyperglycemic and hyperlipidemic animals had a favorable effect on the lipid profile. (jabonline.in)

We investigated whether infliximab, an anti-TNF-alpha therapy, may modify the lipid profile. (researchgate.net)
Lipid profile and CRP were assayed at baseline and before infusion at weeks 6 and 30. (researchgate.net)
A review on role of vitamin supplements on the lipid profile. (alliedacademies.org)
In the present study, we investigated the effects of 1-year therapy with anti-TNF on the lipid profile of RA patients. (bmj.com)
A fasting lipid profile is recommended on a yearly basis for patients with diabetes. (who.int)

Hyperlipidemia can be defined as a medical condition characterized by an increase in plasma lipids and plasma lipoproteins. (alliedacademies.org)
Plasma total homocysteine (Hcy) was also investigated the relationship between assessed by enzyme immunoassay (DRG hyperlipidaemia and VTE. (who.int)
Title Plasma lipid lowering effects of wheat germ in hypercholesterolemic subjects. (cryonet.org)

Screening is important in order to identify patients with suboptimal lipid profiles and then institute corrective measures for either primary or secondary prevention. (who.int)

The role of lipids was established by Kannel et al , 1 who demonstrated correlations between the concentrations of serum cholesterol and the major lipoprotein classes at entry to the study and the development of CHD during the subsequent 14 years. (bmj.com)

Hyperlipidemias are divided into primary and secondary subtypes. (wikipedia.org)
These lipid disorders may occur in primary (inherited) [ 5 - 7 ] or secondary form [ 8 ]. (hindawi.com)

Identify agents and common side effects from each class of medications used to treat hyperlipidemias. (ashp.org)

This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. (hindawi.com)

Diseases1

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Technology, Industry, Agriculture1

Metabolism32

Triglycerides10

Insulin13

Serum lipid profile1

Accumulation7

Types of lipids1

Atherosclerosis4

Obesity2

Hyperglycemia and hyperlipidemia1

Familial hyperlipidemia1

Treatment of hyperlipidemia4

Patients with hyperlipidemia2

VLDL3

Abnormalities1

Hypertriglyceridemia2

Elevated lipid profile1

Triglyceride levels3

Hypertension1

Diabetes mellitus1

Hypercholesterolemia8

Adipose tissue2

Atherogenic4

Fats1

Hyperglycaemia1

Adipocytes3

Levels19

Blood13

Mice3

Cardiovascular6

Dietary1

Density1

Genetic5

Dyslipidemia1

Comorbid2

Protein4

Liver3

Diseases2

Abstract1

High1

Pathophysiology1

Hyperlipidemic2

Profile5

Plasma3

Prevention1

Concentrations1

Secondary2

Medications1

Clinical1