• lung
  • The primary objective of this proposal is to determine how the conducting airway epithelium of the infant lung can influence the adaptive immune response to inhaled allergens. (grantome.com)
  • Our overall hypothesis is that epithelial cells of the infant lung play a central role in the initiation of the asthma phenotype, via constitutive CCL20 chemokine expression to promote airways recruitment of chemokine receptor CCR6+ T lymphocytes. (grantome.com)
  • To test these hypotheses, we will 1) investigate the developmental regulation of CCL20 expression in infant airway epithelium, 2) characterize chemokine receptor CCR6+ lymphocyte populations in the infant monkey lung following allergen exposure, and 3)determine the impact of IL-17/IL-12 imbalance on allergen exposed infant monkeys. (grantome.com)
  • The experiments proposed within this application will contribute to our overall understanding of how the epithelium of the maturing postnatal lung can direct the development of a pathologic immune response to inhaled allergens. (grantome.com)
  • Parotid epithelium was able to develop in lung mesenchyme, but not so well as in its own mesenchyme. (biologists.org)
  • Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. (elsevier.com)
  • Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. (elsevier.com)
  • barrier
  • Important for the barrier function of intenstinal epithelium, its cells are joined securely together by four types of junctions (cell junctions), which can be identified at the ultrastructural level: Gap junctions Desmosomes Adherens junctions Tight junctions Gap junctions bring the adjacent cells within 2 nanometers of each other. (wikipedia.org)
  • organ
  • The results are interpreted in terms of morphogenetic and growth control of salivary epithelium by mesenchyme, the subsequent cytodifferentiation of the terminal buds being typical of the organ from which the epithelium was derived. (biologists.org)
  • survival
  • Retrograde signaling from the brain to the olfactory sensory epithelium is important for neuronal survival, but the importance of the olfactory bulb in retrograde signaling during the naturally-induced, neuronal plasticity occurring during metamorphosis is unclear. (uwindsor.ca)
  • human
  • When organoids cocultured with human foreskin fibroblasts were grafted within chambers, structural organisation of the epithelium was supported. (biologists.org)
  • important
  • Including development, BDNF has important regulatory roles in the development of the visual cortex, enhancing neurogenesis, and improving learning and memory. (wikipedia.org)
  • single
  • Amylase activity was greater when the epithelium from a single parotid rudiment was recombined with submandibular mesenchyme than with its own mesenchyme. (biologists.org)
  • further
  • Our data demonstrate that sAC is expressed by the RPE and that it contributes to the generation of the LP. Further study will be necessary to determine how cAMP generated by sAC may be involved in the LP response as a role for cAMP in generating the LP has not previously been observed. (arvojournals.org)
  • Further evidence of the role of gut flora in the cause of inflammatory bowel disease is that IBD-affected individuals are more likely to have been prescribed antibiotics in the 2-5 year period before their diagnosis than unaffected individuals. (wikipedia.org)
  • development
  • Rothmund, in 1872, speculated that implantation of epithelium at the time of surgery or penetrating trauma resulted in the development of anterior chamber cysts. (springer.com)
  • expression
  • Moreover, the vascular role of RGS2 is evidence that the increased RGS2 expression is related to hypotension and that decreased RGS2 expression is related to hypertension ( Le and Coffman, 2003 ). (aspetjournals.org)