CatalaseSuperoxideExogenousHydrogen peroxideMoleculesPhysiologicalPlantOxidativeHighAntioxidantGenomeWaterGrowthEffectsStudiesShowsEarlyPlaysGlutathioneToxicityReactiveAccumulationGenesElectronEquivalentVitroMechanismsOxidative stressMembraneReactionCompoundsIntracellularEarlySensitiveFamilyProtectiveExpressionCells
Catalase3
- In addition to its peroxidase activity, it acts as a sensor and a signaling molecule to exogenous H2O2, which activates mitochondrial catalase activity. (wikipedia.org)
- production rate, H 2 O 2 content and membrane permeability, maintained high activities of superoxide dismutase (SOD), catalase (CAT) and ascorbate peroxidase (APX), and reduced the increase in activities of lipase, phospholipase D (PLD) and lipoxygenase (LOX). (biomedcentral.com)
- In the human cell, antioxidant molecules include both nonenzymatic compounds such as glutathione (GSH), thioredoxin (Trx), ascorbate, α -tocopherol, β -carotene, and coenzyme Q10 and enzymes such as catalase, glutathione peroxidase, and superoxide dismutase (SOD) [ 8 ]. (hindawi.com)
Superoxide1
- Abstract Rapid generation of superoxide and accumulation of H2O2 is a characteristic early feature of the hypersensitive response following perception of pathogen avirulence signals. (rehabsociety.org.hk)
Exogenous2
- Exogenous copper and iron stimulate the ascorbate-induced [Ca2+]cyt. (deepdyve.com)
- Exogenous ascorbate also induces a moderate increase in programmed cell death symptoms in intact roots, but it does not activate Ca2+ influx currents in patch-clamped root protoplasts. (deepdyve.com)
Hydrogen peroxide4
- Cytochrome c peroxidase, or CCP, is a water-soluble heme-containing enzyme of the peroxidase family that takes reducing equivalents from cytochrome c and reduces hydrogen peroxide to water: CCP + H2O2 + 2 ferrocytochrome c + 2H+ → CCP + 2H2O + 2 ferricytochrome c CCP can be derived from aerobically grown yeast strains and can be isolated in both native and recombinant forms with high yield from Saccharomyces cerevisiae. (wikipedia.org)
- Cytochrome c peroxidase can react with hydroperoxides other than hydrogen peroxide, but the reaction rate is much slower than with hydrogen peroxide. (wikipedia.org)
- Germination of selected vegetable seeds including corn (Zea mays L.), squash (Cucurbita pepo L.), and tomato (Solanum lycopersicum L.) was studied in water with different concentrations of hydrogen peroxide (H2O2) solution ranging from 0, 0. (researchgate.net)
- The use of hydrogen peroxide (H2O2) is recently recommended for use in drip irrigation particularly for cleaning of drip emitters. (researchgate.net)
Molecules2
- In water solutions, this substance is present as a monovalent anion, ascorbate- (Asc-), which easily donates electrons to oxidized molecules and scavenges reactive oxygen species (ROS). (deepdyve.com)
- 2016) also suggested that H2O2 molecules play dual roles in plant physiological and developmental processes. (researchgate.net)
Physiological1
- Overall, these are very important physiological roles of AA relating this molecule exclusively to antioxidant functions. (deepdyve.com)
Plant1
- Plant peroxidase such as horseradish peroxidase and pineapple peroxidase B have low lysine, tryptophan, and tyrosine contents and high cysteine content. (wikipedia.org)
Oxidative4
- an oxidative burst triggered by the treatment of Arabidopsis plants with a cell wall elicitor prepared from the fungus Fusarium oxysporum could be abolished by knocking down the transcript levels of PRX33 and PRX34 through the transgenic expression of a French bean class III peroxidase cDNA (FBP1) in an antisense orientation (Daudi et al. (rehabsociety.org.hk)
- Moreover, this study has elucidated that SA‐induced stomatal closure involves extracellular oxidative burst (Figs 2 & 3) and that the extracellular oxidative burst is mediated with SHAM‐sensitive peroxidases but not NAD(P)H oxidases (Figs 1d & 2). (rehabsociety.org.hk)
- This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. (hindawi.com)
- Nuclear factor erythroid-2-related factor 2 (Nrf2) is a transcription factor that is upregulated in times of oxidative stress. (hindawi.com)
High2
- CCP has high sequence identity to the closely related ascorbate peroxidase enzyme. (wikipedia.org)
- Based on a novel Ion Powered Pump® (IPP®) delivery system that provides a pharmacokinetic (PK) profile that more closely aligns with the body's own natural sleep pattern, REMfresh has demonstrated once again promising results and high levels of satisfaction in a real-world population of patients who have had chronic difficulties sleeping, providing up to seven hours of sleep support," said Dr. Brodner. (pharmaceuticalintelligence.com)
Antioxidant2
- These results indicated that MAP in combination with low temperature storage reduced lignification of minimally processed WBS, which was closely associated with maintenance of energy status and enhanced activities of antioxidant enzymes, as well as reduced alleviation of membrane damage caused by ROS. (biomedcentral.com)
- The Keap1-Nrf2-ARE pathway plays a critical role in the regulation of a comprehensive and protective antioxidant response [ 22 ]. (hindawi.com)
Genome2
- Notably, some genes related to abiotic stress were identified in genome, such as genes regulating heat shock protein, protein kinase activity and signal transduction. (bvsalud.org)
- The gene encoding the Ov-phy-1 open reading frame contained 11 introns, similar in structure to the gene encoding human prolyl 4-hydroxylase isoform I. Genomic Southern blot, EST and genomic PCR studies demonstrated that the O. volvulus genome contained between three and eight genes closely related to Ov-phy-1. (embl.de)
Water2
- showed that the effect of H2O2 on corn seed germination was significantly greater than for seed treated with aerated water but no H2O2. (researchgate.net)
- Relatively less known are the effects of H2O2 in irrigation water on seed germination, seedling growth and establishment. (researchgate.net)
Growth2
- However, the role of MYB TFs in the heat stress response and growth and development of Pleurotus ostreatus remains unclear. (bvsalud.org)
- tested 24-h seed pre-treatments with H2O2 with 50 mM being optimal with improved seed germination, seedling vigour and growth in corn, squash (Cucurbita pepo L.) and tomato (Solanum lycopersicum L.). Increased germination and seedling growth of peas (Pisum sativum L. 'Alaska') was shown by Barba-Espin et al. (researchgate.net)
Effects1
- The enhanced effects on germination with H2O2 have a) been reported for seed with pathogenic infestations (Szopniska, 2014) i.e. a biocidal effect, and b) mediated through the oxidation of germination inhibitors present in the seed coat or/and in the pericarp, i.e. a seed treatment effect. (researchgate.net)
Studies2
- Recent studies suggest that not only increased membrane permeability but also enhanced ROS production is closely associated with low levels of ATP production and energy charge (EC) in harvested horticultural crops [ 10 ]. (biomedcentral.com)
- PRO studies of this kind, which more closely address real-world patient experience, are increasingly being recognized by regulatory authorities and academia in evaluating new therapies. (pharmaceuticalintelligence.com)
Shows2
- The enzyme shows an unusual amino acid pattern compared to other peroxidase. (wikipedia.org)
- Intriguingly, the replacement of gluconate with ascorbate in the patch-clamp pipette reveals a large ascorbate efflux current, which shows sensitivity to the anion channel blocker, anthracene-9-carboxylic acid (A9C), indicative of the ascorbate release via anion channels. (deepdyve.com)
Early2
- Early research on the role of antioxidants in biology focused on their use in preventing the oxidation of unsaturated fats , which is the cause of rancidity . (wikipedia.org)
- An early study by Narimanov (2000) reported enhanced germination, emergence and development of seedlings using a short seed soaking treatment with H2O2 in a wide variety of crops including corn (Zea mays L.), beans (Phaseolus sp. (researchgate.net)
Plays2
- CCP plays an integral role in enabling inter-protein biological electron transfer. (wikipedia.org)
- Energy plays a pivotal role in maintenance of membrane integrity and lipid metabolism. (biomedcentral.com)
Glutathione1
- Many mechanisms contributing to the resistance of mesothelioma remain to be investigated, but γGCS may play an important role in the primary drug resistance of this tumor in vivoin maintaining the intracellular glutathione level. (charismaticplanet.com)
Toxicity2
- Both BSO - and ATZ - treatment enhanced H2O2 toxicity in three mesothelioma cell lines. (charismaticplanet.com)
- Melatonin (MET) has emerged as a protective phytohormone in stress conditions, but the defensive role and underlying mechanisms of MET against Cd toxicity in rice still remain unclear. (bvsalud.org)
Reactive2
- Chromium(VI) reduction by ascorbate: role of reactive intermediates in DNA damage in vitro. (nih.gov)
- Both chemo and radiotherapy act at least partly by provoking reactive oxygen species (ROS) generation suggesting a role for the intracellular antioxidants in drug resistance. (charismaticplanet.com)
Accumulation1
- MET treatment significantly reduced Cd accumulation (39.25%/31.58%), MDA (25.87%/19.45%), H2O2 (17.93%/9.56%), and O2 (29.11%/27.14%) levels in shoot/root tissues, respectively, when compared with Cd treatment. (bvsalud.org)
Genes4
- Previously described virulence-related genes in P. salmonis plasmids were identified by proteomic assays during infection in SHK-1 cells, accompanied by an increase of mobile-related elements. (preprints.org)
- ascorbate peroxidase) and as well as regulating the key stress-responsive genes (OsSOD1, OsPOD1, OsCAT2, OsAPX1), thereby reinstate cellular membrane integrity and confer tolerance to ultrastructural damages under Cd-induced phytotoxicity. (bvsalud.org)
- Co-expression and functional analyses revealed that distinctive metabolic processes distinguish dormancy stages, with genes expressed during endodormancy involved in chromatin remodeling and reproduction, while the genes induced at ecodormancy were mainly related to pollen development and cell wall biosynthesis. (frontiersin.org)
- The downregulated lipids, starch, and cell wall synthesis-related genes resulted in loss of fertility. (gov.tw)
Electron2
- CCP plays an integral role in enabling inter-protein biological electron transfer. (wikipedia.org)
- Reaction of chromium(VI) with one equivalent of ascorbate was studied by electron paramagnetic resonance spectroscopy in the presence of 0.10 M 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) at room temperature in 0.10 M (N-[2-hydroxyethyl]piperazine-N'-[2-ethanesulfonic acid]) (HEPES) and 0.05 M tris(hydroxymethyl)aminomethane hydrochloride (Tris-HCl) buffers (pH 7.0 room temperature). (nih.gov)
Equivalent1
- This is different from most peroxidases, which have the second oxidising equivalent on the porphyrin instead. (wikipedia.org)
Vitro2
- Chromium-DNA binding studies were carried out in vitro for calf thymus DNA incubated with Cr(VI) and ascorbate in both buffers at 37 degrees C. Higher Cr-DNA binding was observed in HEPES buffer. (nih.gov)
- DNA strand-break studies were carried out in vitro on pBR322 DNA incubated with Cr(VI) and ascorbate in both buffers at 37 degrees C. Higher percent nicking was observed in Tris-HCl buffer. (nih.gov)
Mechanisms1
- Asbestos-induced oxidative stress is thought to play an essential role in the pathogenesis of mesothelioma in the process possibly increasing the expression of the major antioxidant defense mechanisms of the cells. (charismaticplanet.com)
Oxidative stress2
- This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. (hindawi.com)
- Nuclear factor erythroid-2-related factor 2 (Nrf2) is a transcription factor that is upregulated in times of oxidative stress. (hindawi.com)
Membrane3
- The negative charge transfer process is carried out by a complex formed between cytochrome c and cytochrome c peroxidase which occurs in the inter-membrane space of mitochondria. (wikipedia.org)
- The enzyme contains a 68-residue sequence at the N-terminus of its monomeric protein, which targets it to the inter-membrane space of the mitochondria where it can the complex with cytochrome c and where it carries out its sensor, signaling and catalytic roles. (wikipedia.org)
- Virulence factors related to membrane, LPS and surface component modifications, cell motility, toxins and secretion systems also varied between the infection stages. (preprints.org)
Reaction1
- Cytochrome c peroxidase can react with hydroperoxides other than hydrogen peroxide, but the reaction rate is much slower than with hydrogen peroxide. (wikipedia.org)
Compounds1
- We analyzed the vector directionalities of the lone pairs of the nitrogen common to these molecules, and the acidic hydrogen of phenols (in aminoindanes, aminotetralins, apomorphines, p-phenol-piperazines, octahydrobenzo(g)quinolines, octahydrobenzo(f)quinolines, and benzazepines) or of nitrogen (in ergoline-type compounds and related structures). (nih.gov)
Intracellular1
- some of them related to key functions for bacterial survival in other intracellular pathogens. (preprints.org)
Early2
- The results of the expression pattern of PvHsfs in response to heat stress showed that PvHsf03 and PvHsf25 might play critical roles in the early and late stages of switchgrass response to heat stress, respectively, and HsfB mainly showed a negative response to heat stress. (bvsalud.org)
- PMID- 3504186 TI - Temperature-related ultrastructural changes in early stage amelogenesis in vascularly perfused rat incisors. (nih.gov)
Sensitive1
- Moreover, this study has elucidated that SA‐induced stomatal closure involves extracellular oxidative burst (Figs 2 & 3) and that the extracellular oxidative burst is mediated with SHAM‐sensitive peroxidases but not NAD(P)H oxidases (Figs 1d & 2). (rehabsociety.org.hk)
Family1
- Hence, this study aimed to identify the Hsf family in switchgrass and understand its functional role in heat stress signal transduction and heat tolerance by using bioinformatics and RT-PCR analysis. (bvsalud.org)
Protective1
- The Keap1-Nrf2-ARE pathway plays a critical role in the regulation of a comprehensive and protective antioxidant response [ 22 ]. (hindawi.com)
Expression1
- an oxidative burst triggered by the treatment of Arabidopsis plants with a cell wall elicitor prepared from the fungus Fusarium oxysporum could be abolished by knocking down the transcript levels of PRX33 and PRX34 through the transgenic expression of a French bean class III peroxidase cDNA (FBP1) in an antisense orientation (Daudi et al. (rehabsociety.org.hk)
Cells1
- When glucose levels in fast growing yeast strains are exhausted, the cells turn to respiration which raises the concentration of mitochondrial H2O2. (wikipedia.org)