Role carcinoma squamous cell. Medical search. Frequent questions

Esophageal squamous cell carcinoma (ESCC) is a common histologic subtype in China. (spandidos-publications.com)
Although Barrett's adenocarcinoma is the most rapidly increasing cancer in Western countries, esophageal squamous cell carcinoma (ESCC) remains dominant in East Asia ( 3 ). (spandidos-publications.com)
The benefits of neoadjuvant chemoradiation (NCRT) compared to upfront esophagectomy (UE) in esophageal squamous cell carcinoma (ESCC) is controversial. (springer.com)
Esophageal carcinoma. (springer.com)
Comparison of neoadjuvant chemotherapy versus upfront surgery with or without chemotherapy for patients with clinical stage III esophageal squamous cell carcinoma. (springer.com)
A propensity-matched analysis comparing survival after esophagectomy followed by adjuvant chemoradiation to surgery alone for esophageal squamous cell carcinoma. (springer.com)
Pre- versus postoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma. (springer.com)
Upfront surgery and pathological stage-based adjuvant chemoradiation strategy in locally advanced esophageal squamous cell carcinoma. (springer.com)
Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications. (bvsalud.org)
whether their expression is associated with clinicopathological factors and prognosis in patients of esophageal squamous cell carcinoma (ESCC) is still under investigation. (gastrores.org)
Esophageal squamous cell carcinoma (ESCC) is the ninth most common cancer in the world and the sixth leading cause of cancer-related death [ 1 ]. (gastrores.org)
ESCC accounts for 90% of esophageal carcinomas in Asian countries [ 2 ] and remains one of the most aggressive carcinomas in the gastrointestinal tract. (gastrores.org)
GB-263 is under development for the treatment of non-small cell lung cancer, gastric cancer, esophageal cancer, head and neck squamous cell carcinoma, metastatic colorectal cancer and other solid tumors. (pharmaceutical-technology.com)
Journal Article] The role of microRNA in esophageal squamous cell carcinoma. (nii.ac.jp)
Increasing evidence suggests that CAP facilitates the growth and migration of esophageal squamous cell carcinoma (ESCC) and human colon cancer cells ( 7 , 8 ). (frontiersin.org)

It was further demonstrated that Th17 cells could be induced and expanded in the tumor microenvironment through cytokines produced by the tumor cells. (spandidos-publications.com)
In conclusion, Th17 cells have a substantial impact on the carcinogenesis of LSCCs, and could serve as a potential therapeutic target to modulate the anti‑tumor response in these carcinomas. (spandidos-publications.com)
Considering these facts, it could be concluded that pro-inflammatory Th17 cells may have extensive effects on LSCC pathogenesis and anti-tumor response. (spandidos-publications.com)
In a recent study, it has also been shown that the deletion or severe down-regulation of a gene titled Tpl2 (tumor progression locus 2) may be involved in the progression of normal keratinocytes into becoming squamous-cell carcinoma. (wikipedia.org)
The TGFβ and Ras-MAPK pathways play critical roles in cell development and cell cycle regulation, as well as in tumor formation and metastasis. (biomedcentral.com)
Overexpression of IRS-1 was associated with cell differentiation, whereas GOLPH3 was related to lymph node metastasis, tumor invasion in-depth and TNM stage in ESCC patients. (spandidos-publications.com)
miR-126 suppressed the proliferation, migration and invasion of ESCC cells, and acted as a tumor suppressor in the carcinogenesis of ESCC. (spandidos-publications.com)
Therefore, miR-126 may have diverse roles in tumor carcinogenesis. (spandidos-publications.com)
However, in squamous cell carcinomas , a key transcriptional factor regulating tumor differentiation is largely unknown. (bvsalud.org)
Levels of PDPN-high tumor basal cells and of expression of genes for DNA repair and antioxidant enzymes were reduced in stable transfectants, and they showed high CDDP and H2 O2 sensitivities, and their xenografts showed a well-differentiated histology . (bvsalud.org)
Reduction of tumor basal cells was restored by knockdown of aryl hydrocarbon receptor nuclear translocator (ARNT) that interacted with SIM2. (bvsalud.org)
The aim of this study was to clarify the role of IL-33 in tumor progression. (mcw.edu)
To examine the influence of IL-33 on the microenvironment of the tumor, we determined the mast cell density (MCD) and microvessel density of the stroma. (mcw.edu)
The hallmarks of cancer can show the basic characteristics of tumor cells. (biomedcentral.com)
In both melanomas, the cutavirus DNA-specific signals could be detected only in the superficial layers and on the surface of the skin but not in the tumor cells ( Appendix Figure). (cdc.gov)
and GB223, a RANKL (receptor activator of NF-kappaB ligand) monoclonal antibody to treat giant-cell tumor of bone (GCTB). (pharmaceutical-technology.com)
It has been suggested that radiation sensitivity and chemosensitivity of cancer cells may play an important role in the local control of the tumor following these therapies. (researchsquare.com)
Increasing evidence has shown that tumor heterogeneity is a result of the hierarchical organization of cancer stem cells (CSCs), which are strongly associated with tumor relapse and metastasis. (nii.ac.jp)
And like any groups of cells it is vulnerable to mutations that cause an abnormal group of cells to form a tumor and if there is a significate mutation (malignity) it is considered a cancer. (differencebetween.net)
Now, we need to separate the concepts of tumor and cancer with the size of it, since we can be in the presence of a big tumor or a small cancer, it all depends in the level of difference we have with the abnormal mutated cell and a normal one. (differencebetween.net)
UV light in the human body, with its high radiation, breaks DNA in skin cells provoking mutations of important genes that suppresses the birth of cancer cells, which may trigger the onset of a tumor. (differencebetween.net)
Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. (pharmiweb.com)
Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
Many tumor suppressor proteins play a role in DNA repair, helping to correct genetic mutations and maintain the stability of the genome. (pharmiweb.com)
Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
The current studies reveal that the clock gene Per2 is expressed at lower levels in a variety of tumors and plays a significant tumor suppressor role. (jcancer.org)
It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. (techscience.com)
Oral squamous cell carcinoma (OSCC) is a common malignant tumor. (techscience.com)
We aimed to determine the signaling pathway regulating cell metabolism and the mechanism related to the regulation of human tumor-associated macrophages (TAMs) in gastric cancer (GC). (cancerindex.org)
The current study aims to investigate the role of primary tumor volume, OTT and estimate α/β-ratio for p16-positive OPSCC, and to quantify the differences in radiosensitivity depending on p16-status. (lu.se)
CONCLUSION: Primary tumor volume plays a crucial role in predicting local tumor response, particularly in p16-positive OPSCC. (lu.se)
The objective of this study was to evaluate clinical and microscopic features of squamous cell carcinomas using immunohistochemical analysis and assessing biological markers of angiogenesis and tumor vascular activity (anti-CD31, anti-CD34, Factor VIII), cell proliferation (Ki-67), and loss of cell suppression (p53). (bvsalud.org)
WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. (lu.se)

Cutaneous squamous-cell carcinoma (cSCC), or squamous-cell carcinoma of the skin, also known as squamous-cell skin cancer, is, with basal-cell carcinoma and melanoma, one of the three principal types of skin cancer. (wikipedia.org)
Cutaneous squamous-cell carcinoma is more likely to spread to distant areas than basal cell cancer. (wikipedia.org)
Avoiding exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing cutaneous squamous-cell carcinoma. (wikipedia.org)
Once keratinocytes begin to grow uncontrollably, they have the potential to become cancerous and produce cutaneous squamous-cell carcinoma. (wikipedia.org)
Cutaneous squamous-cell carcinoma is the second-most common cancer of the skin (after basal-cell carcinoma, but more common than melanoma). (wikipedia.org)
Tobacco smoking also increases the risk for cutaneous squamous-cell carcinoma. (wikipedia.org)
Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the first and second most common types of skin cancer, respectively. (medscape.com)
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and one of the most common cancers overall in the United States. (medscape.com)
Have You Heard of Cutaneous Squamous Cell Carcinoma? (skincancer.org)
You may have heard about a new medication that was recently FDA approved for cutaneous squamous cell carcinoma (CSCC). (skincancer.org)
Preoperative imaging for high-risk cutaneous squamous cell carcinoma (HRcSCC) of the head and neck lacks robust diagnosis-specific data regarding utility and lacks established guidelines regarding indications. (ahns.info)
Appearing as part of the journal's Gems series, the review examines the role of cutaneous beta HPVs in the development of cutaneous squamous cell carcinoma. (who.int)
Evidence indicates that beta HPVs, together with ultraviolet (UV) radiation, contribute to the development of cutaneous squamous cell carcinoma, by facilitating the accumulation of UV-induced DNA mutations. (who.int)
Genetic factors play a role in the development of cutaneous squamous-cell carcinoma. (cdc.gov)
Inherited phenotypic characteristics - such as light skin, red or blonde hair, and light-colored eyes - are associated with an increased risk of cutaneous squamous-cell carcinoma. (cdc.gov)
A family history of cutaneous squamous-cell carcinoma is associated with a risk that is two to four times that in persons without a family history. (cdc.gov)
Inherited disorders such as xeroderma pigmentosum also increase the risk of cutaneous squamous-cell carcinoma, often with an earlier age at onset. (cdc.gov)

Concurrent chemotherapy and radiotherapy (CRT) has become standard treatment for many patients with advanced head and neck squamous cell carcinoma (HNSCC). (nih.gov)
Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease. (ujds.in)
Biologic implications of genetic changes in head and neck squamous cell carcinogenesis. (ujds.in)
The purpose of this work was to evaluate the potential of functional imaging with 18 F-FDG PET, 18 F-fluoromisonidazole PET, diffusion-weighted MRI, and dynamic contrast-enhanced MRI to provide an appropriate and reliable biologic target for dose painting in radiotherapy for head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
Since its introduction in the previous decade, intensity-modulated radiotherapy has been widely applied in head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
This study aims to construct a new prognostic gene signature in survival prediction and risk stratification for patients with Head and neck squamous cell carcinoma (HNSCC). (biomedcentral.com)
Head and neck squamous cell carcinoma (HNSCC), which includes a group of heterogeneous tumors from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx, is the seventh most common cancer in the world [ 1 ]. (biomedcentral.com)
GB-263 is under clinical development by Genor BioPharma and currently in Phase II for Head And Neck Cancer Squamous Cell Carcinoma. (pharmaceutical-technology.com)
According to GlobalData, Phase II drugs for Head And Neck Cancer Squamous Cell Carcinoma have a 26% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
Nasopharyngeal carcinoma (NPC) is a rare head and neck neoplasm worldwide. (intechopen.com)
As per DelveInsight analysis, the head and neck squamous cell carcinoma market is expected to grow positively at a significant CAGR during the study period (2019-2032). (advfn.com)
Head and neck squamous cell carcinoma (HNSCC) is a type of cancer that originates in the squamous cells lining the mucous membranes of the head and neck region. (advfn.com)
The head and neck squamous cell carcinoma epidemiology section provides insights into the historical and current head and neck squamous cell carcinoma patient pool and forecasted trends for individual seven major countries. (advfn.com)
BACKGROUND: Analyses of clinical outcomes following radiotherapy (RT) have advanced our understanding of fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC). (lu.se)
We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)
90% of head and neck cancers are squamous cell (epidermoid) carcinomas. (msdmanuals.com)
As with most head and neck sites, squamous cell carcinoma is the most common oral cancer. (msdmanuals.com)

In vivo and in vitro studies have shown that the upregulation of FGFR2, a subset of the fibroblast growth factor receptor (FGFR) immunoglobin family, has a critical role to play in the progression of cSCC cells. (wikipedia.org)
In conclusion, our research results demonstrate that Per2 suppresses OSCC progression by motivating autophagy, as well as inhibiting cell proliferation and promoting apoptosis, which were mediated by autophagy, in a PI3K/AKT/mTOR pathway-dependent manner. (jcancer.org)
Propidium iodide staining and flow cytometry analysis of Annexin V binding was utilized to measure the progression of the cell cycle and the induction of apoptosis. (techscience.com)
Njainday's research focuses on WNT5A, and its role in tumour cell progression and plasticity. (lu.se)

Furthermore, the proliferation of Th17 cells and Th17‑associated cytokines, including interleukin (IL)17, IL23 and RAR‑related orphan receptor γt, was analyzed by reverse transcription‑quantitative polymerase chain reaction. (spandidos-publications.com)
By using a chemical substance, called a "pan FGFR inhibitor", cell migration and cell proliferation in cSCC have been attenuated in vitro. (wikipedia.org)
Xanthoxyletin significantly inhibited the proliferation of oral cancer cells (IC₅₀, 10-30 µM) with lower cytotoxicity for normal cells. (medscimonit.com)
In addition, the impact of miR-126 on cell proliferation, apoptosis, migration and invasion was detected in ESCC cell lines. (spandidos-publications.com)
miR-126 mimics downregulated the expression of IRS-1 and GOLPH3 protein and suppressed the proliferation, migration and invasion of ESCC cells, whereas miR-126 inhibitors led to the opposite results. (spandidos-publications.com)
miRNAs are involved in biological and pathological processes including cell differentiation, proliferation, apoptosis and metabolism, and they are emerging as highly tissue-specific biomarkers with potential clinical application for defining cancer types and origins. (spandidos-publications.com)
Methods: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. (um.edu.my)
TYRO3 or AXL gene knockdown reduced cell proliferation/colony formation. (nature.com)
In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis. (nih.gov)
With its absence, the human body will be functioning without its "brake" of cell proliferation. (pharmiweb.com)
Moreover, reduction of OPN suppressed cell proliferation, colony formation, and in vivo tumorigenic ability of OSCC cell lines Tca8113. (jcancer.org)
Overexpression of Per2 promoted autophagy and apoptosis in OSCC cells and inhibited proliferation. (jcancer.org)
When the AKT activator SC79 was added to Per2-overexpressing OSCC cells, the increased autophagy, apoptosis and decreased proliferation were significantly rescued. (jcancer.org)
MTT assay was performed to determine the proliferation of cancer cells. (techscience.com)
In addition, overexpression of ZYX in hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration and invasion, whereas ZYX knockdown had the opposite effects (SK HEP-1, Huh-7). (techscience.com)
We treated TMZ-resistant cells U251-TMZ and T98G-TMZ to normoxia or hypoxia and silenced NUPR1 in hypoxia-treated U251-TMZ and T98G-TMZ cells to assess cell viability, proliferation, apoptosis, LC3-II/LC3-I and p62 expressions, and autophagic flux under different concentrations of TMZ. (techscience.com)
Kinesin Family Member C1 (KIFC1) Accelerates Proliferation and Invasion of Endometrial Cancer Cells Through Modulating the PI3K/AKT Signaling Pathway. (nih.gov)
Typically, SCCs show an uncontrolled proliferation of cells on the squamous layer of the epithelium, where cells express various degrees of similarity with their original cells 1 . (bvsalud.org)

Oral squamous cell carcinoma (OSCC) is a prevalent malignancy associated with a poor prognosis. (nih.gov)
We conducted a systematic review to evaluate the differences in GLUT/SGLT expression between OSCC and normal oral keratinocytes (NOK), as well as their role in the pathophysiology and prognosis of OSCC. (nih.gov)
In conclusion, the data demonstrates that GLUT-1 and GLUT-3 have a role in the pathophysiology of OSCC and represent valuable biomarkers to aid OSCC diagnosis and prognostication. (nih.gov)
However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). (hindawi.com)
Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). (hindawi.com)
Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. (hindawi.com)
Oral squamous cell carcinoma (OSCC) is the third most common cancer in developing countries and ranks sixth among systemic cancers worldwide [ 1 , 2 ]. (hindawi.com)
However, there is little known about the role of circRNA in OSCC. (hindawi.com)
We first confirmed that hsa_circ_001242, which is located at chr10: 17157441-17168917 (Figure 1 ), was significantly downregulated in OSCC cell lines and OSCC tissues. (hindawi.com)
Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma (OSCC), especially in patients with advanced tumors. (um.edu.my)
OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. (um.edu.my)
Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. (um.edu.my)
Results: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar concentrations. (um.edu.my)
More than 90% of oral malignant neoplasms are squamous cell carcinomas (OSCC), which are among the ten most frequent malignancies in humans and this entity is the eighth leading cause of cancer-related death worldwide ( 1 ). (iiarjournals.org)
Development and progress of OSCC is a multistep process involving various factors, while individual genetic susceptibility is also believed to play an important role. (iiarjournals.org)
Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. (jcancer.org)
Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. (jcancer.org)
In addition, there was a strong positive correlation between mTORC1 activity and OPN expression in OSCC tissues and cell lines. (jcancer.org)
However, the biological functions and mechanism of Per2 in OSCC (OSCC: oral squamous cell carcinoma) remain unclear. (jcancer.org)
In this study, OSCC cells with stable overexpression or silencing of Per2 were established to explore their biological functions and mechanism in vivo and in vitro . (jcancer.org)
We discovered that the expression of Per2 decreases in OSCC cells. (jcancer.org)
The opposite results were obtained in Per2-silenced OSCC cells. (jcancer.org)
In Per2-overexpressing OSCC cells, the expression levels of PIK3CA, p-AKT, p-mTOR, p62 and Beclin1 were significantly reduced and the LC3B II/I ratio was significantly increased. (jcancer.org)
however, how LAMC2 signaling contributes to the occurrence and development of OSCC and the role of autophagy in OSCC has not been fully explored. (techscience.com)
This study aimed to analyze the role and mechanism of LAMC2 signaling in OSCC and the involvement of autophagy in OSCC. (techscience.com)
A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)

The cause of penile squamous cell carcinoma (SCC) is unclear, although human papillomavirus (HPV) appears to play a major role in many cases. (medscape.com)
Penile squamous cell carcinoma (PSCC) is an orphan malignancy with poorly understood biology and suboptimal systemic therapy. (oncotarget.com)
The biology and drivers of penile squamous cell carcinoma (PSCC), an orphan disease, are poorly understood. (oncotarget.com)

But emerging evidence shows a link between the human papillomavirus (HPV) and squamous cell carcinomas of the skin. (skincancer.org)
The most exciting technology with tremendous potential to transform both research and clinical practice is next generation sequencing and Dr. Smith has been using this powerful technology to study the role that human papillomavirus plays in the development of a number of different cancers. (selectbiosciences.com)
4 - 6 This patient had never received the human papillomavirus (HPV) vaccine, and HPV infection has a potential role in the transformation of cells into precancerous and cancerous oral lesions. (aafp.org)

The results revealed that the prevalence of Th17 cells in patients with LSCC was elevated in their primary tumors, as well as in peripheral blood, compared with that in healthy controls. (spandidos-publications.com)
The present study revealed that patients with LSCC have elevated levels of Th17 cells in their primary tumors and peripheral blood compared with those in healthy controls. (spandidos-publications.com)
These melanocytic cells are of neuroectodermal origin, and melanocytic tumors may arise from these cells. (medscape.com)
Nasopharyngeal carcinoma (NPC) is a rare disease and one of the most common types of malignancies that appear in the nasopharynx, which is the narrow tube passage behind the nasal cavity and one of the malignancies associated with the Epstein-Barr virus (EBV) and is considered one of the malignant and rare tumors in most parts of the world and is distinguished by distribution geographical and ethnic [ 1 ]. (intechopen.com)
GEP-NENs are subdivided according to their differentiation into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). (karger.com)
Specifically the research showed that the most significantly deregulated genes in the HPV-positive tumors are cell cycle regulators. (moffitt.org)
These data provided evidence that HPV-positive tumors may be more sensitive to chemotherapy and molecular inhibitors that specifically target cell cycle. (moffitt.org)
Macrophages are essential inflammatory cells which regulate the features of immune reactions within tumors. (cancerindex.org)
Large tumors should be harder to cure if a successful RT requires the sterilization of all clonogenic cells. (lu.se)

95% of all laryngeal malignancies are squamous cell carcinomas (SCCs) ( 2 ). (spandidos-publications.com)
Squamous cell carcinomas (SCCs) are among the malignancies most commonly diagnosed affecting the oral cavity, accounting for 90% of all cases of neoplasms. (bvsalud.org)

Cell Mol Biol (Noisy-le-grand), 2016 Jan 22. (nih.gov)

Approximately 90% of oral cancers are squamous. (aafp.org)
Half of all hard palate cancers are squamous cell carcinomas (SCCs) as seen in the image below. (medscape.com)

Abstract Hepatocellular carcinoma (HCC) is a common malignancy that is driven by multiple genes and pathways. (techscience.com)
Abstract Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. (techscience.com)
ABSTRACT The study's objective was to evaluate the clinical significance of sCD40L in HCV- associated hepatocellular carcinoma (HCV-HCC) patients. (who.int)

This has led to controversy concerning the role of neck dissection (ND) in this setting. (nih.gov)
After the biopsy confirmed squamous cell carcinoma, he underwent subtotal left glossectomy, bilateral radical neck dissection, tracheotomy, and radical forearm free flap reconstruction. (aafp.org)

Oropharyngeal Squamous Cell Carcinoma Oropharyngeal cancer refers to cancer of the tonsil, base and posterior one third of the tongue, soft palate, and posterior and lateral pharyngeal walls. (msdmanuals.com)
Soft palate carcinomas are staged as oropharyngeal cancers according to the American Joint Committee on Cancer (see Staging). (medscape.com)

cSCC begins from squamous cells found in the upper layers of the skin. (wikipedia.org)
Mutations in the TPL2 gene cause over-expression of FGFR2, which activates the mTORC1 and AKT pathways in both primary and metastatic cSCC cell lines. (wikipedia.org)
Actinic keratosis and basal cell carcinoma are easily excised and have a very good prognosis, while cSCC has a poor prognosis, especially if it invades the lymph nodes and adjacent vital structures. (medscape.com)
of those, approximately 80% were basal cell carcinoma (BCC) and 20% were cSCC. (medscape.com)
Given the central role that ultraviolet radiation (UVR) plays in the pathogenesis of cSCC, methods aimed at decreasing UVR exposure form the cornerstone of cSCC prevention. (medscape.com)

Squamous cell carcinomas are the most commonly diagnosed oral malignancy, accounting for about 90% of all malignant oral lesions. (bvsalud.org)

The current debate is focused on N2-N3 disease and the ability of a clinical complete response to predict the absence of viable cells in the ND specimen. (nih.gov)
The present study investigated the expression of T helper (Th)17 cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their clinical significance in providing new therapeutic insights. (spandidos-publications.com)
Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study. (springer.com)
Results: We failed to find any significant association of CCND1 G870A with risk of oral carcinomas in this German population, with clinical and pathological features of the tumours or with overall survival of the patients. (iiarjournals.org)
Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (pharmaceutical-technology.com)
On therapeutic front, we have developed a hexapeptide, Foxy5 (an agonist of WNT5A) which is currently in Phase1 clinical trial for breast cancer, prostate cancer and colon carcinoma (NCT02020291). (lu.se)

The prevalence of Th17 cells and their receptors in patients with LSCC was studied using immunohistochemical analysis via tissue microarray technology. (spandidos-publications.com)

The effect of miR-126 expression on target proteins was assessed using miR-126 mimics or miR-126 inhibitors in ESCC cell lines. (spandidos-publications.com)
Role of microRNA (miRNA) in identifying the patients of ESCC and monitoring the response to treatment modalities like chemotherapy, radiotherapy and chemoradiotherapy (CRT) is recently emerging. (gastrores.org)

A biopsy should be performed for any lesion suspected of being a cutaneous neoplasm to rule out basal cell carcinoma and other dermal lesions. (medscape.com)
Basal cell carcinoma is the most common of the carcinomas with 70 to 80% prevalence, it is formed in the mother cells of the skin, that has a higher possibility of mutation because from these cells all the other cells in the skins are born. (differencebetween.net)
Basal cell carcinoma (BCC): As a third difference, we have a less colorful pattern in the carcinomas, BCC also grows slower and it appears dry and peeling. (differencebetween.net)

Patterns of recurrence after oesophagectomy and postoperative chemoradiotherapy versus surgery alone for oesophageal squamous cell carcinoma. (springer.com)

Among malignant neoplasms of the penis, squamous cell carcinoma (SCC) is the most common. (medscape.com)
Nonsquamous cell cancers, including minor salivary gland cancers, sarcomas, and melanomas, account for the other half (see the histologic distribution of hard palate malignant neoplasms and the histologic types and frequencies of minor salivary gland neoplasms of the palate below). (medscape.com)

However, studies have also reported that aberrant overexpression of miR-126 contributes to carcinogenesis, suggesting that miR-126 acts as an oncogene in gastric cancer and oral squamous cell carcinoma ( 16 , 17 ). (spandidos-publications.com)
Journal Article] Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells. (nii.ac.jp)
Fra-1 is highly expressed in gastric cancer (GC), affects the cycle distribution and apoptosis of GC cells, and participates in GC occurrence and development. (techscience.com)
Background: Vestigial like family member 3 (VGLL3) is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma, but its role in gastric cancer (GC) is unclear. (researchgate.net)

Squamous-cell cancers of the lip and ears have high rates of local recurrence and distant metastasis. (wikipedia.org)
HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail. (nih.gov)

Cell apoptosis was investigated using 4',6-diamidino-2-phenylindole (DAPI), annexin V, and propidium iodide (PI) fluorescence flow cytometry, which was also used to investigate the cell cycle. (medscimonit.com)
Growing knowledge regarding molecules that control the cell cycle and apoptosis is expected to contribute to the identification of new therapy targets. (iiarjournals.org)
They can trigger apoptosis, a process of programmed cell death, when a cell becomes irreparably damaged or poses a risk of becoming cancerous. (pharmiweb.com)

In situ carcinomas may progress to invasive lesions. (medscape.com)

Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue. (mcw.edu)
Surgical specimens from 81 patients with squamous cell carcinoma of the tongue were studied using immunohistochemistry. (mcw.edu)
We aimed to examine this polymorphism in patients with oral carcinoma. (iiarjournals.org)
Materials and Methods: Genotyping of CCND1 G870A was determined by means of direct sequencing in 83 patients with oral carcinomas and in 102 healthy controls. (iiarjournals.org)
Since the previous findings were of explorative nature, we typed CCND1 G870A in a total of 83 oral carcinoma patients of our own collective and 102 healthy controls, and evaluated its predictive and prognostic value. (iiarjournals.org)
Here we show that T cell immunity against commensal papillomaviruses suppresses skin cancer in immunocompetent hosts, and the loss of this immunity-rather than the oncogenic effect of HPVs-causes the markedly increased risk of skin cancer in immunosuppressed patients. (nature.com)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
Six patients seen at the Stomatology Service of a university hospital in Canoas, southern Brazil, with a suspected diagnosis of squamous cell carcinoma were analyzed. (bvsalud.org)
Bioinformatics analysis revealed that ABHD11-AS1 levels are up-regulated in lung adenocarcinomas (LUADs) tissues and associated with worse overall survival of LUAD patients but not in lung squamous cell carcinomas. (cdc.gov)

Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. (buzzsprout.com)

Cluster of differentiation (CD) 4 + T cells are essential organizers of cell-mediated immunity, participating in each stage of the immune response. (spandidos-publications.com)
SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
[ 12 , 13 ] The time course for the appearance of squamous differentiation in the carcinoma varies from 3 months to many years (up to 9 years) after therapy. (medscape.com)
Transient SIM2 expression followed by 3D culture induced expression of differentiation markers and suppressed epithelial-mesenchymal transition - and basal- cell markers. (bvsalud.org)

Our data therefore argue against an oncogenic role of cutavirus in malignant melanoma. (cdc.gov)
The melanoma is a mutation that starts on the melanocytes, these are the cells that have the pigment (melanin) that defines the different color tones of our skins, so race war is basically a war against a microscopic pigment. (differencebetween.net)
Along with family genetic predisposition, it increases the chances of having a carcinoma or melanoma (3). (differencebetween.net)

Gan N, Zou S, Hang W, Yang D, Zhang X, Yin Y. Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma. (jcancer.org)

Together with mucus-secreting goblet cells within the stratified epithelium, melanocytic cells are found in the basal layer of the conjunctiva. (medscape.com)

Laryngeal carcinoma is the 11th most common form of cancer in humans worldwide ( 1 ). (spandidos-publications.com)
Interleukin (IL)17-producing Th17 cells, which are different from Th1 and Th2 cells, have been described as serving critical roles in inflammation and autoimmune diseases, as well as in cancer development ( 8 - 11 ). (spandidos-publications.com)
This study aimed to investigate the effects of xanthoxyletin, a plant-derived coumarin, on human oral squamous cancer cells in vitro and in mouse xenografts in vivo . (medscimonit.com)
The study included SCC-1 human oral cancer cells and EBTr normal embryonic bovine tracheal epithelial cells, which were treated with 0 µM, 5 µM, 10 µM, and 20 µM of xanthoxyletin for 24 hours. (medscimonit.com)
Recent studies have shown that circular RNAs may play an important role in human cancer. (hindawi.com)
Studies have shown that the expression of miR-126 is downregulated in cancers such as non-small cell lung cancer and colon cancer ( 14 , 15 ), suggesting that the downregulation of miR-126 is significantly related to the occurrence and development of cancer. (spandidos-publications.com)
It is observed that aggregation of genetic alterations is the ground for advancement of a normal cell to cancer cells, which is known as a multi-step carcinogenesis. (ujds.in)
found cutavirus DNA in 1 of 10 melanomas from Denmark and suggested investigating the role of cutavirus in cutaneous cancer ( 3 ). (cdc.gov)
Journal Article] MicroRNA MIR21 and T Cells in Colorectal Cancer. (nii.ac.jp)
Now talking about skin cancer there are 2 major groups: melanomas and non-melanomas (all types of carcinomas on the skin). (differencebetween.net)
Previous studies have not established a causative role for HPVs in driving the development of skin cancer. (nature.com)
RNA and DNA in situ hybridization probes for 25 commensal β-HPVs revealed a significant reduction in viral activity and load in human skin cancer compared with the adjacent healthy skin, suggesting a strong immune selection against virus-positive malignant cells. (nature.com)
Our findings reveal a beneficial role for commensal viruses and establish a foundation for immune-based approaches that could block the development of skin cancer by boosting immunity against the commensal HPVs present in all of our skin. (nature.com)
Fig. 3: Reduced β-HPV transcripts in skin cancer cells and presence of β-HPV-specific CD8 + T cells in healthy human skin indicates a selective pressure by antiviral immunity against malignant cells with active HPV. (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Fruits and seed extracts of Annona montana have significant cytotoxic potential in several cancer cells. (techscience.com)
This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1 (IGF-1) stimulation. (techscience.com)
Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. (techscience.com)
In this study, exosomes released from HeLa cervical cancer cells were loaded with raloxifene to increase its bioavailability, and an aptamer was attached to the exosome membrane for targeting only HeLa cells. (techscience.com)
His laboratory works on studying the molecular alterations that underlie cancer development and he also studies the role that the common fragile sites play in cancer development. (selectbiosciences.com)
The most common oral cancer is squamous cell carcinoma (see image below). (medscape.com)
It was found that the lncRNA ABHD11-AS1 expression levels are up-regulated in chronic Cr(VI) exposure-transformed human bronchial epithelial cells, chronically Cr(VI)-exposed mouse lung tissues, and human lung cancer cells as well. (cdc.gov)
It was further determined that up-regulation of ABHD11-AS1 expression plays an important role in chronic Cr(VI) exposure-induced cell malignant transformation and tumorigenesis, and the stemness of human lung cancer cells. (cdc.gov)
Treatment is with surgery, radiation, or both, although surgery plays a larger role in the treatment of most oral cavity cancer. (msdmanuals.com)
The incidence of keratinocyte cancer (basal cell and squamous cell carcinomas of the skin) is 17-fold lower in Singapore than the UK, despite Singapore receiving 2-3 times more ultraviolet (UV) radiation. (cdc.gov)
Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion. (lu.se)
Squamous cell carcinoma is the most prevalent histologic subtype of vulvar cancer, accounting for the majority of cases. (bvsalud.org)
Imaging plays an important role in managing vulvar cancer. (bvsalud.org)

Mice with natural immunity against MmuPV1 after colonization and acquired immunity through the transfer of T cells from immune mice or by MmuPV1 vaccination were protected against skin carcinogenesis induced by chemicals or by ultraviolet radiation in a manner dependent on CD8 + T cells. (nature.com)
The goal of this study is to investigate the mechanism of Cr(VI)-induced lung carcinogenesis focusing on the role of the lncRNA ABHD11 antisense RNA 1 (tail to tail) (ABHD11-AS1). (cdc.gov)
Together, these findings indicate that lncRNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote cell malignant transformation and lung carcinogenesis. (cdc.gov)

The answer is D: squamous cell carcinoma, which required urgent biopsy and surgical excision. (aafp.org)

The present review spotlights on understanding the molecular mechanism and the genetic factors which is responsible for alteration in the cell which leads to oral squamous cell carcinoma. (ujds.in)
The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. (techscience.com)
However, the detailed mechanism of Fra-1 in GC is unclear, such as the identification of Fra-1-interacting proteins and their role in GC pathogenesis. (techscience.com)
This study investigated the mechanism of NUPR1 in TMZ resistance in hypoxia-treated glioma cells and its mechanism in modulating autophagy. (techscience.com)

Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): A randomised, phase 3, open-label, 2×2 factorial trial. (buzzsprout.com)

It has been reported that miR-126 is located on chromosome 9q34.3 within the host gene encoding for epidermal growth factor like-7 (EGFL-7), an endothelial cell-derived, secreted inhibitor of smooth muscle cell migration and a regulator of blood vessel formation ( 12 , 13 ). (spandidos-publications.com)
L1CAM plays a role in neural development, axon guidance, and cell migration. (pharmiweb.com)
In particular, the interchangeable modes of migration tumour cells utilise during invasion and the factors involved. (lu.se)

Nehal, K. S. & Bichakjian, C. K. Update on keratinocyte carcinomas. (nature.com)

2 cm in diameter, growth into the fat layer and along nerves, presence of lymphovascular invasion, poorly differentiated cell architecture on histology, or thickness greater than 6 mm. (wikipedia.org)

Smad7 is a key negative regulator of the transforming growth factor β (TGF-β) signaling and plays an important role in modulating a large array of biological processes. (biomedcentral.com)

The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)

Squamous cell carcinoma of the tongue may also result from any chronic irritation, such as dental caries, overuse of mouthwash, chewing tobacco, or the use of betel quid. (msdmanuals.com)
About 40% of intraoral squamous cell carcinomas begin on the floor of the mouth or on the lateral and ventral surfaces of the tongue. (msdmanuals.com)

The characteristic features of oral squamous cell carcinoma include lateral location, fungating appearance, whitish color, and central ulceration. (aafp.org)

High expression of TYRO3 and AXL was detected in LMS cell lines. (nature.com)
The expression and significance of the HOXA7 gene in oral squamous cell carcinoma. (nih.gov)
All-trans retinoic acid inhibits HOXA7 expression in leukemia cell NB4. (nih.gov)
Top pathways upregulated in both the kinase activity and gene expression platforms were PTEN, STAT3, GNRH, IL-8 and B cell receptor signaling. (oncotarget.com)
We found that hypoxia upregulated NUPR1 expression and autophagy while NUPR1 silencing suppressed hypoxia-induced TMZ resistance and autophagy in glioma cells. (techscience.com)

Squamous cell carcinoma is common in men, with an average age of onset of 50 years. (aafp.org)

Anatomy16

Organisms7

Diseases109

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Psychiatry and Psychology1

Phenomena and Processes32

Disciplines and Occupations1

Information Science5

Health Care17

Esophageal15

Tumor35

Cutaneous squamous17

Head and Neck19

Progression4

Proliferation19

OSCC26

Penile squamous cell carc3

Human papillomavirus3

Tumors9

Malignancies2

20161

Cancers are squamous2

Abstract3

Neck2

Oropharyngeal2

CSCC5

Malignancy1

Clinical6

Studied using immunohistochemical an1

ESCC2

Basal-cell carc3

Chemoradiotherapy1

Malignant neoplasms2

Gastric cancer4

Metastasis2

Apoptosis3

Lesions1

Patients9

Epidermoid1

Differentiation4

Melanoma3

MTOR1

Epithelium1

Cancer28

Carcinogenesis3

Biopsy1

Mechanism4

Treatment1

Migration3

Keratinocyte1

Poorly1

Biological1

Ligand1

Tongue2

Lateral1

Expression5

Common1