Robust models genetic. Medical search. Frequent questions

The two-stage design is often adopted in genome-wide association studies (GWASs) to search for genetic variants underlying susceptibility for complex diseases. (biomedcentral.com)
We applied the VE-GD model to predict protection mediated by existing vaccines against new genetic variants and validated the results by published real-world and clinical trial data, finding high concordance of predicted VE with observed VE. (nature.com)
However, the protective effect of the various vaccine products is challenged by new genetic variants. (nature.com)
Among all the influencing factors, emerging genetic variants relative to the vaccine strain play a critical role in determining vaccine effectiveness. (nature.com)
Working closely with other collaborators active in this field, we aim to identify specific genetic variants that cause this predisposition and to investigate the kinds of biological processes that they take part in. (brookes.ac.uk)
Genome-wide association studies have identified common genetic effects on handedness or brain asymmetry, which mostly involve variants outside protein-coding regions and may affect gene expression. (mpi.nl)
In this study, we used an enrichment of scRNA-seq mitochondrial reads and a robust computational method to identify clonally relevant mitochondrial variants as endogenous genetic barcodes for clonal tracking of early embryonic hematopoiesis from hPSC. (biorxiv.org)
Our study highlights the power of mitochondrial variants as an endogenous marker for clonal tracking in modeling human development from stem cells. (biorxiv.org)
Our results show that there is a genetic contribution to musical aptitude that is likely to be regulated by several predisposing genes or variants. (bmj.com)
Pharmacogenomic testing, which uses a blood, saliva, or buccal swab sample, could help identify genetic variants involved in drug metabolism and response as well as guide prescribing and reduce adverse effects, the authors write. (medscape.com)
The resultant increase in transmission of the virus has brought about genetic expansion of viruses, providing ample opportunities for successful selections of viral variants of high epidemic potential or virulence as suggested by molecular epidemiological studies on Cuba and Puerto Rico. (who.int)
F6 contains 6555 ClinVar variants with reliable structural models. (lu.se)
DANN: a deep learning approach for annotating the pathogenicity of genetic variants. (lu.se)

Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
Metabolic engineering of microbes has primarily focused on modifying the model organisms E. coli and S. cerevisiae due to their fast and robust growth on inexpensive fermentation broths and the wealth of genetic tools available to them. (aiche.org)
In addition to conventional metabolic engineering to increase biochemical production, we will develop new tools to enhance enzyme expression and create gene knockouts in non-model organisms. (aiche.org)
The EMBL-EBI Complex Portal (www.ebi.ac.uk/intact/complex) is a central service that provides manually curated information on stable, on macromolecular complexes from model organisms. (stanford.edu)
Most organisms are more closely related to nearby than distant members of their species, creating spatial autocorrelations in genetic data. (elifesciences.org)

Thus, the objectives of this study were twofold: 1) to compare four alternative non-linear models: Poisson, negative binomial, zero-inflated Poisson and zero-inflated negative binomial based on their goodness of fit for quantifying genetic variation, as well as heritability for tick-count and 2) to investigate potential response to selection against tick-count based on truncation selection given the estimated genetic parameters from the best fit model. (nofima.no)
Using the first mouse model, they found that variation in the activity of certain genes regulating core E. coli functions correlated with how effectively the strains infected the animals. (nih.gov)
In natural populations, local mate selection and dispersal create correlations between geographic location and genetic variation - each individual's genome is a mosaic of material inherited from recent ancestors that are usually geographically nearby. (elifesciences.org)
Robust classification of protein variation using structural modelling and large-scale data integration. (lu.se)

The Cochran-Armitage trend test (CATT) [ 13 , 14 ] derived under the additive (in log scale) genetic risk model is also used in single-maker analysis, which is optimal when the underlying additive genetic model is true. (biomedcentral.com)
The purpose of this study was to determine if the variability observed in this behavioural characteristic has an additive genetic component and if so, to estimate heritability (h2). (researchgate.net)
and (5) heritability estimated on dam components is hD2=0.46, which implies that the maternal effect (genetic and environmental) is an important factor in this type of behaviour.It is concluded that there is an additive genetic, and therefore, hereditary factor for dominant-aggressive behaviour in the English Cocker Spaniel. (researchgate.net)

The following lists a small number of those studies: Tickman et al, describe developing multi-layer CRIPRa/i circuits for genetic programs using Tellurium/libroadrunner as the computational application. (wikipedia.org)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)
The new Northwestern technology uses computational modeling to more efficiently identify useful genetic designs before building them in the lab. (northwestern.edu)
Her lab uses computational models to better understand -- and subsequently control -- cell decisions. (northwestern.edu)
The research team used a "toolkit" of genetic parts invented in Leonard's lab and paired these parts with computational tools for simulating many potential genetic programs before conducting experiments. (northwestern.edu)
In other situations, interpretability might be able to help scientists gain new ``knowledge'' that is learnt by the neural networks (e.g., computational genomics), and neural network based genetic motif discovery is such a field. (bham.ac.uk)

Structural equation modeling was used to evaluate the genetic and environmental correlations and gene-environment interactions between the career-goal appraisals and depressive symptoms. (cambridge.org)
In this pre-registered study, we use a mouse dataset from the Province of Ontario Neurodevelopmental Network, which comprises structural MRI data from over 2000 mice, including genetic models for autism spectrum disorder, to reveal the scope and magnitude of hemispheric asymmetry in the mouse. (mpi.nl)

Inhibition of parkin or Pink1 through the induction of stable RNAi transgene in the Ddc-Gal4-expressing neurons results in such phenotypes to model PD. (sdbonline.org)
In this study we comprehensively assess the shared genetic basis of impaired lung function and lung cancer risk by conducting genome-wide association analyses in the UK Biobank cohort to identify genetic determinants of three pulmonary phenotypes, forced expiratory volume in 1s (FEV 1 ), forced vital capacity (FVC), and FEV 1 /FVC. (nature.com)
We examine the genetic correlation between pulmonary function phenotypes and lung cancer, followed by Mendelian randomization (MR) using novel genetic instruments to formally test the causal relevance of impaired pulmonary function, using the largest available dataset of 29,266 lung cancer cases and 56,450 controls from the OncoArray lung cancer collaboration 16 . (nature.com)
The model included unique patient characteristics, such as metabolizer phenotypes, and followed the experience of patients through diagnosis, treatment, and recurrence. (medscape.com)

Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)
There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
Several approaches have tried to go from the gene to the whole plant in crop simulation modeling with varying success. (usda.gov)
These ES cells allow for the generation of gene‐targeted mice on a C57BL/6 genetic background without the need for multiple backcrossing of mice. (umassmed.edu)
By comparing this score with how well each strain infected bladders in a standard female mouse model, the researchers determined that having a higher PUF gene score did not correlate with either strength (robust, variable, or deficient) of an acute infection, or with the ability to cause chronic infection in one mouse model. (nih.gov)
Few in vivo studies identified whole lung gene markers associated with MWCNT exposure, but did not compare CNT vs. asbestos genetic response. (cdc.gov)
Here, we present robust SWCNT, MWCNT, ASB and UFCB specific gene marker sets for in vitro chronically exposed SAEC. (cdc.gov)
In conclusion, toxicogenomic profiling in a chronic in vitro exposure model identified particle-specific gene markers and known lung cancer markers which can potentially aid in assessing CNT exposure and detection of early disease markers. (cdc.gov)
The genetic changes associated with Greig cephalopolysyndactyly syndrome include insertions or deletions of a small amount of DNA and changes in single DNA building blocks (base pairs) in critical regions of the gene. (medlineplus.gov)
The genetic changes that cause Greig cephalopolysyndactyly syndrome prevent one copy of the gene in each cell from producing any functional GLI3 protein. (medlineplus.gov)
The vectors are used in the production of disease models, experimental gene therapy and basic experimental research of brain functions. (lu.se)

Data were extracted on statistical properties of models, details of internal or external validation, and use of risk scores beyond the studies that developed them. (nih.gov)
Quantitative data were tabulated to compare model components and statistical properties. (nih.gov)
Some but not all risk models or scores had robust statistical properties (for example, good discrimination and calibration) and had been externally validated on a different population. (nih.gov)
By simple manipulation of a powerful model, students experience the power of statistical techniques and learn why scientists require large numbers of individuals to zone in on a possible genomic location. (concord.org)
To unravel the biological background of music perception, using molecular and statistical genetic approaches. (bmj.com)
Our detailed model-building strategy and robust statistical validation protocols tackle the formidable challenge of working on small datasets, which is often the case in biological and medical data. (lu.se)

The cost efficient two-stage design is often used in genome-wide association studies (GWASs) in searching for genetic loci underlying the susceptibility for complex diseases. (biomedcentral.com)

Our data suggests that targeting the genetic viability of rat populations may be another important component for integrated pest management (IPM) strategies, designed to reduce urban rats. (frontiersin.org)
Group genetic counselling is an effective method for education and decision support in the prenatal context, and may serve as a model for other clinical populations facing genetic screening decisions. (ices.on.ca)
Though the autosomal genome is much more difficult when it comes to implementing many of the tricks & techniques of phylogeography outlined above, it does offer up a much more robust and thorough picture of genetic relationships between contemporary populations. (discovermagazine.com)

The resulting estimates of variance components and high heritability (0.32) led us to conclude that genetic determinism is relevant on tick count. (nofima.no)

The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed. (researchgate.net)
Based on 78 vaccine efficacy or effectiveness (VE) data from 49 studies and 1,984,241 SARS-CoV-2 sequences collected from 31 regions, we analyzed the relationship between genetic distance (GD) of circulating viruses against the vaccine strain and VE against symptomatic infection. (nature.com)
Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
Other autoimmune diseases are included where robust mechanistic data exist. (frontiersin.org)
However, tick-count data is a discrete variable and, thus, standard procedures using linear models may not be appropriate. (nofima.no)
Our results showed that zero-inflated Poisson was the most parsimonious model for the analysis of tick count data. (nofima.no)
Qualitative data were analysed thematically to identify mechanisms by which use of the risk model or score might improve patient outcomes. (nih.gov)
This sort of genetic data is useful because these mtDNA lineages are passed from mother to daughter to daughter to daughter, and so forth, and are not subject to the confounding effects of recombination. (discovermagazine.com)
By taking genetic, environmental and lifestyle factors into account, and by relying heavily on big data analysis, precision medicine aims to identify risk factors and biomarkers that predict health outcomes and help choose the best treatment for the patient. (cambridge.org)
Similarly, US President Barack Obama announced early in 2015 that he aims to launch a US$215 million effort that will couple patients' physiological and genetic data to improve the 'precision' of individual treatment (Reardon, Reference Reardon 2015 ). (cambridge.org)
Recently, we are working on data-driven MOEAs with the help of surrogate models to address the above task, as the data collected is very helpful to guide the search towards the true Pareto front (PF) of the problem. (beacon-center.org)
However, the huge amount of data makes it time-consuming to build data-driven models, hence we resort to data mining techniques as preprocessing. (beacon-center.org)
To define the model structure, most existing MOC methods are primarily driven by the choice of suitable clustering criteria (objectives) in order to address specific types of data. (beacon-center.org)
Still in use today, this platform is now funded by the ERA4TB program under the IMI's AMR Accelerator Initiative and provides a robust and comprehensive set of data which drug developers use for analysis and help evolve concepts such as biomarkers, predictability of earlier stage clinical data, and clinical trial design. (c-path.org)
For the study, the investigators analyzed blood samples, genetic data, and physical and health questionnaires collected by the UK Biobank, a database of information from more than half a million UK participants who were recruited from 2006 to 2010. (medscape.com)
According to British Columbia administrative data from 2015 to 2020, the model simulated a population of 194,149 adults and incorporated 40 different antidepressants and other treatments, including electroconvulsive therapy (ECT) and psychotherapy. (medscape.com)
By incorporating the perspectives of patients with lived and living experience into this model, alongside robust data sets, we were able to carefully simulate the treatment journey of people with major depression," Ghanbarian said. (medscape.com)

In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)
As a result, plasticity may evolve or canalization may occur within a given epoch depending on the relative mutation rate of genic and epigenetic contributions to phenotype, highlighting the importance of genetic conflict on the evolution of plasticity. (rockefeller.edu)
The postnatal restoration of one dystrophin isoform using genetic therapies in the DMD mouse model improves the neurobehavioral phenotype. (europa.eu)
deep phenotype patients to define robust outcome measures. (europa.eu)

Although the mechanisms of immune escape caused by the new mutations are being elucidated in experimental studies, an integrative framework to quantify the effect of genetic mismatch on VE would be instrumental for efficient evaluation of vaccine protection for any country in real time. (nature.com)
We explored the use of naturally occurring somatic mutations in mitochondrial transcripts detected in single-cell RNA-seq as genetic lineage barcodes in HPSC. (biorxiv.org)
Germline genetic testing for pathogenic mutations in people diagnosed with cancer is recommended for several cancer types and has been shown to have a positive effect on survival. (cdc.gov)
Animal models of human BTK mutations are confined to mice at this time. (medscape.com)

After years of frustration, researchers are getting genetic material from old bones in warm places. (natureasia.com)

This approach requires nonlinear optimization, and thus, we use a robust optimization technique (a genetic algorithm) for this fit. (confex.com)
We used an existing crop simulation model, CropSyst, and modified it by incorporating a different phenology algorithm and adding a plant height algorithm that we developed. (usda.gov)
While our main goal of predicting final plant height was met and we were able to capture the genotype by environment interaction, the newly developed plant height algorithm was partially constrained by the phenology algorithm for accurately predicting within-season plant height due to some unique input requirements of the crop simulation model used in this effort. (usda.gov)
The crop simulation model CropSyst was modified by incorporating a different phenology algorithm and adding a plant height algorithm. (usda.gov)

Although the researchers found a link between the genetic predisposition for depression ― as indicated by a polygenic risk score ― and higher levels of inflammation, this association disappeared when higher BMI and smoking were removed from the analysis. (medscape.com)

This contrasted with autoimmune disorders such as rheumatoid arthritis , in which the association between genetic risk and inflammation remained after correcting for behavioral factors. (medscape.com)

These described the prospective development or validation, or both, of 145 risk prediction models and scores, 94 of which were studied in detail here. (nih.gov)
We have deployed a host of machine learning algorithms, including the popular state-of-the-art LightGBM (a gradient boosting model), for building prediction models. (lu.se)

We found that the GD of the receptor-binding domain of the SARS-CoV-2 spike protein is highly predictive of vaccine protection and accounted for 86.3% ( P = 0.038) of the VE change in a vaccine platform-based mixed-effects model and 87.9% ( P = 0.006) in a manufacturer-based model. (nature.com)
In particular, we will develop protein-folding reporters to assess and enhance heterologous enzyme stability in non-model hosts. (aiche.org)
Ang II-induced HTN could be prevented in this model by selective genetic supplementation of the ER chaperone 78-kDa glucose-regulated protein (GRP78) in the SFO. (jci.org)
DAPG was the most effective phloroglucinol derivative for reducing Aß levels, without being toxic, in various models including HEK293 cells overexpressing Swedish mutant amyloid precursor protein (APP) (293sw), primary astrocytes isolated from APPsw/PS1dE9 transgenic mice, and after intrahippocampal injection of DAPG in APPsw/PS1dE9 transgenic mice. (bvsalud.org)
In the largest-ever examination of genetic, environmental, lifestyle, and medical drivers of inflammation in major depressive disorder (MDD), levels of the key inflammation marker C-reactive protein (CRP) were higher in patients with depression than in those with no mental disorder. (medscape.com)

In a nearby building, tens of thousands of mice scurry in cages, each labeled with their specific genetic strain. (concord.org)
However, the resulting targeted G1 mice are of a mixed 129 x C57BL/6 genetic background. (umassmed.edu)
However, a disadvantage of this combination is that a slightly mixed C57BL/6 genetic background (C57BL/6N x C57BL/6J) is produced when breeding the resulting chimeras with C57BL/6J Tyrc-Brd albino mice to test for germline transmission in the G1 generation. (umassmed.edu)
However, the investigators found that mice that differed genetically reacted differently to infection-for example, two bacterial strains that caused robust bladder infection in one mouse model were much less effective in a second mouse model. (nih.gov)
Our study shows potential for the use of mouse models in studying the biological bases of typical and atypical brain asymmetry but also warrants caution as asymmetry patterns seem to differ between humans and mice. (mpi.nl)
However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)

used Tellurium/libroadrunner to investigate the use of genetic algorithms with rank selection optimization. (wikipedia.org)
A challenge for crop simulation modeling is to incorporate existing and rapidly emerging genomic information into models to develop new and improved algorithms. (usda.gov)

However, as a black-box model, the drastic advances in the performance come at the cost of model interpretability. (bham.ac.uk)
Furthermore, we built a secondary model based on SHAP (SHapley Additive exPlanations) that offers crucial insight into model interpretability. (lu.se)

In order to further understand why depressive symptoms are associated with negative goal appraisals, the present study examined the genetic and environmental correlations and interactions between depressive symptoms and career-related goal appraisals. (cambridge.org)
To shed light on the underlying factors, this study investigated possible genetic and environmental factors that are common to negative career-goal appraisals and depressive symptoms among young adults. (cambridge.org)
All this results in a negative feedback loop in which inflammation makes the body believe it is under threat, produces a more robust immune response, and perpetuates or exacerbates depressive symptoms. (medscape.com)

Faced with myriad possibilities, modeling points researchers to designs that offer real opportunity. (northwestern.edu)

Further, we explored whether the relative contribution of genetic and environmental effects in career-goal appraisals differ as a function of depression. (cambridge.org)

Since in most cases there is no evidence suggesting that the additive risk model is most appropriate for the underlying disease model, especially in the typical GWASs where we most likely evaluate only the tagging SNPs, but not the causal SNPs directly. (biomedcentral.com)
Facilitated by these two procedures, we evaluate the performances of the two robust test based joint analyses, in comparison with the ones based on AFDT, under various two-stage design setups and disease models. (biomedcentral.com)
To evaluate current risk models and scores for type 2 diabetes and inform selection and implementation of these in practice. (nih.gov)
Scientists developed a microsimulation model to evaluate the effectiveness of pharmacogenomic testing for adult patients in British Columbia, Canada, with newly diagnosed moderate to severe major depressive disorder (MDD). (medscape.com)
Ghanbarian and colleagues developed a microsimulation model in collaboration with patient partners, clinicians, and the health system to evaluate the effectiveness and cost-effectiveness of pharmacogenomic testing for adult patients with MDD in British Columbia. (medscape.com)

Inclusion criteria Papers in any language describing the development or external validation, or both, of models and scores to predict the risk of an adult developing type 2 diabetes. (nih.gov)
This allows us to predict the location of origin of a genetic sample by comparing it to a set of samples of known geographic origin. (elifesciences.org)

Existing methods for estimating sample location that explicitly model continuous landscapes use a two-step procedure. (elifesciences.org)

These transcription-PCR (RT-PCR) of FMDV serotype O vi- techniques have helped define genetic relationships between ruses: O-1C244F/EUR-2B52R, O-1C272F/EUR-2B52R, FMDV isolates and geographic distribution of lineages and and O-1C283F/EUR-2B52R. (cdc.gov)
and the Lake Tanganyika Haplochromini and closely related riverine lineages received genetic material from Cyphotilapiini. (unboundmedicine.com)
We then applied the multispecies coalescent model to estimate the species tree of Lake Tanganyika cichlids, but excluded the lineages involved in these introgression events, as the multispecies coalescent model does not incorporate introgression. (unboundmedicine.com)

Now he and his team have developed a design-driven process that uses parts from a very different kind of toolkit to build complex genetic circuits for cellular engineering. (northwestern.edu)
This is known as a complex genetic disorder. (brookes.ac.uk)

The lab consists of molecular tools that can be used for genetic modification of neurons. (lu.se)

Recent advances in the speed and efficiency of genetic sequencing technologies mean that clinicians will very soon be able to quickly and cheaply obtain the full genomic sequence and transcriptome of their patients. (cambridge.org)

Genetic and pharmacological interventions have successfully extended healthspan and lifespan in animals, but their genetic interventions are not appropriate options for human applications and pharmacological intervention needs more solid clinical evidence. (mdpi.com)
Genetic markers added nothing to models over clinical and sociodemographic factors. (nih.gov)
CPTR's combination development model established the gold standard for TB drug development programs and clinical trials. (c-path.org)
These advances have been made possible in part by the development of clinical pharmacology models to support such innovative research. (c-path.org)

Precision, stratified or personalized medicine denotes emerging medical models that use molecular diagnostics, genetic sequencing, cellular analysis and pharmacogenomics to tailor individual healthcare treatment and prevention. (cambridge.org)

We modeled the development of embryonic tissues from hPSCs and delineated the ontogeny of hematopoietic cells by mitochondrial variant lineage tracing. (biorxiv.org)

Single cell experiments [ 11 ] could provide iterative validation of models with experimental results. (lu.se)
Systematic controlled experiments show that although accurate models tend to recover the underlying motifs better, the motif identifiability (a measure of the similarity between true motifs and learnt motifs) still varies in a large range. (bham.ac.uk)

Dengue vaccine is not available, and its development is hindered by the lack of suitable animal models and the requirement for a robust tetravalent vaccine that covers all four serotypes of dengue. (who.int)

These rapid declines also led to a strong shift in the genetic structure of rats before and after the eradication campaign. (frontiersin.org)

Multiple sclerosis and T1D have distinct target organs, genetic risk factors, onset ages, and female to male ratios, but target organ-specific T cells as initiators unite these diseases. (frontiersin.org)

Cutaneous phenotyping and radiological variables were combined in a multiple regression model of long-term outcome measures (abnormal neurodevelopment, seizures, requirement for neurosurgery). (medscape.com)

Model-guided design has been explored in cell types such as bacteria and yeast, but this approach is relatively new in mammalian cells," Muldoon said. (northwestern.edu)
In simulations, Locator infers sample location to within 4.1 generations of dispersal and runs at least an order of magnitude faster than a recent model-based approach. (elifesciences.org)

It is likely that we would run into problems such as this with any model, just that the constraints would change with the model as well as problems associated with genotype by environment ineractions. (usda.gov)

Finally, we will discuss the strategies for evaluating the dialogue model and conclude with future directions. (usc.edu)

MAX3 joint analysis is the most robust procedure among the considered joint analyses, and we recommend using it in a two-stage genome-wide association study. (biomedcentral.com)
In this study, we evaluated the link between genetic mismatch of circulating SARS-CoV-2 viruses and reported COVID-19 VE from population studies. (nature.com)
This study established an in vivo PINK1 / Parkin -induced photoreceptor neuron degeneration model in Drosophila with the aim of dissecting the PINK1/Parkin pathway in detail. (sdbonline.org)
This study evaluates the effects of prenatal genetic group counselling on women's anxiety, decisional conflict and levels of knowledge. (ices.on.ca)
In this paper, our objective was to use winter wheat (Triticum aestivum L.) as a case study to discuss how to better address these challenges by simulating plant height across a range of environments in Nebraska using genetic information. (usda.gov)
The study, in which dozens of genetic circuits were designed and tested, was published today (Feb. 19) in the journal Science Advances. (northwestern.edu)
The genetic circuits developed and implemented in this study are also more complex than the previous state of the art. (northwestern.edu)
In a recent study, scientists sought to determine whether there is a universal "genetic signature(s)" defining the ability of UPEC to cause disease. (nih.gov)
Then we formally study the motif identifiability problem in the context of neural network based motif discovery i.e., if we only have access to the predictive performance of a neural network, which is a black-box, how well can we recover the underlying ``true'' motifs by interpreting the learnt model). (bham.ac.uk)
In this exome-sequencing genetic association study of 17?546 men with aggressive and nonaggressive prostate cancer, an association between known genes BRCA2, ATM, and NBN with aggressive prostate cancer was found. (cdc.gov)

Thus, it is advantageous to adopt a more robust single marker test that has a relatively good performance under all possible disease models. (biomedcentral.com)

In order to use selection to genetically improve traits we need reliable estimates of genetic parameters. (nofima.no)
Here, the entity is the contaminant puff or plume, modeled as a Gaussian with three parameters: location, mass, and spread. (confex.com)

Development of libroadrunner is primarily funded through research grants from the National Institutes of Health List of systems biology modeling software Somogyi, Endre T. (wikipedia.org)
Hendrix-Genetics, a leading multi-species international breeding company, is in continuous development of resilient and top performing swine genetic lines that strive particularly well in Asia. (swineweb.com)
Traditional drug development models substituted or added one drug at a time to an existing regimen, meaning the path to a completely novel regimen would take decades. (c-path.org)

We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)

In our lab, we are trying to identify genetic factors that might play a role in these disorders. (brookes.ac.uk)
Previous studies have found that up to 42% of the lack in response stems from genetic factors that affect medication metabolism. (medscape.com)

DNA carries the genetic code of life, with different conformations associated with different biological functions. (lu.se)

Genetic manipulation of the mouse genome has been customarily performed using ES cells derived from the agouti 129-inbred strain of mouse. (umassmed.edu)
The UMass Chan Transgenic Animal Modeling Core (TAMC) also has JM8-strain ES cells for targeting, and routinely injects either JM8.F6-strain ES cells or JM8.A3-strain ES cells into albino C57BL/6J Tyrc-Brd blastocysts. (umassmed.edu)
Bacterial metabolism selected lignin model compounds (vanillin, vanillate, 4- hydroxybenzoate, p-coumarate, benzoate, and ferulate) was carried out with three of the Pseudomonas isolates and in addition with the strain Pseudomonas putida KT2440 from a Introduction culture collection. (lu.se)

Although there is strong evidence for the role of a genetic component in language disorder, we do not know which genes contribute to this disorder or how the inheritance of language problems work. (brookes.ac.uk)
Further clustering analysis identified distinct asymmetry patterns in autism spectrum disorder models, a phenomenon that is also seen in atypically developing participants. (mpi.nl)

BEACON's Greenhouse research team, led by Prof. Lihong Xu (from Tongji University, China) and Prof. Erik D Goodman, has been doing work on BEACON's international collaboration projects to model, optimize and control for the microclimate inside greenhouse with the aid of evolutionary techniques. (beacon-center.org)

Much work has been done to develop diabetes risk models and scores, but most are rarely used because they require tests not routinely available or they were developed without a specific user or clear use in mind. (nih.gov)

In accordance with the most significant results derived from prior models, we demonstrate how plasticity is differentially favored when subjected to small vs large environmental shifts, how plasticity is transiently favorable while accommodating a new environment, and how plasticity decreases during epochs where the environment remains stable (canalization). (rockefeller.edu)
Our findings demonstrate the presence of robust hemispheric asymmetry in the mouse brain, such as larger right hemispheric volumes towards the anterior pole and larger left hemispheric volumes toward the posterior pole, opposite to what has been shown in humans. (mpi.nl)

time alone had a strong significant effect for both knowledge measures, suggesting that the effects of the counselling intervention were robust. (ices.on.ca)

This resulted in a robust species tree, in which the Lamprologini were placed as sister lineage to the H-lineage (including the Eretmodini), and we identify a series of rapid splitting events at the base of the H-lineage. (unboundmedicine.com)

Here, using a genetic model of Schwann cell ablation, we find that Schwann cell loss results in transient PNS demyelination without overt axonal loss. (biorxiv.org)

Yang et al used CompuCell3D/libroadrunner to model transcript factor cooperation in mouse liver. (wikipedia.org)
In a mouse model, electrical stimulation of deep brain regions is found to ameliorate some of the features of the syndrome. (natureasia.com)
Rather than ignore the differences between the mouse models, the scientists investigated whether that could provide a clue to differences in infectivity. (nih.gov)
Mouse models have milder disease than humans. (medscape.com)

Organisms2

Diseases1

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes1

Disciplines and Occupations1

Humanities2

Information Science2

Health Care1

Variants13

Organisms5

Variation4

Additive genetic3

Computational7

Structural2

Phenotypes4

Gene12

Statistical6

Genome-wide as1

Populations3

Heritability1

Data17

Phenotype4

Mutations4

Getting genetic material1

Algorithm4

Predisposition1

Rheumatoid arthritis1

Prediction models2

Protein5

Mice6

Algorithms2

Interpretability2

Depressive symptoms3

Researchers1

Contribution1

Evaluate5

Predict2

Methods1

Lineages3

Complex genetic2

Neurons1

Genomic1

Clinical4

Molecular1

Mitochondrial1

Experiments2

Vaccine1

Rats1

Onset1

Outcome measures1

Approach2

Genotype1

Conclude1

Study10

Marker1

Parameters2

Development3

Derive1

Factors2

Biological1

Strain3

Disorder2

Collaboration1

Risk1

Demonstrate2

Intervention1

Identify1

Results1

Mouse4